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LQSPERIILVTGASRGVGADVARRIAGADTHVIVNHCGRPERAEAVAQAIRDAGGHASTIAADVHDEFAV AAMIETIRARFGRLDALILNASGDDPHDAVRVNGDVHRRLATRAMPLMPTGARIVFVTSHQAHFYPDKAV PKGYAGVAASQRAAETALYAMRSELAHAGIGFTVVSAEMTGETVTAPAVVNAATTAQPVGIVYVGGAAHL MTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1615 | - | - | 100% (214) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5843 | - | 1e-09 | 38.10% (84) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4921 | - | 4e-09 | 30.06% (173) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2153c | - | 9e-13 | 29.03% (186) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0138 | - | 3e-12 | 31.35% (185) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2129c | - | 9e-13 | 29.03% (186) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 6e-09 | 25.94% (212) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4632 | - | 2e-09 | 34.34% (99) | short chain dehydrogenase |
| M. marinum M | MMAR_0030 | - | 6e-10 | 27.62% (210) | shortchain dehydrogenase |
| M. avium 104 | MAV_5221 | - | 3e-11 | 30.50% (200) | NAD dependent epimerase/dehydratase family protein |
| M. smegmatis MC2 155 | MSMEG_0530 | - | 2e-61 | 56.19% (226) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_2552 | - | 3e-11 | 29.90% (194) | PUTATIVE putative short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2359 | - | 9e-11 | 26.04% (192) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0530|M.smegmatis_MC2_155 --------------------------------------------------
Mb2153c|M.bovis_AF2122/97 --------------------------------------------------
Rv2129c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2359|M.ulcerans_Agy99 --------------------------------------------------
MAV_5221|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MMAR_0030|M.marinum_M --------------------------------------------------
Mflv_0138|M.gilvum_PYR-GCK --------------------------------------------------
TH_2552|M.thermoresistible__bu --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0530|M.smegmatis_MC2_155 --------------------------------------------------
Mb2153c|M.bovis_AF2122/97 --------------------------------------------------
Rv2129c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2359|M.ulcerans_Agy99 --------------------------------------------------
MAV_5221|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MMAR_0030|M.marinum_M --------------------------------------------------
Mflv_0138|M.gilvum_PYR-GCK --------------------------------------------------
TH_2552|M.thermoresistible__bu --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0530|M.smegmatis_MC2_155 --------------------------------------------------
Mb2153c|M.bovis_AF2122/97 --------------------------------------------------
Rv2129c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2359|M.ulcerans_Agy99 --------------------------------------------------
MAV_5221|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MMAR_0030|M.marinum_M --------------------------------------------------
Mflv_0138|M.gilvum_PYR-GCK --------------------------------------------------
TH_2552|M.thermoresistible__bu --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0530|M.smegmatis_MC2_155 --------------------------------------------------
Mb2153c|M.bovis_AF2122/97 --------------------------------------------------
Rv2129c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2359|M.ulcerans_Agy99 --------------------------------------------------
MAV_5221|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
MMAR_0030|M.marinum_M --------------------------------------------------
Mflv_0138|M.gilvum_PYR-GCK --------------------------------------------------
TH_2552|M.thermoresistible__bu --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0530|M.smegmatis_MC2_155 --------------------------------------------------
Mb2153c|M.bovis_AF2122/97 --------------------------------------------------
Rv2129c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2359|M.ulcerans_Agy99 --------------------------------------------------
MAV_5221|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
MMAR_0030|M.marinum_M --------------------------------------------------
Mflv_0138|M.gilvum_PYR-GCK --------------------------------------------------
TH_2552|M.thermoresistible__bu --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0530|M.smegmatis_MC2_155 --------------------------------------------------
Mb2153c|M.bovis_AF2122/97 --------------------------------------------------
Rv2129c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2359|M.ulcerans_Agy99 --------------------------------------------------
MAV_5221|M.avium_104 ----------------------------MVQAARTNAAAKVNAIAQALDK
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MMAR_0030|M.marinum_M --------------------------------------------------
Mflv_0138|M.gilvum_PYR-GCK --------------------------------------------------
TH_2552|M.thermoresistible__bu --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1615|M.vanbaalenii_PYR-1 ---------------------MLQ-SPERIILVTGASRGVGADVARRIAG
MSMEG_0530|M.smegmatis_MC2_155 ---------------------MQQDTTARVALITGASRGIGAEVAQQLAT
Mb2153c|M.bovis_AF2122/97 ----------------------MTSLQGKVVFITGAARGIGAEVARRLHN
Rv2129c|M.tuberculosis_H37Rv ----------------------MTSLQGKVVFITGAARGIGAEVARRLHN
MUL_2359|M.ulcerans_Agy99 ----------------------MTSVQDKVVFITGGARGIGAEVARRLHN
MAV_5221|M.avium_104 VLNTVADRVANPARV-SDPDRLRGAVGGRTVLVTGASYGIGEATARRLAA
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
MMAR_0030|M.marinum_M ------------MAVIGKRRAYRVRVESATFLIVGGSSGIGRSVAERAAR
Mflv_0138|M.gilvum_PYR-GCK -------------------MGLPTPSPTTTAVVTGASSGIGADLARELAA
TH_2552|M.thermoresistible__bu ------------------------VLSDSVALITGASGGIGRVLARRYAQ
MAB_4632|M.abscessus_ATCC_1997 ------------------MILDRFKLDGNVAVVTGAGRGLGAAIAEAFAQ
:.*.. *:* *
Mvan_1615|M.vanbaalenii_PYR-1 ADTHVIVNHCGRPERAEAVAQAIRDAGGHASTIAADVHDEFAVAAMIETI
MSMEG_0530|M.smegmatis_MC2_155 SGTHSIVNYRANAERAEGIAETIRAAGGQASTIRADIADEASTAAMIDDI
Mb2153c|M.bovis_AF2122/97 KGAKLVLTDLSKSELAVMGAELGGDD--RLLTVVADVRDLPAMQAAAETA
Rv2129c|M.tuberculosis_H37Rv KGAKLVLTDLSKSELAVMGAELGGDD--RLLTVVADVRDLPAMQAAAETA
MUL_2359|M.ulcerans_Agy99 MGAKLVLTDLSEAELATIAAELGRDD--RVLTVVADVRDLPAMEAAADQA
MAV_5221|M.avium_104 AGATVLVVARSEERLGELTAAINAGGG-RAVAYPTDLTDESAVSALTKQI
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGG-VAYAYALDVSDAAAVEAFAEQV
MMAR_0030|M.marinum_M RGATVAVTARRTDRLASLAATIAEMGG-SCSIHPADATDPVAAQSVVADV
Mflv_0138|M.gilvum_PYR-GCK RGHGVTLVARREDRLRALADELSSSN-VRVEVVACDVADADARAGLFPEI
TH_2552|M.thermoresistible__bu RGARVALVARRRDELNVTAAAVTEAGG-EALVLVADIRDETQCADAVAAT
MAB_4632|M.abscessus_ATCC_1997 AGADVLIASRTESQLREVAAKVQAAGR-QAEVVVADLSDTEASAALAQKA
. : * *
Mvan_1615|M.vanbaalenii_PYR-1 RARFGRLDALILNA---SGD-------DPHDAVRVNGDVHR---RLATRA
MSMEG_0530|M.smegmatis_MC2_155 GRRFGRLDALVLTA---LGGPRVGL--DPRHAMRLNRDAQR---RLARLA
Mb2153c|M.bovis_AF2122/97 VERFGGIDVVVANAGIASYGSVLKV--DPQAFRRVLDVNLLGNFHTVRAT
Rv2129c|M.tuberculosis_H37Rv VERFGGIDVVVANAGIASYGSVLKV--DPQAFRRVLDVNLLGNFHTVRAT
MUL_2359|M.ulcerans_Agy99 VEKFGGIDIVMANAGIASYGSVLQV--DPEAFKRVLDVNVMGVFHTVRAT
MAV_5221|M.avium_104 TEEHGPLDVVVSNAGKSLRRSLHHQYDRPHDFQRTIDVNYLGPVRLLLGL
MLBr_00862|M.leprae_Br4923 SAKHGVPDIVVNNAGIGQAGRFLDT--PPEEFDRVLAVNLGGVVNCCRAF
MMAR_0030|M.marinum_M LERHGKIDVVLLNAGGAPALDLTRL--DAADITSVMDANYDVAVNYLVPV
Mflv_0138|M.gilvum_PYR-GCK ERRGLTVDVLVNNAGIGTIGPVVDS--TPEAEIGQVRVNVEAVIDLTTRA
TH_2552|M.thermoresistible__bu VARWGRLDVLVNNAAVPGSDQSVAEA-TVDNWNQVLATNLVAPMVLSREA
MAB_4632|M.abscessus_ATCC_1997 VDRFGRLDVVVNNVGGTMPKPFLDT--TNDDLAEAFSFNVLSGHALLRAA
. * :: ..
Mvan_1615|M.vanbaalenii_PYR-1 MPLMPT--GARIVFVTSHQAHFYPDKAVPKGYAGVAASQRAAETALYAMR
MSMEG_0530|M.smegmatis_MC2_155 LPLMPA--GGHIVFVTSHQAHFFPHKAVPKGYGPIAASKRAGETALYAMR
Mb2153c|M.bovis_AF2122/97 LPALID--RRGYVLIVSSLAAF----AAPPGMAPYNMSKAGNEHFANALR
Rv2129c|M.tuberculosis_H37Rv LPALID--RRGYVLIVSSLAAF----AAPPGMAPYNMSKAGNEHFANALR
MUL_2359|M.ulcerans_Agy99 LPAVIE--RRGYVLIVSSLAAY----AASPGLAPYNASKAAVEIFANALR
MAV_5221|M.avium_104 LPAMRDN-GRGHVVNVSSVGVR---VVPGPQWGAYQASKGAFDRWLRSVA
MLBr_00862|M.leprae_Br4923 GQRLVERGTGGHIVNVSSMAAY----APLQSLSAYCTSKAATYMFSDCLR
MMAR_0030|M.marinum_M LRHMTER-GTGVIAHTNSLAGWY----AVPLQGPYSAAKAALRVLFDAYR
Mflv_0138|M.gilvum_PYR-GCK VQQMVPR-GRGAILNVGSTAGF----QPFPGQSGYAATKAFVRTYTDGLR
TH_2552|M.thermoresistible__bu LCQAMIPAGSGNIQFLSSAAAR----NVAPGKAHYAAAKLALSALGQTLA
MAB_4632|M.abscessus_ATCC_1997 VPHLLKSDNASVINITSTMGR-----LPGRAFLGYCTAKGALAHYTRTAA
: . . ::
Mvan_1615|M.vanbaalenii_PYR-1 SELAHAGIGFTVVSAEMTGETVT--------------------APAVVNA
MSMEG_0530|M.smegmatis_MC2_155 PEFDRHGVHFTVVSGAMLDEMTIADLWQRREPEAEF-------ASAVVHA
Mb2153c|M.bovis_AF2122/97 LEVAHLGVSVGSAHMSWIDTALVRDTKADLPAFAELLAR----LPWPLNK
Rv2129c|M.tuberculosis_H37Rv LEVAHLGVSVGSAHMSWIDTALVRDTKADLPAFAELLAR----LPWPLNK
MUL_2359|M.ulcerans_Agy99 LEVADRGVSVGSAHMSWIDTALVRDTKGDLPAFAELLSR----LPWPLNK
MAV_5221|M.avium_104 PELHADGVHVSTVYFALVRTRMIAPTPVLGRLPGLSPDQ----AADVIAK
MLBr_00862|M.leprae_Br4923 AELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFR
MMAR_0030|M.marinum_M IEYAGSGVRFVSIYPGFVATEATE--------------------GDGMPA
Mflv_0138|M.gilvum_PYR-GCK GELAGTGVTVTALHPGPVRTEFLDTAGMDERTFASAFPK-----FLWIES
TH_2552|M.thermoresistible__bu LEVGGTGIRVNTLVVGSVEGELLDR------------------YVARRAA
MAB_4632|M.abscessus_ATCC_1997 MDLSPR-IRVNGIAPGSILTSALEVVAGNDEMRNTLEQN------TPLHR
: : .
Mvan_1615|M.vanbaalenii_PYR-1 ATTAQP--VGIVYVGGAAHLMTA---------------------------
MSMEG_0530|M.smegmatis_MC2_155 ATAPKP--SGIVFVGRAEYLMTA---------------------------
Mb2153c|M.bovis_AF2122/97 TTSVNK--CAAAFVNGIEGRKDRVYCPGWVALFRWLKPLLSTRVGQRPIR
Rv2129c|M.tuberculosis_H37Rv TTSVNK--CAAAFVNGIEGRKDRVYCPGWVALFRWLKPLLSTRVGQRPIR
MUL_2359|M.ulcerans_Agy99 TTSVNK--CAAAFIKGIEGRKTRIYCPDWVGLFRWLKPALSTPLGELPVR
MAV_5221|M.avium_104 AVIERPRTLEPPWVLPAELASVLLAGPADRAARLWHRRFFTDAEEAGRER
MLBr_00862|M.leprae_Br4923 LRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARI
MMAR_0030|M.marinum_M PGEISEQEAADHVLRALSSGRESYSFPRAMSTLVGLGRLLPTTLRRKVIK
Mflv_0138|M.gilvum_PYR-GCK REVAEKGIDGLAADRGSVIPGLQNEIPARVFEFLPRRILLPLIRNQHPAL
TH_2552|M.thermoresistible__bu ADGVSPDEVLSGLARSTKLGRLISPEEVADVSLWLASDAASAITGQDIFV
MAB_4632|M.abscessus_ATCC_1997 LGDPADIAAAAVYLASPAGSFLTGKVLEVDGGLIAPNLDIPLPDLA----
Mvan_1615|M.vanbaalenii_PYR-1 -------------------------------
MSMEG_0530|M.smegmatis_MC2_155 -------------------------------
Mb2153c|M.bovis_AF2122/97 NTVAKLMPQMDAEVAALGRFASAYTESLENS
Rv2129c|M.tuberculosis_H37Rv NTVAKLMPQMDAEVAALGRFASAYTESLENS
MUL_2359|M.ulcerans_Agy99 KATAELLPKMDAEMAALGRATSAYNQGLEKP
MAV_5221|M.avium_104 -------------------------------
MLBr_00862|M.leprae_Br4923 RVI----------------------------
MMAR_0030|M.marinum_M KVVTSA-------------------------
Mflv_0138|M.gilvum_PYR-GCK RRSRS--------------------------
TH_2552|M.thermoresistible__bu TGG----------------------------
MAB_4632|M.abscessus_ATCC_1997 -------------------------------