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NTTPPPLSRTAAAMTVVAMGLGYTAAIVDPTILSAEMSTVRIGLGMSTSAASFTASLATLTMAAAVLGAG ALGDVYGMRRMYVAGLLGTIAFGVLGAAAPTAAVLMVARAGLGVALAFLMGLSLAIVNAVSAPERRTTVI AWYFGVGFAVAAPLPAIGGPLATQMGWRAALLVTPALAAVALALTLRYVPHIPRTHRALDLPGLALAAVA LLALVFGIARLETAGDVVAVTALGTAVLAAGGFVAWELRTAQPALDLSVFRSGRFNAAVTAGVVFNFLTG GLVLLFAFYLVTVRGESPEVLGLLLIPATVLAAVAATTAGPAAVRLGDRPVLVGGLAVMLAAVLLLRLFD ENTSLTVVFTAVALMVVGGALVATPQASIMMAAAPAHLGGAVSGVKSAVNQTGYSLGPTVFALVGINLIL AEGTEKLAGSGITLEEAREAFRATHGGSAGGSHLLDPDRAQIVATAATESMLDAIHTISLLMAAIPVVAI VVALIWLKPAPRHQV*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_1083 | - | - | 100% (506) | major facilitator superfamily transporter |
M. vanbaalenii PYR-1 | Mvan_0523 | - | 5e-36 | 28.61% (409) | EmrB/QacA family drug resistance transporter |
M. vanbaalenii PYR-1 | Mvan_4474 | - | 9e-36 | 28.36% (402) | EmrB/QacA family drug resistance transporter |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2361c | - | 6e-47 | 29.25% (506) | integral membrane transport protein |
M. gilvum PYR-GCK | Mflv_0301 | - | 5e-48 | 31.86% (408) | EmrB/QacA family drug resistance transporter |
M. tuberculosis H37Rv | Rv2333c | - | 9e-46 | 29.05% (506) | integral membrane transport protein |
M. leprae Br4923 | MLBr_01562 | - | 7e-23 | 25.63% (437) | putative transmembrane efflux protein |
M. abscessus ATCC 19977 | MAB_0945 | - | 5e-37 | 29.01% (393) | EmrB/QacA family drug resistance transporter |
M. marinum M | MMAR_1146 | - | 9e-44 | 30.12% (508) | integral membrane transport protein |
M. avium 104 | MAV_1387 | - | 1e-33 | 28.03% (421) | drug transporter |
M. smegmatis MC2 155 | MSMEG_5670 | - | 2e-39 | 27.98% (436) | efflux membrane protein |
M. thermoresistible (build 8) | TH_3965 | - | 2e-35 | 29.15% (398) | PUTATIVE drug transporter |
M. ulcerans Agy99 | MUL_0911 | - | 1e-43 | 29.92% (508) | integral membrane transport protein |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0301|M.gilvum_PYR-GCK --------------------------------------------MTGLRM Mb2361c|M.bovis_AF2122/97 -------------------------------------------------- Rv2333c|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1387|M.avium_104 -------------------------------------------------- TH_3965|M.thermoresistible__bu ----------------------------VTSVDAGRSTMSEVFTAYAPRS MAB_0945|M.abscessus_ATCC_1997 ------------------------------------------MEAAVGAL MSMEG_5670|M.smegmatis_MC2_155 ------------------------------------------MNETVGAL MMAR_1146|M.marinum_M --------------------------------------------MRIQPV MUL_0911|M.ulcerans_Agy99 --------------------------------------------MRIQPV Mvan_1083|M.vanbaalenii_PYR-1 ------------------------------------------MNTTPPPL MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF Mflv_0301|M.gilvum_PYR-GCK GTAAGRWVLLATVLGSGIVMVDATVVNVALPHIAADLGGGFGDLQWVVNA Mb2361c|M.bovis_AF2122/97 MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS Rv2333c|M.tuberculosis_H37Rv MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS MAV_1387|M.avium_104 -----------MMIGFFMIMVDSTIVAIANPTIMADLHIGYDTVVWVTSA TH_3965|M.thermoresistible__bu AAANPWHALWAMLIGFFMILVDATIVPVANLEIMADLGADYTAVIWVTSA MAB_0945|M.abscessus_ATCC_1997 SERRKIVILGSCCLSLLIVSMDSTIVNVALPTIRADFGATTSQLQWVIDI MSMEG_5670|M.smegmatis_MC2_155 SARRKAIILVSCCLSLLIVSMDATIVNVAIPSIRSDLGASPSQLQWVIDV MMAR_1146|M.marinum_M FRDHPIPALAVICLSVFVISVDATIVNVALPTLSRQLGADTAQLQWIVDA MUL_0911|M.ulcerans_Agy99 FRDHPILALAVICLSVFVISVDATIVNVALPTLSRELGADTAQLQWIVDA Mvan_1083|M.vanbaalenii_PYR-1 SRTAAAMTVVAMGLGYTAAIVDPTILSAEMSTVRIGLGMSTSAASFTASL MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA :*. : : : : Mflv_0301|M.gilvum_PYR-GCK YTLTLASLILLGGSLGDHFGRRKVFVLGVVWFALASIACGLAPSIEVLIV Mb2361c|M.bovis_AF2122/97 YSLGMAVFIMSAATLADLYGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT Rv2333c|M.tuberculosis_H37Rv YSLGMAVFIMSAATLADLDGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT MAV_1387|M.avium_104 YLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVASVWCGLAGSAAMLIA TH_3965|M.thermoresistible__bu YLLAYAVPLLIAGRLGDRFGPRTMYLIGLAIFTAASLWCGLAGTIGMLIA MAB_0945|M.abscessus_ATCC_1997 YTLGLASLLMLSGAAGDRLGRRKVFHLGLSIFAIGSLLCSVAPTVGLLIA MSMEG_5670|M.smegmatis_MC2_155 YTLVLASLLLLAGATGDRFGRRRTFHLGLTVFAVASLLCSVAPNIETLIA MMAR_1146|M.marinum_M YTLVMSGLLLSAGSLSDRYGRRGWLSAGLILFALTSALAAQVNSADTLIA MUL_0911|M.ulcerans_Agy99 YTLVMSGLLLSAGSLSDRYGRRGWLSAGLILFALTSALAAQVNSADTLVA Mvan_1083|M.vanbaalenii_PYR-1 ATLTMAAAVLGAGALGDVYGMRRMYVAGLLGTIAFGVLGAAAPTAAVLMV MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI * . :: .. .* * : *: . . . * Mflv_0301|M.gilvum_PYR-GCK ARALQGVGGALLTPGSLALISAAFASG-DRGAAVGAWSGLGGIAGAIGPF Mb2361c|M.bovis_AF2122/97 ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT Rv2333c|M.tuberculosis_H37Rv ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT MAV_1387|M.avium_104 ARVVQGVGAGVMTPQTLSTITRIFPAE-RRGVAVSVWSATAGAASLAGPL TH_3965|M.thermoresistible__bu ARVLQGLGAALLTPQTLSMITRIFPAD-RRGVPMGVWGATAGVATLIGPL MAB_0945|M.abscessus_ATCC_1997 ARLLQAVGGSMLNPVALSIISQVFTGRVERARALGFWGAVVGISMALGPI MSMEG_5670|M.smegmatis_MC2_155 ARLLQAIGGSMLNPVAMSIITQVFTGRVERARAIGVWGSVVGISMALGPL MMAR_1146|M.marinum_M ARAAMGVGAAVIFPTTLGLITNIFTDPVPRAKAIGLWTAMVGVGVAVGPI MUL_0911|M.ulcerans_Agy99 ARAAMGVGAAVIFPTTLGLITNIFTDPVPRAKAIGLWTAMVGVGVAVGPI Mvan_1083|M.vanbaalenii_PYR-1 ARAGLGVALAFLMGLSLAIVNAVSAPE-RRTTVIAWYFGVGFAVAAPLPA MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV ** .:. . :. : . : . : . Mflv_0301|M.gilvum_PYR-GCK LGGALV-EWNWRAAFLINVPLAAFVIAVTLLRVPESRDPSASRRLDVGGA Mb2361c|M.bovis_AF2122/97 LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCN-ERARRFDLSGQ Rv2333c|M.tuberculosis_H37Rv LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCN-ERARRFDLSGQ MAV_1387|M.avium_104 AGGVLVDGLGWQWIFFVNVPIGVLGLVLAYWLVPVLPT--QSHRFDLVGV TH_3965|M.thermoresistible__bu AGGVLVDGLGWQWIFIVNVPIGIAGLVLGARLMPRLPR--QDQGFDVLGM MAB_0945|M.abscessus_ATCC_1997 VGGLLIQWVGWRAVFWINLPVCVLAFVLTAVFVPETKS-ATMRDIDPVGQ MSMEG_5670|M.smegmatis_MC2_155 VGGALIEYVDWRAVFWINLPICALAILLTAIFVRESKS-STMRDVDPVGQ MMAR_1146|M.marinum_M TGGWLLEHFSWGSIFLVNVPIAVAAMAGAILFVPTSRD-PAAPRVDVPGL MUL_0911|M.ulcerans_Agy99 TGGWLLEHFSWGSIFLVNVPIAVAAMAGAILFVPTSRD-PAAPRVDVPGL Mvan_1083|M.vanbaalenii_PYR-1 IGGPLATQMGWRAALLVTPALAAVALALTLRYVPHIPR--THRALDLPGL MLBr_01562|M.leprae_Br4923 VGGALT-EVSWRLAFLVNVPIGLVMIYLARTALHETHK--ERMKLDAAGA ** * .* : :. .: : : .* * Mflv_0301|M.gilvum_PYR-GCK VLTVVGLGALTFGLTELGNRG-ASPAAVVSVGGGLVALVVFVLVEQRSSH Mb2361c|M.bovis_AF2122/97 LLFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSN Rv2333c|M.tuberculosis_H37Rv LLFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSN MAV_1387|M.avium_104 GLSGVGMLLIVFGLQQGQAAHWQPWIWALIVAGVGFVTVFVFWQSVNVRE TH_3965|M.thermoresistible__bu VLSAVGLFLIVFALQEAQTHRWAPWIWGTLAGGAGVMAMFVIWQSANRRH MAB_0945|M.abscessus_ATCC_1997 ALAVLFLFGIVFALIEGPSLGWATPGLIVVLAVALAAFAVFLRYESRRRH MSMEG_5670|M.smegmatis_MC2_155 GLGVAFLFGVVFVLIEGPGMGWTDPRTLAVAATALVAFLAFLRYESRRHD MMAR_1146|M.marinum_M MLSAVGITALVYTIIEAPNWGWTSTRASGGFIAAAIVLVGFALWERRSSH MUL_0911|M.ulcerans_Agy99 MLSAVGITALVYTIIEAPNWGWTSTRASGGFIAAAIVLVGFALWERRSSH Mvan_1083|M.vanbaalenii_PYR-1 ALAAVALLALVFGIARLETAG--DVVAVTALGTAVLAAGGFVAWELRTAQ MLBr_01562|M.leprae_Br4923 ILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAEN * .: . . . . Mflv_0301|M.gilvum_PYR-GCK PLMSPKLFADRNFGVANAVTLLIYGALGAVFLLLVLQLQTVSGFSPVAAG Mb2361c|M.bovis_AF2122/97 PMMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTG Rv2333c|M.tuberculosis_H37Rv PMMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTG MAV_1387|M.avium_104 PLIPLVIFSDRDFSLCNIGVAIISFAATAMMLPLTFYAQAVCGLSPTRSA TH_3965|M.thermoresistible__bu PLVPLQIFADRNFMLANVGVATIGFVVTAMVLPAMFFAQAVCGLSPTGSA MAB_0945|M.abscessus_ATCC_1997 PFIDLRFFRSIPFASATLTAICACMAWSAFLFTMSLYLQGQRHFSAMHTG MSMEG_5670|M.smegmatis_MC2_155 PFIDLRFFRSVPFASATLVAVCAFAAYGAFLFMMSLYLQSERGYSAMFTG MMAR_1146|M.marinum_M PMLDVSVFANRRFSGGSLAVTAGFLTLFGFIFVITQYFQFIKDYTALQTG MUL_0911|M.ulcerans_Agy99 PMLDVSVFANRRFSGGSLAVTAGFLTLFGFIFVITQYFQFIKDYTALQTG Mvan_1083|M.vanbaalenii_PYR-1 PALDLSVFRSGRFNAAVTAGVVFNFLTGGLVLLFAFYLVTVRGESPEVLG MLBr_01562|M.leprae_Br4923 PVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRAG * : .* . .. . :. . Mflv_0301|M.gilvum_PYR-GCK TALLPFTIVMLLFSSRAGALSGRIGPRLPMTVGPVLAGLGLLLMLRIGED Mb2361c|M.bovis_AF2122/97 LMILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSEHR Rv2333c|M.tuberculosis_H37Rv LMILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSEHR MAV_1387|M.avium_104 LLIAPMAIANGVFAPFVGKIVDRYHPRPVLGFGFSLLAIALTWLTFEMSP TH_3965|M.thermoresistible__bu LLIAPMAVASGVLAPMAGRIVDRSHPTPVVGFGFSVVAVGLTWLAVEMAP MAB_0945|M.abscessus_ATCC_1997 LIYLPIAVGALVFSPISGRMVGRFGARPSLLA-AGTLFLTASLLLTRVSE MSMEG_5670|M.smegmatis_MC2_155 LIYLPIAIGALIFSPLSGRMVGRFGSRPSLVS-AGVLITAATVMLAQMTA MMAR_1146|M.marinum_M VRLLPVALSIALAAILGPRLVERVGTTAVVAAGLAVFAAALAWAS-TADA MUL_0911|M.ulcerans_Agy99 VRLLPVAFSIALAAILGPRLVERVGTTAVVAAGLAVFAAALAWAS-TADA Mvan_1083|M.vanbaalenii_PYR-1 LLLIPATVLAAVAATTAGPAAVRLGDRPVLVGGLAVMLAAVLLLR-LFDE MLBr_01562|M.leprae_Br4923 IGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMNR * : * Mflv_0301|M.gilvum_PYR-GCK ASWVFDVAPAALVFG-AGMVLVVAPLTATVLDAAPEHMAGSASGVNNAVA Mb2361c|M.bovis_AF2122/97 SSALVLVG--LGLCG-SGVALCLTPITTVAMTAVPAERAGMASGIMSAQR Rv2333c|M.tuberculosis_H37Rv SSALVLVG--LGLCG-SGVALCLTPITTVAMTAVPAERAGMASGIMSAQR MAV_1387|M.avium_104 ATPIWRLVLPFFAMG-VGMAFVWSPLTATATRNLSAQLAGAGSAVYNSVR TH_3965|M.thermoresistible__bu TTPIWRLVLPFVAVG-VGMAFIWSPLATTATRQLPLHLSGAGSGVYNTTR MAB_0945|M.abscessus_ATCC_1997 ATPIWELLVTFAIFG-AGFAMVNAPITNAAVSGMPLDRAGAASAVTSTSR MSMEG_5670|M.smegmatis_MC2_155 TTPVWLLLVIFAVFG-IGFALVNAPITTAAVSGMPLDRAGAASAVASTSR MMAR_1146|M.marinum_M TTPYTQIALQMLLLG-GGLGLTTAPATEAIMGSLPADRAGVGSAVNDTTR MUL_0911|M.ulcerans_Agy99 TTPYTQITLQMLLLG-GGLGLTTAPATEAIMGSLPADRAGVGSAVNDTTR Mvan_1083|M.vanbaalenii_PYR-1 NTSLTVVFTAVALMV-VGGALVATPQASIMMAAAPAHLGGAVSGVKSAVN MLBr_01562|M.leprae_Br4923 GVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALMLQ * : * : . * *.: Mflv_0301|M.gilvum_PYR-GCK RAGGLLAVAVLPGVAGISGNDYADPAAFSAG--FHTAVVISAVLMVAAAV Mb2361c|M.bovis_AF2122/97 AIGSTIGFAVLGSVLAAWLSATLEPHLERAVPDPVQRHVLAEIIIDSANP Rv2333c|M.tuberculosis_H37Rv AIGSTIGFAVLGSVLAAWLSATLEPHLERAVPDPVQRHVLAEIIIDSANP MAV_1387|M.avium_104 QLGAVLGSAGMAAFMTWRIG-AEMPGQPGGGGEDSAGPVLPEFLRGPFAA TH_3965|M.thermoresistible__bu QIGSVLGSAGMAAFLTGRLS-AELPFGATAVPAGEQTRVLPEFLHAPYAA MAB_0945|M.abscessus_ATCC_1997 QVGVSIGVALCGSIG--------------TPALWFMCAGLGLLIATLGIV MSMEG_5670|M.smegmatis_MC2_155 QVGVSIGVALCGSVAGTALAGTGVDFAAASRPLWLICTALGVVIVAIGIV MMAR_1146|M.marinum_M ELGGTLGVAIAGSVFASVYSGQLGSASTLATLPSDVRSAMKGSMAVAHKV MUL_0911|M.ulcerans_Agy99 ELGGTLGVAIAGSVFASVYSGQLGSASALATLPSDVRSAMKGSMAVAHKV Mvan_1083|M.vanbaalenii_PYR-1 QTGYSLGPTVFALVGINLILAEGTEKLAGSGITLEEAREAFRATHGGSAG MLBr_01562|M.leprae_Br4923 SLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDHGYTYGLLW * : : . Mflv_0301|M.gilvum_PYR-GCK LAAIGIRR--APARSDERMAVENCTHCAITGLPAH--------------- Mb2361c|M.bovis_AF2122/97 RAHVGGIV--PRRHIEHRDPVAIAEEDFIEGIRVA--------------- Rv2333c|M.tuberculosis_H37Rv RAHVGGIV--PRRHIEHRDPVAIAEEDFIEGIRVA--------------- MAV_1387|M.avium_104 AMSQSVLL--PAFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYGGDY TH_3965|M.thermoresistible__bu AMAQSMLL--PAFVALFGVLAAIFLAGIVLSTPQP---------DADAQY MAB_0945|M.abscessus_ATCC_1997 STSPAAVR--SAQRLAPLI-EGTTAREMSRVG------------------ MSMEG_5670|M.smegmatis_MC2_155 STSPWALR--SAERLAPLIGQHHRPAEVAHAR------------------ MMAR_1146|M.marinum_M IDQLPAGP--AAGVRDAVNHAFLDGLQVATLVCAG--------------- MUL_0911|M.ulcerans_Agy99 IDQLPAGP--AAGVRDAVNHAFLDGLQVATLVCAG--------------- Mvan_1083|M.vanbaalenii_PYR-1 GSHLLDPD--RAQIVATAATESMLDAIHTISLLMAAIP------------ MLBr_01562|M.leprae_Br4923 VAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL------------- Mflv_0301|M.gilvum_PYR-GCK -PAAETR------------------------------------------- Mb2361c|M.bovis_AF2122/97 -LLVATATLAVVFLAGWRWFPRDVQTAGSDAKR--EAAYSDDRRVRG--- Rv2333c|M.tuberculosis_H37Rv -LLVATATLAVVFLAGWRWFPRDVHTAGSDLSERLPTAMTVECAVSHMPG MAV_1387|M.avium_104 HDDYDDDDAYVELILVREPEPEAQQRAGQPRRPQPTPAPPADVRRRDPVE TH_3965|M.thermoresistible__bu LDEHDD---YLVIELAR-----------------PDPNPRTDIAVTAVIP MAB_0945|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_1146|M.marinum_M -IALAAAIVVGWLLPARAGQPTPAQTEPALAQA----------------- MUL_0911|M.ulcerans_Agy99 -IALAAAIVVGWLLPARAGQPTPAQTEPALAQV----------------- Mvan_1083|M.vanbaalenii_PYR-1 --VVAIVVALIWLKPAPRHQV----------------------------- MLBr_01562|M.leprae_Br4923 -------------------------------------------------- Mflv_0301|M.gilvum_PYR-GCK -------------------------------------------------- Mb2361c|M.bovis_AF2122/97 -------------------------------------------------- Rv2333c|M.tuberculosis_H37Rv ATWCRLWPA----------------------------------------- MAV_1387|M.avium_104 SRRSVLDERPAQVQPIGFAHNGSHVDGGKRLRQVAVRRAPKPGPPADRFT TH_3965|M.thermoresistible__bu ALRPTLRP--------------------------TLR--PSLGPPGGPVV MAB_0945|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_1146|M.marinum_M -------------------------------------------------- MUL_0911|M.ulcerans_Agy99 -------------------------------------------------- Mvan_1083|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_01562|M.leprae_Br4923 -------------------------------------------------- Mflv_0301|M.gilvum_PYR-GCK -------------------------------------------- Mb2361c|M.bovis_AF2122/97 -------------------------------------------- Rv2333c|M.tuberculosis_H37Rv -------------------------------------------- MAV_1387|M.avium_104 RPPRRHHPGPAGHHLGEGESLRGQHHRPDPDDDPTGYGRHSSGN TH_3965|M.thermoresistible__bu QP-------------NNTAALR---------------------- MAB_0945|M.abscessus_ATCC_1997 -------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------- MMAR_1146|M.marinum_M -------------------------------------------- MUL_0911|M.ulcerans_Agy99 -------------------------------------------- Mvan_1083|M.vanbaalenii_PYR-1 -------------------------------------------- MLBr_01562|M.leprae_Br4923 --------------------------------------------