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MTQSAKPSPDIHRRLYALMVLMKTADDRLSRGIGTGEFLCVYWPSRGQEAIAAAMGVSLRPDDQLVTTYR GLHDLIGKGVGLEEIYGEMMGRTIGAGRGKGGTMHIAKPEVGVMLSTGIVGAGPPVAVGLAMAARRKGLD RVTVVSFGDGATNTGSFHEAANMAALWDLPIVFVCQNNRYAEMTPTTDTMKLEHVADRAAGYGMPGVRVD GNDPLAVTAALEEALRRARAGSGPTFLECETFRFRGHYFGDRMPYIPADQLQAALAADPVPRFRRRLAET GVCGEAELARIDDDAAAAVEAALRTVLGADSPAADELDRDVYAAPIPFPT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2947 | - | - | 100% (330) | dehydrogenase E1 component superfamily protein |
| M. avium 104 | MAV_1675 | - | 9e-39 | 37.78% (315) | pyruvate dehydrogenase E1 component, alpha subunit |
| M. avium 104 | MAV_0873 | - | 5e-19 | 31.12% (286) | dehydrogenase E1 component superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2525c | pdhA | 2e-39 | 36.65% (322) | pyruvate dehydrogenase E1 component alpha subunit PdhA |
| M. gilvum PYR-GCK | Mflv_3692 | - | 1e-06 | 31.06% (132) | transketolase |
| M. tuberculosis H37Rv | Rv2497c | pdhA | 2e-39 | 36.65% (322) | pyruvate dehydrogenase E1 component alpha subunit PdhA |
| M. leprae Br4923 | MLBr_00583 | tkt | 3e-07 | 29.17% (144) | transketolase |
| M. abscessus ATCC 19977 | MAB_0897c | - | 9e-39 | 35.29% (323) | pyruvate dehydrogenase E1 component, alpha subunit |
| M. marinum M | MMAR_3489 | - | 2e-42 | 34.41% (279) | pyruvate dehydrogenase E1 component (alpha subunit) |
| M. smegmatis MC2 155 | MSMEG_4712 | - | 2e-40 | 35.62% (320) | pyruvate dehydrogenase E1 component, alpha subunit |
| M. thermoresistible (build 8) | TH_4167 | - | 4e-82 | 49.35% (308) | PUTATIVE acetoin:2,6-dichlorophenolindophenol oxidoreductase |
| M. ulcerans Agy99 | MUL_3775 | pdhA | 5e-36 | 34.49% (316) | pyruvate dehydrogenase E1 component (alpha subunit) PdhA |
| M. vanbaalenii PYR-1 | Mvan_0911 | - | 2e-49 | 36.22% (312) | pyruvate dehydrogenase (acetyl-transferring) |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2947|M.avium_104 ------------------------MTQSAKPSP-------------DIHR
TH_4167|M.thermoresistible__bu -----------------------MATQLDVEAPTS---------ANDRAI
Mb2525c|M.bovis_AF2122/97 --MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAER---RYHRDLPEETLR
Rv2497c|M.tuberculosis_H37Rv --MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAER---RYHRDLPEETLR
MUL_3775|M.ulcerans_Agy99 --------------MTVGLEPVQLVNADGEPTDEH---RYSRDLPEETLC
MSMEG_4712|M.smegmatis_MC2_155 --MAMQYSSAPGYDTGFDPEPVQLVAADGSPSPDRPPSRYSRDLPPETLS
MAB_0897c|M.abscessus_ATCC_199 MTVAEPADRPAYQAFLPADSAVQFLDPEGRPVDGG--ARYPR-PDADRLL
MMAR_3489|M.marinum_M ------------------------MDAKLARELLS---------DMVRVR
Mvan_0911|M.vanbaalenii_PYR-1 ------------------------MDDAVRLELYR---------TMRLIR
Mflv_3692|M.gilvum_PYR-GCK ---------------MTTIEEINSLTRPNHPDDWT-------DLDSRAVD
MLBr_00583|M.leprae_Br4923 ---------------MTTLDQISTLTQPRHPDDWT-------EIDSAAVD
MAV_2947|M.avium_104 RLYALMVLMKTADDRLSRGIGTGEFLCVYWPSRGQEAIAAAMGVSLRPDD
TH_4167|M.thermoresistible__bu ALYRLMSKVHHADARVRKGLSSGEIAMSYWPVTGQEAMSAGAALALSDGD
Mb2525c|M.bovis_AF2122/97 WLYEMMVVTRELDTEFVN-LQRQGELALYTPCRGQEAAQVGAAACLRKTD
Rv2497c|M.tuberculosis_H37Rv WLYEMMVVTRELDTEFVN-LQRQGELALYTPCRGQEAAQVGAAACLRKTD
MUL_3775|M.ulcerans_Agy99 WLYEMMVVTRELDAEFIN-LKRQGELALFASCRGQEAAQVGATACLRKTD
MSMEG_4712|M.smegmatis_MC2_155 WLYESMVVTRNLDVEFVN-LQRQGELALFASCRGQEAAQIGAAACLRKTD
MAB_0897c|M.abscessus_ATCC_199 AMYRNMVLGRRFDEQATA-LTKQGRLAVYPSSRGQEACQIAAAMCLHSDD
MMAR_3489|M.marinum_M RMEEKCAELYSAAK----------IRGFLHLYVGEEAVAAGSLRVLAEDD
Mvan_0911|M.vanbaalenii_PYR-1 TYEEAILREYHADKKPSFDIAKGQIPGEMHLCTGQEPVPAGFGPHLRRDD
Mflv_3692|M.gilvum_PYR-GCK TVRILAADAVQKVGNGHPGTAMSLAPLAYTLFQRQMRHDPSDVHWLGRDR
MLBr_00583|M.leprae_Br4923 TIRVLATDAVQKAGNGHPGTAMSLAPLAYTLFQRTLRHDPNDTAWLGRDR
*
MAV_2947|M.avium_104 QLVTT----YRGLHDLIGKGVGLEEIYGEMMGRTIGAGRGKGGTMHIAKP
TH_4167|M.thermoresistible__bu QLVST----YRGLGDVVAKGIDLAGYFGEILGRRTGLSRGKAGAMGISDP
Mb2525c|M.bovis_AF2122/97 WLFPQ----YRELGVYLVRGIPPGHVGVAWRGTWHGG---------LQFT
Rv2497c|M.tuberculosis_H37Rv WLFPQ----YRELGVYLVRGIPPGHVGVAWRGTWHGG---------LQFT
MUL_3775|M.ulcerans_Agy99 WLFPQ----YRELGAYLVRGIPPGHVGAAWRGTWHGG---------LEFT
MSMEG_4712|M.smegmatis_MC2_155 WLFPQ----YREIGAFLLRGITPAQMGAVWRGKWHGG---------LSFT
MAB_0897c|M.abscessus_ATCC_199 WLFPT----YRDSMALAARGIDTVDILRFLAGDWHCC---------FDPA
MMAR_3489|M.marinum_M AVVAT----YREHAHALLRGIPMTSIMAEMFGKQEGCSRGRGGSMHLFDQ
Mvan_0911|M.vanbaalenii_PYR-1 AVTGP----HRPHGWALAKGVDIERMTAEIFGRIDGLGKGRGGHMHLFDQ
Mflv_3692|M.gilvum_PYR-GCK FVLSCGHSSLTLYIQLYLGGFGLELSDIEALRTFKSKTPG----HPEFRH
MLBr_00583|M.leprae_Br4923 FVLSAGHSSLTLYIQLYLGGFGLELSDIESLRTWGSTTPG----HPEFRH
: *.
MAV_2947|M.avium_104 EVGVMLSTGIVGAGPPVAVGLAMAARRKG-------------LDRVTVVS
TH_4167|M.thermoresistible__bu DHGIAWTTGIVGAGPLFANGIALAASIRG-------------TGQVVLVS
Mb2525c|M.bovis_AF2122/97 TKCCAPMSVPIGTQTLHAVGAAMAAQRLD-------------EDSVTVAF
Rv2497c|M.tuberculosis_H37Rv TKCCAPMSVPIGTQTLHAVGAAMAAQRLD-------------EDSVTVAF
MUL_3775|M.ulcerans_Agy99 KKCCVPISVPIGTQALHAVGAAQAAQRLG-------------EDSVTVAF
MSMEG_4712|M.smegmatis_MC2_155 GKCVAPIAIPIGTHGLHAVGAAMAAQRLG-------------EDSVTVAF
MAB_0897c|M.abscessus_ATCC_199 QHRTAPQATPLATQLLHAAGLAHALARKG-------------SDTAVLAL
MMAR_3489|M.marinum_M ARRFYGGNAIVAGGLPLAVGISLADSMLK-------------RNRVTACY
Mvan_0911|M.vanbaalenii_PYR-1 DAHFS-CSGIIAEGLPTAVGMALAFKKQG-------------SDRVAIAV
Mflv_3692|M.gilvum_PYR-GCK TPGVEITTGPLGQGLASAVGMAMAARYERGLFDPDTAPGESPFDHHIFVI
MLBr_00583|M.leprae_Br4923 TKGVEITTGPLGQGLASAVGMAMASRYERGLFDPDAEPGASPFDHYIYVI
:. * * : * .
MAV_2947|M.avium_104 FGDGATNTGSFHEAANMAALWDLPIVFVCQNNRYAEMTPTTDTMKLEHVA
TH_4167|M.thermoresistible__bu FGDGATSIGYVHEAMNMAALWNLPVVFFCQNNAWAECTAMERYTRTARLS
Mb2525c|M.bovis_AF2122/97 LGDGATSEGDVHEALNFAAVFTTPCVFYVQNNQWAISMPVSRQTAAPSIA
Rv2497c|M.tuberculosis_H37Rv LGDGATSEGDVHEALNFAAVFTTPCVFYVQNNQWAISMPVSRQTAAPSIA
MUL_3775|M.ulcerans_Agy99 LGDGATSEGDVHEALNFAAVFDAGCVFYVQNNQWAISVPVSKQTAAPSIA
MSMEG_4712|M.smegmatis_MC2_155 LGDGATSEGDAHEAFNLATVFRAPCVFFIQNNQWAISVPVSRQQAGPTIA
MAB_0897c|M.abscessus_ATCC_199 CGDGATSEGDFHEALNFAAVFRAPVIFLVQNNGFAISVPLARQSVAPSLA
MMAR_3489|M.marinum_M FGDGAVAEGAFHESLNMAALWKLPVLFLCENNLYAMGTALHRAQSQTDLT
Mvan_0911|M.vanbaalenii_PYR-1 TGEGAANQGAFHESLNLAALWKLPVVFIVEDNGWGVSVSKAQSTCIESNA
Mflv_3692|M.gilvum_PYR-GCK ASDGDIEEGVTSEASSLAGTQQLGNLIVFYDKNHISIEHDTDIALSEDVA
MLBr_00583|M.leprae_Br4923 ASDGDIEEGVTSEASSLAAVQQLGNLIVFYDHNQISIEGDTKITLCEDTA
.:* * *: .:* :: :: :
MAV_2947|M.avium_104 DRAAGYGMPGVRVDGNDPLAVTAALEEALRRARAGSGPTFLECETFR---
TH_4167|M.thermoresistible__bu DRAQGYGMPGVTVDGTDPRAVHDAVAEAVTRARSGGGPTFVEALAYR---
Mb2525c|M.bovis_AF2122/97 HKAIGYGMPGIRVDGNDVLACYAVMAEAAARARAGDGPTLIEAVTYR---
Rv2497c|M.tuberculosis_H37Rv HKAIGYGMPGIRVDGNDVLACYAVMAEAAARARAGDGPTLIEAVTYR---
MUL_3775|M.ulcerans_Agy99 HKAIGYGMPGIRVDGNDVLACYAVTAVAAARARRGDGPTLIEAVTYR---
MSMEG_4712|M.smegmatis_MC2_155 HRAIGYGMPGIRVDGNDVLACYAVMSEAAERARRGEGPTLIEAVTYR---
MAB_0897c|M.abscessus_ATCC_199 HKGIGYGMGSEQVDGNDPVAMLAVLDAAREYVLAGNGPVIVEAHTYR---
MMAR_3489|M.marinum_M VKAASYNVATLAVDGMDVAACMSATQQGVDHIRSTGGPFFIEFRTYR---
Mvan_0911|M.vanbaalenii_PYR-1 DRAVAYGMPGVLVKDNAVEAIYAVAGEAISRARAGGGPTLIEAETLR---
Mflv_3692|M.gilvum_PYR-GCK ARYRAYGWHVQEVEGGE--NVVGIEEAVQAAKAVTDKPSLISVRTIIGYP
MLBr_00583|M.leprae_Br4923 ARYRAYGWHVQEVEGGE--NVVGIEEAIANAKAATDRPSFISLRTIIGYP
: .*. *.. * ::. :
MAV_2947|M.avium_104 -FRGHYFG-DRMPYIPADQLQAALAADPVPRFRRRLAETGVCGEAELARI
TH_4167|M.thermoresistible__bu -LQGHYFG-DTMAYADPDELAAKRADPPFDRYRRRLIDEGIATAATLDQI
Mb2525c|M.bovis_AF2122/97 -LGPHTTADDPTRYRSQEEVDRWATLDPIPRYRTYLQDQGLWSQRLEEQV
Rv2497c|M.tuberculosis_H37Rv -LGPHTTADDPTRYRSQEEVDRWATLDPIPRYRTYLQDQGLWSQRLEEQV
MUL_3775|M.ulcerans_Agy99 -VGAHTTADDPGRYRSQEEVDHWLALDPISRYRSYLQGQGLWSQRLEVRV
MSMEG_4712|M.smegmatis_MC2_155 -MGPHTTSDDPTRYRPAEEVEAWAARDPIARYRTYLQNIGVWTERLEERV
MAB_0897c|M.abscessus_ATCC_199 -MSGHTNADDPLRYRTDDELDEWLARDPIQRLEIHLRAEGLLDDTYVAAV
MMAR_3489|M.marinum_M -FRAHSMF-DPELYRDKAEVQRWRERDPIRLFTEQCLNSGTLTDDDVRDI
Mvan_0911|M.vanbaalenii_PYR-1 -LWGHFEG-DPQLYR--ADLDGVAALDPVPAYEAQLRADSVLSDDIVHEV
Mflv_3692|M.gilvum_PYR-GCK APNKMNTGGVHGSALGDDEVAEVKKILGFDPDKTFEVSEDVITHTRGLVA
MLBr_00583|M.leprae_Br4923 APTLINTGKAHGAALGEDEVAATKRILGFDPDKTFAVREDVITHTRGLIA
:: . .
MAV_2947|M.avium_104 DDDAAAAVEAALRTVLGADSPAADELDRDVYAAP-----------IPFPT
TH_4167|M.thermoresistible__bu DAELAAQVDAAFAAARDAEPLGPEELTGDVFTGNGTELADGTVPRVALPE
Mb2525c|M.bovis_AF2122/97 TARAKHVRSELRDAVFDAPDFDVDEVFTTVYAEITPGLQAQREQLRAELA
Rv2497c|M.tuberculosis_H37Rv TARAKHVRSELRDAVFDAPDFDVDEVFTTVYAEITPGLQAQREQLRAELA
MUL_3775|M.ulcerans_Agy99 AARSGRLRAELREAVFGASDFDVDDVFTTVFAEITPGLQTQRQQLRAELD
MSMEG_4712|M.smegmatis_MC2_155 AARSSRLCAELRDAIVGAPDVDPAEMFDTVYADITPELARQRDQLLSELA
MAB_0897c|M.abscessus_ATCC_199 ASDAEDLAATTRAGMNRDRPVDVDDLFRYVYAQPTSQLREQHAQARADFT
MMAR_3489|M.marinum_M EGSAADEIAAAVAFADAGTWEDASDLERDVLTPPDSCDATAESTWEPAR-
Mvan_0911|M.vanbaalenii_PYR-1 TNWAVERVESAIAFAKSSPEPDPATALNYQFA------------------
Mflv_3692|M.gilvum_PYR-GCK RGKEAHEAWQQEFDAWAQREPERKKLLDRLTAEELPDGWDADITYWEPGS
MLBr_00583|M.leprae_Br4923 RGKEAHERWQLEFEAWAQREPERKALLDRLLAQQLPDGWDADLPNWEPRS
:
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu GETEELGLVQAIHRTLDRAMAADDSIILLGEDIGDRSGGGMFKITAGLSA
Mb2525c|M.bovis_AF2122/97 RTD-----------------------------------------------
Rv2497c|M.tuberculosis_H37Rv RTD-----------------------------------------------
MUL_3775|M.ulcerans_Agy99 RID-----------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 KEA-----------------------------------------------
MAB_0897c|M.abscessus_ATCC_199 AQLSEDRP------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3692|M.gilvum_PYR-GCK KAVATRAAFGQVLNDVAPKLPELWGGSADLAGSNNTTIKGVKSFGPPSIS
MLBr_00583|M.leprae_Br4923 KELATRAASGAVLSAIGPKLPELWGGSADLAGSNNTTIKDVDSFGPPSIS
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu KYGEERVRDTPIAESSIIGAALGASLAGLRPVAELMFMDFLGVAMDQIAN
Mb2525c|M.bovis_AF2122/97 --------------------------------------------------
Rv2497c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0897c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3692|M.gilvum_PYR-GCK TDDFSADWYGRVLHFGIREHAMGSILSGIVLHGPTRAFGGTFLQFSDYMR
MLBr_00583|M.leprae_Br4923 TDEYTAHWYGRTLHFGVREHAMGAILSGIVLHGPTRAYGGTFLQFSDYMR
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu HVAKVRYMSGGRRGAPLVIRTMVGTAAGAQHSQALEAWAMHTPGLKVVWP
Mb2525c|M.bovis_AF2122/97 --------------------------------------------------
Rv2497c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0897c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3692|M.gilvum_PYR-GCK PAVRLASLMDIDTIYIWTHDSIGLGEDGPTHQPIEHLAALRAIPNLSVVR
MLBr_00583|M.leprae_Br4923 PSVRLASLMDIDTIYVWTHDSVGLGEDGPTHQPIEHLAALRAIPRLSVVR
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu STAADAAGLLNACLREDDPCLFIESMKLYYGGGKGPVPVADYVIPLGQAD
Mb2525c|M.bovis_AF2122/97 --------------------------------------------------
Rv2497c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0897c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3692|M.gilvum_PYR-GCK PGDPNETAYAWKSIIARGNGSGPVGFILTRQGIPVLEGTDAEGVSRGGYV
MLBr_00583|M.leprae_Br4923 PADANETAYAWRTILARGANSGPVGLILTRQSVPVLEGTNTEGVARGGYV
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu VKRVGSDVTICTYGVLVHAALEAAKTLAGEGVSVEVVDLRTLVPLDLQTV
Mb2525c|M.bovis_AF2122/97 --------------------------------------------------
Rv2497c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0897c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3692|M.gilvum_PYR-GCK LG--GGNPADDADVILIATGSELQLAVEAKKLLADKDINAAVVSMPCVEW
MLBr_00583|M.leprae_Br4923 LGDGGSSEAKEPDVILIATGSEVQLAVAAQKLLADKDIIVRVVSMPCVEW
MAV_2947|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu LDSVRKTKRLVVAHESVGFCGPGAEIAAAVGTELFAELAAPIQRVAGTYT
Mb2525c|M.bovis_AF2122/97 --------------------------------------------------
Rv2497c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3775|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4712|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0897c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3489|M.marinum_M --------------------------------------------------
Mvan_0911|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3692|M.gilvum_PYR-GCK FESQPKEYRDSVLPPGVSARVAIEAGVAQSWYKLVGDTGEIISIEHYGES
MLBr_00583|M.leprae_Br4923 FESQPYEYRDSVLPPSVSARVAVEAGVAQCWHKLVGDTGKIVSIEHYGES
MAV_2947|M.avium_104 ---------------------------
TH_4167|M.thermoresistible__bu PVPRAATLEAACRPDATKLSDAVRRIM
Mb2525c|M.bovis_AF2122/97 ---------------------------
Rv2497c|M.tuberculosis_H37Rv ---------------------------
MUL_3775|M.ulcerans_Agy99 ---------------------------
MSMEG_4712|M.smegmatis_MC2_155 ---------------------------
MAB_0897c|M.abscessus_ATCC_199 ---------------------------
MMAR_3489|M.marinum_M ---------------------------
Mvan_0911|M.vanbaalenii_PYR-1 ---------------------------
Mflv_3692|M.gilvum_PYR-GCK ADDKTLFREFGFTPEAVVAAAERTIEN
MLBr_00583|M.leprae_Br4923 ADYQTLFREYGFTPEAVVAAAEQVLDN