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MSVTAVDSRTSEQLTVRGVATAACAAELRDEFGDWLRDRGVSPLQTNEILLAVNEALANCVDHAYSGRPT AGTMAVRADFEPAAGCLSICVTDHGTWRRPGPQAAADRRRGRGVALMHAMADHCTINGRRDGTTVCLDYR CR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5233 | - | - | 100% (142) | putative anti-sigma regulatory factor, serine/threonine protein kinase |
| M. gilvum PYR-GCK | Mflv_3283 | - | 4e-18 | 37.70% (122) | putative anti-sigma regulatory factor, serine/threonine protein |
| M. gilvum PYR-GCK | Mflv_4423 | - | 1e-12 | 34.85% (132) | multi-sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1399c | - | 8e-08 | 28.93% (121) | hypothetical protein Mb1399c |
| M. tuberculosis H37Rv | Rv1364c | - | 5e-08 | 28.93% (121) | hypothetical protein Rv1364c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_5186 | - | 4e-13 | 33.07% (127) | sensor-component of a two-component regulator |
| M. avium 104 | MAV_0124 | - | 3e-25 | 40.62% (128) | hypothetical protein MAV_0124 |
| M. smegmatis MC2 155 | MSMEG_6129 | - | 2e-20 | 42.28% (123) | hypothetical protein MSMEG_6129 |
| M. thermoresistible (build 8) | TH_4491 | - | 7e-19 | 41.18% (119) | PUTATIVE putative putative anti-sigma regulatory factor, |
| M. ulcerans Agy99 | MUL_3853 | rsbU | 7e-11 | 29.79% (141) | regulator of sigma subunit, anti-anti-sigma factor RsbU |
| M. vanbaalenii PYR-1 | Mvan_1037 | - | 2e-55 | 69.78% (139) | putative anti-sigma regulatory factor, serine/threonine protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5186|M.marinum_M MTETGDFGAVDAFQTQYADALRAYLDTRDENSLAVGHEFGRRALQEQISI
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5186|M.marinum_M LDIIENHFRLLDEISPNPGSDRSVALEFLLQTLAALDVATRGFLDGTKRY
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5186|M.marinum_M EEQRARAEDLAHRDKFRSALVNSLQEGFFVADDEGAVIDMNSAFAEILGY
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------------------------------
Rv1364c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3853|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5186|M.marinum_M PPEGLPYRWPHPWLVDRKSAAQQQERVRHEGSADYETPVRHQDGHLSWVA
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 --------------------------MAAEMDWDKTVGAAEDVRRIFEHI
Rv1364c|M.tuberculosis_H37Rv --------------------------MAAEMDWDKTVGAAEDVRRIFEHI
MUL_3853|M.ulcerans_Agy99 --MLLLDLLRQRTYSFVRSVHRRDGYMAAEMDWDKNVGTANTVRRIFENV
MMAR_5186|M.marinum_M VSINAVRGSGSDRDVYVGTVRDITAERAFAARESAVLRLATSVSVAKSVS
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 PAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAREVYPELEGQQIYEM
Rv1364c|M.tuberculosis_H37Rv PAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAREVYPELEGQQIYEM
MUL_3853|M.ulcerans_Agy99 PTMLVGLEGPEHRFVAANAAYRRFSPTFTAVGQPAREVYPELESQQIYHM
MMAR_5186|M.marinum_M EVLSITLEECRTAVDVQRVVAVMWPPSDGEPTVQVAGEPAESSWRALDPQ
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 LDRVYQTGEPQSGSEWRLQTDYDGSGVEERYFDFVVTPRRRADGSIEGVQ
Rv1364c|M.tuberculosis_H37Rv LDRVYQTGEPQSGSEWRLQTDYDGSGVEERYFDFVVTPRRRADGSIEGVQ
MUL_3853|M.ulcerans_Agy99 LDRVYETGEPQSGAEWRLQADFDGSGIDERYFDFLVTPRRREDGSIEGVQ
MMAR_5186|M.marinum_M LRETFLGARAQLPLTARPIEWPDSPGRAQGLVAVLSGTADVALWLELGAP
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 LIVDDVTSRVRARQAAEARVEELSERYRNVRDSATVMQQALLAASVPVVP
Rv1364c|M.tuberculosis_H37Rv LIVDDVTSRVRARQAAEARVEELSERYRNVRDSATVMQQALLAASVPVVP
MUL_3853|M.ulcerans_Agy99 ILFDDVTTRVRARLAAEARVEELSERYRHLRDSAIVMQQALLAPSVPVVS
MMAR_5186|M.marinum_M RWVTAEDRLLVTVLVGHLSLAIG--HVRQFESARETSLTLQRAMLPPVKP
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 GADIAAEYLVAAEDTAAGGDWFDALALGDR-LVLVVGDVVGHGVEAAAVM
Rv1364c|M.tuberculosis_H37Rv GADIAAEYLVAAEDTAAGGDWFDALALGDR-LVLVVGDVVGHGVEAAAVM
MUL_3853|M.ulcerans_Agy99 GPDIAAQYLVAAQDTAAGGDWFDAVALGDR-LVLIVGDVVGHGVEAAAVM
MMAR_5186|M.marinum_M PPGFAVRYEPAVPPLEIGGDWYDVLPIGEHRIGIVVGDCVGRGLPAAAIM
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 SQLRTALRMQISTGYTVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGE
Rv1364c|M.tuberculosis_H37Rv SQLRTALRMQISAGYTVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGE
MUL_3853|M.ulcerans_Agy99 SQLRTALRLQIAAGRSIGEALEALDAFHEHVPGSNSATLCVGSLDFTTGE
MMAR_5186|M.marinum_M GQLRSSARALLLTGAQPALLLEQLDAAASLIPDAYCTTVFLAILDTESGI
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 FQYCTAGHPPPLLVTADASARYVEPTGAGPLGSGTG--FPVRSEVLNIGD
Rv1364c|M.tuberculosis_H37Rv FQYCTAGHPPPLLVTADASARYVEPTGAGPLGSGTG--FPVRSEVLNIGD
MUL_3853|M.ulcerans_Agy99 FQYCTAGHPPPLVVTAEAKARYLEPSGAGPLGSDTG--FPVRTELIGVGD
MMAR_5186|M.marinum_M LDYSNAGHMPAVLAEPKSGPVLLTDARSVPLAVRRVEPRPEATQVLPPGS
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 AILFYTDGLIERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRL
Rv1364c|M.tuberculosis_H37Rv AILFYTDGLIERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRL
MUL_3853|M.ulcerans_Agy99 VVLLYTDGLIERPGRPLGASTAEFADLAANITSG-GGFVIDAQSRPIDRL
MMAR_5186|M.marinum_M TLLLFTDGLVERRYESIDEG-------------LGRVADVVADSVMLPID
Mflv_5233|M.gilvum_PYR-GCK -------MSVTAVDSRTS-----------EQLTVRGVATAACAAELRDEF
Mvan_1037|M.vanbaalenii_PYR-1 ------MTVITPLTSTTS-----------EQLTVSGAATATGAAQMRHRF
MSMEG_6129|M.smegmatis_MC2_155 --------MTDAGESTS-------------FIKAGVVAAPERAAQLRREF
TH_4491|M.thermoresistible__bu --------MIEPFPSASSAHPVSAGALADYFERLGVPADAASAAQVREQF
MAV_0124|M.avium_104 -----------------------------MRLTLAGSARPDTVTAWRRAL
Mb1399c|M.bovis_AF2122/97 CSDTLELLLRSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQL
Rv1364c|M.tuberculosis_H37Rv CSDTLELLLRSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQL
MUL_3853|M.ulcerans_Agy99 CSETLELLLRSTGYNDDITLLAVQRRAPTPPLNITEDATIHAARAIRSRL
MMAR_5186|M.marinum_M AVADAVLSQLAPTGGYDDDVAMVAYRYQHGPLRIETSATPDQLVIVRRQL
* * :
Mflv_5233|M.gilvum_PYR-GCK GDWL-RDRGVSPLQTNEILLAVNEALANCVDHAYSGRPTAGTMAVRADFE
Mvan_1037|M.vanbaalenii_PYR-1 GDWL-RERGIPDVERNDILMAVNEALANCVDHAYAGRPSPGPMTVRADFE
MSMEG_6129|M.smegmatis_MC2_155 SEWLGTHFTLDPVRASDIVLAVNEALANAAEFAYTNATEPGLMHVRADYD
TH_4491|M.thermoresistible__bu AAWLGRFFDVDAVKSSDMVLATNEALANAAEFAYVHTERPGTMDVCAHYV
MAV_0124|M.avium_104 HRWLQHEVRAPDDVRDDVVLGVNEALANCVEHAYRSHRGTGAMKLQASYD
Mb1399c|M.bovis_AF2122/97 REWL-AEIGADHSDIADIVHAISEFVENAVEHGYATDVSKG-IVVEAALA
Rv1364c|M.tuberculosis_H37Rv REWL-AEIGADHSDIADIVHAISEFVENAVEHGYATDVSKG-IVVAAALA
MUL_3853|M.ulcerans_Agy99 RQWL-SEIGADSGDISDIVHAISEFVENAVEHGYSTDVSDG-LAVAAALG
MMAR_5186|M.marinum_M LSWL-QAAEVPDEQAGDIVLVVSEACTNCIEHAYRGQ---SVGTMLLDVE
** ::: .* *. :..* . :
Mflv_5233|M.gilvum_PYR-GCK PAAGCLSICVTDHGTWRRPGPQAAADRRRGRGVALMHAMADHCTINGRRD
Mvan_1037|M.vanbaalenii_PYR-1 PVNSCLSVCVTDHGRWRPPGLYRRPDRR-GRGVALMHALTDHCTISGRRD
MSMEG_6129|M.smegmatis_MC2_155 TEAETLTVVVADEGTWRIGDTDHKNPAR-GRGIPLMHALTDRAVIDATPT
TH_4491|M.thermoresistible__bu ADDTSLTVIVTDRGNWRMADPRPATRTR-GRGIPLMHALTDRASVETSAH
MAV_0124|M.avium_104 PGAESIRVCVSDRGRWQSPSCRLSSDPRASRGIMLMHNLAEHCTIHARPD
Mb1399c|M.bovis_AF2122/97 -GDGNVRASVIDRGQWK--DHRDGARGR-GRGLAMAEALVSEARIMHGAG
Rv1364c|M.tuberculosis_H37Rv -GDGNVRASVIDRGQWK--DHRDGARGR-GRGLAMAEALVSEARIMHGAG
MUL_3853|M.ulcerans_Agy99 -GDGKLRVAVIDHGTWK--HHREGERGR-GRGLAMAEALVSETHVSHDGA
MMAR_5186|M.marinum_M AADWAIHARVVDSGSWKKPAADPGNGGR---GMTLIRAISDEVEIDNSPG
: * * * *: * *: : . : .. :
Mflv_5233|M.gilvum_PYR-GCK GTTVCLDYRCR---------------------------------------
Mvan_1037|M.vanbaalenii_PYR-1 GTTVCLDYRCETRPADN---------------------------------
MSMEG_6129|M.smegmatis_MC2_155 GTKVRLQWQNIARS---------VTSELR---------------------
TH_4491|M.thermoresistible__bu GTTAYLRWTGIRRSGSGRGEHVPVTSWSGSGGPPGTGPGNTVCGMPHTTL
MAV_0124|M.avium_104 GTSVYLDYALDPNPVGAQRV------------------------------
Mb1399c|M.bovis_AF2122/97 GTTATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVS-LVESGRIVVRGD
Rv1364c|M.tuberculosis_H37Rv GTTATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVS-LVESGRIVVRGD
MUL_3853|M.ulcerans_Agy99 GTTATVVHRLSRPAQFVTDPVVSRAPNRPAIDSEFASTVTESGHIVVRGD
MMAR_5186|M.marinum_M GTAIDMTFRLPSED------------------------------------
** :
Mflv_5233|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1037|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 VDSTTAATLDRQIAVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRAR
Rv1364c|M.tuberculosis_H37Rv VDSTTAATLDRQIAVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRAR
MUL_3853|M.ulcerans_Agy99 VDSNTAPTLDRQIAVESRSGIASLTIDLSAVTHLGSAGVSALVTARDRAR
MMAR_5186|M.marinum_M --------------------------------------------------
Mflv_5233|M.gilvum_PYR-GCK ---------------------------------------
Mvan_1037|M.vanbaalenii_PYR-1 ---------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 ---------------------------------------
TH_4491|M.thermoresistible__bu ---------------------------------------
MAV_0124|M.avium_104 ---------------------------------------
Mb1399c|M.bovis_AF2122/97 KQGTECVLVAPPGSPAHHVLSLVQLPVVGADTEDIFAQE
Rv1364c|M.tuberculosis_H37Rv KQGTECVLVAPPGSPAHHVLSLVQLPVVGADTEDIFAQE
MUL_3853|M.ulcerans_Agy99 KQGGRCVLMAPPGSPAHHVLSLVQIPVISGETENVFAED
MMAR_5186|M.marinum_M ---------------------------------------