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LNLQDFVKLLRARWITLCVALIVAVLGAVAVSMLTTPLYQASTRLFVSTAAGSSLSDMYQGNRFSQERVV SYAELLKGETLAQRTIDKLGLDMTAGALRANVSASAKPDTVLIDVKVLDPSPVRARDIANTLSDEFVAMI RELETPEDGSRPDSRVVVEQRASLPVTPVVPKTGRNIMFGVALGLLLGFGVAIVRDLLDNTVKDRKTLEE IAGTGVVGAVPLDKERRKQAAISFDSDNSGISEAFRKLRTNLQFLAVDHPPRVIVVTSSMPGEGKSTTAI NIALALAEAGRNVALIDGDLRRPTLHKYLDLVGAVGFSTVLSGGVGLADALQKTRFPGLTVLTSGTIPPN PSELLGSLAARKVVNELRAQFDYVVIDSTPLVAVTDAAILAAGADGVLIIARYGHTKREQLAHAVGSLEG VGAPLLGAILTMMPTRGTGSYGYSYSYYGDDSTSSSSSRRMSAKLAALELPPPKSDHSLKPPQSIAESGP DIVQQTSAKRRRAAD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1681 | - | - | 100% (505) | lipopolysaccharide biosynthesis |
| M. vanbaalenii PYR-1 | Mvan_3279 | - | 1e-07 | 31.85% (157) | cobyrinic acid a,c-diamide synthase |
| M. vanbaalenii PYR-1 | Mvan_6072 | - | 6e-06 | 31.21% (173) | cobyrinic acid a,c-diamide synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3949c | parA | 1e-06 | 28.91% (211) | chromosome partitioning protein ParA |
| M. gilvum PYR-GCK | Mflv_4771 | - | 0.0 | 71.88% (505) | lipopolysaccharide biosynthesis |
| M. tuberculosis H37Rv | Rv3918c | parA | 1e-06 | 28.91% (211) | chromosome partitioning protein ParA |
| M. leprae Br4923 | MLBr_01622 | ffh | 2e-05 | 25.13% (199) | signal recognition particle protein |
| M. abscessus ATCC 19977 | MAB_3533c | - | 1e-07 | 28.64% (199) | putative cobyrinic acid a,c-diamide synthase |
| M. marinum M | MMAR_4516 | - | 2e-59 | 31.08% (444) | hypothetical protein MMAR_4516 |
| M. avium 104 | MAV_1135 | - | 2e-54 | 29.30% (471) | chain length determinant protein |
| M. smegmatis MC2 155 | MSMEG_5955 | - | 4e-22 | 42.24% (161) | protein-tyrosine kinase, putative |
| M. thermoresistible (build 8) | TH_3875 | - | 2e-06 | 28.67% (150) | PUTATIVE Cobyrinic acid a,c-diamide synthase |
| M. ulcerans Agy99 | MUL_5071 | parA | 5e-08 | 29.86% (211) | chromosome partitioning protein ParA |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1681|M.vanbaalenii_PYR-1 -MNLQDFVKLLRARWITLCVALIVAVLGAVAVSMLTTPLYQASTRLFVST
Mflv_4771|M.gilvum_PYR-GCK -MNLQDFVKLLRSRWMTVCVTMVFAVMGAIAYTLLITPQYQASTRLFVST
MSMEG_5955|M.smegmatis_MC2_155 -MNLKSFVAAAQRFWSTYLLVAGLVLIVGAAAIMMLPVTYVSSARLMVSI
MMAR_4516|M.marinum_M -MDFRTFVQTLAKRWKLVVGALLACLAGATAVTAFQTKVYQSSATIFISV
MAV_1135|M.avium_104 -MDFRTFVRILGAHWKLALTALLACTVGAAFVTALQTKHYQSSATVLISF
Mb3949c|M.bovis_AF2122/97 MSAPWGPVAAGPSALVRSGQASTIEPFQREMTPPTPTPEAAHNPTMNVSR
Rv3918c|M.tuberculosis_H37Rv MSAPWGPVAAGPSALVRSGQASTIEPFQREMTPPTPTPEAAHNPTMNVSR
MUL_5071|M.ulcerans_Agy99 MEAT-GPDADGVAS----------------------AAESADNPTVNVSR
MAB_3533c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3875|M.thermoresistible__bu -----------------------------------MTDDAVTAEVVGLTG
MLBr_01622|M.leprae_Br4923 -MFESLSNRLTGVIQGLRGKGRLTDADIEATTREIRLALFEADVSLPVVR
Mvan_1681|M.vanbaalenii_PYR-1 AAGSSLSDMYQGNRFSQERVVSYAELLKGETLAQRTIDKLGLDMTAGALR
Mflv_4771|M.gilvum_PYR-GCK SSSSSVSEIYQGNRFSQERVVSYAELLMGETLAQRTIDKLGLDMSASSLR
MSMEG_5955|M.smegmatis_MC2_155 EG-STTAAAYQNEEVAIRRIRTYIPLLKSDVVTQRVIDKLGLPMTAKQLA
MMAR_4516|M.marinum_M SGQTDVNDVYWGGQAAQDLLSSYAEIAGGREVAQRAISQLQLPISPEALV
MAV_1135|M.avium_104 SGATDLNEVYSGTETAQERLSSYAQIAGGHIVAERAIRQLQLPMSADDLL
Mb3949c|M.bovis_AF2122/97 ETSTEFDTPIGAAAERAMRVLHTTHEPLQRPGRRRVLTIANQKGGVGKTT
Rv3918c|M.tuberculosis_H37Rv ETSTEFDTPIGAAAERAMRVLHTTHEPLQRPGRRRVLTIANQKGGVGKTT
MUL_5071|M.ulcerans_Agy99 ETSSEFDTPIGAAAERAMRVLHTTHDPLKPPHQRRVFTIANQKGGVGKTT
MAB_3533c|M.abscessus_ATCC_199 --------------------------------MTRVLAVANQKGGVAKTT
TH_3875|M.thermoresistible__bu RPPRPIPEPP----------------PKSTHGPAKVIAMCNQKGGVGKTT
MLBr_01622|M.leprae_Br4923 AFVHRIKERARGTEVSAALNPAQQIVKIVNEELIGILGGETRQLAFAKTP
:
Mvan_1681|M.vanbaalenii_PYR-1 ANVSAS----AKPDTVLIDVKVLDPSPVRARDIANTLSDEFVAMIRELET
Mflv_4771|M.gilvum_PYR-GCK ENISAS----AKPDTVLIDVAVRDPSPVRARDIANTLSDEFVAMVRELET
MSMEG_5955|M.smegmatis_MC2_155 EELSATN---VPPKTSLIDIRISDSSPQRAELIANTVAREFVAYTAAIET
MMAR_4516|M.marinum_M QQTQVK----YTPKSMLFTIAVSDTDPKRAALLAGGMADSFATLVGTLG-
MAV_1135|M.avium_104 SQTQVK----YTPKSVMFTISVKDTDPARAAALAGAMANQFSALLPTIAP
Mb3949c|M.bovis_AF2122/97 TAVNIA----AALAVQGLKTLVIDLDPQGNASTALGITDRQSGTPSSYEM
Rv3918c|M.tuberculosis_H37Rv TAVNIA----AALAVQGLKTLVIDLDPQGNASTALGITDRQSGTPSSYEM
MUL_5071|M.ulcerans_Agy99 TAVNLA----AALAIQGLKTLVIDLDPQGNASTALGITDRQSGTPSSYEV
MAB_3533c|M.abscessus_ATCC_199 TVASLG----AALAQAGKKVLLVDLDPQGCLTFSLGQDPDRLG-ISVHEV
TH_3875|M.thermoresistible__bu STINLG----ASLAEYGRRVLLVDLDPQGALSAGLGVPHYDLD-HTVYNL
MLBr_01622|M.leprae_Br4923 PTVVMLAGLQGSGKTTLAGKLAVRLRRQGHTPLLVACDLQRPAAVNQLQV
Mvan_1681|M.vanbaalenii_PYR-1 PEDGSRPDSR-------------------------------------VVV
Mflv_4771|M.gilvum_PYR-GCK PDGGATPDAR-------------------------------------VVV
MSMEG_5955|M.smegmatis_MC2_155 ATGEDDQKVQ-------------------------------------TTM
MMAR_4516|M.marinum_M -SAPRALGAE-------------PQQQAPPTAP-----------MARVTV
MAV_1135|M.avium_104 NTGPNTVGAQATAGPRPEVAETTPAPGQPPEAPAAVGPTGKPWPLARATM
Mb3949c|M.bovis_AF2122/97 LIG-EVSLHT--------------------------------------AL
Rv3918c|M.tuberculosis_H37Rv LIG-EVSLHT--------------------------------------AL
MUL_5071|M.ulcerans_Agy99 LIG-DVSLRE--------------------------------------AL
MAB_3533c|M.abscessus_ATCC_199 LLG-QADIKE--------------------------------------AL
TH_3875|M.thermoresistible__bu LVEPRVSIDE--------------------------------------VL
MLBr_01622|M.leprae_Br4923 VGERAGVPVFAP-----------------------------------HPG
Mvan_1681|M.vanbaalenii_PYR-1 EQRASLPVTPVVPKTGRNIMFGVALGLLLGFGVAIVRDLLDNTVKDRKTL
Mflv_4771|M.gilvum_PYR-GCK EQRATIPEHPVVPNTTRNIAMGLALGVLLGVAIAVVRDLLDNTVKDRETL
MSMEG_5955|M.smegmatis_MC2_155 VSDATPARRDPVERALLYLLAALAALLLGGAAVWLR--------ASREQL
MMAR_4516|M.marinum_M VKRAEVPVSPSRPLPKRNLVMGLAAGLLLGIAVALAREASDRTVHSRRQL
MAV_1135|M.avium_104 VEPPRVPNVPVSPVPLRNMVIGFIAGLLLAIAVALTREAGDRTVRTRAKL
Mb3949c|M.bovis_AF2122/97 RRSPHSERLFCIPATIDLAGAEIELVSMVARENRLRTALAALDNFDFDYV
Rv3918c|M.tuberculosis_H37Rv RRSPHSERLFCIPATIDLAGAEIELVSMVARENRLRTALAALDNFDFDYV
MUL_5071|M.ulcerans_Agy99 RRSPRSDRLFCVPATIDLAGAEIELVSMVARENRLRNALAELDQFDFDYV
MAB_3533c|M.abscessus_ATCC_199 LTT--TEDLTLLPANIDLAGAEAMLLMRAGREYALKRALESLGDQ-FDVV
TH_3875|M.thermoresistible__bu VSTR-VRNLDLVPSNIDLSAAEIQLVTEVGREQALARALHPVLDR-YDYV
MLBr_01622|M.leprae_Br4923 ASPDSGPGDPVAVASAGLVEARAKHFDVVIVDTAGRLGIDDELMAQAGAI
:
Mvan_1681|M.vanbaalenii_PYR-1 EEIAGTGVVGAVPLDKERRKQAAISFDSDNSG--ISEAFRKLRTNLQFLA
Mflv_4771|M.gilvum_PYR-GCK EGITGAGIVGSVPLDKERRKQAAVAFDRDNSG--IAEAFRKLRTNLQFLA
MSMEG_5955|M.smegmatis_MC2_155 DADSDDPVG--------RAPKAAQTVEGS---------------------
MMAR_4516|M.marinum_M DQLSGLPTLAELPGRRGGVPQFGNDAAIDDAV--RGLRTRLLR------A
MAV_1135|M.avium_104 EELSGLPTLAELPGRRGGTPRFGTDTAFDDAV--RGMRTRLLR------A
Mb3949c|M.bovis_AF2122/97 FVDCPPSLGLLTINALVAAPEVMIPIQCEYYA--LEGVSQLMR-------
Rv3918c|M.tuberculosis_H37Rv FVDCPPSLGLLTINALVAAPEVMIPIQCEYYA--LEGVSQLMR-------
MUL_5071|M.ulcerans_Agy99 FVDCPPSLGLLTINALVAAPEVLIPIQCEYYA--LEGVSQLMR-------
MAB_3533c|M.abscessus_ATCC_199 IIDCPPSLGVLTLNGLTAADSVMVPLQCETLA--HRGVGQFLR-------
TH_3875|M.thermoresistible__bu LIDCQPSLGLLTVNGLACSDGVIIPTECEYFS--LRGLALLTD-------
MLBr_01622|M.leprae_Br4923 REAINPDEVLFVLDAMIGQDAVTTAAAFGAGVGFTGVVLTKLDGDARGGA
Mvan_1681|M.vanbaalenii_PYR-1 VDHPPRVIVVTSSMPGEGKSTTAINIALALAEAGRNVALIDGDLRRPTLH
Mflv_4771|M.gilvum_PYR-GCK VDNPPRVIVVTSSMPSEGKSTTAINIALALAEGEHSVVLVDGDMRRPSLH
MSMEG_5955|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4516|M.marinum_M MGPQARRLVVAAPFAGEGTTTTALNLSLSLAELGEDVLLVEGDTRRPVIA
MAV_1135|M.avium_104 MGPDARQVLVTGPFGGEGTTTTAMNLALALAEMGEDALLVEGDSRRHVIA
Mb3949c|M.bovis_AF2122/97 -------------------NIEMVKAHLNPQLEVTTVILTMYDGRTKLAD
Rv3918c|M.tuberculosis_H37Rv -------------------NIEMVKAHLNPQLEVTTVILTMYDGRTKLAD
MUL_5071|M.ulcerans_Agy99 -------------------NIEMVKAHLNPDLEVTTVILTMYDGRTKLAD
MAB_3533c|M.abscessus_ATCC_199 -------------------TVTDVQQITNPRLTLLGALPTLYDSRTTHSR
TH_3875|M.thermoresistible__bu -------------------TVDKVRDRLNPKLEISGILVTRYDPRTVNSR
MLBr_01622|M.leprae_Br4923 ALSVREVTGVPILFATTGEKLDDFDVFHPDRMASRILGMGDVLSLIEQAE
Mvan_1681|M.vanbaalenii_PYR-1 KYLDLVGAVGFSTVLSGGVGLADALQKTRFPG---LTVLTSGTIPPN--P
Mflv_4771|M.gilvum_PYR-GCK KYLGLVGPVGFSTVLSGGTSLSEALQKTRFPG---LTVLTSGAVPPN--P
MSMEG_5955|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4516|M.marinum_M GLLKVESREGLANALANPEIALEVVKPTRISK---LFILASRSVRRETAS
MAV_1135|M.avium_104 GLLRVESGEGLASALANPAAAAEVVKPTPISR---LFILASRSARRESLP
Mb3949c|M.bovis_AF2122/97 QVADEVRQYFGSKVLRTVIPRSVKVSEAPGYS---MTIIDYDPGSRGAMS
Rv3918c|M.tuberculosis_H37Rv QVADEVRQYFGSKVLRTVIPRSVKVSEAPGYS---MTIIDYDPGSRGAMS
MUL_5071|M.ulcerans_Agy99 QVAEEVRSYFGDKALRTVIPRSVKVSEAPGYS---MTIIDYDPGSRGAMS
MAB_3533c|M.abscessus_ATCC_199 DVLLDVADRYQLPVLAPPIPRTVRFAEASASG---ASVLAGR-KNKGALA
TH_3875|M.thermoresistible__bu EVMARVVERFDDLVFDTVITRTVRFPETSVAG---EPITTWAPKSTGAEA
MLBr_01622|M.leprae_Br4923 QVFDAEQAEAAAAKIVAGELTLEDFLEQMLAVRKMGLIGNLLGMLPGAGQ
Mvan_1681|M.vanbaalenii_PYR-1 SELLGSLAARKVVNELRAQFDYVVIDSTPLVAVTDAAILAAGADGVLIIA
Mflv_4771|M.gilvum_PYR-GCK SELLGSQSARKLLSELRAEFDYVIVDSTPLLAVTDAAILGAGADGVLVMA
MSMEG_5955|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4516|M.marinum_M ANAYLPEVIDSVLMDLSARFSRMVIDGPPVLATADTGLLAGAVQATVLVV
MAV_1135|M.avium_104 PSAYLPEVVDRVVQELSSRFDRIVIDGPPVLATADTGLLSGAVPATVLVV
Mb3949c|M.bovis_AF2122/97 YLDASRELAERDRPPSAKGRP-----------------------------
Rv3918c|M.tuberculosis_H37Rv YLDASRELAERDRPPSAKGRP-----------------------------
MUL_5071|M.ulcerans_Agy99 YLDASRELAQRDRPQTGKERA-----------------------------
MAB_3533c|M.abscessus_ATCC_199 YRELAQSLVKHWKSGKAMPTFTPPVD------------------------
TH_3875|M.thermoresistible__bu YRSLAREVIHRFGA------------------------------------
MLBr_01622|M.leprae_Br4923 VKEVLEQVDDKQLDRLQAIIRGMTPQERADPKIINASRRLRIANGSGVTV
Mvan_1681|M.vanbaalenii_PYR-1 RYGHTKREQLAHAVGSLEGVGAPLLGAILTMMPTRGTGSYGYSYSYYGDD
Mflv_4771|M.gilvum_PYR-GCK RFGQTKRDQLAHAVGSLVDVGAPLLGAVFTMVPTRGSSSYSYSYSYYGSE
MSMEG_5955|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4516|M.marinum_M RAGRTTVDEVDDALSALRAAGANVVGTVLTDARISRHTSAAARIYRGKIS
MAV_1135|M.avium_104 RAKRTTADELRDALTALRAAGAHVVGTVLTDARQSLHIRAADRAYRSKVS
Mb3949c|M.bovis_AF2122/97 --------------------------------------------------
Rv3918c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_5071|M.ulcerans_Agy99 --------------------------------------------------
MAB_3533c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3875|M.thermoresistible__bu --------------------------------------------------
MLBr_01622|M.leprae_Br4923 SEVNQLVDRFFEARKMMSSVLGGMGIPGMGRKSATRKSKGGKGKKRARGP
Mvan_1681|M.vanbaalenii_PYR-1 STSSSSSR---RMSAKLAALELPPPKSDHSLKPPQSIAESGPDIVQQTSA
Mflv_4771|M.gilvum_PYR-GCK SAPQQARQDVPVAPTKPAALDAAPSQTGAEPPDPDSSLPRADATPGASRR
MSMEG_5955|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4516|M.marinum_M GLS-----------------------------------------------
MAV_1135|M.avium_104 RPA-----------------------------------------------
Mb3949c|M.bovis_AF2122/97 --------------------------------------------------
Rv3918c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_5071|M.ulcerans_Agy99 --------------------------------------------------
MAB_3533c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3875|M.thermoresistible__bu --------------------------------------------------
MLBr_01622|M.leprae_Br4923 TSPKVRSPFGPARPGMPDMMNMPPSFPDLSQMPDGLNELPPGLAAFDLSK
Mvan_1681|M.vanbaalenii_PYR-1 KRRRAAD
Mflv_4771|M.gilvum_PYR-GCK RRRQVSE
MSMEG_5955|M.smegmatis_MC2_155 -------
MMAR_4516|M.marinum_M -------
MAV_1135|M.avium_104 -------
Mb3949c|M.bovis_AF2122/97 -------
Rv3918c|M.tuberculosis_H37Rv -------
MUL_5071|M.ulcerans_Agy99 -------
MAB_3533c|M.abscessus_ATCC_199 -------
TH_3875|M.thermoresistible__bu -------
MLBr_01622|M.leprae_Br4923 LKFPGKT