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PRPMSIEKPSPAVLFDVDGTLVDSNYLHVYAWLRAFDAESVPVDSWRIHRCIGMDGTTLVRALAGDASER VLDTLKDRHSEFYRETASLLAPLPGARDLLRRVAGLGLQVVLATSAPEDELRMLREVLDCDDAVAAVTSS QDVDTAKPQPDIVAVALDRAGVTADDAVFVGDAVWDCEAARRAGVPSIGVLSGGVSRAELREAGARDVFE DAAELLTELDSTVVGELAGRVSG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1937 | - | - | 100% (234) | HAD family hydrolase |
| M. vanbaalenii PYR-1 | Mvan_0053 | - | 9e-13 | 31.36% (220) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_5751 | - | 3e-09 | 29.69% (229) | beta-phosphoglucomutase family hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3433 | - | 1e-08 | 27.09% (251) | hydrolase |
| M. gilvum PYR-GCK | Mflv_4417 | - | 1e-101 | 78.60% (229) | HAD family hydrolase |
| M. tuberculosis H37Rv | Rv3400 | - | 1e-08 | 27.09% (251) | hydrolase |
| M. leprae Br4923 | MLBr_00393 | - | 2e-08 | 26.47% (238) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_1500 | - | 1e-06 | 23.04% (217) | putative haloacid dehalogenase-like hydrolase |
| M. marinum M | MMAR_3308 | - | 3e-05 | 23.56% (191) | hypothetical protein MMAR_3308 |
| M. avium 104 | MAV_0437 | - | 1e-76 | 67.63% (207) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_4401 | - | 6e-10 | 28.31% (219) | phosphonoacetaldehyde hydrolase |
| M. thermoresistible (build 8) | TH_3516 | - | 3e-11 | 31.50% (200) | PUTATIVE HAD-superfamily hydrolase, subfamily IA, variant 3 |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_1500|M.abscessus_ATCC_1997 ---------------MSDIPIR--LAVLDMAGTTVADGGLVLQAFETAAT
TH_3516|M.thermoresistible__bu -----------------------------MAGTTVTDDGLVLRAFDAAAT
MSMEG_4401|M.smegmatis_MC2_155 -------MNISEGTRMSSTVRRPELVVLDIAGTTVDEGSAVYRVLEQTVV
Mvan_1937|M.vanbaalenii_PYR-1 ------------MPRPMSIEKPSPAVLFDVDGTLVDSNYLHVYAWLRAFD
Mflv_4417|M.gilvum_PYR-GCK ----------------MSTQSVSPAVLFDIDGTLVDSNYLHVHAWMRAFD
MAV_0437|M.avium_104 ----------------------------------MDSNYLHVHSWQRAFD
Mb3433|M.bovis_AF2122/97 MANWYRPNYPEVRSRVLGLPEKVRACLFDLDGVLTDTASLHTKAWKAMFD
Rv3400|M.tuberculosis_H37Rv MANWYRPNYPEVRSRVLGLPEKVRACLFDLDGVLTDTASLHTKAWKAMFD
MLBr_00393|M.leprae_Br4923 MANWDHP-TSKVRSTVLGLPEQVRACLFDLDGVLTDTASVHAKAWQTMFD
MMAR_3308|M.marinum_M -------------------------MIFDLDGTLTDSAHGIVASFRHALN
MAB_1500|M.abscessus_ATCC_1997 AGG-----------------------IEQDGPERERARQYVIETMGQSKI
TH_3516|M.thermoresistible__bu AVG-----------------------MAESGAEREAARRYVVDTMGRSKI
MSMEG_4401|M.smegmatis_MC2_155 AHG-----------------------GTPSEAD-------IAKWHGAAKH
Mvan_1937|M.vanbaalenii_PYR-1 A------------------------------ESVPVDSWRIHRCIGMDGT
Mflv_4417|M.gilvum_PYR-GCK D------------------------------ENLPVSAWRIHRCIGMDGT
MAV_0437|M.avium_104 D------------------------------EDIAVASWQIHRCIGMDGS
Mb3433|M.bovis_AF2122/97 AYLAERAERTGEKFVPFDPAADYHTYVDGKKREDGVRSFLSSRAIEIPDG
Rv3400|M.tuberculosis_H37Rv AYLAERAERTGEKFVPFDPAADYHTYVDGKKREDGVRSFLSSRAIEIPDG
MLBr_00393|M.leprae_Br4923 TYLYQRAKHTGENFVPFDPTADYRQYVDGKKREDGVRSFLGSRGITLPEG
MMAR_3308|M.marinum_M HIG-----------------------------AAVPDGDLVAQIVGPPMD
MAB_1500|M.abscessus_ATCC_1997 AVFRYLLG--DEDKAQHANRTFEDAYDALISDGR--VTPIDGAVQAISRL
TH_3516|M.thermoresistible__bu EVFRALLA--DEDRAQRANAAFESAYDRFIAEG---VAPVPGAAEAIGEL
MSMEG_4401|M.smegmatis_MC2_155 EALRALLAPADDAALQVIVEDFRARLKAAYAEHP--PVPLPGVPDAIRDL
Mvan_1937|M.vanbaalenii_PYR-1 TLVRALAG----DASERVLDTLKDRHSEFYRETASLLAPLPGARDLLRRV
Mflv_4417|M.gilvum_PYR-GCK TLVRTLSG----DAGQGVLDRLKDAHSRYYKENSSLLAPLPGARDLLRRV
MAV_0437|M.avium_104 TLVRTLSG----DAPDDVGERLRDRHSRYYRELTPLLKPLPGARAMLRRV
Mb3433|M.bovis_AF2122/97 SPDDPGAA----ETVYGLGNRKNDMLHKLLRDDG--AQVFDGSRRYLEAV
Rv3400|M.tuberculosis_H37Rv SPDDPGAA----ETVYGLGNRKNDMLHKLLRDDG--AQVFDGSRRYLEAV
MLBr_00393|M.leprae_Br4923 SADNSGDV----ETIYGLGNRKDDLFRQVLKEHG--IEVFDGSRRYLEAI
MMAR_3308|M.marinum_M DTFHAMELG---DRVEDAIAAFRAEYGARGWAMN---TLFDGIAPLLADL
. * : :
MAB_1500|M.abscessus_ATCC_1997 RDAGVKVALTTGFSASTKEKLLAALAWT--DIADLTLAPSEAGRGRPFPD
TH_3516|M.thermoresistible__bu RSAGVKVALTTGFSPATQARILDALGWT--DIADLTLAPDTGVRGRPYPD
MSMEG_4401|M.smegmatis_MC2_155 RASGIKVALNTGFDRDIVDALLASLGWDGDSVVDTVVCGSDVAAGRPAPY
Mvan_1937|M.vanbaalenii_PYR-1 AGLGLQVVLATSAPEDELRMLREVLD--CDDAVAAVTSSQDVDTAKPQPD
Mflv_4417|M.gilvum_PYR-GCK AATGLQVVLATSAPDDELTLLREVLD--CDDVVAAVTSSADVDTAKPKPD
MAV_0437|M.avium_104 ADLGLQVVLASSAPEDELEILRKVLD--CDDVIAATTSSRDVDTAKPEPG
Mb3433|M.bovis_AF2122/97 TAAGLGVAVVSSSANTRDVLATTGLDRFVQQRVDGVTLREEHIAGKPAPD
Rv3400|M.tuberculosis_H37Rv TAAGLGVAVVSSSANTRDVLATTGLDRFVQQRVDGVTLREEHIAGKPAPD
MLBr_00393|M.leprae_Br4923 TYAGLGVAVVSSSTNTRDVLKITGLDRFVQQQVDGITLREEHIAGKPAPD
MMAR_3308|M.marinum_M RAAGVRLAVATCKLEPTARRVLAHFG--LDAHFEVIAGATGDGARRSKTE
*: :.: : : :. .
MAB_1500|M.abscessus_ATCC_1997 LILASLLRLKVNDVREVAVLGDTASDILAGRR--AGAQIVAGTLTGAHDA
TH_3516|M.thermoresistible__bu LVLTAVLRVGIDDVRHVAVAGDTASDIETGLR--AGASIATGVLTGAHDE
MSMEG_4401|M.smegmatis_MC2_155 MIYRAMEHSGVQDISRVLVAGDTPRDLQAGIN--AGAGYVVGVLSGASDE
Mvan_1937|M.vanbaalenii_PYR-1 IVAVALDRAGVT-ADDAVFVGDAVWDCEAARR---AGVPSIGVLSGGVSR
Mflv_4417|M.gilvum_PYR-GCK IVQVALDRAGVG-AQDAVFVGDAVWDCEAAGR---AGVTSIGLLSGGVSR
MAV_0437|M.avium_104 IVRVALDRAGVR-AEEAVFVGDAVWDAHAARG---AGLACIGLCSGGIAR
Mb3433|M.bovis_AF2122/97 SFLRAAELLGVT-PDAAAVFEDALSGVAAGRAGNFAVVVGINRTGRAAQA
Rv3400|M.tuberculosis_H37Rv SFLRAAELLGVT-PDAAAVFEDALSGVAAGRAGNFAVVVGINRTGRAAQA
MLBr_00393|M.leprae_Br4923 SYLRGAQLLDVA-PDAAAVFEDALSGVQAGLSGHFGFVVGINRTGRVDQA
MMAR_3308|M.marinum_M VLAHALAQLHPL-PERVLMVGDRSHDVEGAAAH-GIDTVVVGWGYGKADF
. . . * . . .
MAB_1500|M.abscessus_ATCC_1997 AQLGTAQPTHIVHSVVEFPDIILRRI------------
TH_3516|M.thermoresistible__bu QTLRAAGATHVLESVADLPRLVLR--------------
MSMEG_4401|M.smegmatis_MC2_155 AELSAHPHTHLLSSVADLPELFGVTRTAATAS------
Mvan_1937|M.vanbaalenii_PYR-1 AELREAGARDVFEDAAELLTELDSTVVGELAGRVSG--
Mflv_4417|M.gilvum_PYR-GCK GELREAGAAGVFEDAGDLLAKLDSTVIGDLAARVSDPR
MAV_0437|M.avium_104 DELRAAGADPVFADPQDLLDHLESTRIAALARGG----
Mb3433|M.bovis_AF2122/97 AQLRRHGADVVVTDLAELL-------------------
Rv3400|M.tuberculosis_H37Rv AQLRRHGADVVVTDLAELL-------------------
MLBr_00393|M.leprae_Br4923 EELRRIGANVVVTDLAELL-------------------
MMAR_3308|M.marinum_M AAGTHSGAALHAGTVDELREALGV--------------
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