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RIAQHISDLIGGTPLVRLNSVVPAGTGVVAAKVEYFNSGGSSKDRIAAKMIDAAEASGQLKPGGTIVEPT SGNTGVGLALVAQHRGYKCVFVCPDKVSEDKRNVLLAYGAEVVVCPTAVPPDDPDSYYSVSDRLVAKIDG AWKPDQYANPAGPASHYETTGPEIWADTDGRVTHFVAGIGTGGTITGVGRYLKEVSGGLVRIIGADPEGS VYSGGTGRPYLVEGVGEDFWPAAYDPMVPDQIIAVSDSDSFNMTRRLAREEAMLVGGSCGMAVVAALQVA EEAGPAALVVVLLPDGGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQPIVGDVLRRKSGALPDLVHTHPSE TVRDAIGILREYAVSQIPVVGAEPPVMAGEVVGSVSERELLSAVFEGRASLADAVSEHMGPPLRLIGDGE LVSVAGEALRDSDALMVVEKGKLVGVITRYDLLGFLSEGAPLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_02396 | cysM2 | - | 100% (464) | cystathionine beta-synthase |
| M. leprae Br4923 | MLBr_00839 | cysK | 1e-65 | 44.26% (305) | putative cysteine synthase |
| M. leprae Br4923 | MLBr_01130 | thrC | 2e-05 | 22.65% (309) | threonine synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1106 | cbs | 0.0 | 90.09% (464) | cystathionine beta-synthase CBS (Serine sulfhydrase) |
| M. gilvum PYR-GCK | Mflv_2043 | - | 0.0 | 82.47% (462) | cystathionine beta-synthase |
| M. tuberculosis H37Rv | Rv1077 | cbs | 0.0 | 90.09% (464) | cystathionine beta-synthase CBS (Serine sulfhydrase) |
| M. abscessus ATCC 19977 | MAB_1195 | - | 0.0 | 81.41% (468) | cystathionine beta-synthase |
| M. marinum M | MMAR_4390 | cbs | 0.0 | 90.02% (461) | cystathionine beta-synthase CBS |
| M. avium 104 | MAV_1201 | - | 0.0 | 89.13% (460) | cystathionine beta-synthase |
| M. smegmatis MC2 155 | MSMEG_5270 | - | 0.0 | 84.78% (460) | cystathionine beta-synthase |
| M. thermoresistible (build 8) | TH_1371 | - | 0.0 | 79.70% (463) | cystathionine beta-synthase |
| M. ulcerans Agy99 | MUL_0203 | cbs | 0.0 | 89.37% (461) | cystathionine beta-synthase CBS |
| M. vanbaalenii PYR-1 | Mvan_4674 | - | 0.0 | 85.00% (460) | cystathionine beta-synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1106|M.bovis_AF2122/97 MRIAQHISELIGGTPLVRLNSVVPDGAGTVAAKVEYLNPGGSSKDRIAVK
Rv1077|M.tuberculosis_H37Rv MRIAQHISELIGGTPLVRLNSVVPDGAGTVAAKVEYLNPGGSSKDRIAVK
MLBr_02396|M.leprae_Br4923 MRIAQHISDLIGGTPLVRLNSVVPAGTGVVAAKVEYFNSGGSSKDRIAAK
MMAR_4390|M.marinum_M MRIAQHISDLIGGTPLVRLNAVVPAGIGTVAAKVEYLNPGGSSKDRIAIK
MUL_0203|M.ulcerans_Agy99 MRIAQHISDLIGGTPLVRLNAVVPAGIGTVAAKVEYLNPGGSSKDRIAIK
MAV_1201|M.avium_104 MRIAQHISDLIGGTPLVRLNSVVPDGAGIVAAKVEYLNPGGSSKDRIAVR
Mflv_2043|M.gilvum_PYR-GCK MRIARHISELIGNTPLVQLNSVVPPGAGTVVAKVEYLNPGGSSKDRIAIK
Mvan_4674|M.vanbaalenii_PYR-1 MRIARHISELIGNTPLVQLNSVVPPGAGTVAAKIEYLNPGGSSKDRIAIK
MSMEG_5270|M.smegmatis_MC2_155 MRIARHISELIGNTPLVQLNSVVPEGAGLVAAKIEYLNPGGSSKDRIALK
TH_1371|M.thermoresistible__bu MRYARHVSELIGNTPLVQLNSVVPEGAGMVLAKIEYLNPGGSSKDRIAVK
MAB_1195|M.abscessus_ATCC_1997 MRIAQHVSDLIGNTPLVRLNSVVPEGCATVAAKIEYLNPGGSSKDRIAVK
** *:*:*:***.****:**:*** * . * **:**:*.********* :
Mb1106|M.bovis_AF2122/97 MIEAAEASGQLKPGGTIVEPTSGNTGVGLALVAQRRGYKCVFVCPDKVSE
Rv1077|M.tuberculosis_H37Rv MIEAAEASGQLKPGGTIVEPTSGNTGVGLALVAQRRGYKCVFVCPDKVSE
MLBr_02396|M.leprae_Br4923 MIDAAEASGQLKPGGTIVEPTSGNTGVGLALVAQHRGYKCVFVCPDKVSE
MMAR_4390|M.marinum_M MIDAAEASGALRPGGTIVEPTSGNTGVGLALVAQHRGYKCVFVCPDKVSE
MUL_0203|M.ulcerans_Agy99 MIDAAEASGALRPGGTIVEPTSGNTGVGLALVAQHRGYKCVFVCPDKVSE
MAV_1201|M.avium_104 MIDAAEASGALKPGGTIVEPTSGNTGVGLALVAQQRGYKCVFVCPDKVGE
Mflv_2043|M.gilvum_PYR-GCK MIDAAEASGELKPGGTIVEPTSGNTGVGLAIVAQQRGYKCIFVCPDKVSE
Mvan_4674|M.vanbaalenii_PYR-1 MIDAAEASGELKPGGTIVEPTSGNTGVGLAIVAQQRGYKCIFVCPDKVSE
MSMEG_5270|M.smegmatis_MC2_155 MIEAAEVSGELKPGGTIVEPTSGNTGVGLALVAQQRGYKCVFVCPDKVSE
TH_1371|M.thermoresistible__bu MIEDAEKRGLLKPGGTIVEPTSGNTGVGLAIVAQQRGYKCIFVCPDKVSE
MAB_1195|M.abscessus_ATCC_1997 MIEAAEEAGLLKPGGTIVEPTSGNTGVGLALVAQRKGYHCVFVCPDKVSE
**: ** * *:******************:***::**:*:*******.*
Mb1106|M.bovis_AF2122/97 DKRNVLIAYGAEVVVCPTAVPPHDPASYYSVSDRLVRDIDGAWKPDQYAN
Rv1077|M.tuberculosis_H37Rv DKRNVLIAYGAEVVVCPTAVPPHDPASYYSVSDRLVRDIDGAWKPDQYAN
MLBr_02396|M.leprae_Br4923 DKRNVLLAYGAEVVVCPTAVPPDDPDSYYSVSDRLVAKIDGAWKPDQYAN
MMAR_4390|M.marinum_M DKRNVLRAYGAEVVVCPTAVPPEDPDSYYSVSDRLVREIDGAWKPDQYAN
MUL_0203|M.ulcerans_Agy99 DKRNVLRAYGAEVVVCPTAVPPEDPDSYYSVSDRLVREIDGAWKPDQYAN
MAV_1201|M.avium_104 DKRNVLMAYGAEVVVCPTAVPPEHPDSYYSVSDRLVTEIEGAWKPDQYAN
Mflv_2043|M.gilvum_PYR-GCK DKQNVLRAYGAEVVVCPTAVAPDDPASYYSVSNRLVSEIDGAWKPDQYSN
Mvan_4674|M.vanbaalenii_PYR-1 DKQNVLRAYGADVVVCPTAVAPEDPASYYSVSNRLVEEIDGAWKPDQYSN
MSMEG_5270|M.smegmatis_MC2_155 DKRNVLRAYGAEVVVCPTAVPPDHPDSYYSVSNRLVTEIEGAWKPDQYSN
TH_1371|M.thermoresistible__bu DKQNVLRAYGAEVVVCPTAVPPEHPDSYYSVSDRLTREIDGAWKPDQYSN
MAB_1195|M.abscessus_ATCC_1997 DKRNVLRAYGAEVVVCPTAVPPEHPDSYYNVSDRLVREIEGAWKPDQYSN
**:*** ****:********.*..* ***.**:**. .*:********:*
Mb1106|M.bovis_AF2122/97 PEGPASHYVTTGPEIWADTEGKVTHFVAGIGTGGTITGAGRYLKEVSG--
Rv1077|M.tuberculosis_H37Rv PEGPASHYVTTGPEIWADTEGKVTHFVAGIGTGGTITGAGRYLKEVSG--
MLBr_02396|M.leprae_Br4923 PAGPASHYETTGPEIWADTDGRVTHFVAGIGTGGTITGVGRYLKEVSG--
MMAR_4390|M.marinum_M PEGPASHYATTGPEIWADTDGKITHFVAGIGTGGTITGAGRYLKEVSG--
MUL_0203|M.ulcerans_Agy99 PEGPASHYATTGPEIWADTDGKITHFVAGIGTGGTITGAGCYLKEVSG--
MAV_1201|M.avium_104 PEGPASHYATTGPEIWADTDGKVTHFVAGIGTGGTITGAGRYLKEVSG--
Mflv_2043|M.gilvum_PYR-GCK PMGPESHYETTGPEIWADTDGKITHFVAGVGTGGTITGAGRYLKEVSG--
Mvan_4674|M.vanbaalenii_PYR-1 PMGPESHYETTGPEIWADTDGKVTHFVAGVGTGGTITGAGRYLKEVSG--
MSMEG_5270|M.smegmatis_MC2_155 QMGPESHYETTGPEIWADTEGKITHFVAGVGTGGTITGTGRYLKEVSG--
TH_1371|M.thermoresistible__bu QMGPQSHYETTGPEIWNDTDGKVTHFVAGVGTGGTITGAGRYLKEVSGRR
MAB_1195|M.abscessus_ATCC_1997 PNGPASHYETTGPEIWADTDGKITHFVAGVGTGGTITGAGRYLKEVSGGR
** *** ******* **:*::******:********.* *******
Mb1106|M.bovis_AF2122/97 --GRVRIVGADPEGSVYSGGAGRPYLVEGVGEDFWPAAYDPSVPDEIIAV
Rv1077|M.tuberculosis_H37Rv --GRVRIVGADPEGSVYSGGAGRPYLVEGVGEDFWPAAYDPSVPDEIIAV
MLBr_02396|M.leprae_Br4923 --GLVRIIGADPEGSVYSGGTGRPYLVEGVGEDFWPAAYDPMVPDQIIAV
MMAR_4390|M.marinum_M --GKVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPAAYDPAVPDEIIAV
MUL_0203|M.ulcerans_Agy99 --GKVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPATYDHAVPDEIIAV
MAV_1201|M.avium_104 --GRVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPQAYDRTVPDEIIAV
Mflv_2043|M.gilvum_PYR-GCK --GRVKVIGADPEGSVYSGGTGRPYLVEGVGEDFWPSAYDPSVPDEIIAV
Mvan_4674|M.vanbaalenii_PYR-1 --GRVKVIGVDPEGSVYSGGTGRPYLVEGVGEDFWPAAYDPSVPDEIIAV
MSMEG_5270|M.smegmatis_MC2_155 --GKVKVIGADPEGSVYSGGTGRPYLVEGVGEDFWPTAYDPSVPDEIIAV
TH_1371|M.thermoresistible__bu PEGPVRVVGADPEGSVYSGGTGRPYLVEGVGEDFWPSVYDPSVPDEIIAV
MAB_1195|M.abscessus_ATCC_1997 AIGEVKIVGADPEGSVYSGGTGRPYLVEGVGEDFWPSAYDPSVVDEVIAV
* *:::*.**********:*************** .** * *::***
Mb1106|M.bovis_AF2122/97 SDSDSFDMTRRLAREEAMLVGGSCGMAVVAALKVAEEAGPDALIVVLLPD
Rv1077|M.tuberculosis_H37Rv SDSDSFDMTRRLAREEAMLVGGSCGMAVVAALKVAEEAGPDALIVVLLPD
MLBr_02396|M.leprae_Br4923 SDSDSFNMTRRLAREEAMLVGGSCGMAVVAALQVAEEAGPAALVVVLLPD
MMAR_4390|M.marinum_M SDSDSFDMTRRLAREEAMLVGGSCGMAVVAALRVAEQAGPDALVVVLLPD
MUL_0203|M.ulcerans_Agy99 SDSDSFDMTRRLAREEAMLVGGSCGMAVVAALRVAEQAGPDALVVVLLPD
MAV_1201|M.avium_104 SDSDSFNMTRRLAREEAMLVGGSCGMAVVAALRVAEQAGPDALVVVLLPD
Mflv_2043|M.gilvum_PYR-GCK SDADSFDMTRRLAREEALLVGGSCGMAAVAAIRVAEREGPDALVVVLLPD
Mvan_4674|M.vanbaalenii_PYR-1 SDADSFDMTRRLAREEALLVGGSCGMAAVAAIKVAEREGPDALVVVLLPD
MSMEG_5270|M.smegmatis_MC2_155 SDADSFEMTRRLAREEALLVGGSCGMAVVAAIEVARKAGPDAVVVVLLPD
TH_1371|M.thermoresistible__bu SDADSFEMTRRLAREEGLLVGGSCGMAVVAANKVALEAGPDAVVVVLLPD
MAB_1195|M.abscessus_ATCC_1997 SDADSFEMTRRLAREEGLLVGGSCGMAVVAAIRLAEKVGPDGLVVVLLPD
**:***:*********.:*********.*** .:* . ** .::******
Mb1106|M.bovis_AF2122/97 GGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQSTVGDVLRRKSGALPALVH
Rv1077|M.tuberculosis_H37Rv GGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQSTVGDVLRRKSGALPALVH
MLBr_02396|M.leprae_Br4923 GGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQPIVGDVLRRKSGALPDLVH
MMAR_4390|M.marinum_M GGRGYMSKIFNDAWMSSYGFLRSRLDGRTDASTVGDVLRRKSGALPALVH
MUL_0203|M.ulcerans_Agy99 GGRGYMSKIFNDAWMSSYGFLRSRLDGRTDTSTVGDVLRRKSGALPALVH
MAV_1201|M.avium_104 GGRGYMAKIFNDAWMSSYGFLRTRLDGSTDQSRVGDVLRRKSGELPDLVH
Mflv_2043|M.gilvum_PYR-GCK GGRGYLSKIFNDGWMSSYGFLRTRLDGSVQESTVGDVLRGKSGALPALVH
Mvan_4674|M.vanbaalenii_PYR-1 GGRGYLSKIFNDAWMSSYGFLRSRLDGSVEESTVGDVLRGKSGALPDLVH
MSMEG_5270|M.smegmatis_MC2_155 GGRGYLSKIFNDAWMSSYGFLRTRLDGSVEK-TVGDVLRGKSGALPDLVH
TH_1371|M.thermoresistible__bu GGRGYLSKIFNDEWMSSYGFLRTPLDGKVHQPTVGDVLRGKSGELPDLVH
MAB_1195|M.abscessus_ATCC_1997 GGRGYLSKVFNDAWMSSYGFLRSRLDGSVSEPTVGDVLRGKSGALPDLVH
*****::*:*** *********: *** . ****** *** ** ***
Mb1106|M.bovis_AF2122/97 THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
Rv1077|M.tuberculosis_H37Rv THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
MLBr_02396|M.leprae_Br4923 THPSETVRDAIGILREYAVSQIPVVGAEPPVMAGEVVGSVSERELLSAVF
MMAR_4390|M.marinum_M THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
MUL_0203|M.ulcerans_Agy99 THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
MAV_1201|M.avium_104 THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
Mflv_2043|M.gilvum_PYR-GCK THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERDLVSAVF
Mvan_4674|M.vanbaalenii_PYR-1 THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
MSMEG_5270|M.smegmatis_MC2_155 THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
TH_1371|M.thermoresistible__bu THPSETIRDAINILREYGVSQMPVVGAEPPVMAGEVAGSVTERELLSAVY
MAB_1195|M.abscessus_ATCC_1997 THPSETVRDAIEILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
******:**** *****.***:**************.***:**:*:***:
Mb1106|M.bovis_AF2122/97 EGRAKLADAVSAHMSPPLRMIGAGELVSAAGKALRDWDALMVVEEGKPVG
Rv1077|M.tuberculosis_H37Rv EGRAKLADAVSAHMSPPLRMIGAGELVSAAGKALRDWDALMVVEEGKPVG
MLBr_02396|M.leprae_Br4923 EGRASLADAVSEHMGPPLRLIGDGELVSVAGEALRDSDALMVVEKGKLVG
MMAR_4390|M.marinum_M SGKAKLADAVSQHMSPPLKLIGAGELVGVAGKALRDWDALMVVEEGKPVG
MUL_0203|M.ulcerans_Agy99 SGKAKLADAVSQHMSPPLKLIGAGELVGVAGKALRDWDALMVVEEGKPVG
MAV_1201|M.avium_104 EGRAKLADAVSLHMSPPLPMIGAGESVSAAGKALRDWDALMVVEEGKPVG
Mflv_2043|M.gilvum_PYR-GCK EGRAKLADAVAQHMSPPLPLIGAGELVSAAAKTLRECDAVMVVEEGKPAG
Mvan_4674|M.vanbaalenii_PYR-1 EGRAKLADAVADHMGPPLPLIGVGELVSTAAKALRESDAVMVVEEGKPVG
MSMEG_5270|M.smegmatis_MC2_155 EGRAKLADAVAEHMSPPLPLIGAGELVSTAAKTLRESDAVMVVEDGKPVG
TH_1371|M.thermoresistible__bu EGRAKLTDAVAEHMGAPLPLIGAGEPVQAAAKMLRECDAVMVVEEGKPAG
MAB_1195|M.abscessus_ATCC_1997 EGRAQLADAVAQHMSPPLPLVGSGEPLSTAGSMLRDTDAVMVVDEGKPVG
.*:*.*:***: **..** ::* ** : .*.. **: **:***:.** .*
Mb1106|M.bovis_AF2122/97 VITRYDLLGFLSEG----AGRR
Rv1077|M.tuberculosis_H37Rv VITRYDLLGFLSEG----AGRR
MLBr_02396|M.leprae_Br4923 VITRYDLLGFLSEG----APLR
MMAR_4390|M.marinum_M VITRYDLLGFLSEG----ALRR
MUL_0203|M.ulcerans_Agy99 VITRYDLLGFLSEG----ALRR
MAV_1201|M.avium_104 VITRYDLLGFLSEGPRGSGGRR
Mflv_2043|M.gilvum_PYR-GCK VLTRHDLLGYLSDS----SPGH
Mvan_4674|M.vanbaalenii_PYR-1 VLTRHDLLGYLSEG----NARR
MSMEG_5270|M.smegmatis_MC2_155 VLTRHDLLGFLSEG----GYRH
TH_1371|M.thermoresistible__bu VLTRHDLLGFLSES----TAAH
MAB_1195|M.abscessus_ATCC_1997 VITRHDLLGFVSSGR---GVRH
*:**:****::*.. :