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AGLSALSELDEPIQLVAPDGAPTPESRYRRDLPPETLAWLYESMVVTRELDTEFVNLQRQGELALFASCR GQEAAQIGAAACLRKTDWLFPQYRELGAFLVRAIAPAQLGALWRGRWHGGLGFTDRCVAPVSIPIGTHGL HAVGAAMAAQRLGEDSVTVAFLGDGATSEGDAHEALNLAAVFGAPCVFFVQNNQWAISVPVERQHAGPTL AHRAIGYGMPGVRVDGNDVLACFAVMEQAAARAREGGGPTFIEAVTYRMGPHTTSDDPTRYRSDEEVEHW RARDPIARYRTYLEHTGVWTQRLEERVAHRSQRLRAELRDAVITEPDIDIGEVFDTVYHDITPDLARQRD ELLAELAKEA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4086 | - | - | 100% (361) | pyruvate dehydrogenase (acetyl-transferring) |
| M. vanbaalenii PYR-1 | Mvan_1408 | - | 7e-31 | 30.43% (299) | pyruvate dehydrogenase (acetyl-transferring) |
| M. vanbaalenii PYR-1 | Mvan_0911 | - | 1e-30 | 36.02% (261) | pyruvate dehydrogenase (acetyl-transferring) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2525c | pdhA | 1e-156 | 74.43% (348) | pyruvate dehydrogenase E1 component alpha subunit PdhA |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv2497c | pdhA | 1e-156 | 74.43% (348) | pyruvate dehydrogenase E1 component alpha subunit PdhA |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4918c | - | 9e-80 | 46.33% (354) | pyruvate dehydrogenase E1 component alpha subunit |
| M. marinum M | MMAR_3844 | pdhA | 1e-154 | 74.86% (346) | pyruvate dehydrogenase E1 component (alpha subunit) PdhA |
| M. avium 104 | MAV_1675 | - | 1e-157 | 74.71% (348) | pyruvate dehydrogenase E1 component, alpha subunit |
| M. smegmatis MC2 155 | MSMEG_4712 | - | 1e-174 | 82.44% (353) | pyruvate dehydrogenase E1 component, alpha subunit |
| M. thermoresistible (build 8) | TH_0718 | pdhA | 1e-159 | 76.06% (355) | PROBABLE PYRUVATE DEHYDROGENASE E1 COMPONENT (ALPHA SUBUNIT) |
| M. ulcerans Agy99 | MUL_3775 | pdhA | 1e-152 | 73.99% (346) | pyruvate dehydrogenase E1 component (alpha subunit) PdhA |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2525c|M.bovis_AF2122/97 MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAE---RRYHRDLPEET----
Rv2497c|M.tuberculosis_H37Rv MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAE---RRYHRDLPEET----
MMAR_3844|M.marinum_M MADRPRIP----MTVGLEPVQLVNADGEPTDE---HRYSRDLPEET----
MUL_3775|M.ulcerans_Agy99 ------------MTVGLEPVQLVNADGEPTDE---HRYSRDLPEET----
MAV_1675|M.avium_104 MAQTSQPP----MTVDLQPVQLVAADGTPTSE---HRYSRELPAET----
Mvan_4086|M.vanbaalenii_PYR-1 -MAGLSALSELD-----EPIQLVAPDGAPTPE---SRYRRDLPPET----
MSMEG_4712|M.smegmatis_MC2_155 MAMQYSSAPGYDTGFDPEPVQLVAADGSPSPDRPPSRYSRDLPPET----
TH_0718|M.thermoresistible__bu --MGHPGVLDCE-----ASVQLVAPDGTATDE---HRYSRDLPPGV----
MAB_4918c|M.abscessus_ATCC_199 ----------------METIQLLDSDGNRIENPEYMPLVSDILDEDGLTQ
.:**: .** : ::
Mb2525c|M.bovis_AF2122/97 LRWLYEMMVVTRELDTEFVNLQRQGELALYTPCRGQEAAQVGAAACLRKT
Rv2497c|M.tuberculosis_H37Rv LRWLYEMMVVTRELDTEFVNLQRQGELALYTPCRGQEAAQVGAAACLRKT
MMAR_3844|M.marinum_M LCWLYEMMVVTRELDAEFINLKRQGELALFASCRGQEAAQVGATACLRKT
MUL_3775|M.ulcerans_Agy99 LCWLYEMMVVTRELDAEFINLKRQGELALFASCRGQEAAQVGATACLRKT
MAV_1675|M.avium_104 LSWLYEMMVLTRELDGEFVNLKRQGQLALFASCRGQEAAQVGATACLRKT
Mvan_4086|M.vanbaalenii_PYR-1 LAWLYESMVVTRELDTEFVNLQRQGELALFASCRGQEAAQIGAAACLRKT
MSMEG_4712|M.smegmatis_MC2_155 LSWLYESMVVTRNLDVEFVNLQRQGELALFASCRGQEAAQIGAAACLRKT
TH_0718|M.thermoresistible__bu LRRLYELMVVTRDLDAEFVNLQRQGELALYPSCRGQEAAQVGAAACLRDI
MAB_4918c|M.abscessus_ATCC_199 LRALYRDMVVVRRIDNESTALQRQGELALWAPLLGQEAAQVGSARALRHD
* **. **:.* :* * *:***:***:.. ******:*:: .**.
Mb2525c|M.bovis_AF2122/97 DWLFPQYRELGVYLVRGIPPGHVGVAWRGTWHGGLQFTTKCCAPMSVPIG
Rv2497c|M.tuberculosis_H37Rv DWLFPQYRELGVYLVRGIPPGHVGVAWRGTWHGGLQFTTKCCAPMSVPIG
MMAR_3844|M.marinum_M DWLFPQYRELGAYLVRGIPPGHVGAAWRGTWHGGLEFTKKCCAPISVPIG
MUL_3775|M.ulcerans_Agy99 DWLFPQYRELGAYLVRGIPPGHVGAAWRGTWHGGLEFTKKCCVPISVPIG
MAV_1675|M.avium_104 DWLFPQYRELGAFLVRGIPPGNVGAVWRGTWHGGLGFTDKCCAPLSIPIG
Mvan_4086|M.vanbaalenii_PYR-1 DWLFPQYRELGAFLVRAIAPAQLGALWRGRWHGGLGFTDRCVAPVSIPIG
MSMEG_4712|M.smegmatis_MC2_155 DWLFPQYREIGAFLLRGITPAQMGAVWRGKWHGGLSFTGKCVAPIAIPIG
TH_0718|M.thermoresistible__bu DWLFPQYRELGAFLTRGITPQQLAEVWRGSWHGGSGFTAKRCAPIAIPIA
MAB_4918c|M.abscessus_ATCC_199 DFAFTSFREHGVAYCRGIEPTAMLQFWRGSTQSGWNPRDHNVTAPAIIVG
*: *..:** *. *.* * : *** :.* : .. :: :.
Mb2525c|M.bovis_AF2122/97 TQTLHAVGAAMAAQRLDEDSVTVAFLGDGATSEGDVHEALNFAAVFTTPC
Rv2497c|M.tuberculosis_H37Rv TQTLHAVGAAMAAQRLDEDSVTVAFLGDGATSEGDVHEALNFAAVFTTPC
MMAR_3844|M.marinum_M TQALHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDVHEALNFAAVFDAGC
MUL_3775|M.ulcerans_Agy99 TQALHAVGAAQAAQRLGEDSVTVAFLGDGATSEGDVHEALNFAAVFDAGC
MAV_1675|M.avium_104 TQTLHAVGAAMAAQRLGEDSVTIAFLGDGATSVGDVHEALNFAAVFRTPC
Mvan_4086|M.vanbaalenii_PYR-1 THGLHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDAHEALNLAAVFGAPC
MSMEG_4712|M.smegmatis_MC2_155 THGLHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDAHEAFNLATVFRAPC
TH_0718|M.thermoresistible__bu THTLHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDAHEALNLAAVYRAPC
MAB_4918c|M.abscessus_ATCC_199 AQALHATGYAMGVKFDGSDTAVIAYFGDGATSQGDVSEAFAFASSFGAPV
:: ***.* * ..: ..*:..:*::****** **. **: :*: : :
Mb2525c|M.bovis_AF2122/97 VFYVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGNDVLACYAVM
Rv2497c|M.tuberculosis_H37Rv VFYVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGNDVLACYAVM
MMAR_3844|M.marinum_M VFYVQNNQWAISVPVSKQTAAPSIAHKAIGYGMPGIRVDGNDVLACYAVT
MUL_3775|M.ulcerans_Agy99 VFYVQNNQWAISVPVSKQTAAPSIAHKAIGYGMPGIRVDGNDVLACYAVT
MAV_1675|M.avium_104 VFFVQNNQWAISLPVAKQTASPSLAHKAIGYGMPGIRVDGNDVLACYAVT
Mvan_4086|M.vanbaalenii_PYR-1 VFFVQNNQWAISVPVERQHAGPTLAHRAIGYGMPGVRVDGNDVLACFAVM
MSMEG_4712|M.smegmatis_MC2_155 VFFIQNNQWAISVPVSRQQAGPTIAHRAIGYGMPGIRVDGNDVLACYAVM
TH_0718|M.thermoresistible__bu VFFVQNNGWAISVPVSRQHAAPTLAHRGVGYGMPGIRVDGNDVLACYAVM
MAB_4918c|M.abscessus_ATCC_199 VFFCQNNQWAISEPVRVQSHLP-LAARGIGFGVPGIQVDGNDVLAVTAAT
**: *** **** ** * * :* :.:*:*:**::******** *.
Mb2525c|M.bovis_AF2122/97 AEAAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEVDRWATLDPI
Rv2497c|M.tuberculosis_H37Rv AEAAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEVDRWATLDPI
MMAR_3844|M.marinum_M AEAAARARRGDGPTLIEAVTYRVGAHTTADDPGRYRSQEEVDHWLALDPI
MUL_3775|M.ulcerans_Agy99 AVAAARARRGDGPTLIEAVTYRVGAHTTADDPGRYRSQEEVDHWLALDPI
MAV_1675|M.avium_104 AEAAARARAGGGPTLIEAITYRLGPHTTSDDPTRYRTQDEVDHWAALDPI
Mvan_4086|M.vanbaalenii_PYR-1 EQAAARAREGGGPTFIEAVTYRMGPHTTSDDPTRYRSDEEVEHWRARDPI
MSMEG_4712|M.smegmatis_MC2_155 SEAAERARRGEGPTLIEAVTYRMGPHTTSDDPTRYRPAEEVEAWAARDPI
TH_0718|M.thermoresistible__bu AEAVERARTGGGPTLIEAVTYRMGPHTTSDDPTRYRSEAELQHWAALDPL
MAB_4918c|M.abscessus_ATCC_199 RMALRRAREGSGPTLIEAVTYRMGPHTTSDDPTKYRNAAELDEWRAKDPL
* *** * ***:***:***:*.***:*** :** *:: * : **:
Mb2525c|M.bovis_AF2122/97 PRYRTYLQDQGLWSQRLEEQVTARAKHVRSELRDAVFDAPDFDVDEVFTT
Rv2497c|M.tuberculosis_H37Rv PRYRTYLQDQGLWSQRLEEQVTARAKHVRSELRDAVFDAPDFDVDEVFTT
MMAR_3844|M.marinum_M SRYRSYLQGQGLWSQRLEERVAARSGRLRAELREAVFGASDFDVDDVFTT
MUL_3775|M.ulcerans_Agy99 SRYRSYLQGQGLWSQRLEVRVAARSGRLRAELREAVFGASDFDVDDVFTT
MAV_1675|M.avium_104 PRYRSYLQGQGLWSERLEERVIGRATRMRAELRDAVFDAPDLDVDEVFTA
Mvan_4086|M.vanbaalenii_PYR-1 ARYRTYLEHTGVWTQRLEERVAHRSQRLRAELRDAVITEPDIDIGEVFDT
MSMEG_4712|M.smegmatis_MC2_155 ARYRTYLQNIGVWTERLEERVAARSSRLCAELRDAIVGAPDVDPAEMFDT
TH_0718|M.thermoresistible__bu SRYRDYLTAVGVWTDHLEEHVAAESSRLRTELRDAVVGAPDIDIAEVFDT
MAB_4918c|M.abscessus_ATCC_199 ARVEKYLESRGALSESEKHRIAALADEVAAQLRAGCLGTVEPTAADMFNH
.* . ** * :: : :: : .: ::** . . : ::*
Mb2525c|M.bovis_AF2122/97 VYAEITPGLQAQREQLRAELARTD-------
Rv2497c|M.tuberculosis_H37Rv VYAEITPGLQAQREQLRAELARTD-------
MMAR_3844|M.marinum_M VFAEITPGLQTQRQQLRAELDRID-------
MUL_3775|M.ulcerans_Agy99 VFAEITPGLQTQRQQLRAELDRID-------
MAV_1675|M.avium_104 VYAEITPELQAQRRALRTELEKSD-------
Mvan_4086|M.vanbaalenii_PYR-1 VYHDITPDLARQRDELLAELAKEA-------
MSMEG_4712|M.smegmatis_MC2_155 VYADITPELARQRDQLLSELAKEA-------
TH_0718|M.thermoresistible__bu VFSDITPDLARQRDELLAELGCRRRDGRG--
MAB_4918c|M.abscessus_ATCC_199 VYAEPHPLVSAERRDYLEYLATFEDEGTYAS
*: : * : :* *