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TVGLEPVQLVNADGEPTDEHRYSRDLPEETLCWLYEMMVVTRELDAEFINLKRQGELALFASCRGQEAAQ VGATACLRKTDWLFPQYRELGAYLVRGIPPGHVGAAWRGTWHGGLEFTKKCCVPISVPIGTQALHAVGAA QAAQRLGEDSVTVAFLGDGATSEGDVHEALNFAAVFDAGCVFYVQNNQWAISVPVSKQTAAPSIAHKAIG YGMPGIRVDGNDVLACYAVTAVAAARARRGDGPTLIEAVTYRVGAHTTADDPGRYRSQEEVDHWLALDPI SRYRSYLQGQGLWSQRLEVRVAARSGRLRAELREAVFGASDFDVDDVFTTVFAEITPGLQTQRQQLRAEL DRID*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3775 | pdhA | - | 100% (355) | pyruvate dehydrogenase E1 component (alpha subunit) PdhA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2525c | pdhA | 1e-175 | 83.38% (355) | pyruvate dehydrogenase E1 component alpha subunit PdhA |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv2497c | pdhA | 1e-175 | 83.38% (355) | pyruvate dehydrogenase E1 component alpha subunit PdhA |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0897c | - | 5e-77 | 45.06% (344) | pyruvate dehydrogenase E1 component, alpha subunit |
| M. marinum M | MMAR_3844 | pdhA | 0.0 | 98.87% (355) | pyruvate dehydrogenase E1 component (alpha subunit) PdhA |
| M. avium 104 | MAV_1675 | - | 1e-173 | 81.41% (355) | pyruvate dehydrogenase E1 component, alpha subunit |
| M. smegmatis MC2 155 | MSMEG_4712 | - | 1e-151 | 73.64% (349) | pyruvate dehydrogenase E1 component, alpha subunit |
| M. thermoresistible (build 8) | TH_0718 | pdhA | 1e-144 | 71.51% (344) | PROBABLE PYRUVATE DEHYDROGENASE E1 COMPONENT (ALPHA SUBUNIT) |
| M. vanbaalenii PYR-1 | Mvan_4086 | - | 1e-152 | 73.99% (346) | pyruvate dehydrogenase (acetyl-transferring) |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3775|M.ulcerans_Agy99 --------------MTVGLEPVQLVNADGEPTDE---HRYSRDLPEETLC
MMAR_3844|M.marinum_M --MADRPRIP----MTVGLEPVQLVNADGEPTDE---HRYSRDLPEETLC
Mb2525c|M.bovis_AF2122/97 --MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAE---RRYHRDLPEETLR
Rv2497c|M.tuberculosis_H37Rv --MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAE---RRYHRDLPEETLR
MAV_1675|M.avium_104 --MAQTSQPP----MTVDLQPVQLVAADGTPTSE---HRYSRELPAETLS
MSMEG_4712|M.smegmatis_MC2_155 --MAMQYSSAPGYDTGFDPEPVQLVAADGSPSPDRPPSRYSRDLPPETLS
Mvan_4086|M.vanbaalenii_PYR-1 ---MAGLSALSELD-----EPIQLVAPDGAPTPE---SRYRRDLPPETLA
TH_0718|M.thermoresistible__bu ----MGHPGVLDCE-----ASVQLVAPDGTATDE---HRYSRDLPPGVLR
MAB_0897c|M.abscessus_ATCC_199 MTVAEPADRPAYQAFLPADSAVQFLDPEGRPVDGG--ARYPR-PDADRLL
.:*:: .:* . ** * *
MUL_3775|M.ulcerans_Agy99 WLYEMMVVTRELDAEFINLKRQGELALFASCRGQEAAQVGATACLRKTDW
MMAR_3844|M.marinum_M WLYEMMVVTRELDAEFINLKRQGELALFASCRGQEAAQVGATACLRKTDW
Mb2525c|M.bovis_AF2122/97 WLYEMMVVTRELDTEFVNLQRQGELALYTPCRGQEAAQVGAAACLRKTDW
Rv2497c|M.tuberculosis_H37Rv WLYEMMVVTRELDTEFVNLQRQGELALYTPCRGQEAAQVGAAACLRKTDW
MAV_1675|M.avium_104 WLYEMMVLTRELDGEFVNLKRQGQLALFASCRGQEAAQVGATACLRKTDW
MSMEG_4712|M.smegmatis_MC2_155 WLYESMVVTRNLDVEFVNLQRQGELALFASCRGQEAAQIGAAACLRKTDW
Mvan_4086|M.vanbaalenii_PYR-1 WLYESMVVTRELDTEFVNLQRQGELALFASCRGQEAAQIGAAACLRKTDW
TH_0718|M.thermoresistible__bu RLYELMVVTRDLDAEFVNLQRQGELALYPSCRGQEAAQVGAAACLRDIDW
MAB_0897c|M.abscessus_ATCC_199 AMYRNMVLGRRFDEQATALTKQGRLAVYPSSRGQEACQIAAAMCLHSDDW
:*. **: * :* : * :**.**::...*****.*:.*: **:. **
MUL_3775|M.ulcerans_Agy99 LFPQYRELGAYLVRGIPPGHVGAAWRGTWHGGLEFTKKCCVPISVPIGTQ
MMAR_3844|M.marinum_M LFPQYRELGAYLVRGIPPGHVGAAWRGTWHGGLEFTKKCCAPISVPIGTQ
Mb2525c|M.bovis_AF2122/97 LFPQYRELGVYLVRGIPPGHVGVAWRGTWHGGLQFTTKCCAPMSVPIGTQ
Rv2497c|M.tuberculosis_H37Rv LFPQYRELGVYLVRGIPPGHVGVAWRGTWHGGLQFTTKCCAPMSVPIGTQ
MAV_1675|M.avium_104 LFPQYRELGAFLVRGIPPGNVGAVWRGTWHGGLGFTDKCCAPLSIPIGTQ
MSMEG_4712|M.smegmatis_MC2_155 LFPQYREIGAFLLRGITPAQMGAVWRGKWHGGLSFTGKCVAPIAIPIGTH
Mvan_4086|M.vanbaalenii_PYR-1 LFPQYRELGAFLVRAIAPAQLGALWRGRWHGGLGFTDRCVAPVSIPIGTH
TH_0718|M.thermoresistible__bu LFPQYRELGAFLTRGITPQQLAEVWRGSWHGGSGFTAKRCAPIAIPIATH
MAB_0897c|M.abscessus_ATCC_199 LFPTYRDSMALAARGIDTVDILRFLAGDWHCCFDPAQHRTAPQATPLATQ
*** **: . *.* . .: * ** : : .* : *:.*:
MUL_3775|M.ulcerans_Agy99 ALHAVGAAQAAQRLGEDSVTVAFLGDGATSEGDVHEALNFAAVFDAGCVF
MMAR_3844|M.marinum_M ALHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDVHEALNFAAVFDAGCVF
Mb2525c|M.bovis_AF2122/97 TLHAVGAAMAAQRLDEDSVTVAFLGDGATSEGDVHEALNFAAVFTTPCVF
Rv2497c|M.tuberculosis_H37Rv TLHAVGAAMAAQRLDEDSVTVAFLGDGATSEGDVHEALNFAAVFTTPCVF
MAV_1675|M.avium_104 TLHAVGAAMAAQRLGEDSVTIAFLGDGATSVGDVHEALNFAAVFRTPCVF
MSMEG_4712|M.smegmatis_MC2_155 GLHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDAHEAFNLATVFRAPCVF
Mvan_4086|M.vanbaalenii_PYR-1 GLHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDAHEALNLAAVFGAPCVF
TH_0718|M.thermoresistible__bu TLHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDAHEALNLAAVYRAPCVF
MAB_0897c|M.abscessus_ATCC_199 LLHAAGLAHALARKGSDTAVLALCGDGATSEGDFHEALNFAAVFRAPVIF
***.* * * * ..*:..:*: ****** ** ***:*:*:*: : :*
MUL_3775|M.ulcerans_Agy99 YVQNNQWAISVPVSKQTAAPSIAHKAIGYGMPGIRVDGNDVLACYAVTAV
MMAR_3844|M.marinum_M YVQNNQWAISVPVSKQTAAPSIAHKAIGYGMPGIRVDGNDVLACYAVTAE
Mb2525c|M.bovis_AF2122/97 YVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGNDVLACYAVMAE
Rv2497c|M.tuberculosis_H37Rv YVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGNDVLACYAVMAE
MAV_1675|M.avium_104 FVQNNQWAISLPVAKQTASPSLAHKAIGYGMPGIRVDGNDVLACYAVTAE
MSMEG_4712|M.smegmatis_MC2_155 FIQNNQWAISVPVSRQQAGPTIAHRAIGYGMPGIRVDGNDVLACYAVMSE
Mvan_4086|M.vanbaalenii_PYR-1 FVQNNQWAISVPVERQHAGPTLAHRAIGYGMPGVRVDGNDVLACFAVMEQ
TH_0718|M.thermoresistible__bu FVQNNGWAISVPVSRQHAAPTLAHRGVGYGMPGIRVDGNDVLACYAVMAE
MAB_0897c|M.abscessus_ATCC_199 LVQNNGFAISVPLARQSVAPSLAHKGIGYGMGSEQVDGNDPVAMLAVLDA
:*** :***:*: :* ..*::**:.:**** . :***** :* **
MUL_3775|M.ulcerans_Agy99 AAARARRGDGPTLIEAVTYRVGAHTTADDPGRYRSQEEVDHWLALDPISR
MMAR_3844|M.marinum_M AAARARRGDGPTLIEAVTYRVGAHTTADDPGRYRSQEEVDHWLALDPISR
Mb2525c|M.bovis_AF2122/97 AAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEVDRWATLDPIPR
Rv2497c|M.tuberculosis_H37Rv AAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEVDRWATLDPIPR
MAV_1675|M.avium_104 AAARARAGGGPTLIEAITYRLGPHTTSDDPTRYRTQDEVDHWAALDPIPR
MSMEG_4712|M.smegmatis_MC2_155 AAERARRGEGPTLIEAVTYRMGPHTTSDDPTRYRPAEEVEAWAARDPIAR
Mvan_4086|M.vanbaalenii_PYR-1 AAARAREGGGPTFIEAVTYRMGPHTTSDDPTRYRSDEEVEHWRARDPIAR
TH_0718|M.thermoresistible__bu AVERARTGGGPTLIEAVTYRMGPHTTSDDPTRYRSEAELQHWAALDPLSR
MAB_0897c|M.abscessus_ATCC_199 AREYVLAGNGPVIVEAHTYRMSGHTNADDPLRYRTDDELDEWLARDPIQR
* . * **.::** ***:. **.:*** ***. *:: * : **: *
MUL_3775|M.ulcerans_Agy99 YRSYLQGQGLWSQRLEVRVAARSGRLRAELREAVFGASDFDVDDVFTTVF
MMAR_3844|M.marinum_M YRSYLQGQGLWSQRLEERVAARSGRLRAELREAVFGASDFDVDDVFTTVF
Mb2525c|M.bovis_AF2122/97 YRTYLQDQGLWSQRLEEQVTARAKHVRSELRDAVFDAPDFDVDEVFTTVY
Rv2497c|M.tuberculosis_H37Rv YRTYLQDQGLWSQRLEEQVTARAKHVRSELRDAVFDAPDFDVDEVFTTVY
MAV_1675|M.avium_104 YRSYLQGQGLWSERLEERVIGRATRMRAELRDAVFDAPDLDVDEVFTAVY
MSMEG_4712|M.smegmatis_MC2_155 YRTYLQNIGVWTERLEERVAARSSRLCAELRDAIVGAPDVDPAEMFDTVY
Mvan_4086|M.vanbaalenii_PYR-1 YRTYLEHTGVWTQRLEERVAHRSQRLRAELRDAVITEPDIDIGEVFDTVY
TH_0718|M.thermoresistible__bu YRDYLTAVGVWTDHLEEHVAAESSRLRTELRDAVVGAPDIDIAEVFDTVF
MAB_0897c|M.abscessus_ATCC_199 LEIHLRAEGLLDDTYVAAVASDAEDLAATTRAGMNRDRPVDVDDLFRYVY
. :* *: : * : : : * .: .* ::* *:
MUL_3775|M.ulcerans_Agy99 AEITPGLQTQRQQLRAELDRID-----
MMAR_3844|M.marinum_M AEITPGLQTQRQQLRAELDRID-----
Mb2525c|M.bovis_AF2122/97 AEITPGLQAQREQLRAELARTD-----
Rv2497c|M.tuberculosis_H37Rv AEITPGLQAQREQLRAELARTD-----
MAV_1675|M.avium_104 AEITPELQAQRRALRTELEKSD-----
MSMEG_4712|M.smegmatis_MC2_155 ADITPELARQRDQLLSELAKEA-----
Mvan_4086|M.vanbaalenii_PYR-1 HDITPDLARQRDELLAELAKEA-----
TH_0718|M.thermoresistible__bu SDITPDLARQRDELLAELGCRRRDGRG
MAB_0897c|M.abscessus_ATCC_199 AQPTSQLREQHAQARADFTAQLSEDRP
: *. * *: :::