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TTTETDTGVLAGDERMLIDGELQITGSGATFDVIHPASEQVAGRATDGTVEDMARACSAARRAFDETDWS RDLDFRYHCLTQLHEALERNKERLRRILITEVGCPVSVSGSQIESPIEEVKHWAEHGRDFDYLVDNGVHD TPLGPARRKIHYEAVGVVGAITPWNVPFYLNIAETVPALMAGNTVVLKPAQLTPWSGTEYGRIVAEETDI PAGVFNVVVSNANEVGAALSADPRVDMITFTGSTATGRAILAAGAPTVKKTLLELGGKSAHIVLDDADFN AALPLAAMMACVMSGQSCILPSRILLPRSRYDEGIEILKTMMEGFPVGDPWTPGNMQGPQISEAQRQKVL GLIKSGIDSGARLVTGGGIPENLPVGYYTQPTLLADVDPDSQVAQEEIFGPVLTVTPYDTDDDAIAIANN TIYGLSGEVSSADVDRAFAVACRMRTGNVTINGKSHFGIGSPFGGTKQSGLGYRNGEEGYKEYLEAKTIG MPDQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2226 | - | - | 100% (495) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5157 | - | e-132 | 49.69% (479) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0904 | - | e-132 | 51.98% (481) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 1e-128 | 49.38% (480) | aldehyde dehydrogenase NAD dependant AldA |
| M. gilvum PYR-GCK | Mflv_4119 | - | 0.0 | 93.54% (495) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0768 | aldA | 1e-128 | 49.38% (480) | aldehyde dehydrogenase NAD dependent AldA |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 8e-51 | 30.02% (463) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1218 | - | 1e-122 | 46.58% (483) | aldehyde dehydrogenase AldA |
| M. marinum M | MMAR_4928 | aldA | 1e-122 | 47.29% (480) | NAD-dependent aldehyde dehydrogenase, AldA |
| M. avium 104 | MAV_1275 | - | 1e-125 | 48.26% (489) | aldehyde dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_2552 | - | 0.0 | 92.51% (494) | aldehyde dehydrogenase (NAD) family protein |
| M. thermoresistible (build 8) | TH_3081 | - | 0.0 | 86.46% (495) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_0477 | aldA | 1e-122 | 47.29% (480) | NAD-dependent aldehyde dehydrogenase, AldA |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2226|M.vanbaalenii_PYR-1 ----MTTTETDTGVLAGDERMLIDGELQITGSGATFDVIHPASEQVAGRA
Mflv_4119|M.gilvum_PYR-GCK MLSPMTTAETETGVLAGDERMLIDGELQNTGSGATFDVIHPASEQVAGVA
MSMEG_2552|M.smegmatis_MC2_155 ----MTSVQDETGVLAGDERMLIDGELQTTGSGSTFDVIHPATEQVAGQA
TH_3081|M.thermoresistible__bu ----MTSVQDETGVLAGDERMLIDGELQYTSSGAKFDVIHPANEEVAGQA
MMAR_4928|M.marinum_M ----------MALLADGVSSLFIDGKRCEGAAG-TFATVNPATEETLGVA
MUL_0477|M.ulcerans_Agy99 ----------MALLADGVSSLFIDGKRCEGAAG-TFATVNPATEETLGVA
Mb0791|M.bovis_AF2122/97 ----------MALWGDGISALLIDGKLSDGRAG-TFPTVNPATEEVLGVA
Rv0768|M.tuberculosis_H37Rv ----------MALWGDGISALLIDGKLSDGRAG-TFPTVNPATEEVLGVA
MAB_1218|M.abscessus_ATCC_1997 ----------MTVLSDGDSELFIDGKLLPGGAG-RFPTVNPATEEVLGTA
MAV_1275|M.avium_104 --------------------MMIDGKLVDGQAG-TFTNINPATEEPLGEV
MLBr_02573|M.leprae_Br4923 ---------------------------------MSIATINPATGETVKTF
: ::**. :
Mvan_2226|M.vanbaalenii_PYR-1 TDGTVEDMARACSAARRAFDETDWSRDLDFRYHCLTQLHEALERNKERLR
Mflv_4119|M.gilvum_PYR-GCK TDGTVDDMSRAVGAARRAFDTTDWSRDLDFRYHCITQLHEALERNKERLR
MSMEG_2552|M.smegmatis_MC2_155 TDGTVEDMSRAVAAARRAFDQTDWSRDLDFRYHCLTQLHEALERNKERLR
TH_3081|M.thermoresistible__bu TDGTVADMERAVAAARRAFDTTDWSRDVEFRHHCLIQLAEALEAEKERLR
MMAR_4928|M.marinum_M ADADAGDMDRAIEAARRAFDDTDWSRNTELRVRCVRQLRDAMREHIEELR
MUL_0477|M.ulcerans_Agy99 ADAVAGDMDRAIEAARRAFDDTDWSRNTELRVRCVRQLRDAMREHIEELR
Mb0791|M.bovis_AF2122/97 ADADAEDMGRAIEAARRAFDSTDWSRNTELRVRCVRQLRDAMQQHVEELR
Rv0768|M.tuberculosis_H37Rv ADADAEDMGRAIEAARRAFDSTDWSRNTELRVRCVRQLRDAMQQHVEELR
MAB_1218|M.abscessus_ATCC_1997 ADADSDDMSDAIEAARRAFDDSGWSRDVALRVHCIRQLRDGMKTHIEELR
MAV_1275|M.avium_104 ADASKEDMHRAIDAARRAFDETDWSTNRELRKRCLLQLHEAIESEKEELR
MLBr_02573|M.leprae_Br4923 TPTTQDEVEDAIARAYARFDN-YRHTTFTQRAKWANATADLLEAEANQSA
: :: * * ** * : : :. . :.
Mvan_2226|M.vanbaalenii_PYR-1 RILITEVGCP-VSVSGSQIESPIEE-VKHWAEHGRDFDYLVDNG--VHDT
Mflv_4119|M.gilvum_PYR-GCK RVLITEVGCP-VSVTGSQIESPIEE-VKHWAEHGRNFDYLVDNG--VHDT
MSMEG_2552|M.smegmatis_MC2_155 RILITEVGCP-VTVSGSQIESPIEE-VRHWAEHGRNFDYLVDTG--VHPT
TH_3081|M.thermoresistible__bu RILVTEVGCP-VTVTGSQIDEPINE-VRHWAEHGKAFQYIVDNG--VHDT
MMAR_4928|M.marinum_M ALTISEVGAPRMLTAAAQLEGPVND-LAFSADTAESYSWKQDLG--AAAP
MUL_0477|M.ulcerans_Agy99 ALTISEVGAPRMLTAAAQLEGPVND-LAFSADTAESYSWKQDLG--AAAP
Mb0791|M.bovis_AF2122/97 ELTISEVGAPRMLTASAQLEGPVGD-LSFAADTAESYPWKQDLG--EASP
Rv0768|M.tuberculosis_H37Rv ELTISEVGAPRMLTASAQLEGPVGD-LSFAADTAESYPWKQDLG--EASP
MAB_1218|M.abscessus_ATCC_1997 ELTIAEVGAPRMLTAGAQLEGPVDD-LQFAADTAESFDWTSDLG--VASP
MAV_1275|M.avium_104 EELILEVGSPRAITFGPQLDAPLEDGLKYPARLIDEYAWETDLGDKVISL
MLBr_02573|M.leprae_Br4923 ALMTLEMGKTLQSAKDEAMKCAKGF--RYYAEKAETLLADEPAE----AA
*:* . . :. . . *
Mvan_2226|M.vanbaalenii_PYR-1 PLGPARRKIHYEAVGVVGAITPWNVPFYLNIAETVPALMAGNTVVLKPAQ
Mflv_4119|M.gilvum_PYR-GCK PLGPARRKIHYEAVGVVGAITPWNVPFYLNIAETVPALMAGNTVVLKPAQ
MSMEG_2552|M.smegmatis_MC2_155 QLGPARRKIHYEPVGVVGAITPWNVPFYLNIAETVPALMAGNTVVLKPAQ
TH_3081|M.thermoresistible__bu PLGPAHRKIVYEATGVVGAITPWNVPFYLNIAETMPALMAGNTVVLKPAQ
MMAR_4928|M.marinum_M MGIPTRRTVVREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAP
MUL_0477|M.ulcerans_Agy99 MGIPTRRTVVREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAP
Mb0791|M.bovis_AF2122/97 LGIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAP
Rv0768|M.tuberculosis_H37Rv LGIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAP
MAB_1218|M.abscessus_ATCC_1997 MGIKTRRTLAREAVGVVGAVTPWNFPHQINLAKVGPALAAGNTLVLKPAP
MAV_1275|M.avium_104 TGTLTTRKVWREPVGVVGAIVPWNFPFEVTLNKLGQALGTGNTVVLKPAP
MLBr_02573|M.leprae_Br4923 AVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHAS
: :. *** *: ***.* .: ** :**. :** *
Mvan_2226|M.vanbaalenii_PYR-1 LTPWSGTEYGRIVAEETDIPAGVFNVVVSNANEVGAALSADPRVDMITFT
Mflv_4119|M.gilvum_PYR-GCK LTPWSGSEYGRIVAEETDIPAGVFNVVVSNANEVGAALSSDPRVDMITFT
MSMEG_2552|M.smegmatis_MC2_155 LTPWSGTEYGRIVAEETDIPAGVFNVVVSNANEVGAALSADPRVDMITFT
TH_3081|M.thermoresistible__bu LTPWSGTELGRIVAEHTDIPPGVFNVVVSNANEVGAALTADPRVDMITFT
MMAR_4928|M.marinum_M DTPWCAAVLGELIADCTDIPPGVVNIVTSSEHGLGALLAKDPRVDMVSFT
MUL_0477|M.ulcerans_Agy99 DTPWCAAVLGELIADCTDIPPGVVNIVTSSEHGLGALLAKDPRVDMVSFT
Mb0791|M.bovis_AF2122/97 DTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFT
Rv0768|M.tuberculosis_H37Rv DTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFT
MAB_1218|M.abscessus_ATCC_1997 DTPWCAAVLGRIIAEHTDFPPGVVNIVTSSDHRIGAQLSTDPRVDMVSFT
MAV_1275|M.avium_104 NTPFNATRLGRLIAEKTDIPAGVVNVVTASDHFVGEELTLSPKVDLISFT
MLBr_02573|M.leprae_Br4923 NVPQCALYLADVIARG-GFPEDCFQTLLISANGVEAILR-DPRVAAATLT
.* . . ::. .:* . .: : . : : * .*:* ::*
Mvan_2226|M.vanbaalenii_PYR-1 GSTATGRAILAAGAPTVKKTLLELGGKSAHIVLDD---ADFNAALPLAAM
Mflv_4119|M.gilvum_PYR-GCK GSTATGRAILAAGASTVKKTLLELGGKSAHIVLDD---ADFNSALSMAAM
MSMEG_2552|M.smegmatis_MC2_155 GSTATGRAILAAGAPTVKKTLLELGGKSAHIVLDD---ADFNSALSMAAM
TH_3081|M.thermoresistible__bu GSTATGRAILAAAAPTVKKTMLELGGKSAHIVLDD---ADLNASLPLAAM
MMAR_4928|M.marinum_M GSTATGRSVMADGAATIKRMFLELGGKSAFIVLDD---ADLAAASSVSAF
MUL_0477|M.ulcerans_Agy99 GSTATGRSVMADGAATIKRMFLELGGKSAFIVLDD---ADLAAASSVSAF
Mb0791|M.bovis_AF2122/97 GSTATGRAVMADAAATIKKVFLELGGKSAFVVLDD---ADLAAASAVSAF
Rv0768|M.tuberculosis_H37Rv GSTATGRAVMADAAATIKKVFLELGGKSAFVVLDD---ADLAAASAVSAF
MAB_1218|M.abscessus_ATCC_1997 GSTATGRAVMTDAAATVKKVFLELGGKSAFIVLDDLDEAALGSACSVAAF
MAV_1275|M.avium_104 GSTVVGQRIMEKGAATMKRLFLELGGKSATIVLED---ADFGMACAIG-I
MLBr_02573|M.leprae_Br4923 GSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPS---ADLDAAVATAVT
** .*: : .. :* .*****... :*: . * : : . .
Mvan_2226|M.vanbaalenii_PYR-1 MACVMSGQSCILPSRILLPRSRYDEGIEILKTMMEGFPVGDPWTPGNMQG
Mflv_4119|M.gilvum_PYR-GCK MACVMSGQSCILPSRILLPRSRYDEGIEILKNMMENFPVGDPWTPGIMQG
MSMEG_2552|M.smegmatis_MC2_155 MACVMSGQSCILPSRILLPRSRYDEGIEILKNMMENFPVGDPWTPGVMQG
TH_3081|M.thermoresistible__bu MACVMSGQSCILPSRILLPRSRYDEGLEILKGAMANFPMGDPWTPGNMQG
MMAR_4928|M.marinum_M TASMHAGQGCAITTRLVVPRARYDEAVAIAAGTMSSIKPGDPDDARTVCG
MUL_0477|M.ulcerans_Agy99 TASMHAGQGCAITTRLVVPRARYDEAVAIAAGTMSSIKPGDPDDARTVCG
Mb0791|M.bovis_AF2122/97 SACMHAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCG
Rv0768|M.tuberculosis_H37Rv SACMHAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCG
MAB_1218|M.abscessus_ATCC_1997 TAAMHAGQGCAITTRLVVPRERYDDAVAAAAATMGSLKPGDPAKPGTICG
MAV_1275|M.avium_104 APCMHAGQGCANPTRMLLPRSRYDEGVAILKGIYENVTCGDPQDPGTLCG
MLBr_02573|M.leprae_Br4923 GRVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVG
**.* ..*:: *:: : . *** . *
Mvan_2226|M.vanbaalenii_PYR-1 PQISEAQRQKVLGLIKSGIDSGARLVTGG-GIPENLPVGYYTQPTLLADV
Mflv_4119|M.gilvum_PYR-GCK PQISDTQRQKVLGLIKSGIDSGARLVTGG-GIPENLPVGYYTQPTLLADV
MSMEG_2552|M.smegmatis_MC2_155 PQISETQRQKVLGLIRSGIDSGARLVTGG-GVPENLPVGYYTQATLLADV
TH_3081|M.thermoresistible__bu PQISEAQRQKVLGLIKSGLDSGARLVLGG-GIPENLPVGYYTQPTLLADV
MMAR_4928|M.marinum_M PLISQRQRDRVQGYLDLAIAEGGTFACGG-GRPAGRQVGYFIEPTVIAGL
MUL_0477|M.ulcerans_Agy99 PLISQRQRDRVEGYLDLAIAEGGTFACGG-GRPAGRQVGYFIEPTVIAGL
Mb0791|M.bovis_AF2122/97 PLISARQRDRVQGYLDLAVAEGGRFACGG-ARPADREVGFYIEPTVIAGL
Rv0768|M.tuberculosis_H37Rv PLISARQRDRVQGYLDLAVAEGGRFACGG-ARPADREVGFYIEPTVIAGL
MAB_1218|M.abscessus_ATCC_1997 PVISARQRDRVQSYLDLAVAEGGSFACGG-GRPEGKDRGFFIEPTVVAGL
MAV_1275|M.avium_104 PVISQVQRDRVMGYIRKGVEEGATALVGGPDAPTGFDKGYYVRPTLFTDV
MLBr_02573|M.leprae_Br4923 PLATESGRAQVEQQVDAAAAAGAVIRCGG---KRPDRPGWFYPPTVITDI
* : * :* : . *. ** *:: .*:.:.:
Mvan_2226|M.vanbaalenii_PYR-1 DPDSQVAQEEIFGPVLTVTPYDTDDDAIAIANNTIYGLSGEVSSADVDRA
Mflv_4119|M.gilvum_PYR-GCK DPDSQVAQEEIFGPVLTVTPYDTDDDAVAIANNSIYGLSGEVSGGDLERA
MSMEG_2552|M.smegmatis_MC2_155 DPDSQVAQEEIFGPVLTVTPYDTDDDAVAIANNTIYGLSGEVSGGDLDRA
TH_3081|M.thermoresistible__bu DPNSQVAQEEIFGPVLTVTPYDTEDEAIEIANNTIYGLSGEVSSADVDRA
MMAR_4928|M.marinum_M TNDARPAREEIFGPVLTVLAHDGDDDAVRIANDSPYGLSGTVYGGDPQRA
MUL_0477|M.ulcerans_Agy99 TTDARPAREEIFGPVLTVLAHDGDDDAVRIANDSPYGLSGTVYGGDPQRA
Mb0791|M.bovis_AF2122/97 TNDARVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRA
Rv0768|M.tuberculosis_H37Rv TNDARVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRA
MAB_1218|M.abscessus_ATCC_1997 TNAARVAREEIFGPVLVVIAHDGDEDAVRIANDSPYGLSGTVFGDDDERS
MAV_1275|M.avium_104 DNSMTIAQEEIFGPVLCVIPFDDEEDAIRIANDSRYGLAGNVMSGSLERS
MLBr_02573|M.leprae_Br4923 TKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQ
:*:**** * ::*: *** : :**.. . . ..
Mvan_2226|M.vanbaalenii_PYR-1 FAVACRMRTGNVTINGKSHFGIGSPFGGTKQSGLGYRNGEEGYKEYLEAK
Mflv_4119|M.gilvum_PYR-GCK FAVATRMRTGNVTINGKSHFGIGSPFGGTKQSGLGYRNGEEGYKEYLDAK
MSMEG_2552|M.smegmatis_MC2_155 FAIACRMRTGNVTINGKSHFGITSPFGGTKQSGLGYRNGEEGYKEYLEAK
TH_3081|M.thermoresistible__bu FRVAQRMRTGNVTINGRSHFGINSPFGGTKQSGLGRRNGEEGFKEYLESK
MMAR_4928|M.marinum_M ADVAARLRVGTVNVNGGVWYCADAPFGGYKQSGIGREMGLAGFEEYLETK
MUL_0477|M.ulcerans_Agy99 ADVAARLRVGAVNVNGGVWYCADAPFGGYKQSGIGREMGLAGFEEYLETK
Mb0791|M.bovis_AF2122/97 ARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGIGREMGLLGFEEYLEAK
Rv0768|M.tuberculosis_H37Rv ARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGIGREMGLLGFEEYLEAK
MAB_1218|M.abscessus_ATCC_1997 ARVASRLRVGTVNVNGGVWYSADAPFGGYKQSGNGREMGVAGFEEYLETK
MAV_1275|M.avium_104 LSVARRIRAGFMGVNGGAPYGADTPFGGYKYSGVGRQNGVAGFDQYTEIK
MLBr_02573|M.leprae_Br4923 RHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIK
. .: .* : :** **** * ** * . . * :: : *
Mvan_2226|M.vanbaalenii_PYR-1 TIGMPDQ-
Mflv_4119|M.gilvum_PYR-GCK TIGMPDQ-
MSMEG_2552|M.smegmatis_MC2_155 TIGMPE--
TH_3081|M.thermoresistible__bu TVGMPPQE
MMAR_4928|M.marinum_M LIATAAN-
MUL_0477|M.ulcerans_Agy99 LIATAAN-
Mb0791|M.bovis_AF2122/97 LIATAAN-
Rv0768|M.tuberculosis_H37Rv LIATAAN-
MAB_1218|M.abscessus_ATCC_1997 VIATAVK-
MAV_1275|M.avium_104 SVAYPAG-
MLBr_02573|M.leprae_Br4923 TVWIA---
: .