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MDDAVRLELYRTMRLIRTYEEAILREYHADKKPSFDIAKGQIPGEMHLCTGQEPVPAGFGPHLRRDDAVT GPHRPHGWALAKGVDIERMTAEIFGRIDGLGKGRGGHMHLFDQDAHFSCSGIIAEGLPTAVGMALAFKKQ GSDRVAIAVTGEGAANQGAFHESLNLAALWKLPVVFIVEDNGWGVSVSKAQSTCIESNADRAVAYGMPGV LVKDNAVEAIYAVAGEAISRARAGGGPTLIEAETLRLWGHFEGDPQLYRADLDGVAALDPVPAYEAQLRA DSVLSDDIVHEVTNWAVERVESAIAFAKSSPEPDPATALNYQFA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0911 | - | - | 100% (324) | pyruvate dehydrogenase (acetyl-transferring) |
| M. vanbaalenii PYR-1 | Mvan_1408 | - | 4e-47 | 35.33% (317) | pyruvate dehydrogenase (acetyl-transferring) |
| M. vanbaalenii PYR-1 | Mvan_4086 | - | 1e-30 | 36.02% (261) | pyruvate dehydrogenase (acetyl-transferring) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2525c | pdhA | 1e-34 | 37.07% (259) | pyruvate dehydrogenase E1 component alpha subunit PdhA |
| M. gilvum PYR-GCK | Mflv_3923 | - | 4e-05 | 30.70% (114) | 1-deoxy-D-xylulose-5-phosphate synthase |
| M. tuberculosis H37Rv | Rv2497c | pdhA | 2e-34 | 37.07% (259) | pyruvate dehydrogenase E1 component alpha subunit PdhA |
| M. leprae Br4923 | MLBr_01038 | dxs | 4e-06 | 22.67% (300) | 1-deoxy-D-xylulose-5-phosphate synthase |
| M. abscessus ATCC 19977 | MAB_0897c | - | 3e-29 | 30.67% (326) | pyruvate dehydrogenase E1 component, alpha subunit |
| M. marinum M | MMAR_3489 | - | 4e-47 | 36.68% (319) | pyruvate dehydrogenase E1 component (alpha subunit) |
| M. avium 104 | MAV_2947 | - | 2e-49 | 36.22% (312) | dehydrogenase E1 component superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4712 | - | 2e-32 | 33.33% (294) | pyruvate dehydrogenase E1 component, alpha subunit |
| M. thermoresistible (build 8) | TH_4167 | - | 9e-43 | 34.81% (293) | PUTATIVE acetoin:2,6-dichlorophenolindophenol oxidoreductase |
| M. ulcerans Agy99 | MUL_3775 | pdhA | 3e-31 | 35.89% (248) | pyruvate dehydrogenase E1 component (alpha subunit) PdhA |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2525c|M.bovis_AF2122/97 --MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAER---RYHRDLPEETLR
Rv2497c|M.tuberculosis_H37Rv --MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAER---RYHRDLPEETLR
MUL_3775|M.ulcerans_Agy99 --------------MTVGLEPVQLVNADGEPTDEH---RYSRDLPEETLC
MSMEG_4712|M.smegmatis_MC2_155 --MAMQYSSAPGYDTGFDPEPVQLVAADGSPSPDRPPSRYSRDLPPETLS
MAB_0897c|M.abscessus_ATCC_199 MTVAEPADRPAYQAFLPADSAVQFLDPEGRPVDGG--ARYPR-PDADRLL
MAV_2947|M.avium_104 ------------------------MTQSAKPSP-------------DIHR
TH_4167|M.thermoresistible__bu -----------------------MATQLDVEAPTS---------ANDRAI
Mvan_0911|M.vanbaalenii_PYR-1 ------------------------MDDAVRLELYR---------TMRLIR
MMAR_3489|M.marinum_M ------------------------MDAKLARELLS---------DMVRVR
Mflv_3923|M.gilvum_PYR-GCK -----------------------MLEQIRGPADLQ---------------
MLBr_01038|M.leprae_Br4923 -----------------------MLEQIRRPADLQ---------------
Mb2525c|M.bovis_AF2122/97 WLYEMMVVTRELDTEFVN-LQRQGELALYTPCRGQEAAQVGAAACLRKTD
Rv2497c|M.tuberculosis_H37Rv WLYEMMVVTRELDTEFVN-LQRQGELALYTPCRGQEAAQVGAAACLRKTD
MUL_3775|M.ulcerans_Agy99 WLYEMMVVTRELDAEFIN-LKRQGELALFASCRGQEAAQVGATACLRKTD
MSMEG_4712|M.smegmatis_MC2_155 WLYESMVVTRNLDVEFVN-LQRQGELALFASCRGQEAAQIGAAACLRKTD
MAB_0897c|M.abscessus_ATCC_199 AMYRNMVLGRRFDEQATA-LTKQGRLAVYPSSRGQEACQIAAAMCLHSDD
MAV_2947|M.avium_104 RLYALMVLMKTADDRLSRGIGTGEFLCVYWPSRGQEAIAAAMGVSLRPDD
TH_4167|M.thermoresistible__bu ALYRLMSKVHHADARVRKGLSSGEIAMSYWPVTGQEAMSAGAALALSDGD
Mvan_0911|M.vanbaalenii_PYR-1 TYEEAILREYHADKKPSFDIAKGQIPGEMHLCTGQEPVPAGFGPHLRRDD
MMAR_3489|M.marinum_M RMEEKCAELYSAAK----------IRGFLHLYVGEEAVAAGSLRVLAEDD
Mflv_3923|M.gilvum_PYR-GCK HLSRAQMEDLAREIRDFLIHKVAATGGHLGPNLGVVELTLALHRVFDSPH
MLBr_01038|M.leprae_Br4923 HLSQQQLRDLAAEIRELLVHKVAATGGHLGPNLGVVELTLALHRVFDSPH
* . : .
Mb2525c|M.bovis_AF2122/97 WLFPQYRELGVYLVRGIPPGHVGVAWRGTWHGG---------LQFTTKCC
Rv2497c|M.tuberculosis_H37Rv WLFPQYRELGVYLVRGIPPGHVGVAWRGTWHGG---------LQFTTKCC
MUL_3775|M.ulcerans_Agy99 WLFPQYRELGAYLVRGIPPGHVGAAWRGTWHGG---------LEFTKKCC
MSMEG_4712|M.smegmatis_MC2_155 WLFPQYREIGAFLLRGITPAQMGAVWRGKWHGG---------LSFTGKCV
MAB_0897c|M.abscessus_ATCC_199 WLFPTYRDSMALAARGIDTVDILRFLAGDWHCC---------FDPAQHRT
MAV_2947|M.avium_104 QLVTTYRGLHDLIGKGVGLEEIYGEMMGRTIGAGRGKGGTMHIAKPEVGV
TH_4167|M.thermoresistible__bu QLVSTYRGLGDVVAKGIDLAGYFGEILGRRTGLSRGKAGAMGISDPDHGI
Mvan_0911|M.vanbaalenii_PYR-1 AVTGPHRPHGWALAKGVDIERMTAEIFGRIDGLGKGRGGHMHLFDQDAHF
MMAR_3489|M.marinum_M AVVATYREHAHALLRGIPMTSIMAEMFGKQEGCSRGRGGSMHLFDQARRF
Mflv_3923|M.gilvum_PYR-GCK DPILFDTGHQAYVHKMLTGRSRDFDTLRKKDGLSG-----YPSRSESEHD
MLBr_01038|M.leprae_Br4923 DPIIFDTGHQAYVHKMLTGRCQDFDSLRKKAGLSG-----YPSRAESEHD
: :
Mb2525c|M.bovis_AF2122/97 APMSVPIGTQTLHAVGAAMAAQRLD-EDSVTVAFLGDGATSEGDVHEALN
Rv2497c|M.tuberculosis_H37Rv APMSVPIGTQTLHAVGAAMAAQRLD-EDSVTVAFLGDGATSEGDVHEALN
MUL_3775|M.ulcerans_Agy99 VPISVPIGTQALHAVGAAQAAQRLG-EDSVTVAFLGDGATSEGDVHEALN
MSMEG_4712|M.smegmatis_MC2_155 APIAIPIGTHGLHAVGAAMAAQRLG-EDSVTVAFLGDGATSEGDAHEAFN
MAB_0897c|M.abscessus_ATCC_199 APQATPLATQLLHAAGLAHALARKG-SDTAVLALCGDGATSEGDFHEALN
MAV_2947|M.avium_104 MLSTGIVGAGPPVAVGLAMAARRKG-LDRVTVVSFGDGATNTGSFHEAAN
TH_4167|M.thermoresistible__bu AWTTGIVGAGPLFANGIALAASIRG-TGQVVLVSFGDGATSIGYVHEAMN
Mvan_0911|M.vanbaalenii_PYR-1 S-CSGIIAEGLPTAVGMALAFKKQG-SDRVAIAVTGEGAANQGAFHESLN
MMAR_3489|M.marinum_M YGGNAIVAGGLPLAVGISLADSMLK-RNRVTACYFGDGAVAEGAFHESLN
Mflv_3923|M.gilvum_PYR-GCK WVESSHASSALSYADGLAKAFELNGHRNRHVVAVVGDGALTGGMCWEALN
MLBr_01038|M.leprae_Br4923 WVESSHASTALSYADGLAKAFELAGNRNRHVVAVVGDGALTGGMCWEALN
. * * : * . . *:** * *: *
Mb2525c|M.bovis_AF2122/97 FAAVFTTPCVFYVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGN
Rv2497c|M.tuberculosis_H37Rv FAAVFTTPCVFYVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGN
MUL_3775|M.ulcerans_Agy99 FAAVFDAGCVFYVQNNQWAISVPVSKQTAAPSIAHKAIGYGMPGIRVDGN
MSMEG_4712|M.smegmatis_MC2_155 LATVFRAPCVFFIQNNQWAISVPVSRQQAGPTIAHRAIGYGMPGIRVDGN
MAB_0897c|M.abscessus_ATCC_199 FAAVFRAPVIFLVQNNGFAISVPLARQSVAPSLAHKGIGYGMGSEQVDGN
MAV_2947|M.avium_104 MAALWDLPIVFVCQNNRYAEMTPTTDTMKLEHVADRAAGYGMPGVRVDGN
TH_4167|M.thermoresistible__bu MAALWNLPVVFFCQNNAWAECTAMERYTRTARLSDRAQGYGMPGVTVDGT
Mvan_0911|M.vanbaalenii_PYR-1 LAALWKLPVVFIVEDNGWGVSVSKAQSTCIESNADRAVAYGMPGVLVKDN
MMAR_3489|M.marinum_M MAALWKLPVLFLCENNLYAMGTALHRAQSQTDLTVKAASYNVATLAVDGM
Mflv_3923|M.gilvum_PYR-GCK NIAASRRPVVIVVNDNGRSYAPTIGG--FAEHLAGLRLQPGYERVLEEGR
MLBr_01038|M.leprae_Br4923 NIAATPRPVVIVVNDNGRSYAPTIGG--VADHLATLRLQPAYERLLEKGR
: :: ::* . . : ..
Mb2525c|M.bovis_AF2122/97 DVLACYAVMAEAAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEV
Rv2497c|M.tuberculosis_H37Rv DVLACYAVMAEAAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEV
MUL_3775|M.ulcerans_Agy99 DVLACYAVTAVAAARARRGDGPTLIEAVTYRVGAHTTADDPGRYRSQEEV
MSMEG_4712|M.smegmatis_MC2_155 DVLACYAVMSEAAERARRGEGPTLIEAVTYRMGPHTTSDDPTRYRPAEEV
MAB_0897c|M.abscessus_ATCC_199 DPVAMLAVLDAAREYVLAGNGPVIVEAHTYRMSGHTNADDPLRYRTDDEL
MAV_2947|M.avium_104 DPLAVTAALEEALRRARAGSGPTFLECETFRFRGHYFG-DRMPYIPADQL
TH_4167|M.thermoresistible__bu DPRAVHDAVAEAVTRARSGGGPTFVEALAYRLQGHYFG-DTMAYADPDEL
Mvan_0911|M.vanbaalenii_PYR-1 AVEAIYAVAGEAISRARAGGGPTLIEAETLRLWGHFEG-DPQLYR--ADL
MMAR_3489|M.marinum_M DVAACMSATQQGVDHIRSTGGPFFIEFRTYRFRAHSMF-DPELYRDKAEV
Mflv_3923|M.gilvum_PYR-GCK KAVRGVPMIGEFCYQCMHSIKAGIKDALSPQVMFTDLGLKYVGPIDGHDE
MLBr_01038|M.leprae_Br4923 DALHSLPLIGQIAYRFMHSVKAGIKDSLSPQLLFTDLGLKYVGPVDGHDE
. : : : :. . :
Mb2525c|M.bovis_AF2122/97 DRWATLD--------PIPRYRTYLQDQGLWSQRLEEQVTARAKHVRSELR
Rv2497c|M.tuberculosis_H37Rv DRWATLD--------PIPRYRTYLQDQGLWSQRLEEQVTARAKHVRSELR
MUL_3775|M.ulcerans_Agy99 DHWLALD--------PISRYRSYLQGQGLWSQRLEVRVAARSGRLRAELR
MSMEG_4712|M.smegmatis_MC2_155 EAWAARD--------PIARYRTYLQNIGVWTERLEERVAARSSRLCAELR
MAB_0897c|M.abscessus_ATCC_199 DEWLARD--------PIQRLEIHLRAEGLLDDTYVAAVASDAEDLAATTR
MAV_2947|M.avium_104 QAALAAD--------PVPRFRRRLAETGVCGEAELARIDDDAAAAVEAAL
TH_4167|M.thermoresistible__bu AAKRADP--------PFDRYRRRLIDEGIATAATLDQIDAELAAQVDAAF
Mvan_0911|M.vanbaalenii_PYR-1 DGVAALD--------PVPAYEAQLRADSVLSDDIVHEVTNWAVERVESAI
MMAR_3489|M.marinum_M QRWRERD--------PIRLFTEQCLNSGTLTDDDVRDIEGSAADEIAAAV
Mflv_3923|M.gilvum_PYR-GCK SAVEGALRHARAFNAPVVVHVVTRKGMGYAPAENDVDEQMHACGVIDPET
MLBr_01038|M.leprae_Br4923 HAVEVALRKARGFGGPVIVHVVTRKGMGYPPAEADQAEQMHTCGVMDPTT
*. .
Mb2525c|M.bovis_AF2122/97 DAVFDAPDFDVDEVFTTVYAEITPGLQAQREQLRAELARTD---------
Rv2497c|M.tuberculosis_H37Rv DAVFDAPDFDVDEVFTTVYAEITPGLQAQREQLRAELARTD---------
MUL_3775|M.ulcerans_Agy99 EAVFGASDFDVDDVFTTVFAEITPGLQTQRQQLRAELDRID---------
MSMEG_4712|M.smegmatis_MC2_155 DAIVGAPDVDPAEMFDTVYADITPELARQRDQLLSELAKEA---------
MAB_0897c|M.abscessus_ATCC_199 AGMNRDRPVDVDDLFRYVYAQPTSQLREQHAQARADFTAQLSEDRP----
MAV_2947|M.avium_104 RTVLGADSPAADELDRDVYAAP-----------IPFPT------------
TH_4167|M.thermoresistible__bu AAARDAEPLGPEELTGDVFTGNGTELADGTVPRVALPEGETEELGLVQAI
Mvan_0911|M.vanbaalenii_PYR-1 AFAKSSPEPDPATALNYQFA------------------------------
MMAR_3489|M.marinum_M AFADAGTWEDASDLERDVLTPPDSCDATAESTWEPAR-------------
Mflv_3923|M.gilvum_PYR-GCK GLATSVPGPGWTAAFSETLIELAAKRRDIVAITAAMPGPTGLSAFRKRFP
MLBr_01038|M.leprae_Br4923 GQPTKIAAPDWTAIFSDALIGYAMKRRDIVAITAAMPGPTGLTAFGQCFP
Mb2525c|M.bovis_AF2122/97 --------------------------------------------------
Rv2497c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0897c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu HRTLDRAMAADDSIILLGEDIGDRSGGGMFKITAGLSAKYGEERVRDTPI
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK DRFFDVGIAEQHAMTSAAGLAMGGMHPVVALYSTFLNRAFDQMLMDVALH
MLBr_01038|M.leprae_Br4923 DRLFDVGIAEQHAMTSAAGLAMGRMHPVVAIYSTFLNRAFDQIMMDVALH
Mb2525c|M.bovis_AF2122/97 --------------------------------------------------
Rv2497c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0897c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu AESSIIGAALGASLAGLRPVAELMFMDFLGVAMDQIANHVAKVRYMSGGR
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK KLPVTMVLDRSGITGPDGASHNGMWDLSILGIVPGMRVAAPRDGARLREE
MLBr_01038|M.leprae_Br4923 KLPVTMVIDRAGITGSDGPSHNGMWDLSMLGIVPGMRVAAPRDAIRLREE
Mb2525c|M.bovis_AF2122/97 --------------------------------------------------
Rv2497c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0897c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu RGAPLVIRTMVGTAAGAQHSQALEAWAMHTPGLKVVWPSTAADAAGLLNA
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK LAEAVEVKDGPTAVRFPKGDVGEDIPAIERRDGVDVLAVPADGLSDDVLI
MLBr_01038|M.leprae_Br4923 LGEALDVDDGPTAIRFPKGDVCEDIPALKRRSGVDVLAVPATGLAQDVLL
Mb2525c|M.bovis_AF2122/97 --------------------------------------------------
Rv2497c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0897c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu CLREDDPCLFIESMKLYYGGGKGPVPVADYVIPLGQADVKRVGSDVTICT
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK IAVGAFAAMSVAVAERLRDQGIGVTVVDPRWVLPVPAAINTLAAAHKLVV
MLBr_01038|M.leprae_Br4923 VGVGVFASMALAVAKRLHNQGIGVTVIDPRWVLPVCDGVLELAHTHKLIV
Mb2525c|M.bovis_AF2122/97 --------------------------------------------------
Rv2497c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0897c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu YGVLVHAALEAAKTLAGEGVSVEVVDLRTLVPLDLQTVLDSVRKTKRLVV
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK TVEDNGGHGGVGSAVSAALRRAEIDVPCRDAALPQAFFDHASRGEVLAEV
MLBr_01038|M.leprae_Br4923 TLEDNGVNGGVGAAVSTALRQVEIDTPCRDVGLPQEFYDHASRSEVLADL
Mb2525c|M.bovis_AF2122/97 --------------------------------------------------
Rv2497c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0897c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu AHESVGFCGPGAEIAAAVGTELFAELAAPIQRVAGTYTPVPRAATLEAAC
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK GLTERTIARQITGWVAALG-----ATAGDRQVSESVD-------------
MLBr_01038|M.leprae_Br4923 GLTDQDVARRITGWVVAFGHCGSGDDAGQYGPRSSQTM------------
Mb2525c|M.bovis_AF2122/97 ---------------
Rv2497c|M.tuberculosis_H37Rv ---------------
MUL_3775|M.ulcerans_Agy99 ---------------
MSMEG_4712|M.smegmatis_MC2_155 ---------------
MAB_0897c|M.abscessus_ATCC_199 ---------------
MAV_2947|M.avium_104 ---------------
TH_4167|M.thermoresistible__bu RPDATKLSDAVRRIM
Mvan_0911|M.vanbaalenii_PYR-1 ---------------
MMAR_3489|M.marinum_M ---------------
Mflv_3923|M.gilvum_PYR-GCK ---------------
MLBr_01038|M.leprae_Br4923 ---------------