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MVETSIWMQKVAADPGHSRWYIERFRAMARAGDDLAGEARLVDAMAPRGARILDAGCGPGRVGGYLAAAG HQVVGVDVDPALIEAAEQDYPGPRWLVGDLAELDLPARGITEPFDLIVSAGNVMTFLAPSTRVQVLARLR AHLRDDGRAVIGFGAGREYEYPQFLDDAAAGGLTPDLLLSTWDVRPFTDDSDFLVAVLRPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1534 | - | - | 100% (201) | methyltransferase type 12 |
| M. vanbaalenii PYR-1 | Mvan_4619 | - | 8e-12 | 33.58% (137) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_1774 | - | 4e-09 | 31.77% (192) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0092 | - | 3e-07 | 36.59% (82) | methyltransferase/methylase |
| M. gilvum PYR-GCK | Mflv_4890 | - | 5e-94 | 81.41% (199) | methyltransferase type 12 |
| M. tuberculosis H37Rv | Rv0089 | - | 3e-07 | 36.59% (82) | methyltransferase/methylase |
| M. leprae Br4923 | MLBr_01713 | - | 6e-05 | 27.59% (87) | hypothetical protein MLBr_01713 |
| M. abscessus ATCC 19977 | MAB_2548c | - | 2e-94 | 82.41% (199) | hypothetical protein MAB_2548c |
| M. marinum M | MMAR_1164 | - | 3e-99 | 85.57% (201) | methyltransferase |
| M. avium 104 | MAV_4332 | - | 1e-100 | 87.06% (201) | SAM-dependent methyltransferases |
| M. smegmatis MC2 155 | MSMEG_3430 | - | 4e-96 | 82.09% (201) | SAM-dependent methyltransferase |
| M. thermoresistible (build 8) | TH_1247 | - | 4e-95 | 81.09% (201) | SAM-dependent methyltransferase |
| M. ulcerans Agy99 | MUL_2851 | - | 2e-99 | 85.57% (201) | methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1534|M.vanbaalenii_PYR-1 -----------MVETSIWMQKVAADPGHSRWYIERFRAMARAGDDLAGEA
MAV_4332|M.avium_104 -----------MVEQSIWMQKVAADPGHSHWYIERFRAMARAGDDLAGEA
MSMEG_3430|M.smegmatis_MC2_155 -----------MVEQSLWMQKVAADPGHSQWYIERFRSLARAGEDLFGEA
TH_1247|M.thermoresistible__bu -----------MVEKSLWMRKVEADPGHSQWYIERFRAMARAGEDLVGEA
MMAR_1164|M.marinum_M -----------MVEQSIWMQKVAADPGHSRWYIERFRAMARAGEDLVGEA
MUL_2851|M.ulcerans_Agy99 -----------MVEQSIWMQKVAADPGHSRWYIERFRAMARAGEDLVGEA
MAB_2548c|M.abscessus_ATCC_199 -----------MVEQSLWMQKVAADPNHSQWYIDRFRSMARDGADLAGEA
Mflv_4890|M.gilvum_PYR-GCK -----------MAETSLWMQKVAADPGHSRWYIERFRAMARAGDDLFGEA
Mb0092|M.bovis_AF2122/97 --------------------------------------MDQPWNANIHYD
Rv0089|M.tuberculosis_H37Rv --------------------------------------MDQPWNANIHYD
MLBr_01713|M.leprae_Br4923 MSAFVPDVPNRIPDDPSSIDSTAFHGMLTLTGERTIPDLDIENYWFRRHQ
:
Mvan_1534|M.vanbaalenii_PYR-1 RLVDAMAPRG--ARILDAGCGPGRVGGYLAAAGHQVVGVDVDPALIEAAE
MAV_4332|M.avium_104 RFVDAMAPRG--ARILDAGCGPGRLGSYLAAAGHQVVGVDVDPALIEAAE
MSMEG_3430|M.smegmatis_MC2_155 RLVDAMAPRN--AHILDAGCGPGRLGGYLAGVGHRVVGVDVDPALIAAAE
TH_1247|M.thermoresistible__bu RLVDAMAPRN--AHILDAGCGPGRLGGYLSAAGHRVVGVDVDPALIEAAE
MMAR_1164|M.marinum_M RLVDSIAPRG--AHILDAGCGPGRLGRHLAAAGHRVVGVDVDPALIEAAE
MUL_2851|M.ulcerans_Agy99 RLVDSIAPRG--AHILDAGCGPGRLGRHLAAAGHRVVGVDVDPALIEAAE
MAB_2548c|M.abscessus_ATCC_199 RLVDALVPRG--ARILDAGCGAGRVGGFLAAAGHHVVGVDVDPALIEAAE
Mflv_4890|M.gilvum_PYR-GCK RLIDAMVPRG--ARILDAGCGPGRLGGYLAAAGHHVVGVDVDPVLIDAAE
Mb0092|M.bovis_AF2122/97 ALLDAMVPLGT-QCVLDVGCGDGLLAARLARRIPYVTAVDIDAPVLRRAQ
Rv0089|M.tuberculosis_H37Rv ALLDAMVPLGT-QCVLDVGCGDGLLAARLARRIPYVTAVDIDAPVLRRAQ
MLBr_01713|M.leprae_Br4923 VVYQWLAQRCTGCEVLEAGCGEGYGADLIVDVAYRVIAVDYDEATVAHVR
. : :. :*:.*** * . : * .** * : ..
Mvan_1534|M.vanbaalenii_PYR-1 QDYPGP--RWLVGDLAELDLP-------------------------ARGI
MAV_4332|M.avium_104 HDHPGP--RWLVGDLAELDLP-------------------------ARGI
MSMEG_3430|M.smegmatis_MC2_155 EDYPGP--RWLVGDLAELDLP-------------------------ARGI
TH_1247|M.thermoresistible__bu QDYPGP--QYLVGDLAELDLP-------------------------ARGI
MMAR_1164|M.marinum_M QDYPGP--QWLVGDLAELDLP-------------------------ARGI
MUL_2851|M.ulcerans_Agy99 QDYPGP--QWLVGDLAELDLP-------------------------ARGI
MAB_2548c|M.abscessus_ATCC_199 HDHPGP--RWLVGDLAELDLP-------------------------SRGI
Mflv_4890|M.gilvum_PYR-GCK KDHPGA--TWLVGDLAELDLP-------------------------ARGI
Mb0092|M.bovis_AF2122/97 TRFANAPIRWLHADIMTAELPNAGFDAVVSNAALHHIE-------DTRTA
Rv0089|M.tuberculosis_H37Rv TRFANAPIRWLHADIMTAELPNAGFDAVVSNAALHHIE-------DTRTA
MLBr_01713|M.leprae_Br4923 SRYPRV--QVMQANLIELPLADASVDVVVNFQVIEHLWNQAQFVSECARV
.. : .:: *.
Mvan_1534|M.vanbaalenii_PYR-1 TEPFDLIVSAG---NVMTFLAPSTR---VQVLARLRAHLRDDGRAVIGFG
MAV_4332|M.avium_104 TDPFDVIVSAG---NVMTFLAPSTR---VLVLSRLRAHLAADGRAAIGFG
MSMEG_3430|M.smegmatis_MC2_155 AEPFDIIVSAG---NVMTFLAPSTR---AQVLSRLRAHLTDNGRAVIGFG
TH_1247|M.thermoresistible__bu PDPFDVIVMAG---NVMAFLAPSTR---TTVLSRLRAHLAEDGRAAIGFG
MMAR_1164|M.marinum_M AEPFDVIVSAG---NVMTFLAPSTR---ARVLGRLRAHLCSDGRAVIGFG
MUL_2851|M.ulcerans_Agy99 AEPFDVIVSAG---NVMTFLAPSTR---ARVLGRLRAHLCSDGRAVIGFG
MAB_2548c|M.abscessus_ATCC_199 SEPFDVIVSAG---NVMAFLAPSTR---RQVLRRLRSHLADPGRAVIGFG
Mflv_4890|M.gilvum_PYR-GCK AEPFDVIVSAG---NVMTFLAPSTR---GEVLRRLRTHLAAEGRAVIGFG
Mb0092|M.bovis_AF2122/97 LSRLGGLVTPGGTLAVVTFVTPSLRNGLWHLTSWVACGMANRVKGKWEHS
Rv0089|M.tuberculosis_H37Rv LSRLGGLVTPGGTLAVVTFVTPSLRNGLWHLTSWVACGMANRVKGKWEHS
MLBr_01713|M.leprae_Br4923 LRPSGLLMVSTP--NRITFSPGRDTSINPFHTRELNADELTQLLITADFS
. :: . ::* . : ..
Mvan_1534|M.vanbaalenii_PYR-1 AGREYEYPQ-----FLDDAAAGGLTPDLLLSTWDVRPFTDDSDFLVAVLR
MAV_4332|M.avium_104 AYREYEFTD-----FLNDAADAGFAPDLLLSSWDLRPFTEDSDFLVAVLR
MSMEG_3430|M.smegmatis_MC2_155 AGRDYGFEE-----FLADAKGAGFTPDQLLSTWDVRPFSEDSDFLVAILR
TH_1247|M.thermoresistible__bu AGRDYDFDE-----FLADAATAGLTPDLLLSTWDLRPFTEDSEFLVALLR
MMAR_1164|M.marinum_M AGRDYAFAD-----FLDDAQAAGLVPDLLLSTWDLRPFTDDCDFLVALLR
MUL_2851|M.ulcerans_Agy99 AGRDYAFAD-----FLDDAQAAGLVPDLLLSTWDLRPFTDDCDFLVALLR
MAB_2548c|M.abscessus_ATCC_199 AGRDYEFSE-----FLSDADAAGLVPDLLLSTWDLRPFTDKSDFLVALLR
Mflv_4890|M.gilvum_PYR-GCK ADRDYDFAE-----FLDDAAGAGFVPDLLLSTWDLRPWREDSGFLVAVLR
Mb0092|M.bovis_AF2122/97 APIKWPPPQ-----TLHELRSH--VRALLPGACIRRLLYG--RVLVTWRA
Rv0089|M.tuberculosis_H37Rv APIKWPPPQ-----TLHELRSH--VRALLPGACIRRLLYG--RVLVTWRA
MLBr_01713|M.leprae_Br4923 EVAMYGLFHGPRLKEMDARHGGSIIDAQIARAVSNAPWPPELVADVAAVT
: . : : : *:
Mvan_1534|M.vanbaalenii_PYR-1 PA--------------------------------
MAV_4332|M.avium_104 PA--------------------------------
MSMEG_3430|M.smegmatis_MC2_155 RA--------------------------------
TH_1247|M.thermoresistible__bu RA--------------------------------
MMAR_1164|M.marinum_M PA--------------------------------
MUL_2851|M.ulcerans_Agy99 PA--------------------------------
MAB_2548c|M.abscessus_ATCC_199 RDDAPS----------------------------
Mflv_4890|M.gilvum_PYR-GCK RM--------------------------------
Mb0092|M.bovis_AF2122/97 PV--------------------------------
Rv0089|M.tuberculosis_H37Rv PV--------------------------------
MLBr_01713|M.leprae_Br4923 AADFDIIEASAGPEASDGRDVDESLDLIAIAVRR