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NLQDFVKLLRSRWMTVCVTMVFAVMGAIAYTLLITPQYQASTRLFVSTSSSSSVSEIYQGNRFSQERVVS YAELLMGETLAQRTIDKLGLDMSASSLRENISASAKPDTVLIDVAVRDPSPVRARDIANTLSDEFVAMVR ELETPDGGATPDARVVVEQRATIPEHPVVPNTTRNIAMGLALGVLLGVAIAVVRDLLDNTVKDRETLEGI TGAGIVGSVPLDKERRKQAAVAFDRDNSGIAEAFRKLRTNLQFLAVDNPPRVIVVTSSMPSEGKSTTAIN IALALAEGEHSVVLVDGDMRRPSLHKYLGLVGPVGFSTVLSGGTSLSEALQKTRFPGLTVLTSGAVPPNP SELLGSQSARKLLSELRAEFDYVIVDSTPLLAVTDAAILGAGADGVLVMARFGQTKRDQLAHAVGSLVDV GAPLLGAVFTMVPTRGSSSYSYSYSYYGSESAPQQARQDVPVAPTKPAALDAAPSQTGAEPPDPDSSLPR ADATPGASRRRRRQVSE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4771 | - | - | 100% (508) | lipopolysaccharide biosynthesis |
| M. gilvum PYR-GCK | Mflv_3498 | - | 2e-06 | 28.86% (149) | cobyrinic acid a,c-diamide synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3949c | parA | 5e-05 | 28.40% (169) | chromosome partitioning protein ParA |
| M. tuberculosis H37Rv | Rv3918c | parA | 6e-05 | 28.40% (169) | chromosome partitioning protein ParA |
| M. leprae Br4923 | MLBr_01622 | ffh | 5e-05 | 26.95% (141) | signal recognition particle protein |
| M. abscessus ATCC 19977 | MAB_2367 | - | 2e-05 | 27.92% (154) | hypothetical protein MAB_2367 |
| M. marinum M | MMAR_4516 | - | 7e-57 | 31.98% (444) | hypothetical protein MMAR_4516 |
| M. avium 104 | MAV_1135 | - | 2e-51 | 28.51% (470) | chain length determinant protein |
| M. smegmatis MC2 155 | MSMEG_5955 | - | 5e-21 | 33.33% (192) | protein-tyrosine kinase, putative |
| M. thermoresistible (build 8) | TH_3875 | - | 2e-05 | 27.52% (149) | PUTATIVE Cobyrinic acid a,c-diamide synthase |
| M. ulcerans Agy99 | MUL_5071 | parA | 2e-06 | 30.77% (169) | chromosome partitioning protein ParA |
| M. vanbaalenii PYR-1 | Mvan_1681 | - | 0.0 | 71.88% (505) | lipopolysaccharide biosynthesis |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4771|M.gilvum_PYR-GCK -MNLQDFVKLLRSRWMTVCVTMVFAVMGAIAYTLLITPQYQASTRLFVST
Mvan_1681|M.vanbaalenii_PYR-1 -MNLQDFVKLLRARWITLCVALIVAVLGAVAVSMLTTPLYQASTRLFVST
MSMEG_5955|M.smegmatis_MC2_155 -MNLKSFVAAAQRFWSTYLLVAGLVLIVGAAAIMMLPVTYVSSARLMVSI
MMAR_4516|M.marinum_M -MDFRTFVQTLAKRWKLVVGALLACLAGATAVTAFQTKVYQSSATIFISV
MAV_1135|M.avium_104 -MDFRTFVRILGAHWKLALTALLACTVGAAFVTALQTKHYQSSATVLISF
Mb3949c|M.bovis_AF2122/97 MSAPWGPVAAGPSALVRSGQASTIEPFQREMTPPTPTPEAAHNPTMNVSR
Rv3918c|M.tuberculosis_H37Rv MSAPWGPVAAGPSALVRSGQASTIEPFQREMTPPTPTPEAAHNPTMNVSR
MUL_5071|M.ulcerans_Agy99 MEAT-GPDADGVAS----------------------AAESADNPTVNVSR
MAB_2367|M.abscessus_ATCC_1997 -------MTDGSLD----------------------SDFPADDGDLDLTG
TH_3875|M.thermoresistible__bu -------MTDDAVT----------------------AEVVG------LTG
MLBr_01622|M.leprae_Br4923 -MFESLSNRLTGVIQGLRGKGRLTDADIEATTREIRLALFEADVSLPVVR
:
Mflv_4771|M.gilvum_PYR-GCK SSSSSVSEIYQGNRFSQERVVSYAELLMGETLAQRTIDKLGLDMSASSLR
Mvan_1681|M.vanbaalenii_PYR-1 AAGSSLSDMYQGNRFSQERVVSYAELLKGETLAQRTIDKLGLDMTAGALR
MSMEG_5955|M.smegmatis_MC2_155 EG-STTAAAYQNEEVAIRRIRTYIPLLKSDVVTQRVIDKLGLPMTAKQLA
MMAR_4516|M.marinum_M SGQTDVNDVYWGGQAAQDLLSSYAEIAGGREVAQRAISQLQLPISPEALV
MAV_1135|M.avium_104 SGATDLNEVYSGTETAQERLSSYAQIAGGHIVAERAIRQLQLPMSADDLL
Mb3949c|M.bovis_AF2122/97 ETSTEFDTPIGAAAERAMRVLHTTHEPLQRPGRRRVLTIANQKGGVGKTT
Rv3918c|M.tuberculosis_H37Rv ETSTEFDTPIGAAAERAMRVLHTTHEPLQRPGRRRVLTIANQKGGVGKTT
MUL_5071|M.ulcerans_Agy99 ETSSEFDTPIGAAAERAMRVLHTTHDPLKPPHQRRVFTIANQKGGVGKTT
MAB_2367|M.abscessus_ATCC_1997 RPPKDIPEPK----------------PLTSHGPAKVIAMCNQKGGVGKTT
TH_3875|M.thermoresistible__bu RPPRPIPEPP----------------PKSTHGPAKVIAMCNQKGGVGKTT
MLBr_01622|M.leprae_Br4923 AFVHRIKERARGTEVSAALNPAQQIVKIVNEELIGILGGETRQLAFAKTP
:
Mflv_4771|M.gilvum_PYR-GCK ENISAS----AKPDTVLIDVAVRDPSPVRARDIANTLSDEFVAMVRELET
Mvan_1681|M.vanbaalenii_PYR-1 ANVSAS----AKPDTVLIDVKVLDPSPVRARDIANTLSDEFVAMIRELET
MSMEG_5955|M.smegmatis_MC2_155 EELSATN---VPPKTSLIDIRISDSSPQRAELIANTVAREFVAYTAAIET
MMAR_4516|M.marinum_M QQTQVK----YTPKSMLFTIAVSDTDPKRAALLAGGMADSFATLVGTLG-
MAV_1135|M.avium_104 SQTQVK----YTPKSVMFTISVKDTDPARAAALAGAMANQFSALLPTIAP
Mb3949c|M.bovis_AF2122/97 TAVNIA----AALAVQGLKTLVIDLDPQGNASTALGITDRQSGTPSSYEM
Rv3918c|M.tuberculosis_H37Rv TAVNIA----AALAVQGLKTLVIDLDPQGNASTALGITDRQSGTPSSYEM
MUL_5071|M.ulcerans_Agy99 TAVNLA----AALAIQGLKTLVIDLDPQGNASTALGITDRQSGTPSSYEV
MAB_2367|M.abscessus_ATCC_1997 STINLG----AALAGYGRRVLLVDLDPQGALSAGLGIAHHELETTVHNLL
TH_3875|M.thermoresistible__bu STINLG----ASLAEYGRRVLLVDLDPQGALSAGLGVPHYDLDHTVYNLL
MLBr_01622|M.leprae_Br4923 PTVVMLAGLQGSGKTTLAGKLAVRLRRQGHTPLLVACDLQRPAAVNQLQV
Mflv_4771|M.gilvum_PYR-GCK PDGGATPDAR-------------------------------------VVV
Mvan_1681|M.vanbaalenii_PYR-1 PEDGSRPDSR-------------------------------------VVV
MSMEG_5955|M.smegmatis_MC2_155 ATGEDDQKVQ-------------------------------------TTM
MMAR_4516|M.marinum_M -SAPRALGAE-------------PQQQAPPTAP-----------MARVTV
MAV_1135|M.avium_104 NTGPNTVGAQATAGPRPEVAETTPAPGQPPEAPAAVGPTGKPWPLARATM
Mb3949c|M.bovis_AF2122/97 LIGEVSLHTA-------------------------------------LRR
Rv3918c|M.tuberculosis_H37Rv LIGEVSLHTA-------------------------------------LRR
MUL_5071|M.ulcerans_Agy99 LIGDVSLREA-------------------------------------LRR
MAB_2367|M.abscessus_ATCC_1997 VEPRVSVDDV-------------------------------------LMR
TH_3875|M.thermoresistible__bu VEPRVSIDEV-------------------------------------LVS
MLBr_01622|M.leprae_Br4923 VGERAGVPVFAPHPG-------------------------------ASPD
Mflv_4771|M.gilvum_PYR-GCK EQRATIPEHPVVPNTTRNIAMGLALGVLLGVAIAVVRDLLDNTVKDRETL
Mvan_1681|M.vanbaalenii_PYR-1 EQRASLPVTPVVPKTGRNIMFGVALGLLLGFGVAIVRDLLDNTVKDRKTL
MSMEG_5955|M.smegmatis_MC2_155 VSDATPARRDPVERALLYLLAALAALLLGGAAVWLR--------ASREQL
MMAR_4516|M.marinum_M VKRAEVPVSPSRPLPKRNLVMGLAAGLLLGIAVALAREASDRTVHSRRQL
MAV_1135|M.avium_104 VEPPRVPNVPVSPVPLRNMVIGFIAGLLLAIAVALTREAGDRTVRTRAKL
Mb3949c|M.bovis_AF2122/97 SPHSERLFCIPATIDLAGAEIELVSMVARENRLRTALAALDNFDFDYVFV
Rv3918c|M.tuberculosis_H37Rv SPHSERLFCIPATIDLAGAEIELVSMVARENRLRTALAALDNFDFDYVFV
MUL_5071|M.ulcerans_Agy99 SPRSDRLFCVPATIDLAGAEIELVSMVARENRLRNALAELDQFDFDYVFV
MAB_2367|M.abscessus_ATCC_1997 T-RVEGLDLIPSNIDLSAAEIQLVNEVGREHSLARALHPVLDR-YDYVLI
TH_3875|M.thermoresistible__bu T-RVRNLDLVPSNIDLSAAEIQLVTEVGREQALARALHPVLDR-YDYVLI
MLBr_01622|M.leprae_Br4923 SGPGDPVAVASAGLVEARAKHFDVVIVDTAGRLGIDDELMAQAGAIREAI
: : :
Mflv_4771|M.gilvum_PYR-GCK EGITGAGIVGSVPLDKERRKQAAVAFDRDNSGIAEAFRKLRTNLQFLAVD
Mvan_1681|M.vanbaalenii_PYR-1 EEIAGTGVVGAVPLDKERRKQAAISFDSDNSGISEAFRKLRTNLQFLAVD
MSMEG_5955|M.smegmatis_MC2_155 DADSDDPVG--------RAPKAAQTVEGS---------------------
MMAR_4516|M.marinum_M DQLSGLPTLAELP-----GRRGGVPQFGNDAAIDDAVRGLRT-RLLRAMG
MAV_1135|M.avium_104 EELSGLPTLAELP-----GRRGGTPRFGTDTAFDDAVRGMRT-RLLRAMG
Mb3949c|M.bovis_AF2122/97 DCPPSLGLLT---------INALVAAPEVMIPIQCEYYALEG--------
Rv3918c|M.tuberculosis_H37Rv DCPPSLGLLT---------INALVAAPEVMIPIQCEYYALEG--------
MUL_5071|M.ulcerans_Agy99 DCPPSLGLLT---------INALVAAPEVLIPIQCEYYALEG--------
MAB_2367|M.abscessus_ATCC_1997 DCQPSLGLLT---------VNALACSEGVVIPMECAFFSLRG--------
TH_3875|M.thermoresistible__bu DCQPSLGLLT---------VNGLACSDGVIIPTECEYFSLRG--------
MLBr_01622|M.leprae_Br4923 NPDEVLFVLDAMIG--QDAVTTAAAFGAGVGFTGVVLTKLDGDARGGAAL
:
Mflv_4771|M.gilvum_PYR-GCK NPPRVIVVTSSMPSEGKSTTAINIALALAEGEHSVVLVDGDMRRPSLHKY
Mvan_1681|M.vanbaalenii_PYR-1 HPPRVIVVTSSMPGEGKSTTAINIALALAEAGRNVALIDGDLRRPTLHKY
MSMEG_5955|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4516|M.marinum_M PQARRLVVAAPFAGEGTTTTALNLSLSLAELGEDVLLVEGDTRRPVIAGL
MAV_1135|M.avium_104 PDARQVLVTGPFGGEGTTTTAMNLALALAEMGEDALLVEGDSRRHVIAGL
Mb3949c|M.bovis_AF2122/97 -------VSQLMRNIEMVKAHLNPQLEVTTVILTMYDGRTKLADQVADEV
Rv3918c|M.tuberculosis_H37Rv -------VSQLMRNIEMVKAHLNPQLEVTTVILTMYDGRTKLADQVADEV
MUL_5071|M.ulcerans_Agy99 -------VSQLMRNIEMVKAHLNPDLEVTTVILTMYDGRTKLADQVAEEV
MAB_2367|M.abscessus_ATCC_1997 -------LALLTDTVAKVRDRLNPKLAVSGIVITMFDARTLHAREVMARV
TH_3875|M.thermoresistible__bu -------LALLTDTVDKVRDRLNPKLEISGILVTRYDPRTVNSREVMARV
MLBr_01622|M.leprae_Br4923 SVREVTGVPILFATTGEKLDDFDVFHPDRMASRILGMGDVLSLIEQAEQV
Mflv_4771|M.gilvum_PYR-GCK LGLVGPVGFSTVLSGGTSLSEALQKTRFPGLTVLTSGAVPPN--PSELLG
Mvan_1681|M.vanbaalenii_PYR-1 LDLVGAVGFSTVLSGGVGLADALQKTRFPGLTVLTSGTIPPN--PSELLG
MSMEG_5955|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4516|M.marinum_M LKVESREGLANALANPEIALEVVKPTRISKLFILASRSVRRETASANAYL
MAV_1135|M.avium_104 LRVESGEGLASALANPAAAAEVVKPTPISRLFILASRSARRESLPPSAYL
Mb3949c|M.bovis_AF2122/97 RQYFGSKVLRTVIPRSVKVSEAPGYS------------MTIIDYDPGSRG
Rv3918c|M.tuberculosis_H37Rv RQYFGSKVLRTVIPRSVKVSEAPGYS------------MTIIDYDPGSRG
MUL_5071|M.ulcerans_Agy99 RSYFGDKALRTVIPRSVKVSEAPGYS------------MTIIDYDPGSRG
MAB_2367|M.abscessus_ATCC_1997 IEVFGDQVFHTVITRTVRFPETSVAG------------EPITTWAPKSSG
TH_3875|M.thermoresistible__bu VERFDDLVFDTVITRTVRFPETSVAG------------EPITTWAPKSTG
MLBr_01622|M.leprae_Br4923 FDAEQAEAAAAKIVAGELTLEDFLEQMLAVRKMGLIG-NLLGMLPGAGQV
Mflv_4771|M.gilvum_PYR-GCK SQSARKLLSELRAEFDYVIVDSTPLLAVTDAAILGAGADGVLVMARFGQT
Mvan_1681|M.vanbaalenii_PYR-1 SLAARKVVNELRAQFDYVVIDSTPLVAVTDAAILAAGADGVLIIARYGHT
MSMEG_5955|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4516|M.marinum_M PEVIDSVLMDLSARFSRMVIDGPPVLATADTGLLAGAVQATVLVVRAGRT
MAV_1135|M.avium_104 PEVVDRVVQELSSRFDRIVIDGPPVLATADTGLLSGAVPATVLVVRAKRT
Mb3949c|M.bovis_AF2122/97 AMSYLDASRELAERDRPPSAKGRP--------------------------
Rv3918c|M.tuberculosis_H37Rv AMSYLDASRELAERDRPPSAKGRP--------------------------
MUL_5071|M.ulcerans_Agy99 AMSYLDASRELAQRDRPQTGKERA--------------------------
MAB_2367|M.abscessus_ATCC_1997 AQAYISLAREVIDRFET---------------------------------
TH_3875|M.thermoresistible__bu AEAYRSLAREVIHRFGA---------------------------------
MLBr_01622|M.leprae_Br4923 KEVLEQVDDKQLDRLQAIIRGMTPQERADPKIINASRRLRIANGSGVTVS
Mflv_4771|M.gilvum_PYR-GCK KRDQLAHAVGSLVDVGAPLLG----AVFTMVPTRGSSSYSYSYSYYGSES
Mvan_1681|M.vanbaalenii_PYR-1 KREQLAHAVGSLEGVGAPLLG----AILTMMPTRGTGSYGYSYSYYGDDS
MSMEG_5955|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4516|M.marinum_M TVDEVDDALSALRAAGANVVG----TVLTDARISRHTSAAARIYRGKISG
MAV_1135|M.avium_104 TADELRDALTALRAAGAHVVG----TVLTDARQSLHIRAADRAYRSKVSR
Mb3949c|M.bovis_AF2122/97 --------------------------------------------------
Rv3918c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_5071|M.ulcerans_Agy99 --------------------------------------------------
MAB_2367|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3875|M.thermoresistible__bu --------------------------------------------------
MLBr_01622|M.leprae_Br4923 EVNQLVDRFFEARKMMSSVLGGMGIPGMGRKSATRKSKGGKGKKRARGPT
Mflv_4771|M.gilvum_PYR-GCK APQQARQDVPVAPTKPAALDAAPSQTGAEPPDPDSSLPRADATPGASRRR
Mvan_1681|M.vanbaalenii_PYR-1 TSSSSSR---RMSAKLAALELPPPKSDHSLKPPQSIAESGPDIVQQTSAK
MSMEG_5955|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4516|M.marinum_M LS------------------------------------------------
MAV_1135|M.avium_104 PA------------------------------------------------
Mb3949c|M.bovis_AF2122/97 --------------------------------------------------
Rv3918c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_5071|M.ulcerans_Agy99 --------------------------------------------------
MAB_2367|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3875|M.thermoresistible__bu --------------------------------------------------
MLBr_01622|M.leprae_Br4923 SPKVRSPFGPARPGMPDMMNMPPSFPDLSQMPDGLNELPPGLAAFDLSKL
Mflv_4771|M.gilvum_PYR-GCK RRQVSE
Mvan_1681|M.vanbaalenii_PYR-1 RRRAAD
MSMEG_5955|M.smegmatis_MC2_155 ------
MMAR_4516|M.marinum_M ------
MAV_1135|M.avium_104 ------
Mb3949c|M.bovis_AF2122/97 ------
Rv3918c|M.tuberculosis_H37Rv ------
MUL_5071|M.ulcerans_Agy99 ------
MAB_2367|M.abscessus_ATCC_1997 ------
TH_3875|M.thermoresistible__bu ------
MLBr_01622|M.leprae_Br4923 KFPGKT