For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. tuberculosis H37Rv Rv3575c (-)

annotation: TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LACI-FAMILY)
coordinates: 4017089 - 4018168
length: 359

SPTPRRRATLASLAAELKVSRTTVSNAFNRPDQLSADLRERVLATAKRLGYAGPDPVARSLRTRKAGAVG
LVMAEPLTYFFSDPAARDFVAGVAQSCEELGQGLQLVSVGSSRSLADGTAAVLGAGVDGFVVYSVGDDDP
YLQVVLQRRLPVVVVDQPKDLSGVSRVGIDDRAAMRELAGYVLGLGHRELGLLTMRLGRDRRQDLVDAER
LRSPTFDVQRERIVGVWEAMTAAGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTADILALS
AMDYLRAHGIYVPGQMTVTGFDGVPEALSRGLTTVAQPSLHKGHRAGELLLKPPRSGLPVIEVLDTELVR
GRTAGPPA*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv3575c - - 100% (359) TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LACI-FAMILY)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3606c - 0.0 100.00% (359) transcriptional regulatory protein LacI-family
M. gilvum PYR-GCK Mflv_1457 - 1e-157 77.07% (362) periplasmic binding protein/LacI transcriptional regulator
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 MAB_2023c - 5e-07 24.28% (313) LacI family transcriptional regulator
M. marinum M MMAR_5070 - 0.0 90.25% (359) PurR family transcriptional regulator
M. avium 104 MAV_0585 - 0.0 90.53% (359) transcriptional regulator, LacI family protein
M. smegmatis MC2 155 MSMEG_6044 - 1e-152 74.93% (363) ligand-binding /sugar binding domain-containing protein
M. thermoresistible (build 8) - - - - -
M. ulcerans Agy99 MUL_4146 - 0.0 89.69% (359) PurR family transcriptional regulator
M. vanbaalenii PYR-1 Mvan_5317 - 1e-159 79.06% (363) periplasmic binding protein/LacI transcriptional regulator

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1457|M.gilvum_PYR-GCK          MSRSPTPRRRATLASLAAELKVSRTTVSNAYNRPDQLSAELRERVLSTAK
Mvan_5317|M.vanbaalenii_PYR-1       MPRSPTPRRRATLASLAAELKVSRTTVSNAYNRPDQLSAELRERVLSTAE
MSMEG_6044|M.smegmatis_MC2_155      MPRSPHPPRRATLASLAAELKVSRTTISNAYNRPDQLSADLRERIFDAAK
Rv3575c|M.tuberculosis_H37Rv        --MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQLSADLRERVLATAK
Mb3606c|M.bovis_AF2122/97           --MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQLSADLRERVLATAK
MMAR_5070|M.marinum_M               --MSPTPRRRATLASLAAELKVSRSTISNAFNRPDQLSAELRERVLATAK
MUL_4146|M.ulcerans_Agy99           --MSPTPRRRATLASLAAELKVSRSTISNAFNRPDQLSVELRERVLATAK
MAV_0585|M.avium_104                --MSPTPRRRATLASLADELKVSRTTVSNAFNRPDQLSADLRERVLATAK
MAB_2023c|M.abscessus_ATCC_199      -------------------MGLSKTTVADALGGSGRVSEATREKTRLVAE
                                                       : :*::*:::* . ..::*   **:   .*:

Mflv_1457|M.gilvum_PYR-GCK          RLGYPGPDPVARSLRTRRAGAVGLVITEPLNYSFSDPAALDFVAGLAESC
Mvan_5317|M.vanbaalenii_PYR-1       RLGYPGPDPVARSLRTRRAGAVGLVITEPLNYSFSDPAALDFVAGLAESC
MSMEG_6044|M.smegmatis_MC2_155      RLGYPGPDPVARSLRTRKAGAVGLMITEPLDYSFSDPAALDFVAGLAESC
Rv3575c|M.tuberculosis_H37Rv        RLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVAGVAQSC
Mb3606c|M.bovis_AF2122/97           RLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVAGVAQSC
MMAR_5070|M.marinum_M               RMGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVTGVAQSC
MUL_4146|M.ulcerans_Agy99           RMGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVTGVAQSC
MAV_0585|M.avium_104                RLGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVTGVAQSC
MAB_2023c|M.abscessus_ATCC_199      RMGYVS-NRAARLLRRNETGALGLYIPGDVRNLS---FYMELAFGAADES
                                    *:** . : .** ** ..:**:** :.  :          ::. * *:..

Mflv_1457|M.gilvum_PYR-GCK          EAVGQGLLLVAVGPNRSVAEGSAAVLAAGVDGFVVYSASDDDPYLPAVME
Mvan_5317|M.vanbaalenii_PYR-1       EAVGQGLLLVAVGPNRSVADGSAAVLAAGVDGFVVYSASDDDPYLPAVLQ
MSMEG_6044|M.smegmatis_MC2_155      EEAGQGLLLVAVGPNRTFEEGSNSVLAAGVDGFVVYSASDDDPYLPVLQQ
Rv3575c|M.tuberculosis_H37Rv        EELGQGLQLVSVGSSRSLADGTAAVLGAGVDGFVVYSVGDDDPYLQVVLQ
Mb3606c|M.bovis_AF2122/97           EELGQGLQLVSVGSSRSLADGTAAVLGAGVDGFVVYSVGDDDPYLQVVLQ
MMAR_5070|M.marinum_M               EELGQGLLLVAVGASRSLEDGTAAVLNAGVDGFVVYSVRDDDPYLQVVLQ
MUL_4146|M.ulcerans_Agy99           EELGQGLLLVAVGASRSLEDGTAAVLNAGVDGFVVYSVRDDDPYLQVVLQ
MAV_0585|M.avium_104                EALGQGLLLVAVGPSRSLDEGTAAVLSAGVDGFVVYSVCDDDPYLQAVLQ
MAB_2023c|M.abscessus_ATCC_199      AALGLDLTLIGR-----HLTGENRSRPPQVDGIIAVDPVPGDAALESLLT
                                       * .* *:.         *      . ***::. .   .*. *  :  

Mflv_1457|M.gilvum_PYR-GCK          RHLPVVVVDQPRDVPG---ASQVRIDDRAAMRSLAEHVIDLGHREIGLLT
Mvan_5317|M.vanbaalenii_PYR-1       RHLPVVVVDQPRDVAG---TSRVCIDDRAAMRRLAEHVIELGHREIGLLT
MSMEG_6044|M.smegmatis_MC2_155      RQLPMVVVDQPKDVPG---VSRISIDDRGAMRELAEYVLELGHRDIGLLT
Rv3575c|M.tuberculosis_H37Rv        RRLPVVVVDQPKDLSG---VSRVGIDDRAAMRELAGYVLGLGHRELGLLT
Mb3606c|M.bovis_AF2122/97           RRLPVVVVDQPKDLSG---VSRVGIDDRAAMRELAGYVLGLGHRELGLLT
MMAR_5070|M.marinum_M               RRLPVVVVDQPKELAG---VSRVGIDDRAAMRKIADYVLGLGHRQIGLLT
MUL_4146|M.ulcerans_Agy99           RRLPVVVVDQPKELAG---VSRVGIDDRAAMRKIADYVLSLGHRQIGLLT
MAV_0585|M.avium_104                RRLPVVVVDQPKGLTG---VSRVGIDDRAAMRELADYVLGLGHREIGLLT
MAB_2023c|M.abscessus_ATCC_199      SNVPIVTVGRILDKDVSHHAAEIEIDHYRMVTLLLDAIRAAGGKRPALAA
                                     .:*:*.*.:         .:.: **.   :  :   :   * :  .* :

Mflv_1457|M.gilvum_PYR-GCK          MRLGRDWPHG-PGPALADPERVRAPNFHVQCERIHGVYDAMTAAGLDPAS
Mvan_5317|M.vanbaalenii_PYR-1       MRLGRDRPHGGSTPVLADPERLRTPHFHVQGERIRGVYDAMTAAGLDPGS
MSMEG_6044|M.smegmatis_MC2_155      MRLGRDWPHGDPRPALADPERVLSPHFHVQRERIHGVYDAMSAAGLDPSS
Rv3575c|M.tuberculosis_H37Rv        MRLGRDRRQD-----LVDAERLRSPTFDVQRERIVGVWEAMTAAGVDPDS
Mb3606c|M.bovis_AF2122/97           MRLGRDRRQD-----LVDAERLRSPTFDVQRERIVGVWEAMTAAGVDPDS
MMAR_5070|M.marinum_M               MRLGRDRRQD-----LVDAERLKSPTFDVQRERITGVWEAMTAAGVDPES
MUL_4146|M.ulcerans_Agy99           MRLGRDRRQD-----LVDAERLKSPTFDVQRERITGVWEAMTAAGVDPES
MAV_0585|M.avium_104                MRLGRDRRQG-----LVDAERLRSPAFDVQRERITGVWEAMTAAGVDPDS
MAB_2023c|M.abscessus_ATCC_199      LDQGAD----------------SSYVFDVSR----GYQEWCAKAGVVPLA
                                    :  * *                 :  *.*.     *  :  : **: * :

Mflv_1457|M.gilvum_PYR-GCK          LTLVESYEHLPTSGGAGADIALEANPRITALMCTADVLALSAMDHLRAKG
Mvan_5317|M.vanbaalenii_PYR-1       LTVVESYEHLPSSGGAGADVALDANPRITALMCTADVLALSAMDHLRAKG
MSMEG_6044|M.smegmatis_MC2_155      LTVVESYEHLPTSGGAAAEVALEVNPRITALMCTADVLALSAMDHLRSRG
Rv3575c|M.tuberculosis_H37Rv        LTVVESYEHLPTSGGTAAKVALQANPRLTALMCTADILALSAMDYLRAHG
Mb3606c|M.bovis_AF2122/97           LTVVESYEHLPTSGGTAAKVALQANPRLTALMCTADILALSAMDYLRAHG
MMAR_5070|M.marinum_M               LTVVESYEHLPTSGGDAAKVALEANPRITALMCTADILALSAMDYLRGHG
MUL_4146|M.ulcerans_Agy99           LTVVESYEHLPTSGGDAAKVALEANPRITALMCTADILALSAMDYLRGHG
MAV_0585|M.avium_104                LTVVESYEHLPESGGAAAKVALEANPRITALMCTADILALSAMDYLRAHG
MAB_2023c|M.abscessus_ATCC_199      TRLSATPTDVELAQAIRGIVEHQG---IDALVVGAQGLAARSLPVLQSLG
                                      :  :  .:  : .  . :  :    : **:  *: **  ::  *:. *

Mflv_1457|M.gilvum_PYR-GCK          IYVPGQMTVTGFDG--VPEARQRGLTTVAQPGVEKGRRAGELLH--NPPR
Mvan_5317|M.vanbaalenii_PYR-1       IYVPGQMTVTGFDG--VPEARRRGLTTVVQPSVEKGRRAGELLH--HPPR
MSMEG_6044|M.smegmatis_MC2_155      IYVPGHMTVTGFDG--VRDALRRGLTTVKQPSMEKGRRAGHLLH--NPPG
Rv3575c|M.tuberculosis_H37Rv        IYVPGQMTVTGFDG--VPEALSRGLTTVAQPSLHKGHRAGELLL--KPPR
Mb3606c|M.bovis_AF2122/97           IYVPGQMTVTGFDG--VPEALSRGLTTVAQPSLHKGHRAGELLL--KPPR
MMAR_5070|M.marinum_M               IYVPGQMTVTGFDG--VPEAISRGLTTVSQPSLQKGRRAGELLQ--NPPR
MUL_4146|M.ulcerans_Agy99           IYVPGQMTVTGFDG--VPEAISRGLTTVSQPSLQKGRRAGELLQ--NPPR
MAV_0585|M.avium_104                VYVPGQLTVTGFDG--VPDAISRGLTTVSQSSLHKGRRAGELLL--KPAR
MAB_2023c|M.abscessus_ATCC_199      HEVGSNFHLGTLVGDPATELTNPDIHAVDLRPREFGHQAVTFLHDIIAGR
                                      * .:: :  : *  . :    .: :*     . *::*  :*    .  

Mflv_1457|M.gilvum_PYR-GCK          SGLPVVEVLDTEVIRGRTSGPPA-------
Mvan_5317|M.vanbaalenii_PYR-1       SGLPVIEVLDTEMVRGRTSGPPA-------
MSMEG_6044|M.smegmatis_MC2_155      SGLPVIDVLETEVVRGRTSGPPA-------
Rv3575c|M.tuberculosis_H37Rv        SGLPVIEVLDTELVRGRTAGPPA-------
Mb3606c|M.bovis_AF2122/97           SGLPVIEVLDTELVRGRTAGPPA-------
MMAR_5070|M.marinum_M               SGLPVVELLDTELIRGRTAGPPA-------
MUL_4146|M.ulcerans_Agy99           SGLPVVELLDTELIRGRTAGPPA-------
MAV_0585|M.avium_104                SGLPVVELLDTELIRGRTAGPPA-------
MAB_2023c|M.abscessus_ATCC_199      ASANDRRTHQARLKIAGVSSPPAIRRAMSD
                                    :.       ::.:  . .:.***

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv3575c	-	-	100% (359)	TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY LACI-FAMILY)