For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MDSGQARDLLTDMIRVRRMEEKCAELYSESKIRGFLHLYVGEEAVAAGSLRALGPDDAVVATYREHAHAL LRGVPMTSIMAEMFGKVQGCSRGRGGSMHLFDADRRFYGGNAIVSGGLPLAAGLALADAHQGRNRVTACY FGEGAVAEGAFHESLNMAVLWRLPVLFCCENNLYAMGTALRRELSQTDLTVKAAAYNVPTLAVDGMDVAA CQFAAQEAVEHIRRGGGPFFVEFRTYRFRAHSMFDPELYRDKAEVEQWRQRDPIAMFTDRCTGEGLLAPE DVAAIEESVGVELSDAVAYAEAGTWEDVEDLERDVLTPAGGQR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1408 | - | - | 100% (323) | pyruvate dehydrogenase (acetyl-transferring) |
| M. vanbaalenii PYR-1 | Mvan_0911 | - | 4e-47 | 35.33% (317) | pyruvate dehydrogenase (acetyl-transferring) |
| M. vanbaalenii PYR-1 | Mvan_4086 | - | 6e-31 | 30.43% (299) | pyruvate dehydrogenase (acetyl-transferring) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0866 | - | 3e-30 | 31.89% (301) | dehydrogenase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv0843 | - | 1e-30 | 32.12% (302) | dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4918c | - | 6e-34 | 31.40% (293) | pyruvate dehydrogenase E1 component alpha subunit |
| M. marinum M | MMAR_3489 | - | 1e-146 | 78.30% (318) | pyruvate dehydrogenase E1 component (alpha subunit) |
| M. avium 104 | MAV_2947 | - | 1e-45 | 35.64% (275) | dehydrogenase E1 component superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4712 | - | 5e-32 | 31.46% (302) | pyruvate dehydrogenase E1 component, alpha subunit |
| M. thermoresistible (build 8) | TH_4167 | - | 2e-43 | 33.44% (308) | PUTATIVE acetoin:2,6-dichlorophenolindophenol oxidoreductase |
| M. ulcerans Agy99 | MUL_3775 | pdhA | 5e-28 | 31.12% (286) | pyruvate dehydrogenase E1 component (alpha subunit) PdhA |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1408|M.vanbaalenii_PYR-1 ---------------------------------------------MDSGQ
MMAR_3489|M.marinum_M ---------------------------------------------MDAKL
MAV_2947|M.avium_104 -----------------------------------MTQSAKPSP----DI
TH_4167|M.thermoresistible__bu ----------------------------------MATQLDVEAPTSANDR
MSMEG_4712|M.smegmatis_MC2_155 MAMQYSSAPGYDTGFDPEPVQLVAADGSPSPDRPPSRYSRDLPPET----
MUL_3775|M.ulcerans_Agy99 ------------MTVGLEPVQLVNADGEPTDEH---RYSRDLPEET----
MAB_4918c|M.abscessus_ATCC_199 ----------------METIQLLDSDGNRIENPEYMPLVSDILDEDGLTQ
Mb0866|M.bovis_AF2122/97 -----------------------------------MTRTSEGLAAFVVDQ
Rv0843|M.tuberculosis_H37Rv -----------------------------------MTRTSEGLAAFVVDQ
Mvan_1408|M.vanbaalenii_PYR-1 ARDLLTDMIRVRRMEEKCAELYSESKIRGFLHLYVGEEAVAAGSLRALGP
MMAR_3489|M.marinum_M ARELLSDMVRVRRMEEKCAELYSAAKIRGFLHLYVGEEAVAAGSLRVLAE
MAV_2947|M.avium_104 HRRLYALMVLMKTADDRLSRGIGTGEFLCVYWPSRGQEAIAAAMGVSLRP
TH_4167|M.thermoresistible__bu AIALYRLMSKVHHADARVRKGLSSGEIAMSYWPVTGQEAMSAGAALALSD
MSMEG_4712|M.smegmatis_MC2_155 LSWLYESMVVTRNLDVEFVNLQRQGE-LALFASCRGQEAAQIGAAACLRK
MUL_3775|M.ulcerans_Agy99 LCWLYEMMVVTRELDAEFINLKRQGE-LALFASCRGQEAAQVGATACLRK
MAB_4918c|M.abscessus_ATCC_199 LRALYRDMVVVRRIDNESTALQRQGE-LALWAPLLGQEAAQVGSARALRH
Mb0866|M.bovis_AF2122/97 LEELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAAAALGE
Rv0843|M.tuberculosis_H37Rv LEELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAAAALGE
* * : : . *:** . *
Mvan_1408|M.vanbaalenii_PYR-1 DDAVVATYREHAHALLRGVPMTSIMAEMFGKVQGCSRGRGGSMHLFDADR
MMAR_3489|M.marinum_M DDAVVATYREHAHALLRGIPMTSIMAEMFGKQEGCSRGRGGSMHLFDQAR
MAV_2947|M.avium_104 DDQLVTTYRGLHDLIGKGVGLEEIYGEMMGRTIGAGRGKGGTMHIAKPEV
TH_4167|M.thermoresistible__bu GDQLVSTYRGLGDVVAKGIDLAGYFGEILGRRTGLSRGKAGAMGISDPDH
MSMEG_4712|M.smegmatis_MC2_155 TDWLFPQYREIGAFLLRGITPAQMGAVWRGKWHGG---------LSFTGK
MUL_3775|M.ulcerans_Agy99 TDWLFPQYRELGAYLVRGIPPGHVGAAWRGTWHGG---------LEFTKK
MAB_4918c|M.abscessus_ATCC_199 DDFAFTSFREHGVAYCRGIEPTAMLQFWRGSTQSG---------WNPRDH
Mb0866|M.bovis_AF2122/97 GDVIITTHRPHAQHVGTDAPLGPVIADMLGATAGDLEGADEDAHIADPRA
Rv0843|M.tuberculosis_H37Rv GDVIITTHRPHAQHVGTDAPLGPVIADMLGATAGDLEGADEDAHIADPRA
* .. .* . * .
Mvan_1408|M.vanbaalenii_PYR-1 RFYGGNAIVSGGLPLAAGLALADAHQGRNRVTACYFGEGAVAEGAFHESL
MMAR_3489|M.marinum_M RFYGGNAIVAGGLPLAVGISLADSMLKRNRVTACYFGDGAVAEGAFHESL
MAV_2947|M.avium_104 GVMLSTGIVGAGPPVAVGLAMAARRKGLDRVTVVSFGDGATNTGSFHEAA
TH_4167|M.thermoresistible__bu GIAWTTGIVGAGPLFANGIALAASIRGTGQVVLVSFGDGATSIGYVHEAM
MSMEG_4712|M.smegmatis_MC2_155 CVAPIAIPIGTHGLHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDAHEAF
MUL_3775|M.ulcerans_Agy99 CCVPISVPIGTQALHAVGAAQAAQRLGEDSVTVAFLGDGATSEGDVHEAL
MAB_4918c|M.abscessus_ATCC_199 NVTAPAIIVGAQALHATGYAMGVKFDGSDTAVIAYFGDGATSQGDVSEAF
Mb0866|M.bovis_AF2122/97 GLPAAIRVVKQSPLLAIGHAYALWLRDTGRVTLCVTQDCDVDADAFNEAA
Rv0843|M.tuberculosis_H37Rv GLPAAIRVVKQSPLLAIGHAYALWLRDTGRVTLCVTQDCDVDADAFNEAA
: * * : . . .. : . . *:
Mvan_1408|M.vanbaalenii_PYR-1 NMAVLWRLPVLFCCENNLYAMGTALRRELSQTDLTVKAAAYNVPTLAVDG
MMAR_3489|M.marinum_M NMAALWKLPVLFLCENNLYAMGTALHRAQSQTDLTVKAASYNVATLAVDG
MAV_2947|M.avium_104 NMAALWDLPIVFVCQNNRYAEMTPTTDTMKLEHVADRAAGYGMPGVRVDG
TH_4167|M.thermoresistible__bu NMAALWNLPVVFFCQNNAWAECTAMERYTRTARLSDRAQGYGMPGVTVDG
MSMEG_4712|M.smegmatis_MC2_155 NLATVFRAPCVFFIQNNQWAISVPVSRQQAGPTIAHRAIGYGMPGIRVDG
MUL_3775|M.ulcerans_Agy99 NFAAVFDAGCVFYVQNNQWAISVPVSKQTAAPSIAHKAIGYGMPGIRVDG
MAB_4918c|M.abscessus_ATCC_199 AFASSFGAPVVFFCQNNQWAISEPVRVQSHLP-LAARGIGFGVPGIQVDG
Mb0866|M.bovis_AF2122/97 DLAAVWQLPVVILVENIRGALSVHLGRYTHEPRVYRRAVAYGMPGVSVDG
Rv0843|M.tuberculosis_H37Rv DLAAVWQLPVVILVENIRGALSVHLDRYTHEPRVYRRAVAYGMPGVSVDG
:* : :: :* * : :. .:.:. : ***
Mvan_1408|M.vanbaalenii_PYR-1 MDVAACQFAAQEAVEHIRRGGGPFFVEFRTYRFRAHSMF-DPELYRDKAE
MMAR_3489|M.marinum_M MDVAACMSATQQGVDHIRSTGGPFFIEFRTYRFRAHSMF-DPELYRDKAE
MAV_2947|M.avium_104 NDPLAVTAALEEALRRARAGSGPTFLECETFRFRGHYFG-DRMPYIPADQ
TH_4167|M.thermoresistible__bu TDPRAVHDAVAEAVTRARSGGGPTFVEALAYRLQGHYFG-DTMAYADPDE
MSMEG_4712|M.smegmatis_MC2_155 NDVLACYAVMSEAAERARRGEGPTLIEAVTYRMGPHTTSDDPTRYRPAEE
MUL_3775|M.ulcerans_Agy99 NDVLACYAVTAVAAARARRGDGPTLIEAVTYRVGAHTTADDPGRYRSQEE
MAB_4918c|M.abscessus_ATCC_199 NDVLAVTAATRMALRRAREGSGPTLIEAVTYRMGPHTTSDDPTKYRNAAE
Mb0866|M.bovis_AF2122/97 NDVEAVRDCVANAVVRARAGGGPTLVQAITYRTTDFSGS-DRGGYRDLAG
Rv0843|M.tuberculosis_H37Rv NDVEAVRDCVANAVVRARAGGGPTLVQAITYRTTDFSGS-DRGGYRDLAG
* * . : * ** ::: ::* . * *
Mvan_1408|M.vanbaalenii_PYR-1 VEQWRQRDPIAMFTDRCTGEGLLAPEDVAAIEESVGVELSDAVAYAEAGT
MMAR_3489|M.marinum_M VQRWRERDPIRLFTEQCLNSGTLTDDDVRDIEGSAADEIAAAVAFADAGT
MAV_2947|M.avium_104 LQAALAADPVPRFRRRLAETGVCGEAELARIDDDAAAAVEAALRTVLGAD
TH_4167|M.thermoresistible__bu LAAKRADPPFDRYRRRLIDEGIATAATLDQIDAELAAQVDAAFAAARDAE
MSMEG_4712|M.smegmatis_MC2_155 VEAWAARDPIARYRTYLQNIGVWTERLEERVAARSSRLCAELRDAIVGAP
MUL_3775|M.ulcerans_Agy99 VDHWLALDPISRYRSYLQGQGLWSQRLEVRVAARSGRLRAELREAVFGAS
MAB_4918c|M.abscessus_ATCC_199 LDEWRAKDPLARVEKYLESRGALSESEKHRIAALADEVAAQLRAGCLGTV
Mb0866|M.bovis_AF2122/97 SEQFL--DPLIFARRRLIAAGTTRGRLDEQERAACQQVADAVAFAKDRAR
Rv0843|M.tuberculosis_H37Rv SEQFL--DPLIFARRRLIAAGTTRGRLDEQERAACQQVADAVAFAKARAR
*. *
Mvan_1408|M.vanbaalenii_PYR-1 WEDVEDLERDVLTP-----AGGQR--------------------------
MMAR_3489|M.marinum_M WEDASDLERDVLTPPDSCDATAESTWEPAR--------------------
MAV_2947|M.avium_104 SPAADELDRDVYAAP-----------IPFPT-------------------
TH_4167|M.thermoresistible__bu PLGPEELTGDVFTGNGTELADGTVPRVALPEGETEELGLVQAIHRTLDRA
MSMEG_4712|M.smegmatis_MC2_155 DVDPAEMFDTVYADITPELARQRDQLLSELAKEA----------------
MUL_3775|M.ulcerans_Agy99 DFDVDDVFTTVFAEITPGLQTQRQQLRAELDRID----------------
MAB_4918c|M.abscessus_ATCC_199 EPTAADMFNHVYAEPHPLVSAERRDYLEYLATFEDEGTYAS---------
Mb0866|M.bovis_AF2122/97 PNGGGPISRPTSGWHQQPKTRF----------------------------
Rv0843|M.tuberculosis_H37Rv PNGGGPISRPTSGWHQQPKTRF----------------------------
: .
Mvan_1408|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu MAADDSIILLGEDIGDRSGGGMFKITAGLSAKYGEERVRDTPIAESSIIG
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_1408|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu AALGASLAGLRPVAELMFMDFLGVAMDQIANHVAKVRYMSGGRRGAPLVI
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_1408|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu RTMVGTAAGAQHSQALEAWAMHTPGLKVVWPSTAADAAGLLNACLREDDP
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_1408|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu CLFIESMKLYYGGGKGPVPVADYVIPLGQADVKRVGSDVTICTYGVLVHA
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_1408|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu ALEAAKTLAGEGVSVEVVDLRTLVPLDLQTVLDSVRKTKRLVVAHESVGF
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_1408|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu CGPGAEIAAAVGTELFAELAAPIQRVAGTYTPVPRAATLEAACRPDATKL
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_1408|M.vanbaalenii_PYR-1 --------
MMAR_3489|M.marinum_M --------
MAV_2947|M.avium_104 --------
TH_4167|M.thermoresistible__bu SDAVRRIM
MSMEG_4712|M.smegmatis_MC2_155 --------
MUL_3775|M.ulcerans_Agy99 --------
MAB_4918c|M.abscessus_ATCC_199 --------
Mb0866|M.bovis_AF2122/97 --------
Rv0843|M.tuberculosis_H37Rv --------