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MMIDGKLVDGQAGTFTNINPATEEPLGEVADASKEDMHRAIDAARRAFDETDWSTNRELRKRCLLQLHEA IESEKEELREELILEVGSPRAITFGPQLDAPLEDGLKYPARLIDEYAWETDLGDKVISLTGTLTTRKVWR EPVGVVGAIVPWNFPFEVTLNKLGQALGTGNTVVLKPAPNTPFNATRLGRLIAEKTDIPAGVVNVVTASD HFVGEELTLSPKVDLISFTGSTVVGQRIMEKGAATMKRLFLELGGKSATIVLEDADFGMACAIGIAPCMH AGQGCANPTRMLLPRSRYDEGVAILKGIYENVTCGDPQDPGTLCGPVISQVQRDRVMGYIRKGVEEGATA LVGGPDAPTGFDKGYYVRPTLFTDVDNSMTIAQEEIFGPVLCVIPFDDEEDAIRIANDSRYGLAGNVMSG SLERSLSVARRIRAGFMGVNGGAPYGADTPFGGYKYSGVGRQNGVAGFDQYTEIKSVAYPAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1275 | - | - | 100% (482) | aldehyde dehydrogenase family protein |
| M. avium 104 | MAV_1825 | - | e-150 | 56.64% (482) | aldehyde dehydrogenase family protein |
| M. avium 104 | MAV_0713 | - | e-148 | 56.16% (479) | aldehyde dehydrogenase (NAD) family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 1e-146 | 54.15% (482) | aldehyde dehydrogenase NAD dependant AldA |
| M. gilvum PYR-GCK | Mflv_4340 | - | 1e-147 | 56.85% (482) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0768 | aldA | 1e-146 | 54.15% (482) | aldehyde dehydrogenase NAD dependent AldA |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 4e-44 | 29.79% (470) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1218 | - | 1e-141 | 52.90% (482) | aldehyde dehydrogenase AldA |
| M. marinum M | MMAR_4322 | aldA_2 | 0.0 | 88.59% (482) | aldehyde dehydrogenase NAD dependent AldA_2 |
| M. smegmatis MC2 155 | MSMEG_5859 | - | 1e-146 | 54.04% (483) | aldehyde dehydrogenase (NAD) family protein |
| M. thermoresistible (build 8) | TH_3892 | - | 0.0 | 81.50% (481) | PUTATIVE aldehyde dehydrogenase NAD dependent AldA_2 |
| M. ulcerans Agy99 | MUL_0477 | aldA | 1e-143 | 54.36% (482) | NAD-dependent aldehyde dehydrogenase, AldA |
| M. vanbaalenii PYR-1 | Mvan_5157 | - | 1e-149 | 54.77% (482) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1275|M.avium_104 --------------------------MMIDGKLVDGQAG-TFTNINPATE
MMAR_4322|M.marinum_M -MADTTEAVEVRFES----------KMMIDGKLVDGQAG-TFTNINPATE
TH_3892|M.thermoresistible__bu --------------------------MMIDGKLVEGSAG-TFTTINPATE
Mflv_4340|M.gilvum_PYR-GCK MSATPTERTETSLEWGRRAAQRAENRMLIDGELVGAASGEMFDNLSPATG
MSMEG_5859|M.smegmatis_MC2_155 -MPLLADRQSQ---------------LLIDGKLVAGRKG-VFDTVNPATE
Mvan_5157|M.vanbaalenii_PYR-1 -MAILADRESR---------------LLIDGKLVAGSSG-TFTTVNPATE
Mb0791|M.bovis_AF2122/97 -MALWGDGISA---------------LLIDGKLSDGRAG-TFPTVNPATE
Rv0768|M.tuberculosis_H37Rv -MALWGDGISA---------------LLIDGKLSDGRAG-TFPTVNPATE
MUL_0477|M.ulcerans_Agy99 -MALLADGVSS---------------LFIDGKRCEGAAG-TFATVNPATE
MAB_1218|M.abscessus_ATCC_1997 -MTVLSDGDSE---------------LFIDGKLLPGGAG-RFPTVNPATE
MLBr_02573|M.leprae_Br4923 ---------------------------------------MSIATINPATG
: .:.***
MAV_1275|M.avium_104 EPLGEVADASKEDMHRAIDAARRAFDETDWSTNRELRKRCLLQLHEAIES
MMAR_4322|M.marinum_M EPLGEVADASKTDMHRAIDAARRAFDETDWSTNRALRKRCLEQLQEAIEA
TH_3892|M.thermoresistible__bu EPLGEVADASVADMHRAIDAARRAFDETDWSTNHAFRQRCLLQLQEALET
Mflv_4340|M.gilvum_PYR-GCK AVLGATAAAGADDMDRAIAAARRAFDTTDWSTDKELRRRCLQQLQAAIES
MSMEG_5859|M.smegmatis_MC2_155 EVLGVAADATAEDMGDAIEAARRAFDDTDWSTDTELRVRCIRQLRDALRE
Mvan_5157|M.vanbaalenii_PYR-1 ETLGVAADASAEDMSAAIGAARRSFDETDWATNTDLRVRCIRQLQQAMRD
Mb0791|M.bovis_AF2122/97 EVLGVAADADAEDMGRAIEAARRAFDSTDWSRNTELRVRCVRQLRDAMQQ
Rv0768|M.tuberculosis_H37Rv EVLGVAADADAEDMGRAIEAARRAFDSTDWSRNTELRVRCVRQLRDAMQQ
MUL_0477|M.ulcerans_Agy99 ETLGVAADAVAGDMDRAIEAARRAFDDTDWSRNTELRVRCVRQLRDAMRE
MAB_1218|M.abscessus_ATCC_1997 EVLGTAADADSDDMSDAIEAARRAFDDSGWSRDVALRVHCIRQLRDGMKT
MLBr_02573|M.leprae_Br4923 ETVKTFTPTTQDEVEDAIARAYARFDN-YRHTTFTQRAKWANATADLLEA
: : : :: ** * ** * : :.
MAV_1275|M.avium_104 EKEELREELILEVGSPRAITFGPQLDAPLEDGLKYPARLIDEYAWETDLG
MMAR_4322|M.marinum_M EREELREELILEAGAPRAITFGPQLDAPLADALRYPVKLIDEYPWETDLG
TH_3892|M.thermoresistible__bu EQEELREELILEVGCPRSITHGPQLDAPLSDALRYPAELIDEYSWETALG
Mflv_4340|M.gilvum_PYR-GCK EKEDLRTELVAEVGCPVMTTESAQLDWPLAEALRYPAGLIDDFEWERVLD
MSMEG_5859|M.smegmatis_MC2_155 HVEELRDLTIAEVGAPRMLTSGAQLEGPIDD-LAFSADTAENYPWRTDLG
Mvan_5157|M.vanbaalenii_PYR-1 HVEELRELTIAEVGAPRMLTSAAQLEGPVED-LSFCADTAESYAWTTDLG
Mb0791|M.bovis_AF2122/97 HVEELRELTISEVGAPRMLTASAQLEGPVGD-LSFAADTAESYPWKQDLG
Rv0768|M.tuberculosis_H37Rv HVEELRELTISEVGAPRMLTASAQLEGPVGD-LSFAADTAESYPWKQDLG
MUL_0477|M.ulcerans_Agy99 HIEELRALTISEVGAPRMLTAAAQLEGPVND-LAFSADTAESYSWKQDLG
MAB_1218|M.abscessus_ATCC_1997 HIEELRELTIAEVGAPRMLTAGAQLEGPVDD-LQFAADTAESFDWTSDLG
MLBr_02573|M.leprae_Br4923 EANQSAALMTLEMG--KTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAE
. :: * * . : . : : . :
MAV_1275|M.avium_104 DKVISLTGTLTTRKVWREPVGVVGAIVPWNFPFEVTLNKLGQALGTGNTV
MMAR_4322|M.marinum_M DVLVSITGQMTTRKVWREPVGVVGAIVPWNFPFEVTINKLGQALGTGNTV
TH_3892|M.thermoresistible__bu DAMVSVTGMNTTRRVWREPAGVVGAIVPWNFPFEVSIQKIGQALGTGCTV
Mflv_4340|M.gilvum_PYR-GCK AG--GLFGERNIRMVVKEAVGVVAAVTPSNFPLEVILNKLGPALAAGNTV
MSMEG_5859|M.smegmatis_MC2_155 HA--TPQGIPTDRVIAREAVGVVGAITPWNFPHQINLAKVGPALAAGNTL
Mvan_5157|M.vanbaalenii_PYR-1 IA--SPMGIKTHRTIAREAVGVVGAITPWNFPHQINLAKIGPALAAGNTL
Mb0791|M.bovis_AF2122/97 EA--SPLGIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTV
Rv0768|M.tuberculosis_H37Rv EA--SPLGIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTV
MUL_0477|M.ulcerans_Agy99 AA--APMGIPTRRTVVREAVGVVGAITPWNFPHQINLAKLGPALAAGNTV
MAB_1218|M.abscessus_ATCC_1997 VA--SPMGIKTRRTLAREAVGVVGAVTPWNFPHQINLAKVGPALAAGNTL
MLBr_02573|M.leprae_Br4923 AA---AVG-ASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVG
* . :. *** *: * *** : . ** :* .
MAV_1275|M.avium_104 VLKPAPNTPFNATRLGRLIAEKTDIPAGVVNVVTASDHFVGEELTLSPKV
MMAR_4322|M.marinum_M VLKPAPDTPFNATRLGRLIAEKTDIPPGVVSVVTASDHLVGEELTLSPKV
TH_3892|M.thermoresistible__bu VLKPAPDTPFNATRLGRLIAERTDIPPGVVNVVTASDHLIGEELTLSPKV
Mflv_4340|M.gilvum_PYR-GCK VLKPDPHTPWNATRLGRLIAEKTDFPPGVVNVVTTPSNAVAGLLGTDARV
MSMEG_5859|M.smegmatis_MC2_155 VLKPAPDTPWAAAVLGQIITEHTDFPPGVINIVTSSDHSVGALLSKDPRV
Mvan_5157|M.vanbaalenii_PYR-1 VLKPAPDTPWAAAVLGELIAEHTDFPAGVINIVTSSDHGVGALLSKDPRV
Mb0791|M.bovis_AF2122/97 VLKPAPDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRV
Rv0768|M.tuberculosis_H37Rv VLKPAPDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRV
MUL_0477|M.ulcerans_Agy99 VLKPAPDTPWCAAVLGELIADCTDIPPGVVNIVTSSEHGLGALLAKDPRV
MAB_1218|M.abscessus_ATCC_1997 VLKPAPDTPWCAAVLGRIIAEHTDFPPGVVNIVTSSDHRIGAQLSTDPRV
MLBr_02573|M.leprae_Br4923 LLKHASNVPQCALYLADVIARG-GFPEDCFQTLLISANGVEAILR-DPRV
:** ...* * *. :*. .:* . .. : . : : * ..:*
MAV_1275|M.avium_104 DLISFTGSTVVGQRIMEKGAATMKRLFLELGGKSATIVLED---ADFGMA
MMAR_4322|M.marinum_M DLISFTGSTGVGKRIMEKGAATMKRLFLELGGKSATIVLED---AEFGLA
TH_3892|M.thermoresistible__bu DLISFTGSTAVGKRIMAKGAATMKRLFLELGGKSATIVLED---ADFALG
Mflv_4340|M.gilvum_PYR-GCK DLVSFTGSTAVGKLLMRQGADSMKRMFLELGGKSAAIVLDD---ANPAVI
MSMEG_5859|M.smegmatis_MC2_155 DMVSFTGSTATGRAVMTDAALTIKKVFLELGGKSAFLVLDD---ADLTGA
Mvan_5157|M.vanbaalenii_PYR-1 DMVSFTGSTNTGRAVMADGAATLKKVFLELGGKSAFLVIDD---ADLAGA
Mb0791|M.bovis_AF2122/97 DMISFTGSTATGRAVMADAAATIKKVFLELGGKSAFVVLDD---ADLAAA
Rv0768|M.tuberculosis_H37Rv DMISFTGSTATGRAVMADAAATIKKVFLELGGKSAFVVLDD---ADLAAA
MUL_0477|M.ulcerans_Agy99 DMVSFTGSTATGRSVMADGAATIKRMFLELGGKSAFIVLDD---ADLAAA
MAB_1218|M.abscessus_ATCC_1997 DMVSFTGSTATGRAVMTDAAATVKKVFLELGGKSAFIVLDDLDEAALGSA
MLBr_02573|M.leprae_Br4923 AAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPS---ADLDAA
::*** .*: : .. :* .*****... :*: . *
MAV_1275|M.avium_104 CAIG-IAPCMHAGQGCANPTRMLLPRSRYDEGVAILKGIYENVTCGDPQD
MMAR_4322|M.marinum_M CAIG-IAPCMHAGQGCANPTRMLLPRSRYDEGVAILKSIYDNVMPGDPQD
TH_3892|M.thermoresistible__bu CMMG-IAPCMHAGQGCANPTRLLLPRSRYDEGIEILRGIYEGVAPGDPQD
Mflv_4340|M.gilvum_PYR-GCK VPTA-VGVCVHAGQACAATSRMLIHRSLYDQAVADITMAYQYVPVGDPTD
MSMEG_5859|M.smegmatis_MC2_155 CSMAAFTVAMHAGQGCAITTRLVVPRARYDEAVEIAAGTLGSIKPGDPTS
Mvan_5157|M.vanbaalenii_PYR-1 CSMAAFTASMHAGQGCAITTRLVVPRDRYDEAVEAAAATMGGLKAGDPTK
Mb0791|M.bovis_AF2122/97 SAVSAFSACMHAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPND
Rv0768|M.tuberculosis_H37Rv SAVSAFSACMHAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPND
MUL_0477|M.ulcerans_Agy99 SSVSAFTASMHAGQGCAITTRLVVPRARYDEAVAIAAGTMSSIKPGDPDD
MAB_1218|M.abscessus_ATCC_1997 CSVAAFTAAMHAGQGCAITTRLVVPRERYDDAVAAAAATMGSLKPGDPAK
MLBr_02573|M.leprae_Br4923 VATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTD
. : **.* ..*:: *:: : : *** .
MAV_1275|M.avium_104 PGTLCGPVISQVQRDRVMGYIRKGVEEGATALVGG---PDAPTGFDKGYY
MMAR_4322|M.marinum_M PATLCGPVISDKQRKRVLGYLNKGVEEGATCLVGG---PDAPTGFDRGFY
TH_3892|M.thermoresistible__bu PATLCGPVINEKQRTRIRGYIRKGVEEGARLVVGG---EDPPDGLDKGFF
Mflv_4340|M.gilvum_PYR-GCK PGTLVGPVISAAQQERVLSAIEGARRDGAEITAGGGLVAGLPDHLAGGHF
MSMEG_5859|M.smegmatis_MC2_155 KRTVCGPVISARQRDRVQSYLDLAIKEGGRFACGG----GRPADMDKGFW
Mvan_5157|M.vanbaalenii_PYR-1 PGTVCGPLISERQRERVQGYLDSAIAEGGRFACGG----GRPADRDTGFF
Mb0791|M.bovis_AF2122/97 PGTVCGPLISARQRDRVQGYLDLAVAEGGRFACGG----ARPADREVGFY
Rv0768|M.tuberculosis_H37Rv PGTVCGPLISARQRDRVQGYLDLAVAEGGRFACGG----ARPADREVGFY
MUL_0477|M.ulcerans_Agy99 ARTVCGPLISQRQRDRVEGYLDLAIAEGGTFACGG----GRPAGRQVGYF
MAB_1218|M.abscessus_ATCC_1997 PGTICGPVISARQRDRVQSYLDLAVAEGGSFACGG----GRPEGKDRGFF
MLBr_02573|M.leprae_Br4923 PDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGG----KRPD--RPGWF
* **: . : :: : . *. ** * * :
MAV_1275|M.avium_104 VRPTLFTDVDNSMTIAQEEIFGPVLCVIPFDDEEDAIRIANDSRYGLAGN
MMAR_4322|M.marinum_M VRPTLFVDVDNSMTIAQEEIFGPVLSVIPFDTEEDAIRIANDSVYGLAGN
TH_3892|M.thermoresistible__bu VRPTLFADVDNSMTIAQEEIFGPVLAVIPYDDEDDAVRIANDTAYGLAGN
Mflv_4340|M.gilvum_PYR-GCK VAPTVITGVDNSAAIAQQEVFGPVLVLLPFDDDDEAVRLANDSAFGLAGA
MSMEG_5859|M.smegmatis_MC2_155 IEPTVIAGLDNNARVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGT
Mvan_5157|M.vanbaalenii_PYR-1 IDPTVIAGLDNNAKVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGT
Mb0791|M.bovis_AF2122/97 IEPTVIAGLTNDARVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGT
Rv0768|M.tuberculosis_H37Rv IEPTVIAGLTNDARVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGT
MUL_0477|M.ulcerans_Agy99 IEPTVIAGLTTDARPAREEIFGPVLTVLAHDGDDDAVRIANDSPYGLSGT
MAB_1218|M.abscessus_ATCC_1997 IEPTVVAGLTNAARVAREEIFGPVLVVIAHDGDEDAVRIANDSPYGLSGT
MLBr_02573|M.leprae_Br4923 YPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSN
**:...: . :*:**** : ::*:.:** : :**..
MAV_1275|M.avium_104 VMSGSLERSLSVARRIRAGFMGVNGGAPYGADTPFGGYKYSGVGRQNGVA
MMAR_4322|M.marinum_M VMSGSLEHSLAVARRLRAGFIGVNGGAPYGADTPFGGYKDSGVGRQNGVA
TH_3892|M.thermoresistible__bu VMSSSIEHALAVARRLRAGFIGINGAAGYGADTPFGGYKDSGVGRQNGVA
Mflv_4340|M.gilvum_PYR-GCK VMSRSAERGMNIARRIRTGAFGVNGGMFYGADAPFGGYKSSGVGRQCGIE
MSMEG_5859|M.smegmatis_MC2_155 VFSGDDARAQAVASRMRVGTVNVNGGIWYSADAPFGGYKQSGVGREMGLA
Mvan_5157|M.vanbaalenii_PYR-1 VFSADPERAAGIAARMRVGTVNVNGGVWYSADMPFGGYKQSGIGREMGLA
Mb0791|M.bovis_AF2122/97 VYGADPQRAARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGIGREMGLL
Rv0768|M.tuberculosis_H37Rv VYGADPQRAARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGIGREMGLL
MUL_0477|M.ulcerans_Agy99 VYGGDPQRAADVAARLRVGAVNVNGGVWYCADAPFGGYKQSGIGREMGLA
MAB_1218|M.abscessus_ATCC_1997 VFGDDDERSARVASRLRVGTVNVNGGVWYSADAPFGGYKQSGNGREMGVA
MLBr_02573|M.leprae_Br4923 AWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELSTH
. . . . .: .* . :** .: **** * ** **: .
MAV_1275|M.avium_104 GFDQYTEIKSVAYPAG---
MMAR_4322|M.marinum_M GFDQYTQIKSLGYPAG---
TH_3892|M.thermoresistible__bu GFDQYTEIKSVAYPA----
Mflv_4340|M.gilvum_PYR-GCK GFSQYLETKTIARRERRKG
MSMEG_5859|M.smegmatis_MC2_155 GFEEYTEIKLIATLAG---
Mvan_5157|M.vanbaalenii_PYR-1 GFEEYLEIKAIATAAN---
Mb0791|M.bovis_AF2122/97 GFEEYLEAKLIATAAN---
Rv0768|M.tuberculosis_H37Rv GFEEYLEAKLIATAAN---
MUL_0477|M.ulcerans_Agy99 GFEEYLETKLIATAAN---
MAB_1218|M.abscessus_ATCC_1997 GFEEYLETKVIATAVK---
MLBr_02573|M.leprae_Br4923 GIREFCNIKTVWIA-----
*: :: : * :