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IDSMPPAQVANAERFERLGLAADAGAVARVRQEFGEWLKRFFVIDEVRFSDVVLAINEALANAAEFAYAL ADRPGTIDIQATYDPRGQTLTVCIEDRGVWRQRQTEPAPRTRGRGIPLMETLSDGATIEPSTSGTTVQLV WHGVDRL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3002 | - | - | 100% (148) | putative anti-sigma regulatory factor, serine/threonine protein kinase |
| M. vanbaalenii PYR-1 | Mvan_1037 | - | 7e-21 | 41.18% (119) | putative anti-sigma regulatory factor, serine/threonine protein |
| M. vanbaalenii PYR-1 | Mvan_1931 | - | 4e-11 | 38.52% (122) | multi-sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1399c | - | 5e-08 | 33.33% (120) | hypothetical protein Mb1399c |
| M. gilvum PYR-GCK | Mflv_3283 | - | 4e-65 | 79.73% (148) | putative anti-sigma regulatory factor, serine/threonine protein |
| M. tuberculosis H37Rv | Rv1364c | - | 1e-07 | 33.33% (120) | hypothetical protein Rv1364c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_5186 | - | 1e-07 | 28.35% (127) | sensor-component of a two-component regulator |
| M. avium 104 | MAV_0124 | - | 2e-15 | 39.37% (127) | hypothetical protein MAV_0124 |
| M. smegmatis MC2 155 | MSMEG_6129 | - | 9e-32 | 48.48% (132) | hypothetical protein MSMEG_6129 |
| M. thermoresistible (build 8) | TH_4491 | - | 2e-39 | 52.60% (154) | PUTATIVE putative putative anti-sigma regulatory factor, |
| M. ulcerans Agy99 | MUL_3853 | rsbU | 7e-07 | 29.57% (115) | regulator of sigma subunit, anti-anti-sigma factor RsbU |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3002|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3283|M.gilvum_PYR-GCK --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 ------------------------------MAAEMDWDKTVGAAEDVRRI
Rv1364c|M.tuberculosis_H37Rv ------------------------------MAAEMDWDKTVGAAEDVRRI
MUL_3853|M.ulcerans_Agy99 ------MLLLDLLRQRTYSFVRSVHRRDGYMAAEMDWDKNVGTANTVRRI
MMAR_5186|M.marinum_M MTETGDFGAVDAFQTQYADALRAYLDTRDENSLAVGHEFGRRALQEQISI
Mvan_3002|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3283|M.gilvum_PYR-GCK --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 FEHIPAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAREVYPELEGQQ
Rv1364c|M.tuberculosis_H37Rv FEHIPAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAREVYPELEGQQ
MUL_3853|M.ulcerans_Agy99 FENVPTMLVGLEGPEHRFVAANAAYRRFSPTFTAVGQPAREVYPELESQQ
MMAR_5186|M.marinum_M LDIIENHFRLLDEISPNPGSDRSVALEFLLQTLAALDVATRGFLDGTKRY
Mvan_3002|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3283|M.gilvum_PYR-GCK --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 IYEMLDRVYQTGEPQSGSEWRLQTDYDGSGVEERYFDFVVTPRRRADGSI
Rv1364c|M.tuberculosis_H37Rv IYEMLDRVYQTGEPQSGSEWRLQTDYDGSGVEERYFDFVVTPRRRADGSI
MUL_3853|M.ulcerans_Agy99 IYHMLDRVYETGEPQSGAEWRLQADFDGSGIDERYFDFLVTPRRREDGSI
MMAR_5186|M.marinum_M EEQRARAEDLAHRDKFRSALVNSLQEGFFVADDEGAVIDMNSAFAEILGY
Mvan_3002|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3283|M.gilvum_PYR-GCK --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 EGVQLIVDDVTSRVRARQAAEARVEELSERYRNVRDSATVMQQALLAASV
Rv1364c|M.tuberculosis_H37Rv EGVQLIVDDVTSRVRARQAAEARVEELSERYRNVRDSATVMQQALLAASV
MUL_3853|M.ulcerans_Agy99 EGVQILFDDVTTRVRARLAAEARVEELSERYRHLRDSAIVMQQALLAPSV
MMAR_5186|M.marinum_M PPEGLPYRWPHPWLVDRKSAAQQQERVRHEGSADYETPVRHQDGHLSWVA
Mvan_3002|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3283|M.gilvum_PYR-GCK --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 PVVPGADIAAEYLVAAEDTAAGGDWFDALALGDRLVLVVGDVVGHGVEAA
Rv1364c|M.tuberculosis_H37Rv PVVPGADIAAEYLVAAEDTAAGGDWFDALALGDRLVLVVGDVVGHGVEAA
MUL_3853|M.ulcerans_Agy99 PVVSGPDIAAQYLVAAQDTAAGGDWFDAVALGDRLVLIVGDVVGHGVEAA
MMAR_5186|M.marinum_M VSINAVRGSGSDRDVYVGTVRDITAERAFAARESAVLRLATSVSVAKSVS
Mvan_3002|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3283|M.gilvum_PYR-GCK --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 AVMSQLRTALRMQISTGYTVVEALEAVDRFHKQVPGSKSATMCVGSLDFT
Rv1364c|M.tuberculosis_H37Rv AVMSQLRTALRMQISAGYTVVEALEAVDRFHKQVPGSKSATMCVGSLDFT
MUL_3853|M.ulcerans_Agy99 AVMSQLRTALRLQIAAGRSIGEALEALDAFHEHVPGSNSATLCVGSLDFT
MMAR_5186|M.marinum_M EVLSITLEECRTAVDVQRVVAVMWPPSDGEPTVQVAGEPAESSWRALDPQ
Mvan_3002|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3283|M.gilvum_PYR-GCK --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 SGEFQYCTAGHPPPLLVTADASARYVEPTGAGPLGSGTGFPVRSEVLNIG
Rv1364c|M.tuberculosis_H37Rv SGEFQYCTAGHPPPLLVTADASARYVEPTGAGPLGSGTGFPVRSEVLNIG
MUL_3853|M.ulcerans_Agy99 TGEFQYCTAGHPPPLVVTAEAKARYLEPSGAGPLGSDTGFPVRTELIGVG
MMAR_5186|M.marinum_M LRETFLGARAQLPLTARPIEWPDSPGRAQGLVAVLSGTADVALWLELGAP
Mvan_3002|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3283|M.gilvum_PYR-GCK --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 DAILFYTDGLIERPGRPLEASTAEFADLAAS-------------IASGSG
Rv1364c|M.tuberculosis_H37Rv DAILFYTDGLIERPGRPLEASTAEFADLAAS-------------IASGSG
MUL_3853|M.ulcerans_Agy99 DVVLLYTDGLIERPGRPLGASTAEFADLAAN-------------ITSG-G
MMAR_5186|M.marinum_M RWVTAEDRLLVTVLVGHLSLAIGHVRQFESARETSLTLQRAMLPPVKPPP
Mvan_3002|M.vanbaalenii_PYR-1 ----------------------MIDSMPPAQVAN-------AERFERLGL
Mflv_3283|M.gilvum_PYR-GCK ----------------------MIDAMPPTEVAN-------AERFERFGL
TH_4491|M.thermoresistible__bu ----------------------MIEPFPSASSAHPVSAGALADYFERLGV
MSMEG_6129|M.smegmatis_MC2_155 ----------------------MTDAG---ESTS----------FIKAGV
MAV_0124|M.avium_104 -------------------------------------------MRLTLAG
Mb1399c|M.bovis_AF2122/97 GFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLLAMQRRAPTPPLHITL
Rv1364c|M.tuberculosis_H37Rv GFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLLAMQRRAPTPPLHITL
MUL_3853|M.ulcerans_Agy99 GFVIDAQSRPIDRLCSETLELLLRSTGYNDDITLLAVQRRAPTPPLNITE
MMAR_5186|M.marinum_M GFAVRYEPAVPPLEIGGDWYDVLPIGEHRIGIVVGDCVGRGLPAAAIMGQ
Mvan_3002|M.vanbaalenii_PYR-1 AADAGAVARVRQEFGEWLKRFFVIDEVRF-----SDVVLAINEALANAAE
Mflv_3283|M.gilvum_PYR-GCK AADAGAVARVRQDFTEWLRRFFDVDDVRR-----SDVVLAINEALANAAE
TH_4491|M.thermoresistible__bu PADAASAAQVREQFAAWLGRFFDVDAVKS-----SDMVLATNEALANAAE
MSMEG_6129|M.smegmatis_MC2_155 VAAPERAAQLRREFSEWLGTHFTLDPVRA-----SDIVLAVNEALANAAE
MAV_0124|M.avium_104 SARPDTVTAWRRALHRWLQHEVRAPDDVR-----DDVVLGVNEALANCVE
Mb1399c|M.bovis_AF2122/97 DATINAARTVRAQLREWLA-EIGADHSDI-----ADIVHAISEFVENAVE
Rv1364c|M.tuberculosis_H37Rv DATINAARTVRAQLREWLA-EIGADHSDI-----ADIVHAISEFVENAVE
MUL_3853|M.ulcerans_Agy99 DATIHAARAIRSRLRQWLS-EIGADSGDI-----SDIVHAISEFVENAVE
MMAR_5186|M.marinum_M LRSSARALLLTGAQPALLLEQLDAAASLIPDAYCTTVFLAILDTESGILD
. * . :. . : . :
Mvan_3002|M.vanbaalenii_PYR-1 FAYALADRPGTIDIQATYDPRGQTLTVCIEDRGVWRQRQTEPAPRTRG-R
Mflv_3283|M.gilvum_PYR-GCK FAYVQADRPGTVDIQAVYDAPTQTLSVCVEDRGRWRTRQTEPAPRTRG-R
TH_4491|M.thermoresistible__bu FAYVHTERPGTMDVCAHYVADDTSLTVIVTDRGNWRMADPRPATRTRG-R
MSMEG_6129|M.smegmatis_MC2_155 FAYTNATEPGLMHVRADYDTEAETLTVVVADEGTWRIGDTDHKNPARG-R
MAV_0124|M.avium_104 HAYRSHRGTGAMKLQASYDPGAESIRVCVSDRGRWQSPSCRLSSDPRASR
Mb1399c|M.bovis_AF2122/97 HGYATDVSKGIVVEAALA--GDGNVRASVIDRGQWK--DHRDGARGRG-R
Rv1364c|M.tuberculosis_H37Rv HGYATDVSKGIVVAAALA--GDGNVRASVIDRGQWK--DHRDGARGRG-R
MUL_3853|M.ulcerans_Agy99 HGYSTDVSDGLAVAAALG--GDGKLRVAVIDHGTWK--HHREGERGRG-R
MMAR_5186|M.marinum_M YSNAGHMPAVLAEPKSGPVLLTDARSVPLAVRRVEPRPEATQVLPPGS-T
.. : . : . .
Mvan_3002|M.vanbaalenii_PYR-1 GIPLMETLSDG--ATIEPSTSGTTVQLVWHG------VDRL---------
Mflv_3283|M.gilvum_PYR-GCK GIPLMETLSDS--AEIEPSASGTTVKLEWRG------ITRL---------
TH_4491|M.thermoresistible__bu GIPLMHALTDR--ASVETSAHGTTAYLRWTG------IRRSGSGRGEHVP
MSMEG_6129|M.smegmatis_MC2_155 GIPLMHALTDR--AVIDATPTGTKVRLQWQN------IARSVTSELR---
MAV_0124|M.avium_104 GIMLMHNLAEH--CTIHARPDGTSVYLDYAL------DPNPVGAQRV---
Mb1399c|M.bovis_AF2122/97 GLAMAEALVSE--ARIMHGAGGTTATLTHRLSRPARFVTDTMVRRAAFQQ
Rv1364c|M.tuberculosis_H37Rv GLAMAEALVSE--ARIMHGAGGTTATLTHRLSRPARFVTDTMVRRAAFQQ
MUL_3853|M.ulcerans_Agy99 GLAMAEALVSE--THVSHDGAGTTATVVHRLSRPAQFVTDPVVSRAPNRP
MMAR_5186|M.marinum_M LLLFTDGLVERRYESIDEGLGRVADVVADSVMLPIDAVADAVLSQLAPTG
: : . * . : . :
Mvan_3002|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3283|M.gilvum_PYR-GCK --------------------------------------------------
TH_4491|M.thermoresistible__bu VTSWSGSGGPPGTGPGNTVCGMPHTTL-----------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 TIDSEFVS-LVESGRIVVRGDVDSTTAATLDRQIAVESRSGIAPVTIDLS
Rv1364c|M.tuberculosis_H37Rv TIDSEFVS-LVESGRIVVRGDVDSTTAATLDRQIAVESRSGIAPVTIDLS
MUL_3853|M.ulcerans_Agy99 AIDSEFASTVTESGHIVVRGDVDSNTAPTLDRQIAVESRSGIASLTIDLS
MMAR_5186|M.marinum_M GYDDDVAMVAYRYQHGPLRIETSATPDQLVIVRRQLLSWLQAAEVPDEQA
Mvan_3002|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3283|M.gilvum_PYR-GCK --------------------------------------------------
TH_4491|M.thermoresistible__bu --------------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0124|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 AVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAHHVLSLVQLPVVG
Rv1364c|M.tuberculosis_H37Rv AVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAHHVLSLVQLPVVG
MUL_3853|M.ulcerans_Agy99 AVTHLGSAGVSALVTARDRARKQGGRCVLMAPPGSPAHHVLSLVQIPVIS
MMAR_5186|M.marinum_M GDIVLVVSEACTNCIEHAYRGQSVGTMLLDVEAADWAIHARVVDSGSWKK
Mvan_3002|M.vanbaalenii_PYR-1 -------------------------------------------
Mflv_3283|M.gilvum_PYR-GCK -------------------------------------------
TH_4491|M.thermoresistible__bu -------------------------------------------
MSMEG_6129|M.smegmatis_MC2_155 -------------------------------------------
MAV_0124|M.avium_104 -------------------------------------------
Mb1399c|M.bovis_AF2122/97 ADTEDIFAQE---------------------------------
Rv1364c|M.tuberculosis_H37Rv ADTEDIFAQE---------------------------------
MUL_3853|M.ulcerans_Agy99 GETENVFAED---------------------------------
MMAR_5186|M.marinum_M PAADPGNGGRGMTLIRAISDEVEIDNSPGGTAIDMTFRLPSED