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AILADRESRLLIDGKLVAGSSGTFTTVNPATEETLGVAADASAEDMSAAIGAARRSFDETDWATNTDLRV RCIRQLQQAMRDHVEELRELTIAEVGAPRMLTSAAQLEGPVEDLSFCADTAESYAWTTDLGIASPMGIKT HRTIAREAVGVVGAITPWNFPHQINLAKIGPALAAGNTLVLKPAPDTPWAAAVLGELIAEHTDFPAGVIN IVTSSDHGVGALLSKDPRVDMVSFTGSTNTGRAVMADGAATLKKVFLELGGKSAFLVIDDADLAGACSMA AFTASMHAGQGCAITTRLVVPRDRYDEAVEAAAATMGGLKAGDPTKPGTVCGPLISERQRERVQGYLDSA IAEGGRFACGGGRPADRDTGFFIDPTVIAGLDNNAKVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGLS GTVFSADPERAAGIAARMRVGTVNVNGGVWYSADMPFGGYKQSGIGREMGLAGFEEYLEIKAIATAAN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5157 | - | - | 100% (489) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4156 | - | e-140 | 53.14% (478) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0904 | - | e-133 | 50.73% (479) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 0.0 | 79.96% (489) | aldehyde dehydrogenase NAD dependant AldA |
| M. gilvum PYR-GCK | Mflv_1600 | - | 0.0 | 90.80% (489) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0768 | aldA | 0.0 | 79.96% (489) | aldehyde dehydrogenase NAD dependent AldA |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 4e-61 | 33.26% (466) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1218 | - | 0.0 | 77.55% (490) | aldehyde dehydrogenase AldA |
| M. marinum M | MMAR_4928 | aldA | 0.0 | 79.55% (489) | NAD-dependent aldehyde dehydrogenase, AldA |
| M. avium 104 | MAV_0713 | - | 0.0 | 82.55% (487) | aldehyde dehydrogenase (NAD) family protein |
| M. smegmatis MC2 155 | MSMEG_5859 | - | 0.0 | 82.38% (488) | aldehyde dehydrogenase (NAD) family protein |
| M. thermoresistible (build 8) | TH_2814 | - | 0.0 | 84.19% (487) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_0477 | aldA | 0.0 | 78.94% (489) | NAD-dependent aldehyde dehydrogenase, AldA |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5157|M.vanbaalenii_PYR-1 MAILADRESRLLIDGKLVAGSSGTFTTVNPATEETLGVAADASAEDMSAA
Mflv_1600|M.gilvum_PYR-GCK MAILADRDSKLLIDGKLVAGSAGTFPTVNPATEETLGVAADAGADDMDAA
MSMEG_5859|M.smegmatis_MC2_155 MPLLADRQSQLLIDGKLVAGRKGVFDTVNPATEEVLGVAADATAEDMGDA
TH_2814|M.thermoresistible__bu MSLLADRESRLLIDGKLVAGSAGAFTTINPATEDVLGVAANADADDMVRA
Mb0791|M.bovis_AF2122/97 MALWGDGISALLIDGKLSDGRAGTFPTVNPATEEVLGVAADADAEDMGRA
Rv0768|M.tuberculosis_H37Rv MALWGDGISALLIDGKLSDGRAGTFPTVNPATEEVLGVAADADAEDMGRA
MMAR_4928|M.marinum_M MALLADGVSSLFIDGKRCEGAAGTFATVNPATEETLGVAADADAGDMDRA
MUL_0477|M.ulcerans_Agy99 MALLADGVSSLFIDGKRCEGAAGTFATVNPATEETLGVAADAVAGDMDRA
MAV_0713|M.avium_104 MALLADGVSELFIDGKMSAGNAGTFPTVNPATEEVLGVAANADAADMDRA
MAB_1218|M.abscessus_ATCC_1997 MTVLSDGDSELFIDGKLLPGGAGRFPTVNPATEEVLGTAADADSDDMSDA
MLBr_02573|M.leprae_Br4923 ----------------------MSIATINPATGETVKTFTPTTQDEVEDA
: *:**** :.: . : : :: *
Mvan_5157|M.vanbaalenii_PYR-1 IGAARRSFDETDWATNTDLRVRCIRQLQQAMRDHVEELRELTIAEVGAPR
Mflv_1600|M.gilvum_PYR-GCK IGAARRAFDETGWSTDTALRVRCIRQLQNAMRAHVEELRELTIAEVGAPR
MSMEG_5859|M.smegmatis_MC2_155 IEAARRAFDDTDWSTDTELRVRCIRQLRDALREHVEELRDLTIAEVGAPR
TH_2814|M.thermoresistible__bu IDAARRAFDDTDWSTNTALRVRCLRQLQQAMRDHLEELRELTIAEVGAPR
Mb0791|M.bovis_AF2122/97 IEAARRAFDSTDWSRNTELRVRCVRQLRDAMQQHVEELRELTISEVGAPR
Rv0768|M.tuberculosis_H37Rv IEAARRAFDSTDWSRNTELRVRCVRQLRDAMQQHVEELRELTISEVGAPR
MMAR_4928|M.marinum_M IEAARRAFDDTDWSRNTELRVRCVRQLRDAMREHIEELRALTISEVGAPR
MUL_0477|M.ulcerans_Agy99 IEAARRAFDDTDWSRNTELRVRCVRQLRDAMREHIEELRALTISEVGAPR
MAV_0713|M.avium_104 IDAARRAFDETDWSRNTELRVRCVRQLRDAMREHIEELRDITIAEVGAPR
MAB_1218|M.abscessus_ATCC_1997 IEAARRAFDDSGWSRDVALRVHCIRQLRDGMKTHIEELRELTIAEVGAPR
MLBr_02573|M.leprae_Br4923 IARAYARFDN-YRHTTFTQRAKWANATADLLEAEANQSAALMTLEMGKT-
* * **. *.: . : :. . :: : *:* .
Mvan_5157|M.vanbaalenii_PYR-1 MLTSAAQLEGPVEDLSFCADTAESYAWTTDLGIASPMGIKTHRTIAREAV
Mflv_1600|M.gilvum_PYR-GCK MLTAAAQLEGPVDDLSFCADTAESYRWSTDLGIASPMGIKTRRTVTREAI
MSMEG_5859|M.smegmatis_MC2_155 MLTSGAQLEGPIDDLAFSADTAENYPWRTDLGHATPQGIPTDRVIAREAV
TH_2814|M.thermoresistible__bu MLTSGGQLETPVEDLSFAADTAENYRWSTDLGRATPQGIPTDRRIVREPV
Mb0791|M.bovis_AF2122/97 MLTASAQLEGPVGDLSFAADTAESYPWKQDLGEASPLGIATRRTLAREAV
Rv0768|M.tuberculosis_H37Rv MLTASAQLEGPVGDLSFAADTAESYPWKQDLGEASPLGIATRRTLAREAV
MMAR_4928|M.marinum_M MLTAAAQLEGPVNDLAFSADTAESYSWKQDLGAAAPMGIPTRRTVVREAV
MUL_0477|M.ulcerans_Agy99 MLTAAAQLEGPVNDLAFSADTAESYSWKQDLGAAAPMGIPTRRTVVREAV
MAV_0713|M.avium_104 MLTSAAQLEGPVGDLSFAADTAESYEWNQDLGQASPMGIPTRRTIAREAV
MAB_1218|M.abscessus_ATCC_1997 MLTAGAQLEGPVDDLQFAADTAESFDWTSDLGVASPMGIKTRRTLAREAV
MLBr_02573|M.leprae_Br4923 LQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVG--ASKALARYQPL
: :: : .: : *:.**. *: : :.:
Mvan_5157|M.vanbaalenii_PYR-1 GVVGAITPWNFPHQINLAKIGPALAAGNTLVLKPAPDTPWAAAVLGELIA
Mflv_1600|M.gilvum_PYR-GCK GVVGAITPWNFPHQINLAKVGPALAAGNTLVLKPAPDTPWAAAVLGELIT
MSMEG_5859|M.smegmatis_MC2_155 GVVGAITPWNFPHQINLAKVGPALAAGNTLVLKPAPDTPWAAAVLGQIIT
TH_2814|M.thermoresistible__bu GVVGAITPWNFPHQINLAKIGPALAAGNTLVLKPAPDTPWAGAVLGELIT
Mb0791|M.bovis_AF2122/97 GVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAALGEIIV
Rv0768|M.tuberculosis_H37Rv GVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAALGEIIV
MMAR_4928|M.marinum_M GVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAVLGELIA
MUL_0477|M.ulcerans_Agy99 GVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAVLGELIA
MAV_0713|M.avium_104 GVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAVLGQLIA
MAB_1218|M.abscessus_ATCC_1997 GVVGAVTPWNFPHQINLAKVGPALAAGNTLVLKPAPDTPWCAAVLGRIIA
MLBr_02573|M.leprae_Br4923 GVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCALYLADVIA
*** *: ***** .: .*** ***. :** *.:.* .. *. :*.
Mvan_5157|M.vanbaalenii_PYR-1 EHTDFPAGVINIVTSSDHGVGALLSKDPRVDMVSFTGSTNTGRAVMADGA
Mflv_1600|M.gilvum_PYR-GCK EHTDFPAGVINIVTSSDHGVGALLSKDPRVDMVSFTGSTNTGRAVMADGA
MSMEG_5859|M.smegmatis_MC2_155 EHTDFPPGVINIVTSSDHSVGALLSKDPRVDMVSFTGSTATGRAVMTDAA
TH_2814|M.thermoresistible__bu GHTDFPPGVINIVTSSDHAVGAVLASDPRVDMVSFTGSTATGRSVMTDAA
Mb0791|M.bovis_AF2122/97 EHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFTGSTATGRAVMADAA
Rv0768|M.tuberculosis_H37Rv EHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFTGSTATGRAVMADAA
MMAR_4928|M.marinum_M DCTDIPPGVVNIVTSSEHGLGALLAKDPRVDMVSFTGSTATGRSVMADGA
MUL_0477|M.ulcerans_Agy99 DCTDIPPGVVNIVTSSEHGLGALLAKDPRVDMVSFTGSTATGRSVMADGA
MAV_0713|M.avium_104 EHTDFPPGVVNIITSDDHGVGALLSKDPRVDMVSFTGSTVTGRSVMSDAA
MAB_1218|M.abscessus_ATCC_1997 EHTDFPPGVVNIVTSSDHRIGAQLSTDPRVDMVSFTGSTATGRAVMTDAA
MLBr_02573|M.leprae_Br4923 RG-GFPEDCFQTLLISANGVEAILR-DPRVAAATLTGSEPAGQAVGAIAG
.:* . .: : . : : * * **** ::*** :*::* : ..
Mvan_5157|M.vanbaalenii_PYR-1 ATLKKVFLELGGKSAFLVIDD---ADLAGACSMAAFTASMHAGQGCAITT
Mflv_1600|M.gilvum_PYR-GCK ATLTKVFLELGGKSAFLVLDD---ADLAGACSMAAFTASMHAGQGCAITT
MSMEG_5859|M.smegmatis_MC2_155 LTIKKVFLELGGKSAFLVLDD---ADLTGACSMAAFTVAMHAGQGCAITT
TH_2814|M.thermoresistible__bu ATIKKVFLELGGKSAFLVLDD---ADLAGACSMAAFTAAMHAGQGCAITT
Mb0791|M.bovis_AF2122/97 ATIKKVFLELGGKSAFVVLDD---ADLAAASAVSAFSACMHAGQGCAITT
Rv0768|M.tuberculosis_H37Rv ATIKKVFLELGGKSAFVVLDD---ADLAAASAVSAFSACMHAGQGCAITT
MMAR_4928|M.marinum_M ATIKRMFLELGGKSAFIVLDD---ADLAAASSVSAFTASMHAGQGCAITT
MUL_0477|M.ulcerans_Agy99 ATIKRMFLELGGKSAFIVLDD---ADLAAASSVSAFTASMHAGQGCAITT
MAV_0713|M.avium_104 ATIKRVFLELGGKSAFVVLDD---ADLGGACSMSAFTAAMHAGQGCAITT
MAB_1218|M.abscessus_ATCC_1997 ATVKKVFLELGGKSAFIVLDDLDEAALGSACSVAAFTAAMHAGQGCAITT
MLBr_02573|M.leprae_Br4923 NEIKPTVLELGGSDPFIVMPS---ADLDAAVATAVTGRVQNNGQSCIAAK
:. .*****...*:*: . * * .* : :. : **.* :.
Mvan_5157|M.vanbaalenii_PYR-1 RLVVPRDRYDEAVEAAAATMGGLKAGDPTKPGTVCGPLISERQRERVQGY
Mflv_1600|M.gilvum_PYR-GCK RLLVPRARYDEAVEAAAATMGGLKPGDPDKPGTICGPVISARQRDRIQSY
MSMEG_5859|M.smegmatis_MC2_155 RLVVPRARYDEAVEIAAGTLGSIKPGDPTSKRTVCGPVISARQRDRVQSY
TH_2814|M.thermoresistible__bu RLVVPRARYDEAVEAAAATMGSLKPGDPTDKRTVCGPVISARQRDRVQGY
Mb0791|M.bovis_AF2122/97 RLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLISARQRDRVQGY
Rv0768|M.tuberculosis_H37Rv RLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLISARQRDRVQGY
MMAR_4928|M.marinum_M RLVVPRARYDEAVAIAAGTMSSIKPGDPDDARTVCGPLISQRQRDRVQGY
MUL_0477|M.ulcerans_Agy99 RLVVPRARYDEAVAIAAGTMSSIKPGDPDDARTVCGPLISQRQRDRVEGY
MAV_0713|M.avium_104 RLLVPRDRYDEAVAAAAGTMGSIKPGDPNDPGTVCGPVISARQRDRVQGY
MAB_1218|M.abscessus_ATCC_1997 RLVVPRERYDDAVAAAAATMGSLKPGDPAKPGTICGPVISARQRDRVQSY
MLBr_02573|M.leprae_Br4923 RFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRAQVEQQ
*::. *:: * .. : :: *** . * **: : * :::
Mvan_5157|M.vanbaalenii_PYR-1 LDSAIAEGGRFACGGGRPADRDTGFFIDPTVIAGLDNNAKVAREEIFGPV
Mflv_1600|M.gilvum_PYR-GCK LDSAVAEGGRFACGGGRPADRDTGFFIEPTVIAGLDNNAKVAREEIFGPV
MSMEG_5859|M.smegmatis_MC2_155 LDLAIKEGGRFACGGGRPADMDKGFWIEPTVIAGLDNNARVAREEIFGPV
TH_2814|M.thermoresistible__bu LDLAVAEGGRFACGGGRPADRDVGFFIEPTVIAGLTNDARVAREEIFGPV
Mb0791|M.bovis_AF2122/97 LDLAVAEGGRFACGGARPADREVGFYIEPTVIAGLTNDARVAREEIFGPV
Rv0768|M.tuberculosis_H37Rv LDLAVAEGGRFACGGARPADREVGFYIEPTVIAGLTNDARVAREEIFGPV
MMAR_4928|M.marinum_M LDLAIAEGGTFACGGGRPAGRQVGYFIEPTVIAGLTNDARPAREEIFGPV
MUL_0477|M.ulcerans_Agy99 LDLAIAEGGTFACGGGRPAGRQVGYFIEPTVIAGLTTDARPAREEIFGPV
MAV_0713|M.avium_104 LDLAIAEGGTFACGGGRPADKDVGFFIEPTVIAGLTNDARPAREEIFGPV
MAB_1218|M.abscessus_ATCC_1997 LDLAVAEGGSFACGGGRPEGKDRGFFIEPTVVAGLTNAARVAREEIFGPV
MLBr_02573|M.leprae_Br4923 VDAAAAAGAVIRCGGKRPD--RPGWFYPPTVITDITKDMALYTDEVFGPV
:* * *. : *** ** *:: ***::.: . :*:****
Mvan_5157|M.vanbaalenii_PYR-1 LTVIAHDGDDDAVRIANDSPYGLSGTVFSADPERAAGIAARMRVGTVNVN
Mflv_1600|M.gilvum_PYR-GCK LTVIAHDGDDDAVRIANDSPYGLSGTVFSPDLERANGVAARLRVGTVNIN
MSMEG_5859|M.smegmatis_MC2_155 LTVIAHDGDDDAVRIANDSPYGLSGTVFSGDDARAQAVASRMRVGTVNVN
TH_2814|M.thermoresistible__bu LTVIAHDGDDDAVRIANDSPYGLSGTVFSGDDERAQAVAARLRVGTVNVN
Mb0791|M.bovis_AF2122/97 LTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIASRLRVGTVNVN
Rv0768|M.tuberculosis_H37Rv LTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIASRLRVGTVNVN
MMAR_4928|M.marinum_M LTVLAHDGDDDAVRIANDSPYGLSGTVYGGDPQRAADVAARLRVGTVNVN
MUL_0477|M.ulcerans_Agy99 LTVLAHDGDDDAVRIANDSPYGLSGTVYGGDPQRAADVAARLRVGAVNVN
MAV_0713|M.avium_104 LTVIAYDGEEDALRIANDSPYGLSGTVFSADPERAANFASRMRVGTVNVN
MAB_1218|M.abscessus_ATCC_1997 LVVIAHDGDEDAVRIANDSPYGLSGTVFGDDDERSARVASRLRVGTVNVN
MLBr_02573|M.leprae_Br4923 ASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVAGQVFIN
* . . :**:.*** :*:**....: : . . .: .* * :*
Mvan_5157|M.vanbaalenii_PYR-1 GGVWYSADMPFGGYKQSGIGREMGLAGFEEYLEIKAIATAAN-
Mflv_1600|M.gilvum_PYR-GCK GGVWYSADMPFGGYKQSGIGREMGLAGFEEYLEIKAIATAVN-
MSMEG_5859|M.smegmatis_MC2_155 GGIWYSADAPFGGYKQSGVGREMGLAGFEEYTEIKLIATLAG-
TH_2814|M.thermoresistible__bu GGIWYSADAPFGGYKQSGIGREMGVAGFEEYTELKVIATAVAQ
Mb0791|M.bovis_AF2122/97 GGVWYCADAPFGGYKQSGIGREMGLLGFEEYLEAKLIATAAN-
Rv0768|M.tuberculosis_H37Rv GGVWYCADAPFGGYKQSGIGREMGLLGFEEYLEAKLIATAAN-
MMAR_4928|M.marinum_M GGVWYCADAPFGGYKQSGIGREMGLAGFEEYLETKLIATAAN-
MUL_0477|M.ulcerans_Agy99 GGVWYCADAPFGGYKQSGIGREMGLAGFEEYLETKLIATAAN-
MAV_0713|M.avium_104 GGVWYSADAPFGGYKQSGNGREMGLAGFEEYLEIKTIATAVQ-
MAB_1218|M.abscessus_ATCC_1997 GGVWYSADAPFGGYKQSGNGREMGVAGFEEYLETKVIATAVK-
MLBr_02573|M.leprae_Br4923 GMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA---
* .: **** *:** ***:. *:.*: : * :