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MTGYWLDLALVGVLVLVNGLLSGSEAAFISLGEGQLREMERRGGRSDRIVVRLAREPNRFLATIQLGITL AGFLASATAAVSLAQPLESRLQFLGGAAAPVSIAAVTILVTASTLVVGELAPKRLGMQYARRWAALVAPV LRALAIAATPVVWALGQATDIVVRLLGGDPDVGKGEMTFGELRELIAGHSELNPEQRKIISGALEIHERA LREVVVPRPRVFRLRADLPVPQALTALAASGHTRAPVVPSGELDDAIGVVHLRDLLGSTGTVADVARPAL LLPDSLRVTAAMSRLMDEREQFALVIGERGGVTGIVALEDLLEEVVGEIYDEQDKDVRAVRVLPDGSRIL PGSFPIHDLVDVGVDASSLPSGDYTTVAGLMLSILGRIPSGPGDHVQIAGYRFDVTAVDRHAIAEVRLWP QQQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1422 | - | - | 100% (423) | hypothetical protein Mvan_1422 |
| M. vanbaalenii PYR-1 | Mvan_3860 | - | 1e-37 | 30.86% (418) | hypothetical protein Mvan_3860 |
| M. vanbaalenii PYR-1 | Mvan_3094 | - | 2e-36 | 28.95% (418) | hypothetical protein Mvan_3094 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2387c | - | 2e-35 | 31.13% (424) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_4979 | - | 0.0 | 86.36% (418) | hypothetical protein Mflv_4979 |
| M. tuberculosis H37Rv | Rv2366c | - | 2e-35 | 31.13% (424) | transmembrane protein |
| M. leprae Br4923 | MLBr_02396 | cysM2 | 6e-05 | 25.73% (241) | cystathionine beta-synthase |
| M. abscessus ATCC 19977 | MAB_2411c | - | 6e-35 | 27.80% (428) | hypothetical protein MAB_2411c |
| M. marinum M | MMAR_2716 | - | 2e-35 | 27.36% (424) | hypothetical protein MMAR_2716 |
| M. avium 104 | MAV_2028 | - | 5e-35 | 28.98% (421) | CBS domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4495 | - | 4e-40 | 32.13% (417) | CBS domain-containing protein |
| M. thermoresistible (build 8) | TH_2796 | - | 1e-141 | 60.90% (422) | PUTATIVE protein of unknown function DUF21 |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1422|M.vanbaalenii_PYR-1 MTGYWLDLALVGVLVLVN--GLLSGSEAAFISLGEGQLREMERRGGRSDR
Mflv_4979|M.gilvum_PYR-GCK MDGYWLDLALVAVLVLVN--GLLSGSEAAFISLGEGQLREMERRGTRRDR
TH_2796|M.thermoresistible__bu MGDYWSSVLLIAALLLLN--AVFAGSEIALISLREGQLRQLERRGGRTAR
MAB_2411c|M.abscessus_ATCC_199 MTVLLTGLSLLAFVALTAGTALFVAAEFSLTALERSGIEARAKTGDSRDR
MMAR_2716|M.marinum_M MMFTATTVSIVAILVLTLGTAVFVGAEFSLTALDRSTVEANARGGDSRDR
Mb2387c|M.bovis_AF2122/97 ---MTGYYQLLGSIVLIGLGGLFAAIDAAISTVSPARVDELVRDQRPGAG
Rv2366c|M.tuberculosis_H37Rv ---MTGYYQLLGSIVLIGLGGLFAAIDAAISTVSPARVDELVRDQRPGAG
MAV_2028|M.avium_104 ---MTGWSELLGAVALIALGGLFAAIDAAISTVSLARVQELVRDERPGAV
MSMEG_4495|M.smegmatis_MC2_155 ---MTGLLPLIGVITLVVFGGLFAAIDAALSTVSIARIDELVRDERPGAA
MLBr_02396|M.leprae_Br4923 MRIAQHISDLIGGTPLVRLNSVVPAG-TGVVAAKVEYFNSGGSSKDRIAA
::. * .:. . .. : .
Mvan_1422|M.vanbaalenii_PYR-1 IVVRLAREPNRFLATIQLGITLAGFLASATAAVSLAQPLESRLQFLGGA-
Mflv_4979|M.gilvum_PYR-GCK IVVDLAREPNRFLATIQLGITLAGFLASATAAVSLAEPVESRLQFLGGA-
TH_2796|M.thermoresistible__bu TLVRLARDPNRFLATIQIGITLSGYLASAAAAVTLAQPLIGMLGFLGTA-
MAB_2411c|M.abscessus_ATCC_199 LVKRAHSTLSFQLSGAQLGITITTLVTGYLAEPVIARLLSQLFGYTGIA-
MMAR_2716|M.marinum_M FIRRAQHRLSFHLSGAQLGISITTLATGYLTEPLVDALPHPALTAIGISD
Mb2387c|M.bovis_AF2122/97 SLRKVMADRPRYVNLVVLLRTSCEITATALLVVFIRYHFSMVWGLYLAAG
Rv2366c|M.tuberculosis_H37Rv SLRKVMADRPRYVNLVVLLRTSCEITATALLVVFIRYHFSMVWGLYLAAG
MAV_2028|M.avium_104 ALSKVMSERPRYINLVVLLRITCEITATVLLVVFLYDNFGLRWGLFGAAA
MSMEG_4495|M.smegmatis_MC2_155 RLATVVAERPRYINLVVLLRIICEVTATVLLASILDGLLGVSWGLVTAAA
MLBr_02396|M.leprae_Br4923 KMIDAAEASGQLKPGGTIVEPTSGNTGVGLALVAQHRGYKCVFVCPDKVS
: :
Mvan_1422|M.vanbaalenii_PYR-1 --AAPVSIAAVTILVTASTLVVGELAPKRLGMQYARRWAALVAPVLRALA
Mflv_4979|M.gilvum_PYR-GCK --AAAVSIAAVTIVVTASTLVFGELAPKRLGMQYARRWAGLVAPLLRFLA
TH_2796|M.thermoresistible__bu --APAVGIGLVTLILTFITLVVGELAPKRLAMQHAQRWALLVARPLNVIA
MAB_2411c|M.abscessus_ATCC_199 -VSSAISLALALIIATSISMIFGELVPKNFALARPVWTSRATSGPMVLFS
MMAR_2716|M.marinum_M QMSDAITVFLALVVVTSVSMVFGELVPKYLAVARPLPTARAVVLPQWLFS
Mb2387c|M.bovis_AF2122/97 -------------IMVLASFVVVGVGPRTLGRQNAYSISLATALPLRLIS
Rv2366c|M.tuberculosis_H37Rv -------------IMVLASFVVVGVGPRTLGRQNAYSISLATALPLRLIS
MAV_2028|M.avium_104 -------------IMVVTSFVVMGVGPRTLGRQNAYSIALTTVLPLQVIS
MSMEG_4495|M.smegmatis_MC2_155 -------------IMVVTSFVAMGVGPRTVGRQNAYSIALMSAIPLQALS
MLBr_02396|M.leprae_Br4923 EDKRNVLLAYGAEVVVCPTAVPPDDPDSYYSVSDRLVAKIDGAWKPDQYA
: . : : . :
Mvan_1422|M.vanbaalenii_PYR-1 IAATPVVWALGQATDIVVRLLGGDPDVGKGEM-TFGELRELIAG---HSE
Mflv_4979|M.gilvum_PYR-GCK IVTKPVIWGLGQSTDIAVRVVGGDPDVGKKEP-TFGELRELIAG---HSG
TH_2796|M.thermoresistible__bu GFSRPVVWLLSKATNLVVRLLGGDPDIRQQPL-TPEELRDLVAG---HRG
MAB_2411c|M.abscessus_ATCC_199 AVFAFAIRALNGTANWVLRRMGIEPAEELRSARSPQELGSLVRTSARSGA
MMAR_2716|M.marinum_M VLLTPAIRLTNGAANWIVRQLGIEPAEELRSARTPQELVSLVRSSARSGS
Mb2387c|M.bovis_AF2122/97 WLLMPISRLLVLLGNALTPGRG----FRNGPFASEIELREVVDLAQQRGV
Rv2366c|M.tuberculosis_H37Rv WLLMPISRLLVLLGNALTPGRG----FRNGPFASEIELREVVDLAQQRGV
MAV_2028|M.avium_104 WLLMPISRLLVVLGNAVTPGRG----LRNGPFASEIELREVVDLAQQRGV
MSMEG_4495|M.smegmatis_MC2_155 VLLTPISRLLVLLGNALTPGRG----FRNGPFASEIELREVVDLAQQRGV
MLBr_02396|M.leprae_Br4923 NPAGPASHYETTGPEIWADTDGRVTHFVAGIGTGGTITGVGRYLKEVSGG
: *
Mvan_1422|M.vanbaalenii_PYR-1 LNPEQRKIISGALEIHERALREVVVPRPRVFRLRADLPVPQALTALAASG
Mflv_4979|M.gilvum_PYR-GCK LNPEQRTIISGALEIHERALREIVVPRPRVFRLRADLPVPQALHALAASG
TH_2796|M.thermoresistible__bu LTSEQRMIISGALEINERTLREVVVPRLAVVTLGADMPVVEARRVLAEAG
MAB_2411c|M.abscessus_ATCC_199 LDETTAVLVDRSLRFGSRTAEELMTPRTEIESLEATDTVADLVTIAVETG
MMAR_2716|M.marinum_M LDDVTASLMRRSLQFGTLTAEELMTPRSKVVALQTDDTIADLVAAVAASG
Mb2387c|M.bovis_AF2122/97 VAADERRMIESVFELGDTPAREVMVPRTEMIWIESDKTAGQAMTLAVRSG
Rv2366c|M.tuberculosis_H37Rv VAADERRMIESVFELGDTPAREVMVPRTEMIWIESDKTAGQAMTLAVRSG
MAV_2028|M.avium_104 VAAEERRMIQSVFELGDTPAREVMVPRTEMIWIESDKSASQAINLAVRSG
MSMEG_4495|M.smegmatis_MC2_155 VADEERRMIQSVFELGDTAAREVMVPRTEMVWIEADKTAGQATSLAVRSG
MLBr_02396|M.leprae_Br4923 LVRIIGADPEGSVYSGGTGRPYLVEGVGEDFWPAAYDPMVPDQIIAVSDS
: . :: : . . .
Mvan_1422|M.vanbaalenii_PYR-1 HTRAPVVPSGELDDAIGVVHLRDLLGSTG---------TVADVARPALLL
Mflv_4979|M.gilvum_PYR-GCK HTRAPVVPAGELDDAIGVVHLRDLLGSAG---------TVADVARPALLL
TH_2796|M.thermoresistible__bu HQRAPVVRNASLDEVVGVVHLRDLLGDEG---------ITADVARPVVRF
MAB_2411c|M.abscessus_ATCC_199 FSRFPITEG-DLDATIGIVHVKQVFEVPRDRRA---TTTLASLARPVAVV
MMAR_2716|M.marinum_M YSRFPVVQG-DLDETFGIVHVKQVFQVPAAKRA---HTLLSSIAKPVPVV
Mb2387c|M.bovis_AF2122/97 HSRIPVIGE-NVDDIVGVVYLKDLVEQTFCSTNGGRETTVARVMRPAVFV
Rv2366c|M.tuberculosis_H37Rv HSRIPVIGE-NVDDIVGVVYLKDLVEQTFCSTNGGRETTVARVMRPAVFV
MAV_2028|M.avium_104 HSRIPVIGE-NVDDIVGVVYLKDLVQQALLPGGSGRATPVSQVMRPAVFV
MSMEG_4495|M.smegmatis_MC2_155 HSRIPVIGE-NVDDIVGVVYLKDLVQQTYYSTNGGRDTTVAQVMRPAVFV
MLBr_02396|M.leprae_Br4923 DS-FNMTRRLAREEAMLVGGSCGMAVVAALQVA----EEAGPAALVVVLL
: : . : : . . .
Mvan_1422|M.vanbaalenii_PYR-1 PDSLRVTAAMSRLMDEREQFALVIGERGGVTGIVALEDLLEEVVGEIYDE
Mflv_4979|M.gilvum_PYR-GCK PDSLRVTAALSRLMDEHEQFALVIGERGGVSGIVALEDLLEEVVGEIYDE
TH_2796|M.thermoresistible__bu PDSLRVSEALRRFKAEREQFAVVLDEHGGAEGIITLEDLLEEIVGEIYDE
MAB_2411c|M.abscessus_ATCC_199 PSTLDGDAVMEQVRANGMQTALVVDEYGGTAGLVTVEDMIEEIVGDVRDE
MMAR_2716|M.marinum_M PSTLDGDALMAQIRANSLQTAMVVDEYGGTAGMVTVEDLVEEIVGDVRDE
Mb2387c|M.bovis_AF2122/97 PDSKPLDALLREMQRDRNHMALLVDEYGAIAGLVSIEDVLEEIVGEIADE
Rv2366c|M.tuberculosis_H37Rv PDSKPLDALLREMQRDRNHMALLVDEYGAIAGLVSIEDVLEEIVGEIADE
MAV_2028|M.avium_104 PDSKPLDALLREMQRDRNHMALLVDEYGAIAGLVSIEDVLEEIVGEIADE
MSMEG_4495|M.smegmatis_MC2_155 PDSKPLDELLSEMQRDRNHMALLVDEYGATAGLVTIEDVLEEIVGEIADE
MLBr_02396|M.leprae_Br4923 PDGGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQPIVGDVLRRKSGALPDL
*. ..: .. .. : *::.. * : *
Mvan_1422|M.vanbaalenii_PYR-1 QD-KDVRAVRVLPDGSRILPGSFPIHDLVDVGVDASSLPSGDYTTVAGLM
Mflv_4979|M.gilvum_PYR-GCK QD-KDIRAARLLPDGSRILPGSFPVHDLGDVGVDGSRLPRGNHTTVAGLI
TH_2796|M.thermoresistible__bu AD-SDVQQVQNLPDGSVVLPGTFPIHDLTDIGVDLGPAAEGDFTTIAGLV
MAB_2411c|M.abscessus_ATCC_199 HD-DATPDVVSSGGG-WVVSGLLRIDEVAAATG--YRAPEGEYETIGGLV
MMAR_2716|M.marinum_M HD-DATPDVVAAGNG-WRVSGLLRIDEVAIAIG--YQAPEGPYETIGGLV
Mb2387c|M.bovis_AF2122/97 YDQAETAPVEDLGDKRFRVSARLPIEDVGELYG-VEFDDDLDVDTVGGLL
Rv2366c|M.tuberculosis_H37Rv YDQAETAPVEDLGDKRFRVSARLPIEDVGELYG-VEFDDDLDVDTVGGLL
MAV_2028|M.avium_104 YDQAETAPIEDLGDKRFRVSARLPIEDLGELYG-VEFDDDLDVDTVGGLL
MSMEG_4495|M.smegmatis_MC2_155 YDTDEVAPVDEIDDHIYRVSARLPIEDLAELYE-LELDEDLDVDTVGGLM
MLBr_02396|M.leprae_Br4923 VHTHPSETVRD-AIGILREYAVSQIPVVGAEPPVMAGEVVGSVSERELLS
. . : : *
Mvan_1422|M.vanbaalenii_PYR-1 LSILGRIPSG-----------PGDHVQIAG----YRFDVTAVDRHA----
Mflv_4979|M.gilvum_PYR-GCK LDSLGRMPEG-----------PGDRIEIGG----YRWEVTAVDAHA----
TH_2796|M.thermoresistible__bu LDALGRIPTE-----------PGDCVELPD----WAVEVTAVAQHT----
MAB_2411c|M.abscessus_ATCC_199 LQELGHIPTVGETVELTAVVPDHPLAELPR----WRARVAGMDGRR----
MMAR_2716|M.marinum_M LRQLGHIPVAGETVELPALDEDRVPDQSVR----WRATVVQMDGRR----
Mb2387c|M.bovis_AF2122/97 ALELGRVPLP------------GAEVISHG----LRLHAEGGTDHRGRVR
Rv2366c|M.tuberculosis_H37Rv ALELGRVPLP------------GAEVISHG----LRLHAEGGTDHRGRVR
MAV_2028|M.avium_104 ALELGRVPLP------------GAEVISHG----LRLHAEGGTDHRGRVR
MSMEG_4495|M.smegmatis_MC2_155 AFELGRVPLP------------GAEVTWEG----LRLRAEGGPDHRGRVR
MLBr_02396|M.leprae_Br4923 AVFEGRASLADAVS-----EHMGPPLRLIGDGELVSVAGEALRDSDALMV
*: .
Mvan_1422|M.vanbaalenii_PYR-1 IAEVRLWPQQQ---------------------------------
Mflv_4979|M.gilvum_PYR-GCK ITEVRVVPSPH---------------------------------
TH_2796|M.thermoresistible__bu ITEVRLIPRRT----------AGPKTDQ----------------
MAB_2411c|M.abscessus_ATCC_199 IDQIELTELTD----------ADSRGNNDDG-------------
MMAR_2716|M.marinum_M IDLLELTELAG----------AEDGQDDSDPERGGR--------
Mb2387c|M.bovis_AF2122/97 IGTVLLSPAEP-----------DGADD-EEADHPG---------
Rv2366c|M.tuberculosis_H37Rv IGTVLLSPAEP-----------DGADD-EEADHPG---------
MAV_2028|M.avium_104 VGTVLLSPVES-----------DGSPDGEEPEHHD---------
MSMEG_4495|M.smegmatis_MC2_155 INTVLVCPTEPVEPELHTVPGDENSGRTRRGDRGDRSRGGEKDE
MLBr_02396|M.leprae_Br4923 VEKGKLVGVITR---------YDLLGFLSEGAPLR---------
: :