For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TVITPLTSTTSEQLTVSGAATATGAAQMRHRFGDWLRERGIPDVERNDILMAVNEALANCVDHAYAGRPS PGPMTVRADFEPVNSCLSVCVTDHGRWRPPGLYRRPDRRGRGVALMHALTDHCTISGRRDGTTVCLDYRC ETRPADN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1037 | - | - | 100% (148) | putative anti-sigma regulatory factor, serine/threonine protein kinase |
| M. vanbaalenii PYR-1 | Mvan_3002 | - | 7e-21 | 41.18% (119) | putative anti-sigma regulatory factor, serine/threonine protein |
| M. vanbaalenii PYR-1 | Mvan_1931 | - | 1e-13 | 36.51% (126) | multi-sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1399c | - | 1e-09 | 30.61% (147) | hypothetical protein Mb1399c |
| M. gilvum PYR-GCK | Mflv_5233 | - | 2e-55 | 69.78% (139) | putative anti-sigma regulatory factor, serine/threonine protein |
| M. tuberculosis H37Rv | Rv1364c | - | 9e-10 | 30.61% (147) | hypothetical protein Rv1364c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_5186 | - | 3e-14 | 31.75% (126) | sensor-component of a two-component regulator |
| M. avium 104 | MAV_0124 | - | 2e-26 | 42.54% (134) | hypothetical protein MAV_0124 |
| M. smegmatis MC2 155 | MSMEG_6129 | - | 2e-20 | 43.97% (116) | hypothetical protein MSMEG_6129 |
| M. thermoresistible (build 8) | TH_4491 | - | 6e-19 | 37.41% (147) | PUTATIVE putative putative anti-sigma regulatory factor, |
| M. ulcerans Agy99 | MUL_3853 | rsbU | 2e-11 | 31.97% (147) | regulator of sigma subunit, anti-anti-sigma factor RsbU |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5186|M.marinum_M MTETGDFGAVDAFQTQYADALRAYLDTRDENSLAVGHEFGRRALQEQISI
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5186|M.marinum_M LDIIENHFRLLDEISPNPGSDRSVALEFLLQTLAALDVATRGFLDGTKRY
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5186|M.marinum_M EEQRARAEDLAHRDKFRSALVNSLQEGFFVADDEGAVIDMNSAFAEILGY
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5186|M.marinum_M PPEGLPYRWPHPWLVDRKSAAQQQERVRHEGSADYETPVRHQDGHLSWVA
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------MAAEMDWDKTVGAAEDVRRIFEHI
Rv1364c|M.tuberculosis_H37Rv --------------------------MAAEMDWDKTVGAAEDVRRIFEHI
MUL_3853|M.ulcerans_Agy99 --MLLLDLLRQRTYSFVRSVHRRDGYMAAEMDWDKNVGTANTVRRIFENV
MMAR_5186|M.marinum_M VSINAVRGSGSDRDVYVGTVRDITAERAFAARESAVLRLATSVSVAKSVS
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 PAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAREVYPELEGQQIYEM
Rv1364c|M.tuberculosis_H37Rv PAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAREVYPELEGQQIYEM
MUL_3853|M.ulcerans_Agy99 PTMLVGLEGPEHRFVAANAAYRRFSPTFTAVGQPAREVYPELESQQIYHM
MMAR_5186|M.marinum_M EVLSITLEECRTAVDVQRVVAVMWPPSDGEPTVQVAGEPAESSWRALDPQ
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 LDRVYQTGEPQSGSEWRLQTDYDGSGVEERYFDFVVTPRRRADGSIEGVQ
Rv1364c|M.tuberculosis_H37Rv LDRVYQTGEPQSGSEWRLQTDYDGSGVEERYFDFVVTPRRRADGSIEGVQ
MUL_3853|M.ulcerans_Agy99 LDRVYETGEPQSGAEWRLQADFDGSGIDERYFDFLVTPRRREDGSIEGVQ
MMAR_5186|M.marinum_M LRETFLGARAQLPLTARPIEWPDSPGRAQGLVAVLSGTADVALWLELGAP
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 LIVDDVTSRVRARQAAEARVEELSERYRNVRDSATVMQQALLAASVPVVP
Rv1364c|M.tuberculosis_H37Rv LIVDDVTSRVRARQAAEARVEELSERYRNVRDSATVMQQALLAASVPVVP
MUL_3853|M.ulcerans_Agy99 ILFDDVTTRVRARLAAEARVEELSERYRHLRDSAIVMQQALLAPSVPVVS
MMAR_5186|M.marinum_M RWVTAEDRLLVTVLVGHLSLAIG--HVRQFESARETSLTLQRAMLPPVKP
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 GADIAAEYLVAAEDTAAGGDWFDALALGDR-LVLVVGDVVGHGVEAAAVM
Rv1364c|M.tuberculosis_H37Rv GADIAAEYLVAAEDTAAGGDWFDALALGDR-LVLVVGDVVGHGVEAAAVM
MUL_3853|M.ulcerans_Agy99 GPDIAAQYLVAAQDTAAGGDWFDAVALGDR-LVLIVGDVVGHGVEAAAVM
MMAR_5186|M.marinum_M PPGFAVRYEPAVPPLEIGGDWYDVLPIGEHRIGIVVGDCVGRGLPAAAIM
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 SQLRTALRMQISTGYTVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGE
Rv1364c|M.tuberculosis_H37Rv SQLRTALRMQISAGYTVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGE
MUL_3853|M.ulcerans_Agy99 SQLRTALRLQIAAGRSIGEALEALDAFHEHVPGSNSATLCVGSLDFTTGE
MMAR_5186|M.marinum_M GQLRSSARALLLTGAQPALLLEQLDAAASLIPDAYCTTVFLAILDTESGI
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 FQYCTAGHPPPLLVTADASARYVEPTGAGPLGSGTG--FPVRSEVLNIGD
Rv1364c|M.tuberculosis_H37Rv FQYCTAGHPPPLLVTADASARYVEPTGAGPLGSGTG--FPVRSEVLNIGD
MUL_3853|M.ulcerans_Agy99 FQYCTAGHPPPLVVTAEAKARYLEPSGAGPLGSDTG--FPVRTELIGVGD
MMAR_5186|M.marinum_M LDYSNAGHMPAVLAEPKSGPVLLTDARSVPLAVRRVEPRPEATQVLPPGS
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 AILFYTDGLIERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRL
Rv1364c|M.tuberculosis_H37Rv AILFYTDGLIERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRL
MUL_3853|M.ulcerans_Agy99 VVLLYTDGLIERPGRPLGASTAEFADLAANITSG-GGFVIDAQSRPIDRL
MMAR_5186|M.marinum_M TLLLFTDGLVERRYESIDEG-------------LGRVADVVADSVMLPID
Mvan_1037|M.vanbaalenii_PYR-1 ------MTVITPLTSTTS-----------EQLTVSGAATATGAAQMRHRF
Mflv_5233|M.gilvum_PYR-GCK -------MSVTAVDSRTS-----------EQLTVRGVATAACAAELRDEF
MSMEG_6129|M.smegmatis_MC2_155 --------MTDAGESTS-------------FIKAGVVAAPERAAQLRREF
TH_4491|M.thermoresistible__bu --------MIEPFPSASSAHPVSAGALADYFERLGVPADAASAAQVREQF
MAV_0124|M.avium_104 -----------------------------MRLTLAGSARPDTVTAWRRAL
Mb1399c|M.bovis_AF2122/97 CSDTLELLLRSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQL
Rv1364c|M.tuberculosis_H37Rv CSDTLELLLRSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQL
MUL_3853|M.ulcerans_Agy99 CSETLELLLRSTGYNDDITLLAVQRRAPTPPLNITEDATIHAARAIRSRL
MMAR_5186|M.marinum_M AVADAVLSQLAPTGGYDDDVAMVAYRYQHGPLRIETSATPDQLVIVRRQL
* * :
Mvan_1037|M.vanbaalenii_PYR-1 GDWL-RERGIPDVERNDILMAVNEALANCVDHAYAGRPSPGPMTVRADFE
Mflv_5233|M.gilvum_PYR-GCK GDWL-RDRGVSPLQTNEILLAVNEALANCVDHAYSGRPTAGTMAVRADFE
MSMEG_6129|M.smegmatis_MC2_155 SEWLGTHFTLDPVRASDIVLAVNEALANAAEFAYTNATEPGLMHVRADYD
TH_4491|M.thermoresistible__bu AAWLGRFFDVDAVKSSDMVLATNEALANAAEFAYVHTERPGTMDVCAHYV
MAV_0124|M.avium_104 HRWLQHEVRAPDDVRDDVVLGVNEALANCVEHAYRSHRGTGAMKLQASYD
Mb1399c|M.bovis_AF2122/97 REWL-AEIGADHSDIADIVHAISEFVENAVEHGYATDVSKG-IVVEAALA
Rv1364c|M.tuberculosis_H37Rv REWL-AEIGADHSDIADIVHAISEFVENAVEHGYATDVSKG-IVVAAALA
MUL_3853|M.ulcerans_Agy99 RQWL-SEIGADSGDISDIVHAISEFVENAVEHGYSTDVSDG-LAVAAALG
MMAR_5186|M.marinum_M LSWL-QAAEVPDEQAGDIVLVVSEACTNCIEHAYRGQ---SVGTMLLDVE
** ::: .* *. :..* . :
Mvan_1037|M.vanbaalenii_PYR-1 PVNSCLSVCVTDHGRWRPPGLYRRPDRR-GRGVALMHALTDHCTISGRRD
Mflv_5233|M.gilvum_PYR-GCK PAAGCLSICVTDHGTWRRPGPQAAADRRRGRGVALMHAMADHCTINGRRD
MSMEG_6129|M.smegmatis_MC2_155 TEAETLTVVVADEGTWRIGDTDHKNPAR-GRGIPLMHALTDRAVIDATPT
TH_4491|M.thermoresistible__bu ADDTSLTVIVTDRGNWRMADPRPATRTR-GRGIPLMHALTDRASVETSAH
MAV_0124|M.avium_104 PGAESIRVCVSDRGRWQSPSCRLSSDPRASRGIMLMHNLAEHCTIHARPD
Mb1399c|M.bovis_AF2122/97 -GDGNVRASVIDRGQWK--DHRDGARGR-GRGLAMAEALVSEARIMHGAG
Rv1364c|M.tuberculosis_H37Rv -GDGNVRASVIDRGQWK--DHRDGARGR-GRGLAMAEALVSEARIMHGAG
MUL_3853|M.ulcerans_Agy99 -GDGKLRVAVIDHGTWK--HHREGERGR-GRGLAMAEALVSETHVSHDGA
MMAR_5186|M.marinum_M AADWAIHARVVDSGSWKKPAADPGNGGR---GMTLIRAISDEVEIDNSPG
: * * * *: * *: : . : .. :
Mvan_1037|M.vanbaalenii_PYR-1 GTTVCLDYRCETRPADN---------------------------------
Mflv_5233|M.gilvum_PYR-GCK GTTVCLDYRCR---------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 GTKVRLQWQNIARS---------VTSELR---------------------
TH_4491|M.thermoresistible__bu GTTAYLRWTGIRRSGSGRGEHVPVTSWSGSGGPPGTGPGNTVCGMPHTTL
MAV_0124|M.avium_104 GTSVYLDYALDPNPVGAQRV------------------------------
Mb1399c|M.bovis_AF2122/97 GTTATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVS-LVESGRIVVRGD
Rv1364c|M.tuberculosis_H37Rv GTTATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVS-LVESGRIVVRGD
MUL_3853|M.ulcerans_Agy99 GTTATVVHRLSRPAQFVTDPVVSRAPNRPAIDSEFASTVTESGHIVVRGD
MMAR_5186|M.marinum_M GTAIDMTFRLPSED------------------------------------
** :
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 VDSTTAATLDRQIAVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRAR
Rv1364c|M.tuberculosis_H37Rv VDSTTAATLDRQIAVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRAR
MUL_3853|M.ulcerans_Agy99 VDSNTAPTLDRQIAVESRSGIASLTIDLSAVTHLGSAGVSALVTARDRAR
MMAR_5186|M.marinum_M --------------------------------------------------
Mvan_1037|M.vanbaalenii_PYR-1 ---------------------------------------
Mflv_5233|M.gilvum_PYR-GCK ---------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 ---------------------------------------
TH_4491|M.thermoresistible__bu ---------------------------------------
MAV_0124|M.avium_104 ---------------------------------------
Mb1399c|M.bovis_AF2122/97 KQGTECVLVAPPGSPAHHVLSLVQLPVVGADTEDIFAQE
Rv1364c|M.tuberculosis_H37Rv KQGTECVLVAPPGSPAHHVLSLVQLPVVGADTEDIFAQE
MUL_3853|M.ulcerans_Agy99 KQGGRCVLMAPPGSPAHHVLSLVQIPVISGETENVFAED
MMAR_5186|M.marinum_M ---------------------------------------