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SLREALDDPAVAAARPRVLAGWERLDAPIRWVHTSEVLDIAELLSGGEMLLVAGVILGDSTPDQLRSYVD SLADVGAAALAVERPRIGVLSEALVDRAVARGFPLIELTEVVRFVEVTRALNSRLVNESVRALHFNDEVT HMLAWVLAAQGDLDEMVAGLSALSGCAIMVRSVSGAVLASAEVPDARPRSYAHVAPIESAGVTIATLEVL PRPGVDLQMINAIARRAPESLALALLRWRPLTRSDQAVREVFRLLALAEDTTRPPSLLAETASALRRATR SLGLPPGGWYVGVVAISVDGPLQVAELAAVLRRDERQVLSEIRNGQYRSIVRFDNRTDPAELVEGLVGQL YSTALPSSLRVGITEPQREMADVATTMTVAATAAMHSTESDYVGLARDFTLDHFLTQVDSAAVERFLDAA LGPLRTANRSEELIATLAALFRTGSRVAAAESLRIHRQTMYQRLARIESILGRKLGTADRSTGALRVAVE IAAARGGPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0861 | - | - | 100% (500) | transcriptional regulator, CdaR |
| M. vanbaalenii PYR-1 | Mvan_1854 | - | 7e-19 | 26.47% (476) | purine catabolism PurC domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1825 | - | 1e-15 | 23.14% (523) | purine catabolism PurC domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_0356 | - | 2e-20 | 25.99% (554) | purine catabolism PurC domain-containing protein |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4347 | - | 1e-20 | 25.33% (537) | putative regulatory protein |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_4933 | - | 8e-06 | 27.70% (278) | hypothetical protein MAV_4933 |
| M. smegmatis MC2 155 | MSMEG_2447 | - | 7e-26 | 25.60% (539) | regulatory protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0356|M.gilvum_PYR-GCK MPLTLADVIALPVVQRGRPEVLS-SRRWDDTIRWVHVSDLADLSTLLQGG
MSMEG_2447|M.smegmatis_MC2_155 MIPTVRDVIGLPVVQAGDPEVVS-AENLDCPVRWVHVSDMPDLAGLLHGG
MAB_4347|M.abscessus_ATCC_1997 --MTVAEILALPVVLAGDPQVVG-GGSLDRPVRWVHVSDVADLSGLLQGG
Mvan_0861|M.vanbaalenii_PYR-1 --MSLREALDDPAVAAARPRVLAGWERLDAPIRWVHTSEVLDIAELLSGG
MAV_4933|M.avium_104 ---------------------------------------MKDFRAPVNG-
: *: : *
Mflv_0356|M.gilvum_PYR-GCK ELVLTTGAAMAR----SPRTYLRGLAEAGAVGVVVEVGAVVPEVPPGVGG
MSMEG_2447|M.smegmatis_MC2_155 ELVLTTGAGLAE----APDDYLERMTRAGAVGLVVELGTRVSRLPRGVSD
MAB_4347|M.abscessus_ATCC_1997 ELVLTTGGPLADPD--ACTRYLGGLFAAGAAGVVVELGTSLQAIPSGVAR
Mvan_0861|M.vanbaalenii_PYR-1 EMLLVAGVILGDSTPDQLRSYVDSLADVGAAALAVER-PRIGVLSEALVD
MAV_4933|M.avium_104 ---------------------VDGDSASALVAVPKSQGAQTIRPDSVSRL
: . ..: . .
Mflv_0356|M.gilvum_PYR-GCK IAEQLDLALVVLHRTVRFVEVTEAVHRMIVAEQYDVVEFDRRVHETFTDL
MSMEG_2447|M.smegmatis_MC2_155 VARSLGLPLVLLHRQTRFVEITEAVHRLIVADQYEELAFAHRTHETFTDL
MAB_4347|M.abscessus_ATCC_1997 EADKLQLPVIALHRKIRFVDVTEQVHRSIVAEQYDEVAFARHVHEVFTEL
Mvan_0861|M.vanbaalenii_PYR-1 RAVARGFPLIELTEVVRFVEVTRALNSRLVNESVRALHFNDEVTHMLAWV
MAV_4933|M.avium_104 VGALLDDHAAVVGRVRSVIRSRLPVYRSVADEALEAELEWVLRSAVGGRE
. : . .: : :. :
Mflv_0356|M.gilvum_PYR-GCK SMKRASLSGIVDAAAKLLGEHVVLEDLSHQALVASTG--IPADLLTDWAR
MSMEG_2447|M.smegmatis_MC2_155 SMRRASLADIVRAAADMINESVVLEDLSHQVLAISPRGEAATAVLAEWQR
MAB_4347|M.abscessus_ATCC_1997 TMRRATLGEIVDACGQIAESAIVLEDLNRQVVAFTTHGDSPTGVIHDWER
Mvan_0861|M.vanbaalenii_PYR-1 LAAQGDLDEMVAGLSALSGCAIMVRSVSGAVLASAEVPDARPRSYAHVAP
MAV_4933|M.avium_104 ALHEPQIAGLAAIGEARARDGVPVDDMLRAWRIGVEVVVECAR-------
. : :. : : .: .
Mflv_0356|M.gilvum_PYR-GCK RSRRS----PGGGAGAEPWSATDVGPRFEQWGRLVVPYAPADATRAATVL
MSMEG_2447|M.smegmatis_MC2_155 RSR----------AMAEPWITTSVGPRTEEWGRLIIPHTPAAPARAKTVL
MAB_4347|M.abscessus_ATCC_1997 RSRLTPVLPETGETGPESWLTTPVGPGRQEWGRLIAPSG-GSSLRGRMAL
Mvan_0861|M.vanbaalenii_PYR-1 IES-----------AGVTIATLEVLPRPGVDLQMINAIARRAPESLALAL
MAV_4933|M.avium_104 ----------------------EAARRLGVDDARVLELVQSALAWSDIAM
. : .:
Mflv_0356|M.gilvum_PYR-GCK ERAAAALAMHRMVEQNRTGLQHQAQSGLIDDVLRGRVVDDRDAAARAQAL
MSMEG_2447|M.smegmatis_MC2_155 ERAAQALALHRMAERGRSGLEHQAQSGLIEDVLGGRIADDREAAARAEAL
MAB_4347|M.abscessus_ATCC_1997 ERAAQALALHRMIEQHQTTLEQQAQSGLVEELRRGRIKDEAEASARARAL
Mvan_0861|M.vanbaalenii_PYR-1 LRWRPLTRSDQAVREVFRLLALAEDTTRPPSLLAETASALRRATR---SL
MAV_4933|M.avium_104 ATSAKAHR---RTERALALEAEESDAEFVRGALMGSLP-AAELRMHAELR
.. ::
Mflv_0356|M.gilvum_PYR-GCK GLRSNAQYLPVVVR-VARPAEIDDPVAGHRRNVAVLDAVAHTVNACGHTG
MSMEG_2447|M.smegmatis_MC2_155 GLRAGGPYLPVTVR-TEAPAERLDPVGVQRRNIRILDAVTHSVRSQGHTA
MAB_4347|M.abscessus_ATCC_1997 GVKPALSYIPLTVR-VRE-EPCADQVLLQRRQIRLLDAVRHAVRTARLSA
Mvan_0861|M.vanbaalenii_PYR-1 GLPPGGWYVGVVAISVDGPLQVAELAAVLRR---------------DERQ
MAV_4933|M.avium_104 GLDPGAEYVAVRAR--------------------------------LGGD
*: . *: : .
Mflv_0356|M.gilvum_PYR-GCK LFSLRGDGEVGAVLSLKDSRTRSVDQALGALARRIHTEIRRVDGSDRVVV
MSMEG_2447|M.smegmatis_MC2_155 ICSIRRDGEIGFVLALTPRRNLTADAALARLAEGLRESVTRSGVTTKVVV
MAB_4347|M.abscessus_ATCC_1997 LTANPRPGQIDVLLSQTHAS--SAEEILTNVSSVIRASLQRLDDISRCVV
Mvan_0861|M.vanbaalenii_PYR-1 VLSEIRNGQYRSIVRFDNRT------DPAELVEGLVGQLYSTALPSSLRV
MAV_4933|M.avium_104 GPHLRLEQSLGFQDPAHSRR-----GLCALLDGDLAGFLIEPPRDVEGVV
. : : : *
Mflv_0356|M.gilvum_PYR-GCK TLGPSARNVTDAIAGLAEAIDTAEVALSLRG----DVRDFYRTSDIRLRG
MSMEG_2447|M.smegmatis_MC2_155 AVANNATAFADAVHGLREAAHIAEVALPMAGTARLSGRAFVRASDVRLRG
MAB_4347|M.abscessus_ATCC_1997 GVGPASTRLIDAAVSLDDSAHVAEVALSLPD----DAKAFHRASDTRLRG
Mvan_0861|M.vanbaalenii_PYR-1 GITEPQREMADVATTMTVAATAAMHST--------ESDYVGLARDFTLDH
MAV_4933|M.avium_104 GFGPP-RPLTRLSESYRMAARALVTAEACG---------LRGAYDIAALG
. . : : . : *
Mflv_0356|M.gilvum_PYR-GCK LISLLRDDPRIRRFAETELRALLAHDAGAEPSNISVLREYLRLAGNKSAL
MSMEG_2447|M.smegmatis_MC2_155 LITLMSDDPRVQTFAETELRSLLIHDADHGEDDMAVLRGYLELAGNKSAL
MAB_4347|M.abscessus_ATCC_1997 LLALIRSDPRVQAFAEVELRGVLENRARHGDDLFQLLREFLNTGGNKTEL
Mvan_0861|M.vanbaalenii_PYR-1 FLTQVDS-AAVERFLDAALG--PLRTANRSEELIATLAALFRT-GSRVAA
MAV_4933|M.avium_104 LRTAVAIDADVGELLRKRYLEPLSVGGS-SRELIATVRTYLACGMHVERT
: : : . : : . . : : :
Mflv_0356|M.gilvum_PYR-GCK AERLHMSRPALYKRLRGIEDALGVDLDDGE-SMTSLHVAVMVLDSLTGSG
MSMEG_2447|M.smegmatis_MC2_155 AKRLHMSRPALYSRLAAIQRRLGVDLDDGE-SMTSLHVALLILDTHRSAN
MAB_4347|M.abscessus_ATCC_1997 AKRLHLSRPTLYTKLAIVQRLLGVDLDDAE-SRTSLHTAMLVLDHVNP--
Mvan_0861|M.vanbaalenii_PYR-1 AESLRIHRQTMYQRLARIESILGRKLGTADRSTGALRVAVEIAAARGGPR
MAV_4933|M.avium_104 ATRLFVHQNTVRYRLARFEELTGASLRDTEVVTEVWWVLELAAMRL----
* * : : :: :* .: * .* : .
Mflv_0356|M.gilvum_PYR-GCK -----
MSMEG_2447|M.smegmatis_MC2_155 PEPAR
MAB_4347|M.abscessus_ATCC_1997 -----
Mvan_0861|M.vanbaalenii_PYR-1 -----
MAV_4933|M.avium_104 -----