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QQDTTARVALITGASRGIGAEVAQQLATSGTHSIVNYRANAERAEGIAETIRAAGGQASTIRADIADEAS TAAMIDDIGRRFGRLDALVLTALGGPRVGLDPRHAMRLNRDAQRRLARLALPLMPAGGHIVFVTSHQAHF FPHKAVPKGYGPIAASKRAGETALYAMRPEFDRHGVHFTVVSGAMLDEMTIADLWQRREPEAEFASAVVH AATAPKPSGIVFVGRAEYLMTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0530 | - | - | 100% (233) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5300 | - | 5e-17 | 31.39% (223) | short-chain type dehydrogenase/reductase |
| M. smegmatis MC2 155 | MSMEG_5596 | - | 3e-12 | 30.77% (143) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0950c | - | 5e-12 | 34.53% (139) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1825 | - | 5e-12 | 28.15% (238) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0927c | - | 5e-12 | 34.53% (139) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-07 | 28.27% (191) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4632 | - | 8e-12 | 33.58% (137) | short chain dehydrogenase |
| M. marinum M | MMAR_0295 | - | 1e-13 | 31.44% (194) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_5221 | - | 6e-15 | 32.32% (198) | NAD dependent epimerase/dehydratase family protein |
| M. thermoresistible (build 8) | TH_3893 | - | 2e-14 | 40.19% (107) | PUTATIVE putative short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4828 | - | 9e-14 | 31.44% (194) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_1615 | - | 2e-61 | 56.19% (226) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0530|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1615|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0295|M.marinum_M --------------------------------------------------
MUL_4828|M.ulcerans_Agy99 --------------------------------------------------
MAV_5221|M.avium_104 --------------------------------------------------
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1825|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3893|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MSMEG_0530|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1615|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0295|M.marinum_M --------------------------------------------------
MUL_4828|M.ulcerans_Agy99 --------------------------------------------------
MAV_5221|M.avium_104 --------------------------------------------------
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1825|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3893|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MSMEG_0530|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1615|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0295|M.marinum_M --------------------------------------------------
MUL_4828|M.ulcerans_Agy99 --------------------------------------------------
MAV_5221|M.avium_104 --------------------------------------------------
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1825|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3893|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MSMEG_0530|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1615|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0295|M.marinum_M --------------------------------------------------
MUL_4828|M.ulcerans_Agy99 --------------------------------------------------
MAV_5221|M.avium_104 --------------------------------------------------
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1825|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3893|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
MSMEG_0530|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1615|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0295|M.marinum_M --------------------------------------------------
MUL_4828|M.ulcerans_Agy99 --------------------------------------------------
MAV_5221|M.avium_104 --------------------------------------------------
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1825|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3893|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
MSMEG_0530|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1615|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0295|M.marinum_M -----------------------------------------MNLATQALA
MUL_4828|M.ulcerans_Agy99 -----------------------------------------MNLATQALA
MAV_5221|M.avium_104 -----------------------------MVQAARTNAAAKVNAIAQALD
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1825|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3893|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MSMEG_0530|M.smegmatis_MC2_155 ---------------------MQQDTTARVALITGASRGIGAEVAQQLAT
Mvan_1615|M.vanbaalenii_PYR-1 ---------------------MLQ-SPERIILVTGASRGVGADVARRIAG
MMAR_0295|M.marinum_M KAFERASNGLANPATLADPDRLRGAVTGKTALVTGASYGIGEATARKLAA
MUL_4828|M.ulcerans_Agy99 KAFERASNGLANPATLADPDRLRGAVTGKTALVTGASYGIGEATARKLAA
MAV_5221|M.avium_104 KVLNTVADRVANPARVSDPDRLRGAVGGRTVLVTGASYGIGEATARRLAA
Mb0950c|M.bovis_AF2122/97 ------------------MILDMFRLDDKVAVITGGGRGLGAAIALAFAQ
Rv0927c|M.tuberculosis_H37Rv ------------------MILDMFRLDDKVAVITGGGRGLGAAIALAFAQ
Mflv_1825|M.gilvum_PYR-GCK ------------------MILDRFRLDDQVAVVTGAGRGLGAAMALAFAE
MAB_4632|M.abscessus_ATCC_1997 ------------------MILDRFKLDGNVAVVTGAGRGLGAAIAEAFAQ
TH_3893|M.thermoresistible__bu ---------------------MDFDLNGKRALVTGSSSGIGAGIVETLAA
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
:**.. *:* . :*
MSMEG_0530|M.smegmatis_MC2_155 SGTHSIVNYRANAERAEGIAETIRAAGGQASTIRADIADEASTAAMIDDI
Mvan_1615|M.vanbaalenii_PYR-1 ADTHVIVNHCGRPERAEAVAQAIRDAGGHASTIAADVHDEFAVAAMIETI
MMAR_0295|M.marinum_M AGATVLMVARS-AERLEDLVSAIAAGGGAAVAYPTDLTDEAAVGVLTKQV
MUL_4828|M.ulcerans_Agy99 AGATVLMVARS-AERLEDLVSAIAAGGGAAVAYPTDLTDEAAVGVLTKQV
MAV_5221|M.avium_104 AGATVLVVARS-EERLGELTAAINAGGGRAVAYPTDLTDESAVSALTKQI
Mb0950c|M.bovis_AF2122/97 AGADVLIASRT-SSELDAVAEQIRAAGRRAHTVAADLAHPEVTAQLAGQA
Rv0927c|M.tuberculosis_H37Rv AGADVLIASRT-SSELDAVAEQIRAAGRRAHTVAADLAHPEVTAQLAGQA
Mflv_1825|M.gilvum_PYR-GCK AGADVLIAART-QSQLEAVAEQIAGTGRRAHIVVADLARPEDTAGLAAQA
MAB_4632|M.abscessus_ATCC_1997 AGADVLIASRT-ESQLREVAAKVQAAGRQAEVVVADLSDTEASAALAQKA
TH_3893|M.thermoresistible__bu EGVSVVVHGRN-AERAEAVADRIRADGGTAATAVGDLATEDGAAQVADTA
MLBr_00862|M.leprae_Br4923 RGAEVVVSDID-EAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQV
.. :: . : * * *: .
MSMEG_0530|M.smegmatis_MC2_155 GRRFGRLDALVLTALGGPRVGL---------DPRHAMRLNRDAQRRLARL
Mvan_1615|M.vanbaalenii_PYR-1 RARFGRLDALILNASGD--------------DPHDAVRVNGDVHRRLATR
MMAR_0295|M.marinum_M NQNHGPLDIVVSNAGKSLRRSLHDQYDRPH-DFQRTIDINYLGPIWLLLG
MUL_4828|M.ulcerans_Agy99 NQNHGPLDIVVSNAGKSLRRSLHDQYDRPH-DFQRTIDINYLGPIWLLLG
MAV_5221|M.avium_104 TEEHGPLDVVVSNAGKSLRRSLHHQYDRPH-DFQRTIDVNYLGPVRLLLG
Mb0950c|M.bovis_AF2122/97 VGAFGKLDIVVNNVGGTMPNTLLS--TSTK-DLADAFAFNVGTAHALTVA
Rv0927c|M.tuberculosis_H37Rv VGAFGKLDIVVNNVGGTMPNTLLS--TSTK-DLADAFAFNVGTAHALTVA
Mflv_1825|M.gilvum_PYR-GCK VEAFGRLDIVVNNVGGTMPNALLN--TSTK-DMRDAFTFNVATAHALTTA
MAB_4632|M.abscessus_ATCC_1997 VDRFGRLDVVVNNVGGTMPKPFLD--TTND-DLAEAFSFNVLSGHALLRA
TH_3893|M.thermoresistible__bu AAAFSGIDILVNNAGGSSETGIQSWFALPVSEWGVTYQRNVMSAGYLIHA
MLBr_00862|M.leprae_Br4923 SAKHGVPDIVVNNAGIGQAGRFLD---TPPEEFDRVLAVNLGGVVNCCRA
.. * :: .. : . *
MSMEG_0530|M.smegmatis_MC2_155 ALPLMPAG--GHIVFVTSHQAHFFPHKAVPKGYGPIAASKRAGETALYAM
Mvan_1615|M.vanbaalenii_PYR-1 AMPLMPTG--ARIVFVTSHQAHFYPDKAVPKGYAGVAASQRAAETALYAM
MMAR_0295|M.marinum_M LLPAMRESGRGHVVNVSSVGVRLVPG---PQ-WGAYQASKGAFDRWLRSV
MUL_4828|M.ulcerans_Agy99 LLPAMRESGRGHVVNVSSVGVRLVPG---PQ-WGAYQASKGAFDRWLRSV
MAV_5221|M.avium_104 LLPAMRDNGRGHVVNVSSVGVRVVPG---PQ-WGAYQASKGAFDRWLRSV
Mb0950c|M.bovis_AF2122/97 AVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDL
Rv0927c|M.tuberculosis_H37Rv AVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDL
Mflv_1825|M.gilvum_PYR-GCK AVPLMLEHSGGGSIINITSTMGRVAGRGFAAYGTAKAALAHYTRLSALDL
MAB_4632|M.abscessus_ATCC_1997 AVPHLLK-SDNASVINITSTMGRLPGRAFLGYCTAKGALAHYTRTAAMDL
TH_3893|M.thermoresistible__bu LVPAMKESGWGRIIQIAS-AAGIIPTSGQPDYGPSKAAMINMSMGLSKAL
MLBr_00862|M.leprae_Br4923 FGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAEL
: : : . * :
MSMEG_0530|M.smegmatis_MC2_155 R-PEFDRHGVHFTVVSGA----MLDEMTIADL--------WQRREPEAEF
Mvan_1615|M.vanbaalenii_PYR-1 R-SELAHAGIGFTVVSAE----MTGETVT---------------------
MMAR_0295|M.marinum_M A-PELHGDGVDVTSVYFA----LVRTRMIEPTPMLGRLPGLEPDQAADAV
MUL_4828|M.ulcerans_Agy99 A-PELHGDGVDVTSVYFA----LVRTRMIEPTPMLGRLPGLEPDQAADAV
MAV_5221|M.avium_104 A-PELHADGVHVSTVYFA----LVRTRMIAPTPVLGRLPGLSPDQAADVI
Mb0950c|M.bovis_AF2122/97 C-PRVRVNAIAPGSILTS----ALEVVAANDE---------LRAPMEQAT
Rv0927c|M.tuberculosis_H37Rv C-PRVRVNAIAPGSILTS----ALEVVAANDE---------LRAPMEQAT
Mflv_1825|M.gilvum_PYR-GCK A-PRIRVNAIAPGSILTS----ALEIVASNDD---------LRDPMEKAT
MAB_4632|M.abscessus_ATCC_1997 S-PRIRVNGIAPGSILTS----ALEVVAGNDE---------MRNTLEQNT
TH_3893|M.thermoresistible__bu AGTGITVNTVMPGMIMTEGLRDFLRTFADHRGWGDDLDKAADYILKGTGQ
MLBr_00862|M.leprae_Br4923 DAVGVGLTTICPGVIDTN----IIQSTRIDTPTAKQERVRDRRGQLDMMF
. : :
MSMEG_0530|M.smegmatis_MC2_155 ASAVVHAATAPKP--------SGIVFVGRAEYLMTA--------------
Mvan_1615|M.vanbaalenii_PYR-1 APAVVNAATTAQP--------VGIVYVGGAAHLMTA--------------
MMAR_0295|M.marinum_M AKAIVERPRTNEPPWLWPAELASVLLAGPAEQAARVWHRRFFAPTAEAGK
MUL_4828|M.ulcerans_Agy99 AKAIVERPRTNEPPWLWPAELASVLLAGPAEQAARVWHRRFFAPTAEAGK
MAV_5221|M.avium_104 AKAVIERPRTLEPPWVLPAELASVLLAGPADRAARLWHRRFFTDAEEAGR
Mb0950c|M.bovis_AF2122/97 PLRRLGDPVDIAAAAVYLASPAGSFLTGKTLEVDGGLTFPNLDLPIPDL-
Rv0927c|M.tuberculosis_H37Rv PLRRLGDPVDIAAAAVYLASPAGSFLTGKTLEVDGGLTFPNLDLPIPDL-
Mflv_1825|M.gilvum_PYR-GCK PMKRLGDPLDIAAAAVYLASPAGSYLTGKTLEVDGGITFPNLELPIPDL-
MAB_4632|M.abscessus_ATCC_1997 PLHRLGDPADIAAAAVYLASPAGSFLTGKVLEVDGGLIAPNLDIPLPDLA
TH_3893|M.thermoresistible__bu TVHRIGQVSDVAYAVAFLASPRADFLNGINLHLDGGATQSIY--------
MLBr_00862|M.leprae_Br4923 RLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTAR
.
MSMEG_0530|M.smegmatis_MC2_155 ----
Mvan_1615|M.vanbaalenii_PYR-1 ----
MMAR_0295|M.marinum_M S---
MUL_4828|M.ulcerans_Agy99 S---
MAV_5221|M.avium_104 ER--
Mb0950c|M.bovis_AF2122/97 ----
Rv0927c|M.tuberculosis_H37Rv ----
Mflv_1825|M.gilvum_PYR-GCK ----
MAB_4632|M.abscessus_ATCC_1997 ----
TH_3893|M.thermoresistible__bu ----
MLBr_00862|M.leprae_Br4923 IRVI