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MLDGLRVLDLATLAAAPLVATYLGEFGADVIKVEEPRHGDPIRGWGNQRDGVGLMWKSISRNKKSITLDL RSADGQQLVRRLVEHADVAIFNTRPQTLRKWGLDYESLRAVNERLVMLHITGYGLSGPKSERPGFGTLGE AMSGFAHITGQAGAPPTLPPFMLADGVASLNAAYAVMMALYHRDVHGGPGQLIDVNLIDPLARLLEQTLL GYDQLGLVPERSGNRWDISAPRNTYQTADGRWLAMSGSSPALALRVFRAIGRDDLLGDPDFSDPQRRLAR AREVDTLVADWVAGKTLSEAMAVFEAHEVAAAPVYDISDLVADEQLAHRGVFVSVDDQQLGPMTVQAPVP RFSSASGTVEHLGPRLGEHNAEVYGELLGLTPDEIDQLRARGVV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0341 | - | - | 100% (394) | caib/baif family protein |
| M. avium 104 | MAV_4024 | - | 7e-73 | 38.79% (397) | caib/baif family protein |
| M. avium 104 | MAV_5261 | - | 1e-52 | 31.67% (401) | caib/baif family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1897 | - | 2e-35 | 28.18% (401) | hypothetical protein Mb1897 |
| M. gilvum PYR-GCK | Mflv_0637 | - | 1e-79 | 39.95% (398) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. tuberculosis H37Rv | Rv1866 | - | 2e-35 | 28.18% (401) | hypothetical protein Rv1866 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4651c | - | 1e-71 | 37.78% (397) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_1494 | - | 7e-73 | 38.29% (397) | hypothetical protein MMAR_1494 |
| M. smegmatis MC2 155 | MSMEG_6642 | - | 0.0 | 80.71% (394) | caib/baif family protein |
| M. thermoresistible (build 8) | TH_3905 | - | 2e-76 | 39.04% (397) | PUTATIVE Formyl-CoA transferase |
| M. ulcerans Agy99 | MUL_2446 | - | 9e-72 | 38.17% (393) | hypothetical protein MUL_2446 |
| M. vanbaalenii PYR-1 | Mvan_0528 | - | 1e-79 | 39.95% (398) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6642|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0637|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0528|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3905|M.thermoresistible__bu --------------------------------------------------
Mb1897|M.bovis_AF2122/97 MVTRLLADLGADVLKVQPPGGSPGRHVRPTLAGTSIGFAMHNANKRSAVL
Rv1866|M.tuberculosis_H37Rv MVTRLLADLGADVLKVEPPGGSPGRHVRPTLAGTSIGFAMHNANKRSAVL
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6642|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0637|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0528|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3905|M.thermoresistible__bu --------------------------------------------------
Mb1897|M.bovis_AF2122/97 NPLDESDRRRFLDLAASADIVVDCGLPGQAAAYGASCAELADRYRHLVAL
Rv1866|M.tuberculosis_H37Rv NPLDESDRRRFLDLAASADIVVDCGLPGQAAAYGASCAELADRYRHLVAL
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6642|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0637|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0528|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3905|M.thermoresistible__bu --------------------------------------------------
Mb1897|M.bovis_AF2122/97 SITDFGAAGPRSSWRATDPVLYAMSGALSRSGPTAGTPVLPPDGIASATA
Rv1866|M.tuberculosis_H37Rv SITDFGAAGPRSSWRATDPVLYAMSGALSRSGPTAGTPVLPPDGIASATA
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6642|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0637|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0528|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3905|M.thermoresistible__bu --------------------------------------------------
Mb1897|M.bovis_AF2122/97 AVQAAWAVLVAYFNRLRCGTGDYIDFSRFDAVVMALDPPFGAHGQVAAGI
Rv1866|M.tuberculosis_H37Rv AVQAAWAVLVAYFNRLRCGTGDYIDFSRFDAVVMALDPPFGAHGQVAAGI
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6642|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0637|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0528|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3905|M.thermoresistible__bu --------------------------------------------------
Mb1897|M.bovis_AF2122/97 RSTGRWRGRPKNQDAYPIYPCRDGYVRFCVMAPRQWRGLRRWLGEPEDFQ
Rv1866|M.tuberculosis_H37Rv RSTGRWRGRPKNQDAYPIYPCRDGYVRFCVMAPRQWRGLRRWLGEPEDFQ
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6642|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0637|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0528|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3905|M.thermoresistible__bu --------------------------------------------------
Mb1897|M.bovis_AF2122/97 DPKYDVIGARLAAWPQISVLVAKLCAEKTMKELVAAGQALGVPITAVLTP
Rv1866|M.tuberculosis_H37Rv DPKYDVIGARLAAWPQISVLVAKLCAEKTMKELVAAGQALGVPITAVLTP
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6642|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0637|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0528|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3905|M.thermoresistible__bu --------------------------------------------------
Mb1897|M.bovis_AF2122/97 SRILASEHFQAVGAITDAELVPGVRTGVPTGYFVVDGKRAGFRTPAPAAG
Rv1866|M.tuberculosis_H37Rv SRILASEHFQAVGAITDAELVPGVRTGVPTGYFVVDGKRAGFRTPAPAAG
MAV_0341|M.avium_104 -----------------------MLDGLRVLDLATLAAAPLVATYLGEFG
MSMEG_6642|M.smegmatis_MC2_155 ------------------MTPNAMLEGVRVLDFATLAAAPLAATYLGEFG
Mflv_0637|M.gilvum_PYR-GCK ----------------MSANMESLFDGLTILELGHVIAAPFAASLIGDFG
Mvan_0528|M.vanbaalenii_PYR-1 ----------------MSANMESLFDGLTILELGHVIAAPFAASLIGDFG
MMAR_1494|M.marinum_M ------------------MTEPGALDGIRVLELGTLIAGPFAGRLLGDMG
MUL_2446|M.ulcerans_Agy99 ------------------MTEPGALDGIRVLELGTLIAGPFAGRLLGDMG
MAB_4651c|M.abscessus_ATCC_199 --------------------MTGALDGIRVLELGTLIAGPFAGRLLGDMG
TH_3905|M.thermoresistible__bu ------------------VTVTGPLDGIRVLELGTLIAGPFAGRLLGDMG
Mb1897|M.bovis_AF2122/97 QDEPRWLADPAPVPPPSGRVGGYPFEGLRILDLGIIVAGGELSRLFGDLG
Rv1866|M.tuberculosis_H37Rv QDEPRWLADPAPVPPPSGRVGGYPFEGLRILDLGIIVAGGELSRLFGDLG
::*: :*::. : *. . :*::*
MAV_0341|M.avium_104 ADVIKVEEPRHGDPIRGWGNQR-DGVGLMWKSISRNKKSITLDLRSADGQ
MSMEG_6642|M.smegmatis_MC2_155 AEVIKVEQPHHGDPIRTWGNQR-DGIGLMWKSVSRNKKSITLDLRSAEGQ
Mflv_0637|M.gilvum_PYR-GCK AQVIKIEDPGSGDMLRRSGPRK-DGVPLWWKSAARNKSSVAVDLRLAEGQ
Mvan_0528|M.vanbaalenii_PYR-1 AQVIKIEDPGSGDMLRRSGPRK-DGVPLWWKSAARNKSSVAVDLRLAEGQ
MMAR_1494|M.marinum_M ADVIKVEAPGAPDPLRTWGQAEVDGHHVFWTVHARNKRAITLDLRRPQGR
MUL_2446|M.ulcerans_Agy99 ADVIKVEAPGAPDPLRTWGQAEVDGHHVFWTVHARNKRAITLDLRRPQGR
MAB_4651c|M.abscessus_ATCC_199 AEVLKIEPPGAPDPLRTWGQAEVDGHHVFWTVHARNKKAITLDLRTEAGR
TH_3905|M.thermoresistible__bu AEVIKIELPGAPDPLRTWGQAELDGHHFFWTVHARNKKAITLNLREPAGR
Mb1897|M.bovis_AF2122/97 AEVIKVESADHPDGLR--QTRVGDAMSESFAWTHRNHLALGLDLRNSEGK
Rv1866|M.tuberculosis_H37Rv AEVIKVESADHPDGLR--QTRVGDAMSESFAWTHRNHLALGLDLRNSEGK
*:*:*:* . * :* *. : **: :: ::** *:
MAV_0341|M.avium_104 QLVRRLVEHADVAIFNTRPQTLRKWGLDYESLRAVNERLVMLHITGYGLS
MSMEG_6642|M.smegmatis_MC2_155 ALAHRLVEHADVVVVNTRPQTLARWNMSYETLRRINDQIVMLHITGYGLS
Mflv_0637|M.gilvum_PYR-GCK ALVRKMVERADVVIENFRPGTLERWGLGWEELHAANPRLIMLRISGYGQI
Mvan_0528|M.vanbaalenii_PYR-1 ALVRKMVERADVVIENFRPGTLERWGLGWEELHAANPRLIMLRISGYGQI
MMAR_1494|M.marinum_M ELFLELVDKSDIVVENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQT
MUL_2446|M.ulcerans_Agy99 ELFLELVDKSDIVVENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQT
MAB_4651c|M.abscessus_ATCC_199 ALFLDLVDKSDVIVENFRPGTLERWGLGYDVLAQRNKGIILVRVSGYGQT
TH_3905|M.thermoresistible__bu DVFLELVERSDIVVENFRPGTLERWDLGYDVLRSHNNRVILVRVSGYGQT
Mb1897|M.bovis_AF2122/97 AIFGRLVAESDAVFANFKPGTLTSLGFSYDVLHAFNPRIVLAGSSAFGNR
Rv1866|M.tuberculosis_H37Rv AIFGRLVAESDAVFANFKPGTLTSLGFSYDVLHAFNPRIVLAGSSAFGNR
: :* .:* . * :* ** .:.:: * * ::: :.:*
MAV_0341|M.avium_104 GPKSERPGFGTLGEAMSGFAHITGQAGAPPTL-------PPFMLADGVAS
MSMEG_6642|M.smegmatis_MC2_155 GPKAERPGFGTLGEAMSGFAHLTGEADGPPTL-------PPFMLADGVAS
Mflv_0637|M.gilvum_PYR-GCK GPESAKPGYGRVGEAMSGAVHITGHPDRPPTH-------FGFSLGDVTTG
Mvan_0528|M.vanbaalenii_PYR-1 GPESAKPGYGRVGEAMSGAVHITGHPDRPPTH-------FGFSLGDVTTG
MMAR_1494|M.marinum_M GPDAHKAGYASVAEAASGLRHLNGFPGGPPPR-------LALSLGDSLAG
MUL_2446|M.ulcerans_Agy99 GPDAHKAGYASVAEAASGLRHLNGFPGGPPPR-------LALSLGDSLAG
MAB_4651c|M.abscessus_ATCC_199 GPDAHKAGYASVAEAASGLRHLNGFPGGPPPR-------MALSIGDTLAG
TH_3905|M.thermoresistible__bu GPDAHKAGYASVAEAASGLRHLNGFPGGPPPR-------LALSLGDTLAG
Mb1897|M.bovis_AF2122/97 GPWSTRMGYGPLVRAATGVTRVWTSDEAQPDNSRHPFYDATTIFPDHVVG
Rv1866|M.tuberculosis_H37Rv GPWSTRMGYGPLVRAATGVTRVWTSDEAQPDNSRHPFYDATTIFPDHVVG
** : : *:. : .* :* :: * : * ..
MAV_0341|M.avium_104 LNAAYAVMMALYHRDVHGG--PGQLIDVNLIDPLARLLEQTLLGYDQLGL
MSMEG_6642|M.smegmatis_MC2_155 LNAAYAVMMALYHRDVHGG--DSQLIDINLIDPLARLLEQTLLGYDQLGL
Mflv_0637|M.gilvum_PYR-GCK IMGAFAVAGALFKREAIGDRFDGECIDLALYESLFRGIDWQVILYDQLNF
Mvan_0528|M.vanbaalenii_PYR-1 IMGAFAVAGALFKREAIGDRFDGECIDLALYESLFRGIDWQVILYDQLNF
MMAR_1494|M.marinum_M MFGAQGALAALYRRSVTGT---GQVVDVALTESCLALQESTISDYDVGGV
MUL_2446|M.ulcerans_Agy99 MFGPQGALAALYRRSVTGT---GQVVDVALTESCLALQESTISDYDVGGV
MAB_4651c|M.abscessus_ATCC_199 MFAAQGALAALYRRTVTGR---GQVVDAALTESCLAVQESTIPDYDVGRV
TH_3905|M.thermoresistible__bu MFAAQGAMAALYRRTVTGE---GQVVDAALTEACLAVQESTIPDYDIGGV
Mb1897|M.bovis_AF2122/97 RVGALLALAALIHRDRTGG---GAHVHISQAEVVVNQLDTMFVAEAAR--
Rv1866|M.tuberculosis_H37Rv RVGALLALAALIHRDRTGG---GAHVHISQAEVVVNQLDTMFVAEAAR--
.. . ** :* * . :. : : .
MAV_0341|M.avium_104 VPERSGNRWDISAP--RNTYQTADGRWLAMSGSSPALALRVFRAIGRDDL
MSMEG_6642|M.smegmatis_MC2_155 VPMRAGNRWDISAP--RNTYQTADGKWLAMSGSSPALALRVFKAIGRADL
Mflv_0637|M.gilvum_PYR-GCK VAERQGNQFQVSPSPVSDTYLSGDGVWYTVATGTVRSVQSLLELLGGTTL
Mvan_0528|M.vanbaalenii_PYR-1 VAERQGNQFQVSPSPVSDTYLSGDGVWYTVATGTVRSVQSLLELLGGTTL
MMAR_1494|M.marinum_M VRGPSGTRLEGIAP--SNIYRSADESWVVIAANQDTVFTRLCQAMGCPEL
MUL_2446|M.ulcerans_Agy99 VRGPSGTRLKGIAP--SNIYRSADESWVVIAANQDTVFTRLCQAMGCPEL
MAB_4651c|M.abscessus_ATCC_199 VRGPSGTRLEGIAP--SNIYQSADGSWVVIAANQDTVFRRLCEAMGRPEL
TH_3905|M.thermoresistible__bu VRGPSGTRLEGIAP--SNIYRSADGSWVVIAANQDTVFRRLCAAMGRPEL
Mb1897|M.bovis_AF2122/97 --ATDVAEIHPDTSVHAVYPCAGDDEWCVISIRSDDEWRRATSVFGQPEL
Rv1866|M.tuberculosis_H37Rv --ATDVAEIHPDTSVHAVYPCAGDDEWCVISIRSDDEWRRATSVFGQPEL
. . .. :.* * .:: :* *
MAV_0341|M.avium_104 LGDPDFSDPQRRLARAREVDTLVADWVAGKTLSEAMAVFEAHEVAAAPVY
MSMEG_6642|M.smegmatis_MC2_155 VSDADFSDPQRRLARAREVDAVVAEWVATKTLAEAMAVFDNAEVAAAPVY
Mflv_0637|M.gilvum_PYR-GCK RNDPKYATQELQMLHREELGEMVRQWFAENNSDIVEKACASSGVVAARIF
Mvan_0528|M.vanbaalenii_PYR-1 RNDPKYATQELQMLHREELGEMVRQWFAENNSDIVEKACASSGVVAARIF
MMAR_1494|M.marinum_M ATDDRFATHRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAGVIAGPIN
MUL_2446|M.ulcerans_Agy99 ATDDRFATHRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAGVIAGPIN
MAB_4651c|M.abscessus_ATCC_199 SSDARFANHVARGRNQDDLDAIIAQWAAQRLPTDIIDVLSAAGVIAGPIN
TH_3905|M.thermoresistible__bu ATDDRFATHTARGRNQDELDKIIADWAAERAPGEIIDTLNAAGVIAGPIN
Mb1897|M.bovis_AF2122/97 ANDPRFGASRSRVANRSELVAAVSAWTSTRTPVQAAGALQAAGVAAGPMN
Rv1866|M.tuberculosis_H37Rv ANDPRFGASRSRVANRSELVAAVSAWTSTRTPVQAAGALQAAGVAAGPMN
* :. : . :: : * : . . * *. :
MAV_0341|M.avium_104 DISDLVADEQLAHRGVFVSVDDQQLGP-MTVQAPVPRFSSASGTVEHLGP
MSMEG_6642|M.smegmatis_MC2_155 DIEGLVADEQLRHRGIFVAVEDSQLGR-VTVQAPVPRFSDSDGRIDHLGP
Mflv_0637|M.gilvum_PYR-GCK TPAEMFSSPTFAARQSLVEVADQELGP-VRVTGVVPRLTNFPGSVRSTGP
Mvan_0528|M.vanbaalenii_PYR-1 TPAEMFSSPTFAARQSLVEVADQELGP-VRVTGVVPRLTNFPGSVRSTGP
MMAR_1494|M.marinum_M TVAEVVKDRQLRARGMLVEHYDERIGRNVLGPGIVPALSESPGQVRSAGP
MUL_2446|M.ulcerans_Agy99 TVAEVVKDRQLRARGMLVEHYDERIGRNVLGPGIVPALSESPGQVRSAGP
MAB_4651c|M.abscessus_ATCC_199 TVADVVQDPQLKAREMLVEHFDERLGRSVLGPGVVPVLSESPGGVRNAGP
TH_3905|M.thermoresistible__bu TVAEVVEDPQLRARGMIADHFDERIGRNVKGPGVVPVLSESPGTIRNAGP
Mb1897|M.bovis_AF2122/97 RPSDILEDPQLIERNLFRDMVHPLIARPLPAETGPAPFRHIPQAPQRPAP
Rv1866|M.tuberculosis_H37Rv RPSDILEDPQLIERNLFRDMVHPLIARPLPAETGPAPFRHIPQAPQRPAP
:. . : * : . :. : . : .*
MAV_0341|M.avium_104 R-LGEHNAEVYGELLGLTPDEIDQLRARGVV------------
MSMEG_6642|M.smegmatis_MC2_155 A-LGEHNDEIYGNLLGLLPAELDELRARGVL------------
Mflv_0637|M.gilvum_PYR-GCK G-LGIHGQEVLTEWLGMADSEYEALVSSGVVGAVDVDGEVPGH
Mvan_0528|M.vanbaalenii_PYR-1 G-LGIHGQEVLTEWLGMADSEYEALVSSGVVGAVDVDGEVPGH
MMAR_1494|M.marinum_M ARPGQHNDDVYIGLLGKSIEELEQLRAEEVL------------
MUL_2446|M.ulcerans_Agy99 ARPGQHNDDVYIGLLGKSIEELEQLRAVEVL------------
MAB_4651c|M.abscessus_ATCC_199 ARPGQDNDDVYVGLLGKSAQDIERLRAEGVL------------
TH_3905|M.thermoresistible__bu ARPGQHNEEIYTGLLGKTAAELRQLRAQGVI------------
Mb1897|M.bovis_AF2122/97 L-PGQDSVQICRKLLGMTADETERLINERVMFGPAVTA-----
Rv1866|M.tuberculosis_H37Rv L-PGQDSVQICRKLLGMTADETERLINERVMFGPAVTA-----
* .. :: ** : * *: