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VLGLMQNRPLVLPHIFHRAERYFGHKQVITATAGGAVAMSTVADVCGQVRRLATVFDELGISSDARVATF CWNTEEHLALYLAAPCTGRVLHTVNIRLFPEQIAYVVNHARDEIIFVERSLLSVLWPLADQLPEVRYFVV IDDGTDHEIPDSARILSYSSLLADSTPFDGAFVVDDENTAAAMCYTSGTTGNPKGVVYSHRSTVLHSLAA LAADVLGLSERDVVMPVVPMFHANSWGLPYAALLTGAGVVLPGPNMSPKALLGLLADHRVTVTAGVPTIW MGAAPLLADYDLSALRYILCGGSAVPKALSEEYRQAIGVSITQVWGMTETSPIAAACTPRTQYAELTTQE KAVALARQGQAVPLVDLRLVDPDTGADVPWDNHSTGEVQAAGPWIASSYYNSDDQQSSFTDDGWLRTGDV GVCDEFGSLLLVDRTKDLVKSGGEWISSVQLENEIMAHPKVSEAAVIAIPHERWVERPLACVVVKQGESM TTEEVIRHLSARVAKWWLPDAVEFIDAVPKTSVGKFSKKTLRARFENYRFPDQGAPV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0905 | - | - | 100% (547) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_5172 | - | e-123 | 41.82% (550) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_3993 | - | 6e-60 | 31.81% (503) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1087 | fadD14 | 1e-134 | 46.64% (536) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4589 | - | 1e-126 | 45.34% (536) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1058 | fadD14 | 1e-134 | 46.64% (536) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_01051 | xclC | 1e-33 | 30.30% (363) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2080 | - | 1e-131 | 46.54% (535) | acyl-CoA synthetase |
| M. marinum M | MMAR_4412 | fadD14 | 1e-136 | 48.23% (537) | medium chain fatty-acid-CoA ligase FadD14 |
| M. avium 104 | MAV_1186 | - | 1e-139 | 48.14% (538) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5348 | - | 1e-149 | 50.75% (530) | medium-chain fatty acid-CoA ligase |
| M. thermoresistible (build 8) | TH_2961 | - | 1e-136 | 46.86% (542) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_0229 | fadD14 | 1e-137 | 48.60% (537) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1087|M.bovis_AF2122/97 MYGTMQDFPLTITAIMRHGCGVHGRRTVTTATGEG-YRHSSYRDVGQRAG
Rv1058|M.tuberculosis_H37Rv MYGTMQDFPLTITAIMRHGCGVHGRRTVTTATGEG-YRHSSYRDVGQRAG
MMAR_4412|M.marinum_M MYSTMQDFPLTITAIMRHGCGVHGSRQVITATGDA-YRQTTYREVGQRAA
MUL_0229|M.ulcerans_Agy99 MYSTMQDFPLTITAIMRHGCGVHGSRQVITATGDA-YRQTTYREVGQRAA
MAV_1186|M.avium_104 MDGTMQDFPLTITAIMRHGCSVHGARTVTTATGDG-YRRTSYRELGDRAA
TH_2961|M.thermoresistible__bu MQSTMQPIPLTVAAIMRYAIEVHGDRTVTTATGDGGYRHATYADLGREAA
MAB_2080|M.abscessus_ATCC_1997 ----MQNVPLTVSAIVQHAAAIHGDSEVVTPTGNG-YRRTPYRIVLARVA
Mflv_4589|M.gilvum_PYR-GCK ----MQDVALTVPAIVAHAAAVHGDREVLTARGPQQISGVSYHELGQRAA
Mvan_0905|M.vanbaalenii_PYR-1 MLGLMQNRPLVLPHIFHRAERYFGHKQVITATAGGAVAMSTVADVCGQVR
MSMEG_5348|M.smegmatis_MC2_155 MHGLMQDRPLSLPLLMSGLDGRFSHKTVTTNHPDA-PTVATYGAVAQRVR
MLBr_01051|M.leprae_Br4923 ---------------------------MLLASLNP--SVVTATDIADAVC
: . : .
Mb1087|M.bovis_AF2122/97 QLANALRRLGVTGDQRVATFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFP
Rv1058|M.tuberculosis_H37Rv QLANALRRLGVTGDQRVATFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFP
MMAR_4412|M.marinum_M QLANALRGLGISGDQRVATFMWNNAEHLVAYLAVPSMGAVLHTLNIRLFA
MUL_0229|M.ulcerans_Agy99 QLANALRGLGISGDQRVATFMWNNAEHLVTYLAVPSMGAVLHTLNIRLFA
MAV_1186|M.avium_104 QLANALRGLGVTGDQRVATFMWNNAEHLAAYLAVPSMGAVLHTLNIRLFP
TH_2961|M.thermoresistible__bu RLANALRRLGITGDERVATFQWNNQEHLATYVAVPSMGAVLHTLNIRLFP
MAB_2080|M.abscessus_ATCC_1997 RLANALRSLGVTADQRVATFQWSNQEHLEAYCAIPSMGAVLHTLNIRLAP
Mflv_4589|M.gilvum_PYR-GCK RLANALREIGVRGDERVATLQWSNQEHLDCYAAVPSMGAVLHTLNLRLPP
Mvan_0905|M.vanbaalenii_PYR-1 RLATVFDELGISSDARVATFCWNTEEHLALYLAAPCTGRVLHTVNIRLFP
MSMEG_5348|M.smegmatis_MC2_155 RLAGVLDALAVPVGARVGSFGWNTQRHLELYLAVPCTNRVLHTVNHRLFA
MLBr_01051|M.leprae_Br4923 VDGVVLSRSGLVG-AATSVAERVGGARLVAVLATPTASTVLAITGCLIAG
. .: .: .. :* * * . ** . :
Mb1087|M.bovis_AF2122/97 EQIAYVTNEAEDRVILVDLSLARLLAPVLPKLDTVHTVIAVGEGDTTPLR
Rv1058|M.tuberculosis_H37Rv EQIAYVTNEAEDRVILVDLSLARLLAPVLPKLDTVHTVIAVGEGDTTPLR
MMAR_4412|M.marinum_M EQIAYVANEAEDQVVLVDLSLTNLLAPVLPDLGTVHTVIAVGEGDTAPLE
MUL_0229|M.ulcerans_Agy99 EQIAYVANEAEDQVVLVDLSLTNLLAPVLPNLDTVHTVIAVGEGDTAALE
MAV_1186|M.avium_104 EQIAYVANEAGDQVVLVDASLVKLLAPVLPGLHTVHTVIVVGDGDTEPLR
TH_2961|M.thermoresistible__bu EQLQFIAYEAQDRVVIVDASLVPLLAPVLPTMETVHTVIVVGAGDLSPLQ
MAB_2080|M.abscessus_ATCC_1997 EQLAYIANHASDQIVLVDASVAPLLARALPAMASVHTVIVTGEGDLAPLQ
Mflv_4589|M.gilvum_PYR-GCK EQLTWIANHAEDQVIIVDGTVLNLLAGALPSMTSVHTVLVTGTGDLAAVQ
Mvan_0905|M.vanbaalenii_PYR-1 EQIAYVVNHARDEIIFVERSLLSVLWPLADQLPEVRYFVVIDDGTDHEIP
MSMEG_5348|M.smegmatis_MC2_155 DDIVYIVNDAADDVLFVDRSLLDVVWPLVGRFTTVRHVIVMNDGSGPQIP
MLBr_01051|M.leprae_Br4923 VPVVPVP----ADIGVVERRHMLTDSGAQAWLGPGPSADSAPDG------
: : : .*: : *
Mb1087|M.bovis_AF2122/97 EAGKTVLRFAELIDAESPDFG--WPQIDENSAAAMCYTSGTTGNPKGVVY
Rv1058|M.tuberculosis_H37Rv EAGKTVLRFAELIDAESPDFG--WPQIDENSAAAMCYTSGTTGNPKGVVY
MMAR_4412|M.marinum_M ESGKTVLRYDELLDGQPTEFD--WPHIDENSAAAMCYTSGTTGHPKGVVY
MUL_0229|M.ulcerans_Agy99 ESGKTVLRYDELLDGQSTEFD--WPHIDENSAAAMCYTSGTTGHPKGVVY
MAV_1186|M.avium_104 ASGKTVLRYADVIGAEPAEFD--WPRIDENSAAAMCYTSGTTGNPKGVVY
TH_2961|M.thermoresistible__bu VPGKQVLRYEEILAAESDEFD--WPELDENSAAAMCYTSGTTGHPKGVVY
MAB_2080|M.abscessus_ATCC_1997 GCGKTVLRYEEVLAGQEESFD--WPRLDELSAAAMCYTSGTTGDPKGVVY
Mflv_4589|M.gilvum_PYR-GCK GCGKDVLRYDDVVGAQSSTFD--WPDVDEQSAAAMCYTSGTTGRPKGVVY
Mvan_0905|M.vanbaalenii_PYR-1 DSAR-ILSYSSLL-ADSTPFDGAFVVDDENTAAAMCYTSGTTGNPKGVVY
MSMEG_5348|M.smegmatis_MC2_155 DGAH---DYEHLLAEARPVAR--FEVSDERTAAALCYTSGTTGRPKGVLY
MLBr_01051|M.leprae_Br4923 ------LPHIPVQLDARSWNR--YPEPSPDATAMVIYTSGTTGPPKGVLL
. : : . ::* : ******* ****:
Mb1087|M.bovis_AF2122/97 SHRSSFLHTMAACTTNGIGVGSSDKVLPIVPMFHANGWGLPYAALMAGAD
Rv1058|M.tuberculosis_H37Rv SHRSSFLHTMAACTTNGIGVGSSDKVLPIVPMFHANGWGLPYAALMAGAD
MMAR_4412|M.marinum_M SHRSSFLHSMATCTANGIGVGSNDRVLPIVPMFHANAWGLPYAALMAGAD
MUL_0229|M.ulcerans_Agy99 SHRSSFLHSMATCTANGIGLGSSDRVLPIVPMFHANAWGLPYAALMAGAD
MAV_1186|M.avium_104 SHRSSFLHTMAACTANGIGIGATDSLLPIVPMFHANAWGLPYAALMAGAD
TH_2961|M.thermoresistible__bu SHRSSYLHSTAVCSGNGLGLGFEDRVLPIVPMFHANAWGLPYAALMAGAD
MAB_2080|M.abscessus_ATCC_1997 SHRSTYLHSLTACTANALSVSEADRVLAIVPMFHANAWGLIYAALMSGAD
Mflv_4589|M.gilvum_PYR-GCK SHRSTWLHSQAACTSNALGIGHDDTVLAIVPMFHANAWGLPYAAMMAGAQ
Mvan_0905|M.vanbaalenii_PYR-1 SHRSTVLHSLAALAADVLGLSERDVVMPVVPMFHANSWGLPYAALLTGAG
MSMEG_5348|M.smegmatis_MC2_155 DHRSIVLHAMSLLMADAFGIGEADVVMPIVPMFHVNAWGLPYAAVMSGAS
MLBr_01051|M.leprae_Br4923 SRRAIAVD--LDALAQAWQWTADDVLVHGLPLFHVHGLVLGLLGSLRIGN
.:*: :. : * :: :*:**.:. * . : .
Mb1087|M.bovis_AF2122/97 LVLPDRHLDARSLIHMVETLKPTLAGAVPTIWNDVMHYLEKDPDHDMSSL
Rv1058|M.tuberculosis_H37Rv LVLPDRHLDARSLIHMVETLKPTLAGAVPTIWNDVMHYLEKDPDHDMSSL
MMAR_4412|M.marinum_M LVLPDRHLDARSLVHMVENLRPTRAGAVPTIWNDVMHYLEKNPGHDVSSL
MUL_0229|M.ulcerans_Agy99 LVLPDRHLDARSLVHMVENLRPTRAGAVPTIWNDVMHYLEKNPGHDVSSL
MAV_1186|M.avium_104 LVLPDCHLDPRSLVRMVEDLRPTVTGAVPTIWNAVLHHLEDDPDHDMSSL
TH_2961|M.thermoresistible__bu LVMPDRYLDAKSLVNLIETQRPTVAGAVPTIWNDVLHHLDSEPDHDISSL
MAB_2080|M.abscessus_ATCC_1997 LVLPDRYLQAEPLVSIIEDTRPTVAGAVPTIWNDVDRYLDSHPERDISSL
Mflv_4589|M.gilvum_PYR-GCK LLLPDRFLQAGPLVEMIEAARPTMAGAVPTIWTDVLHYLRDNPGHDLSSL
Mvan_0905|M.vanbaalenii_PYR-1 VVLPGPNMSPKALLGLLADHRVTVTAGVPTIWMGAAPLLAD---YDLSAL
MSMEG_5348|M.smegmatis_MC2_155 LVLPGPAMQPASLAETLDTAGVTFAAAVTTVWRNVLPHLSG---RSLPSV
MLBr_01051|M.leprae_Br4923 RFVHTGKPTPTAYAQACSEAGGSLYFGVPTVWSRLVA--DEAVARALRPA
.: . . : .*.*:* : .
Mb1087|M.bovis_AF2122/97 RLVACGGSAVPESLMRTFEDKHDVQIRQLWGMTETSPLATMAWPP---PG
Rv1058|M.tuberculosis_H37Rv RLVACGGSAVPESLMRTFEDKHDVQIRQLWGMTETSPLATMAWPP---PG
MMAR_4412|M.marinum_M GLVACGGSAVPESLMRTFEEKYGVQIRQLWGMTETSPLATMAWPP---PG
MUL_0229|M.ulcerans_Agy99 GLVACGGSAVPESLMRTFEEKYGVQIRQLWGMTETSPLATMAWPP---PG
MAV_1186|M.avium_104 RLVVCGGSAVPVSLMRTFEEKHGVQIRQLWGMTETSPLATMAWPP---PG
TH_2961|M.thermoresistible__bu RLVGCGGSAVPVSLMQSFEEKFGVQIRQLWGMTETSPVCTLAWPA---PN
MAB_2080|M.abscessus_ATCC_1997 RLVACGGSAVPLSLMRAFEEKYNVPIVQAWGMTETSPLATVARPA---HR
Mflv_4589|M.gilvum_PYR-GCK KMVACGGSAVPRSLMTAYDELG-IRIVQAWGMTETSPLAAVALPR---DT
Mvan_0905|M.vanbaalenii_PYR-1 RYILCGGSAVPKALSEEYRQAIGVSITQVWGMTETSPIAAACTPRTQYAE
MSMEG_5348|M.smegmatis_MC2_155 RRLVSGGGPLPESLSRRYASEIGVPLCSSWGMTETSPLVCSARIP----T
MLBr_01051|M.leprae_Br4923 RLLVSGSASLPVPVFDRLAHLTGHRPIERYGSTESLITLSTLADG-----
: .*...:* .: . :* **:
Mb1087|M.bovis_AF2122/97 TPDDQHWAFRITQGQPVCGVETRIVD-DDGQVLPNDGNAVGEVEVRGPWI
Rv1058|M.tuberculosis_H37Rv TPDDQHWAFRITQGQPVCGVETRIVD-DDGQVLPNDGNAVGEVEVRGPWI
MMAR_4412|M.marinum_M TPPDRHWAIRSTQGQPVCGVETRIVD-DNGEALPNDGQAVGEVEVRGPWI
MUL_0229|M.ulcerans_Agy99 TPPDRHWAIRSTQGQPVCGVETRIVD-DNGEALPNDGQAVGEVEVRGPWI
MAV_1186|M.avium_104 TPEDQHWAYRGTQGQPVCGVQMRIVD-DDGRVLPNDGTAVGEVEVRGPWI
TH_2961|M.thermoresistible__bu TPADRHWEVRGSQGRPICGVEARIVD-DEGNVLPRDNEAVGELEVRGPWI
MAB_2080|M.abscessus_ATCC_1997 ADATRRWEMRASQGRPICGVEIRLRD-DDGKDVPWDGQSVGEIQARGPWI
Mflv_4589|M.gilvum_PYR-GCK DTPERSLYLRGTQGRVVAGVQARIVD-DSGAEQPWDGKSVGEIQIRGPWI
Mvan_0905|M.vanbaalenii_PYR-1 LTTQEKAVALARQGQAVPLVDLRLVDPDTGADVPWDNHSTGEVQAAGPWI
MSMEG_5348|M.smegmatis_MC2_155 GHSGDEVETLCLPGVSIPLVQLRLQR-DDGSFAPHDGKSSGELQVAGPTI
MLBr_01051|M.leprae_Br4923 ------ERRAGWVGLPLAGVQTRLVD-ESGGPVPYDGETVGRLQVRSPTM
* : *: *: : * * *. : *.:: .* :
Mb1087|M.bovis_AF2122/97 AGSYYGGRDE--SKFDS-GWLRTGDVGRIDEQGFITLTDR-AKDVIKSGG
Rv1058|M.tuberculosis_H37Rv AGSYYGGRDE--SKFDS-GWLRTGDVGRIDEQGFITLTDR-AKDVIKSGG
MMAR_4412|M.marinum_M TGAYYLGYDQ--SKFDS-GWLRTGDVGRIDELGFITLTDR-AKDVIKSGG
MUL_0229|M.ulcerans_Agy99 TGAYYLGYDQ--SEFDS-GWLRTGDVGRIDELGFITLTDR-AKDVIKSGG
MAV_1186|M.avium_104 AGSYYLGRDD--SKFDS-GWLRTGDVGRIDERGFVTLTDR-AKDVIKSGG
TH_2961|M.thermoresistible__bu TGSYYHDADP--SKFEN-GWLRTGDVGRMDAQSYITLTDR-AKDVIKSGG
MAB_2080|M.abscessus_ATCC_1997 TGSYFGDNDT--EKFDE-GWLRTGDVGKIDAEGYLTLTDR-SKDVIKSGG
Mflv_4589|M.gilvum_PYR-GCK TQSYYEYDSP--AVSPD-GWLCTGDVGTISADAFITLTDR-AKDVIKSGG
Mvan_0905|M.vanbaalenii_PYR-1 ASSYYNSDDQQSSFTDD-GWLRTGDVGVCDEFGSLLLVDR-TKDLVKSGG
MSMEG_5348|M.smegmatis_MC2_155 ASGYYGATDGSAAFTED-GWLRTGDVATIDAHGLVRIVDR-IKDLIKSGG
MLBr_01051|M.leprae_Br4923 FGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGGMHRIVGRESVDLIKLGG
.* . . ** ****. . . :..* *::* **
Mb1087|M.bovis_AF2122/97 EWISSVELENCLIAHPDVLEAAVVGVPDERWQERPLAVVVVREGATVSAG
Rv1058|M.tuberculosis_H37Rv EWISSVELENCLIAHPDVLEAAVVGVPDERWQERPLAVVVVREGATVSAG
MMAR_4412|M.marinum_M EWISSVELENCLIAHPDVVEAAVVGVPDERWQERPLAVVVRREGATVSAA
MUL_0229|M.ulcerans_Agy99 EWISSVELENCLIAHPDVVEAAVVGVPDERWQERPLAVVVRREGATVSAA
MAV_1186|M.avium_104 EWISSVELENCLIGHPDVVEAAVVGVPDERWEERPLAVVVVKDGASVDAD
TH_2961|M.thermoresistible__bu EWISSVELENHLIGHPKVREAAVVGVPDDRWQERPLAAVVLHEGQQATPE
MAB_2080|M.abscessus_ATCC_1997 EWISSVELENTLIGHPAVYEAAVVGVADDKWQERPLALVVVHPGTDVDID
Mflv_4589|M.gilvum_PYR-GCK EWISSVELENELAAHPAVRTATVIGVPDDKWQERPLAVVVLAADCTATAA
Mvan_0905|M.vanbaalenii_PYR-1 EWISSVQLENEIMAHPKVSEAAVIAIPHERWVERPLACVVVKQGESMTTE
MSMEG_5348|M.smegmatis_MC2_155 EWISSVELENAIMTCPAVAEAAVVGAPHERWGERPLAFVVPAAGHDATPD
MLBr_01051|M.leprae_Br4923 YRIGAGEIEMALLGHPDVREVAVVGLPDEDLGQRIVAFVVG--AEALDAD
*.: ::* : * * .:*:. ..: :* :* **
Mb1087|M.bovis_AF2122/97 DLRAFLADKVVRWWLPERWAFVDEIPRTSVGKYDKKAIRSRYAEGAYQIT
Rv1058|M.tuberculosis_H37Rv DLRAFLADKVVRWWLPERWAFVDEIPRTSVGKYDKKAIRSRYAEGAYQIT
MMAR_4412|M.marinum_M ELRKFLADRVVRWWLPERWAFADQVPRTSVGKYDKKTIRAGYAEGVYQVT
MUL_0229|M.ulcerans_Agy99 ELRKFLADRVVRWWLPERWAFADQVPRTSVGKYDKKTIRAGYAESVYQVT
MAV_1186|M.avium_104 QLRKFLADKVVRWWLPERWTFVDEIPRTSVGKYDKKAVRSRYADGGYRVI
TH_2961|M.thermoresistible__bu ELREFLSDKVVRWWLPERWTFVEEIPRTSVGKYDKKTIRARYADGAYQVT
MAB_2080|M.abscessus_ATCC_1997 QLRSFLADKVAKWWIPERWSFVSDIPRTSVGKYDKKAIRARHSAGEYLIE
Mflv_4589|M.gilvum_PYR-GCK ELTEFLRARVAKWWLPERWAFVADVPLTSTGKFDKKKLRSQHADGDLAVE
Mvan_0905|M.vanbaalenii_PYR-1 EVIRHLSARVAKWWLPDAVEFIDAVPKTSVGKFSKKTLRARFENYRFPDQ
MSMEG_5348|M.smegmatis_MC2_155 LVRDHLQQRVARWWIPDDIVIVDELPKTATGKISKRALRQNLCAPAG---
MLBr_01051|M.leprae_Br4923 ELINYVAQQLSIHKRPREVRFVDALPRNAMGKVLKKQLLFEG--------
: .: :: * : :* .: ** *: :
Mb1087|M.bovis_AF2122/97 EVHT
Rv1058|M.tuberculosis_H37Rv EVHT
MMAR_4412|M.marinum_M EVHN
MUL_0229|M.ulcerans_Agy99 DVHN
MAV_1186|M.avium_104 EARD
TH_2961|M.thermoresistible__bu HLGG
MAB_2080|M.abscessus_ATCC_1997 IETS
Mflv_4589|M.gilvum_PYR-GCK TLA-
Mvan_0905|M.vanbaalenii_PYR-1 GAPV
MSMEG_5348|M.smegmatis_MC2_155 ----
MLBr_01051|M.leprae_Br4923 ----