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MTGLLINGAVRDSAGARTFPNINPATEQSIGSAPDADLSDLDAAVAAARRAFDDTDWSRDHDFRAHCLRQ LHEGLCAEQERLRDVLVMEAGVPVALTHSIWLDTILDSVLYWADLATSYPYEVQLTARQTLAAVTSTRTV VREPVGVVAAITPWNYPLPLNIFKVAAALAAGCTVVLKPAPDTPWSGTELGRIILERTDIPAGVVNVVTA ADPLIGAALVADPRIDMVTFTGSTEVGKRIMAAAADNVTRVCLELGGKSANIVLDDADLPALAADIAGVC AHAGQGCALTTRLLLPRHRYDEGIAVARAAFEQLRCGDPTDPAVVVGPVINARQRDRILRMIDVGKQEAR LLVGGGTPESLPVGYYVEPTLFCDVGPDAVIAQQEIFGPVLAIIPYEDDDHAVQIANNSIYGLSAAVHSK DTDRAMGIARRLRTGTVGVNGGVWLAADTPFGGYKQSGLGRELGIDGFAEFLETKSIALPC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0904 | - | - | 100% (481) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5157 | - | e-133 | 50.73% (479) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2226 | - | e-132 | 51.98% (481) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 1e-140 | 52.92% (480) | aldehyde dehydrogenase NAD dependant AldA |
| M. gilvum PYR-GCK | Mflv_1600 | - | 1e-137 | 53.03% (479) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0768 | aldA | 1e-140 | 52.92% (480) | aldehyde dehydrogenase NAD dependent AldA |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 2e-46 | 29.35% (460) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1218 | - | 1e-134 | 52.24% (469) | aldehyde dehydrogenase AldA |
| M. marinum M | MMAR_4928 | aldA | 1e-135 | 51.56% (481) | NAD-dependent aldehyde dehydrogenase, AldA |
| M. avium 104 | MAV_1825 | - | 1e-137 | 52.08% (480) | aldehyde dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_3387 | - | 1e-139 | 53.24% (479) | aldehyde dehydrogenase (NAD) family protein |
| M. thermoresistible (build 8) | TH_3892 | - | 1e-140 | 54.15% (482) | PUTATIVE aldehyde dehydrogenase NAD dependent AldA_2 |
| M. ulcerans Agy99 | MUL_0477 | aldA | 1e-133 | 51.14% (481) | NAD-dependent aldehyde dehydrogenase, AldA |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0791|M.bovis_AF2122/97 ------------------------------MALWGDGISALLIDGKLSDG
Rv0768|M.tuberculosis_H37Rv ------------------------------MALWGDGISALLIDGKLSDG
MMAR_4928|M.marinum_M ------------------------------MALLADGVSSLFIDGKRCEG
MUL_0477|M.ulcerans_Agy99 ------------------------------MALLADGVSSLFIDGKRCEG
Mflv_1600|M.gilvum_PYR-GCK ------------------------------MAILADRDSKLLIDGKLVAG
MAB_1218|M.abscessus_ATCC_1997 ------------------------------MTVLSDGDSELFIDGKLLPG
Mvan_0904|M.vanbaalenii_PYR-1 -------------------------------------MTGLLINGAVRDS
MSMEG_3387|M.smegmatis_MC2_155 MTTSFDLIELKRVLGGLWGAQDPTDSTMAALKRGVHGEEAMLIAGELVTA
MAV_1825|M.avium_104 ----------------------MTASSVAATTVQFNPESRLYIAGRLRDS
TH_3892|M.thermoresistible__bu ----------------------------------------MMIDGKLVEG
MLBr_02573|M.leprae_Br4923 --------------------------------------------------
Mb0791|M.bovis_AF2122/97 RAG-TFPTVNPATEEVLGVAADADAEDMGRAIEAARRAFDSTDWSRNTEL
Rv0768|M.tuberculosis_H37Rv RAG-TFPTVNPATEEVLGVAADADAEDMGRAIEAARRAFDSTDWSRNTEL
MMAR_4928|M.marinum_M AAG-TFATVNPATEETLGVAADADAGDMDRAIEAARRAFDDTDWSRNTEL
MUL_0477|M.ulcerans_Agy99 AAG-TFATVNPATEETLGVAADAVAGDMDRAIEAARRAFDDTDWSRNTEL
Mflv_1600|M.gilvum_PYR-GCK SAG-TFPTVNPATEETLGVAADAGADDMDAAIGAARRAFDETGWSTDTAL
MAB_1218|M.abscessus_ATCC_1997 GAG-RFPTVNPATEEVLGTAADADSDDMSDAIEAARRAFDDSGWSRDVAL
Mvan_0904|M.vanbaalenii_PYR-1 AGARTFPNINPATEQSIGSAPDADLSDLDAAVAAARRAFDDTDWSRDHDF
MSMEG_3387|M.smegmatis_MC2_155 SHGKTFDNVNPATGQVIGAVADAGAADVDRAIDAARRAFDESSWPHDAEF
MAV_1825|M.avium_104 STGKVAENINPATEEVLGTCADAGAEDMDEAIAAARRAFDTTDWSTNREF
TH_3892|M.thermoresistible__bu SAGTFTT-INPATEEPLGEVADASVADMHRAIDAARRAFDETDWSTNHAF
MLBr_02573|M.leprae_Br4923 ---MSIATINPATGETVKTFTPTTQDEVEDAIARAYARFDN---YRHTTF
:**** : : . : :: *: * ** . :
Mb0791|M.bovis_AF2122/97 RVRCVRQLRDAMQQHVEELRELTISEVGAPRMLTASAQLEGPVGDLSFA-
Rv0768|M.tuberculosis_H37Rv RVRCVRQLRDAMQQHVEELRELTISEVGAPRMLTASAQLEGPVGDLSFA-
MMAR_4928|M.marinum_M RVRCVRQLRDAMREHIEELRALTISEVGAPRMLTAAAQLEGPVNDLAFS-
MUL_0477|M.ulcerans_Agy99 RVRCVRQLRDAMREHIEELRALTISEVGAPRMLTAAAQLEGPVNDLAFS-
Mflv_1600|M.gilvum_PYR-GCK RVRCIRQLQNAMRAHVEELRELTIAEVGAPRMLTAAAQLEGPVDDLSFC-
MAB_1218|M.abscessus_ATCC_1997 RVHCIRQLRDGMKTHIEELRELTIAEVGAPRMLTAGAQLEGPVDDLQFA-
Mvan_0904|M.vanbaalenii_PYR-1 RAHCLRQLHEGLCAEQERLRDVLVMEAGVPVALTHSIWLDTILDSVLYW-
MSMEG_3387|M.smegmatis_MC2_155 RRHCLLQLHKAMAESADQFRATAVAEIGVAVRTTNTFHSDWPISSIPYW-
MAV_1825|M.avium_104 RQHCLLQLHEALQEEKEDARAELIAEAGAPVGMTYIAQLDWPLADAVRWP
TH_3892|M.thermoresistible__bu RQRCLLQLQEALETEQEELREELILEVGCPRSITHGPQLDAPLSDALRYP
MLBr_02573|M.leprae_Br4923 TQRAKWANATADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRYY
:. . : : : .
Mb0791|M.bovis_AF2122/97 ADTAESYPWKQDLG--EASPLGIATRRTLAREAVGVVGAITPWNFPHQIN
Rv0768|M.tuberculosis_H37Rv ADTAESYPWKQDLG--EASPLGIATRRTLAREAVGVVGAITPWNFPHQIN
MMAR_4928|M.marinum_M ADTAESYSWKQDLG--AAAPMGIPTRRTVVREAVGVVGAITPWNFPHQIN
MUL_0477|M.ulcerans_Agy99 ADTAESYSWKQDLG--AAAPMGIPTRRTVVREAVGVVGAITPWNFPHQIN
Mflv_1600|M.gilvum_PYR-GCK ADTAESYRWSTDLG--IASPMGIKTRRTVTREAIGVVGAITPWNFPHQIN
MAB_1218|M.abscessus_ATCC_1997 ADTAESFDWTSDLG--VASPMGIKTRRTLAREAVGVVGAVTPWNFPHQIN
Mvan_0904|M.vanbaalenii_PYR-1 ADLATSYPYEVQLTARQTLAAVTSTRTVVR-EPVGVVAAITPWNYPLPLN
MSMEG_3387|M.smegmatis_MC2_155 ADMATNFEYEHTMPDRP---WASGTRHVIRQEPIGVVAAITPWNFPLQTA
MAV_1825|M.avium_104 AQYISEFAWERQL--DVDAKMGEPYNRVVVKEPMGVVGAITPWNFPVEII
TH_3892|M.thermoresistible__bu AELIDEYSWETALGDAMVSVTGMNTTRRVWREPAGVVGAIVPWNFPFEVS
MLBr_02573|M.leprae_Br4923 AEKAETLLADEPAE----AAAVGASKALARYQPLGVVLAVMPWNFPLWQT
*: :. *** *: ***:*
Mb0791|M.bovis_AF2122/97 LAKLGPALAAGNTVVLKPAPDTPWCAAALGEIIVEHTDFPPGVVNIVTSS
Rv0768|M.tuberculosis_H37Rv LAKLGPALAAGNTVVLKPAPDTPWCAAALGEIIVEHTDFPPGVVNIVTSS
MMAR_4928|M.marinum_M LAKLGPALAAGNTVVLKPAPDTPWCAAVLGELIADCTDIPPGVVNIVTSS
MUL_0477|M.ulcerans_Agy99 LAKLGPALAAGNTVVLKPAPDTPWCAAVLGELIADCTDIPPGVVNIVTSS
Mflv_1600|M.gilvum_PYR-GCK LAKVGPALAAGNTLVLKPAPDTPWAAAVLGELITEHTDFPAGVINIVTSS
MAB_1218|M.abscessus_ATCC_1997 LAKVGPALAAGNTLVLKPAPDTPWCAAVLGRIIAEHTDFPPGVVNIVTSS
Mvan_0904|M.vanbaalenii_PYR-1 IFKVAAALAAGCTVVLKPAPDTPWSGTELGRIILERTDIPAGVVNVVTAA
MSMEG_3387|M.smegmatis_MC2_155 MTKILPALAAGATVVLKPAFQTPWHATLLARLIAEKTDIPAGVINVVTPS
MAV_1825|M.avium_104 ANKVGQILATGNTMVLKPAIETPWSALRWGRIIAEKTDIPAGVVNIVPAS
TH_3892|M.thermoresistible__bu IQKIGQALGTGCTVVLKPAPDTPFNATRLGRLIAERTDIPPGVVNVVTAS
MLBr_02573|M.leprae_Br4923 VRFAAPALMAGNVGLLKHASNVPQCALYLADVIARG-GFPEDCFQTLLIS
* :* . :** * :.* . . :* .:* . .: : :
Mb0791|M.bovis_AF2122/97 SHALGALLAKDPRVDMISFTGSTATGRAVMADAAATIKKVFLELGGKSAF
Rv0768|M.tuberculosis_H37Rv SHALGALLAKDPRVDMISFTGSTATGRAVMADAAATIKKVFLELGGKSAF
MMAR_4928|M.marinum_M EHGLGALLAKDPRVDMVSFTGSTATGRSVMADGAATIKRMFLELGGKSAF
MUL_0477|M.ulcerans_Agy99 EHGLGALLAKDPRVDMVSFTGSTATGRSVMADGAATIKRMFLELGGKSAF
Mflv_1600|M.gilvum_PYR-GCK DHGVGALLSKDPRVDMVSFTGSTNTGRAVMADGAATLTKVFLELGGKSAF
MAB_1218|M.abscessus_ATCC_1997 DHRIGAQLSTDPRVDMVSFTGSTATGRAVMTDAAATVKKVFLELGGKSAF
Mvan_0904|M.vanbaalenii_PYR-1 DPLIGAALVADPRIDMVTFTGSTEVGKRIMAAAADNVTRVCLELGGKSAN
MSMEG_3387|M.smegmatis_MC2_155 DNAVAERLAVDPRVDLVHFTGSTAVGKKLMADASGRVARVALELGGKSAN
MAV_1825|M.avium_104 DNDVAQRLVTDPRVDMVSFTGSTAVGKLIQRLSADMMKRNLLELGGKSVY
TH_3892|M.thermoresistible__bu DHLIGEELTLSPKVDLISFTGSTAVGKRIMAKGAATMKRLFLELGGKSAT
MLBr_02573|M.leprae_Br4923 ANGVEAILR-DPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPF
: * .*:: :*** .*: : .. : *****..
Mb0791|M.bovis_AF2122/97 VVLDDADLAA---ASAVSAFSACMHAGQGCAITTRLVVPRARYEEAVAIA
Rv0768|M.tuberculosis_H37Rv VVLDDADLAA---ASAVSAFSACMHAGQGCAITTRLVVPRARYEEAVAIA
MMAR_4928|M.marinum_M IVLDDADLAA---ASSVSAFTASMHAGQGCAITTRLVVPRARYDEAVAIA
MUL_0477|M.ulcerans_Agy99 IVLDDADLAA---ASSVSAFTASMHAGQGCAITTRLVVPRARYDEAVAIA
Mflv_1600|M.gilvum_PYR-GCK LVLDDADLAG---ACSMAAFTASMHAGQGCAITTRLLVPRARYDEAVEAA
MAB_1218|M.abscessus_ATCC_1997 IVLDDLDEAALGSACSVAAFTAAMHAGQGCAITTRLVVPRERYDDAVAAA
Mvan_0904|M.vanbaalenii_PYR-1 IVLDDADLPA---LAADIAG-VCAHAGQGCALTTRLLLPRHRYDEGIAVA
MSMEG_3387|M.smegmatis_MC2_155 ILLEDADFTQ---IVPQAAGVVCMNAGQGCVLPTRLLVPRSRYDEARELA
MAV_1825|M.avium_104 LLLDDADLAT---TVPGCIG-ALMHSGQGCALTTRMLVPRERYDEAVELA
TH_3892|M.thermoresistible__bu IVLEDADFAL---GCMMGIA-PCMHAGQGCANPTRLLLPRSRYDEGIEIL
MLBr_02573|M.leprae_Br4923 IVMPSADLDA---AVATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKF
::: . * : **.* ..*:: *::
Mb0791|M.bovis_AF2122/97 AATMSSIRPGDPNDPGTVCGPLISARQRDRVQGYLDLAVAEGGRFACGG-
Rv0768|M.tuberculosis_H37Rv AATMSSIRPGDPNDPGTVCGPLISARQRDRVQGYLDLAVAEGGRFACGG-
MMAR_4928|M.marinum_M AGTMSSIKPGDPDDARTVCGPLISQRQRDRVQGYLDLAIAEGGTFACGG-
MUL_0477|M.ulcerans_Agy99 AGTMSSIKPGDPDDARTVCGPLISQRQRDRVEGYLDLAIAEGGTFACGG-
Mflv_1600|M.gilvum_PYR-GCK AATMGGLKPGDPDKPGTICGPVISARQRDRIQSYLDSAVAEGGRFACGG-
MAB_1218|M.abscessus_ATCC_1997 AATMGSLKPGDPAKPGTICGPVISARQRDRVQSYLDLAVAEGGSFACGG-
Mvan_0904|M.vanbaalenii_PYR-1 RAAFEQLRCGDPTDPAVVVGPVINARQRDRILRMIDVGKQE-ARLLVGG-
MSMEG_3387|M.smegmatis_MC2_155 RITFEHMPFGDPTDPGTVQGPQISKVQQDRVLGLIAQGVAEGATLLTGG-
MAV_1825|M.avium_104 TATFASVTVGDPTDPANFCGPLVSAKQRDRVMDYIRIGKEEGARVTIGG-
TH_3892|M.thermoresistible__bu RGIYEGVAPGDPQDPATLCGPVINEKQRTRIRGYIRKGVEEGARLVVGGE
MLBr_02573|M.leprae_Br4923 VARMETLRVGDPTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGG-
: *** .. ** . : :: : . . . **
Mb0791|M.bovis_AF2122/97 ARPADREVGFYIEPTVIAGLTNDARVAREEIFGPVLTVIAHD-GDDDAVR
Rv0768|M.tuberculosis_H37Rv ARPADREVGFYIEPTVIAGLTNDARVAREEIFGPVLTVIAHD-GDDDAVR
MMAR_4928|M.marinum_M GRPAGRQVGYFIEPTVIAGLTNDARPAREEIFGPVLTVLAHD-GDDDAVR
MUL_0477|M.ulcerans_Agy99 GRPAGRQVGYFIEPTVIAGLTTDARPAREEIFGPVLTVLAHD-GDDDAVR
Mflv_1600|M.gilvum_PYR-GCK GRPADRDTGFFIEPTVIAGLDNNAKVAREEIFGPVLTVIAHD-GDDDAVR
MAB_1218|M.abscessus_ATCC_1997 GRPEGKDRGFFIEPTVVAGLTNAARVAREEIFGPVLVVIAHD-GDEDAVR
Mvan_0904|M.vanbaalenii_PYR-1 GTPESLPVGYYVEPTLFCDVGPDAVIAQQEIFGPVLAIIPYE-DDDHAVQ
MSMEG_3387|M.smegmatis_MC2_155 RIPDGFDGGFFVEPTLFADVDPHSTIAQREIFGPVLAMIPYD-NVEHAID
MAV_1825|M.avium_104 GKPEGLDSGYFVAPTVFADVTPDMRIFQEEIFGPVITITPYDGGDDGAIE
TH_3892|M.thermoresistible__bu DPPDGLDKGFFVRPTLFADVDNSMTIAQEEIFGPVLAVIPYDDEDD-AVR
MLBr_02573|M.leprae_Br4923 KRPD--RPGWFYPPTVITDITKDMALYTDEVFGPVASVYCAT-NIDDAIE
* *:: **:. .: *:**** : : *:
Mb0791|M.bovis_AF2122/97 IANDSPYGLSGTVYGADPQRAARIASRLRVGTVNVNGGVWYCADAPFGGY
Rv0768|M.tuberculosis_H37Rv IANDSPYGLSGTVYGADPQRAARIASRLRVGTVNVNGGVWYCADAPFGGY
MMAR_4928|M.marinum_M IANDSPYGLSGTVYGGDPQRAADVAARLRVGTVNVNGGVWYCADAPFGGY
MUL_0477|M.ulcerans_Agy99 IANDSPYGLSGTVYGGDPQRAADVAARLRVGAVNVNGGVWYCADAPFGGY
Mflv_1600|M.gilvum_PYR-GCK IANDSPYGLSGTVFSPDLERANGVAARLRVGTVNINGGVWYSADMPFGGY
MAB_1218|M.abscessus_ATCC_1997 IANDSPYGLSGTVFGDDDERSARVASRLRVGTVNVNGGVWYSADAPFGGY
Mvan_0904|M.vanbaalenii_PYR-1 IANNSIYGLSAAVHSKDTDRAMGIARRLRTGTVGVNGGVWLAADTPFGGY
MSMEG_3387|M.smegmatis_MC2_155 IANNTSYGLAGYVWG-DEDAAVTVARRIRSGMVAVNGGFFYGHDVPSGGY
MAV_1825|M.avium_104 MANNSMYGLAGTVLGS-KERAIAVGRRIRTGSVCVNSAIFYGADAPFGGY
TH_3892|M.thermoresistible__bu IANDTAYGLAGNVMSSSIEHALAVARRLRAGFIGINGAAGYGADTPFGGY
MLBr_02573|M.leprae_Br4923 IANATPFGLGSNAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGI
:** : :**.. . . . .: * : :*. : * **
Mb0791|M.bovis_AF2122/97 KQSGIGREMGLLGFEEYLEAKLIATAAN
Rv0768|M.tuberculosis_H37Rv KQSGIGREMGLLGFEEYLEAKLIATAAN
MMAR_4928|M.marinum_M KQSGIGREMGLAGFEEYLETKLIATAAN
MUL_0477|M.ulcerans_Agy99 KQSGIGREMGLAGFEEYLETKLIATAAN
Mflv_1600|M.gilvum_PYR-GCK KQSGIGREMGLAGFEEYLEIKAIATAVN
MAB_1218|M.abscessus_ATCC_1997 KQSGNGREMGVAGFEEYLETKVIATAVK
Mvan_0904|M.vanbaalenii_PYR-1 KQSGLGRELGIDGFAEFLETKSIALPC-
MSMEG_3387|M.smegmatis_MC2_155 KESGLGRESGVEGFQEFLETKVIAVAG-
MAV_1825|M.avium_104 KMSGIGRQNGIEGFEQHLQTKVIAYPID
TH_3892|M.thermoresistible__bu KDSGVGRQNGVAGFDQYTEIKSVAYPA-
MLBr_02573|M.leprae_Br4923 KRSGYGRELSTHGIREFCNIKTVWIA--
* ** **: . *: :. : * : .