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VTRTSEGLAAFVVDQLEELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAAAALGEGDVII TTHRPHAQHVGTDAPLGPVIADMLGATAGDLEGADEDAHIADPRAGLPAAIRVVKQSPLLAIGHAYALWL RDTGRVTLCVTQDCDVDADAFNEAADLAAVWQLPVVILVENIRGALSVHLGRYTHEPRVYRRAVAYGMPG VSVDGNDVEAVRDCVANAVVRARAGGGPTLVQAITYRTTDFSGSDRGGYRDLAGSEQFLDPLIFARRRLI AAGTTRGRLDEQERAACQQVADAVAFAKDRARPNGGGPISRPTSGWHQQPKTRF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0866 | - | - | 100% (334) | dehydrogenase |
| M. bovis AF2122 / 97 | Mb2525c | pdhA | 4e-28 | 33.44% (305) | pyruvate dehydrogenase E1 component alpha subunit PdhA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv0843 | - | 0.0 | 99.40% (334) | dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4918c | - | 2e-22 | 30.41% (296) | pyruvate dehydrogenase E1 component alpha subunit |
| M. marinum M | MMAR_4784 | - | 8e-72 | 48.58% (317) | dehydrogenase |
| M. avium 104 | MAV_0873 | - | 1e-50 | 43.41% (311) | dehydrogenase E1 component superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4712 | - | 8e-25 | 32.01% (303) | pyruvate dehydrogenase E1 component, alpha subunit |
| M. thermoresistible (build 8) | TH_4167 | - | 4e-39 | 36.89% (309) | PUTATIVE acetoin:2,6-dichlorophenolindophenol oxidoreductase |
| M. ulcerans Agy99 | MUL_3775 | pdhA | 3e-25 | 32.73% (275) | pyruvate dehydrogenase E1 component (alpha subunit) PdhA |
| M. vanbaalenii PYR-1 | Mvan_0911 | - | 3e-30 | 32.58% (310) | pyruvate dehydrogenase (acetyl-transferring) |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4712|M.smegmatis_MC2_155 MAMQYSSAPGYDTGFDPEPVQLVAADGSPSPDRPPSRYSRDLPPET----
MUL_3775|M.ulcerans_Agy99 ------------MTVGLEPVQLVNADGEPTDEH---RYSRDLPEET----
MAB_4918c|M.abscessus_ATCC_199 ----------------METIQLLDSDGNRIENPEYMPLVSDILDEDGLTQ
TH_4167|M.thermoresistible__bu -----------------MATQLDVEAPTSANDR-----------------
Mb0866|M.bovis_AF2122/97 -----------------MTRTSEGLAAFVVDQLE----------------
Rv0843|M.tuberculosis_H37Rv -----------------MTRTSEGLAAFVVDQLE----------------
MMAR_4784|M.marinum_M -----------------MTHASARPAALLPDHL-----------------
MAV_0873|M.avium_104 -----------------MTAPEH-------DDRL----------------
Mvan_0911|M.vanbaalenii_PYR-1 ---------------MDDAVRLELYRTMRLIR------------------
.
MSMEG_4712|M.smegmatis_MC2_155 LSWLYESMVVTRNLDVEFVNLQRQGELAL-FASCRGQEAAQIGAAACLRK
MUL_3775|M.ulcerans_Agy99 LCWLYEMMVVTRELDAEFINLKRQGELAL-FASCRGQEAAQVGATACLRK
MAB_4918c|M.abscessus_ATCC_199 LRALYRDMVVVRRIDNESTALQRQGELAL-WAPLLGQEAAQVGSARALRH
TH_4167|M.thermoresistible__bu AIALYRLMSKVHHADARVRKGLSSGEIAMSYWPVTGQEAMSAGAALALSD
Mb0866|M.bovis_AF2122/97 --ELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAAAALGE
Rv0843|M.tuberculosis_H37Rv --ELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAAAALGE
MMAR_4784|M.marinum_M --EMYRRMWVLRLLDMALEEMRADGLMESPVSTALGQEAVSIGATAALTE
MAV_0873|M.avium_104 --EPYRRMWVLRLLDMALDESAVGAAIDDDAPVDFGQEAVAVGAVAALRP
Mvan_0911|M.vanbaalenii_PYR-1 --TYEEAILREYHADKKPSFDIAKGQIPGEMHLCTGQEPVPAGFGPHLRR
. : * . : ***. * *
MSMEG_4712|M.smegmatis_MC2_155 TDWLFPQYR--EIGAFLLRGITPAQMGAVWRGKWHG---------GLSFT
MUL_3775|M.ulcerans_Agy99 TDWLFPQYR--ELGAYLVRGIPPGHVGAAWRGTWHG---------GLEFT
MAB_4918c|M.abscessus_ATCC_199 DDFAFTSFR--EHGVAYCRGIEPTAMLQFWRGSTQS---------GWNPR
TH_4167|M.thermoresistible__bu GDQLVSTYR--GLGDVVAKGIDLAGYFGEILGRRTGLSRGKAGAMGISDP
Mb0866|M.bovis_AF2122/97 GDVIITTHR--PHAQHVGTDAPLGPVIADMLGATAGDLEGADEDAHIADP
Rv0843|M.tuberculosis_H37Rv GDVIITTHR--PHAQHVGTDAPLGPVIADMLGATAGDLEGADEDAHIADP
MMAR_4784|M.marinum_M GDLVLASRR--AHALHVGVDLPLGPMIAELIGQDS----TCDHADQLNSP
MAV_0873|M.avium_104 GDLVNATTPRFRHAQQIGLGLPLGPAIAELLGTTRGGAGGSRKSGAADWK
Mvan_0911|M.vanbaalenii_PYR-1 DDAVTGPHR--PHGWALAKGVDIERMTAEIFGRIDGLGKGRGGHMHLFDQ
* . . *
MSMEG_4712|M.smegmatis_MC2_155 GKCVAPIAIPIGTHGLHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDAHE
MUL_3775|M.ulcerans_Agy99 KKCCVPISVPIGTQALHAVGAAQAAQRLGEDSVTVAFLGDGATSEGDVHE
MAB_4918c|M.abscessus_ATCC_199 DHNVTAPAIIVGAQALHATGYAMGVKFDGSDTAVIAYFGDGATSQGDVSE
TH_4167|M.thermoresistible__bu DHGIAWTTGIVGAGPLFANGIALAASIRGTGQVVLVSFGDGATSIGYVHE
Mb0866|M.bovis_AF2122/97 RAGLPAAIRVVKQSPLLAIGHAYALWLRDTGRVTLCVTQDCDVDADAFNE
Rv0843|M.tuberculosis_H37Rv RAGLPAAIRVVKQSPLLAIGHAYALWLRDTGRVTLCVTQDCDVDADAFNE
MMAR_4784|M.marinum_M ER-----SGAADQCPLLAVGHAYSQWLDNSDRVTLCITGPDDVNSGAFVQ
MAV_0873|M.avium_104 QALAN--ESALGQSTLFALGDANAQRMAGDGRVTLCAIAGSDTHSVEFAT
Mvan_0911|M.vanbaalenii_PYR-1 DAHFS-CSGIIAEGLPTAVGMALAFKKQGSDRVAIAVTGEGAANQGAFHE
* * * . . . ..: .
MSMEG_4712|M.smegmatis_MC2_155 AFNLATVFRAPCVFFIQNNQWAISVPVSRQQAGPTIAHRAIGYGMPGIRV
MUL_3775|M.ulcerans_Agy99 ALNFAAVFDAGCVFYVQNNQWAISVPVSKQTAAPSIAHKAIGYGMPGIRV
MAB_4918c|M.abscessus_ATCC_199 AFAFASSFGAPVVFFCQNNQWAISEPVRVQSHLP-LAARGIGFGVPGIQV
TH_4167|M.thermoresistible__bu AMNMAALWNLPVVFFCQNNAWAECTAMERYTRTARLSDRAQGYGMPGVTV
Mb0866|M.bovis_AF2122/97 AADLAAVWQLPVVILVENIRGALSVHLGRYTHEPRVYRRAVAYGMPGVSV
Rv0843|M.tuberculosis_H37Rv AADLAAVWQLPVVILVENIRGALSVHLDRYTHEPRVYRRAVAYGMPGVSV
MMAR_4784|M.marinum_M AANMAVLWHLPVVIVVESVPGVG--VAGRLRGAPGHGGDACQR-IPSVTV
MAV_0873|M.avium_104 AAKIAASWRLPVVFVVQNVRGGPDARRCAYRSET----------MPMALV
Mvan_0911|M.vanbaalenii_PYR-1 SLNLAALWKLPVVFIVEDNGWGVSVSKAQSTCIESNADRAVAYGMPGVLV
: :* : *: :. :* *
MSMEG_4712|M.smegmatis_MC2_155 DGNDVLACYAVMSEAAERARRGEGPTLIEAVTYRMGPHTTSDDPTRYRPA
MUL_3775|M.ulcerans_Agy99 DGNDVLACYAVTAVAAARARRGDGPTLIEAVTYRVGAHTTADDPGRYRSQ
MAB_4918c|M.abscessus_ATCC_199 DGNDVLAVTAATRMALRRAREGSGPTLIEAVTYRMGPHTTSDDPTKYRNA
TH_4167|M.thermoresistible__bu DGTDPRAVHDAVAEAVTRARSGGGPTFVEALAYRLQGHYFG-DTMAYADP
Mb0866|M.bovis_AF2122/97 DGNDVEAVRDCVANAVVRARAGGGPTLVQAITYRTTDFSGSDRGGYR---
Rv0843|M.tuberculosis_H37Rv DGNDVEAVRDCVANAVVRARAGGGPTLVQAITYRTTDFSGSDRGGYR---
MMAR_4784|M.marinum_M DGHDVQAVRRCVATAVQRARAGAGPTVVRAITYRSSDFPSFD-GDY----
MAV_0873|M.avium_104 DGRDVVAVGDSVGQAVRHASAGDGPSLVEAITYRTN--------------
Mvan_0911|M.vanbaalenii_PYR-1 KDNAVEAIYAVAGEAISRARAGGGPTLIEAETLRLWGHFEGDPQLYR---
.. * * :* * **:.:.* : *
MSMEG_4712|M.smegmatis_MC2_155 EEVEAWAARDPIARYRTYLQNIGVWTER----LEERVAARSSRLCAELRD
MUL_3775|M.ulcerans_Agy99 EEVDHWLALDPISRYRSYLQGQGLWSQR----LEVRVAARSGRLRAELRE
MAB_4918c|M.abscessus_ATCC_199 AELDEWRAKDPLARVEKYLESRGALSES----EKHRIAALADEVAAQLRA
TH_4167|M.thermoresistible__bu DELAAKRADPPFDRYRRRLIDEGIATAATLDQIDAELAAQVDAAFAAARD
Mb0866|M.bovis_AF2122/97 DLAGSEQFLDPLIFARRRLIAAGTTRGR-----LDEQERAACQQVADAVA
Rv0843|M.tuberculosis_H37Rv DLAGSEQFLDPLIFARRRLIAAGTTRGR-----LDEQERAACQQVADAVA
MMAR_4784|M.marinum_M DAAATEPFLDPLVFTGGRLKAGGADAAQ-----LCDVERTARKLVADAVA
MAV_0873|M.avium_104 ----HPVAIDPLVLARRRLMADGVDPDR-----LVEVERGARHLVAEAMA
Mvan_0911|M.vanbaalenii_PYR-1 ADLDGVAALDPVPAYEAQLRADSVLSDD----IVHEVTNWAVERVESAIA
*. * .
MSMEG_4712|M.smegmatis_MC2_155 AIVGAPDVDPAEMFD---------TVYADITPELARQRDQLLSELAKEA-
MUL_3775|M.ulcerans_Agy99 AVFGASDFDVDDVFT---------TVFAEITPGLQTQRQQLRAELDRID-
MAB_4918c|M.abscessus_ATCC_199 GCLGTVEPTAADMFN---------HVYAEPHPLVSAERRDYLEYLATFED
TH_4167|M.thermoresistible__bu AEPLGPEELTGDVFTGNGTELADGTVPRVALPEGETEELGLVQAIHRTLD
Mb0866|M.bovis_AF2122/97 FAKDRARPNGGGPIS---------------RPTSGWHQQPKTRF------
Rv0843|M.tuberculosis_H37Rv FAKARARPNGGGPIS---------------RPTSGWHQQPKTRF------
MMAR_4784|M.marinum_M LAKSGTCPGHDG------------------RS------------------
MAV_0873|M.avium_104 CAKALVRARRSDAVS---------------APDR-WSAAS----------
Mvan_0911|M.vanbaalenii_PYR-1 FAKSSPEPDPATALN--------------------YQFA-----------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 EGTYAS--------------------------------------------
TH_4167|M.thermoresistible__bu RAMAADDSIILLGEDIGDRSGGGMFKITAGLSAKYGEERVRDTPIAESSI
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4784|M.marinum_M --------------------------------------------------
MAV_0873|M.avium_104 --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4167|M.thermoresistible__bu IGAALGASLAGLRPVAELMFMDFLGVAMDQIANHVAKVRYMSGGRRGAPL
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4784|M.marinum_M --------------------------------------------------
MAV_0873|M.avium_104 --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4167|M.thermoresistible__bu VIRTMVGTAAGAQHSQALEAWAMHTPGLKVVWPSTAADAAGLLNACLRED
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4784|M.marinum_M --------------------------------------------------
MAV_0873|M.avium_104 --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4167|M.thermoresistible__bu DPCLFIESMKLYYGGGKGPVPVADYVIPLGQADVKRVGSDVTICTYGVLV
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4784|M.marinum_M --------------------------------------------------
MAV_0873|M.avium_104 --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4167|M.thermoresistible__bu HAALEAAKTLAGEGVSVEVVDLRTLVPLDLQTVLDSVRKTKRLVVAHESV
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4784|M.marinum_M --------------------------------------------------
MAV_0873|M.avium_104 --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MAB_4918c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4167|M.thermoresistible__bu GFCGPGAEIAAAVGTELFAELAAPIQRVAGTYTPVPRAATLEAACRPDAT
Mb0866|M.bovis_AF2122/97 --------------------------------------------------
Rv0843|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4784|M.marinum_M --------------------------------------------------
MAV_0873|M.avium_104 --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 ----------
MUL_3775|M.ulcerans_Agy99 ----------
MAB_4918c|M.abscessus_ATCC_199 ----------
TH_4167|M.thermoresistible__bu KLSDAVRRIM
Mb0866|M.bovis_AF2122/97 ----------
Rv0843|M.tuberculosis_H37Rv ----------
MMAR_4784|M.marinum_M ----------
MAV_0873|M.avium_104 ----------
Mvan_0911|M.vanbaalenii_PYR-1 ----------