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QDVALTVPAIVAHAAAVHGDREVLTARGPQQISGVSYHELGQRAARLANALREIGVRGDERVATLQWSNQ EHLDCYAAVPSMGAVLHTLNLRLPPEQLTWIANHAEDQVIIVDGTVLNLLAGALPSMTSVHTVLVTGTGD LAAVQGCGKDVLRYDDVVGAQSSTFDWPDVDEQSAAAMCYTSGTTGRPKGVVYSHRSTWLHSQAACTSNA LGIGHDDTVLAIVPMFHANAWGLPYAAMMAGAQLLLPDRFLQAGPLVEMIEAARPTMAGAVPTIWTDVLH YLRDNPGHDLSSLKMVACGGSAVPRSLMTAYDELGIRIVQAWGMTETSPLAAVALPRDTDTPERSLYLRG TQGRVVAGVQARIVDDSGAEQPWDGKSVGEIQIRGPWITQSYYEYDSPAVSPDGWLCTGDVGTISADAFI TLTDRAKDVIKSGGEWISSVELENELAAHPAVRTATVIGVPDDKWQERPLAVVVLAADCTATAAELTEFL RARVAKWWLPERWAFVADVPLTSTGKFDKKKLRSQHADGDLAVETLA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4589 | - | - | 100% (538) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_1585 | - | e-133 | 44.94% (543) | AMP-dependent synthetase and ligase |
| M. gilvum PYR-GCK | Mflv_4616 | - | 4e-60 | 32.00% (525) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1087 | fadD14 | 0.0 | 59.32% (531) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1058 | fadD14 | 0.0 | 59.32% (531) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 3e-42 | 31.03% (493) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2080 | - | 0.0 | 63.25% (536) | acyl-CoA synthetase |
| M. marinum M | MMAR_3151 | - | 0.0 | 92.94% (538) | medium chain fatty-acid-CoA ligase |
| M. avium 104 | MAV_1186 | - | 0.0 | 60.00% (535) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5291 | - | 0.0 | 61.02% (531) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2961 | - | 0.0 | 61.52% (538) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_0229 | fadD14 | 0.0 | 62.26% (530) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_5172 | - | 1e-129 | 44.04% (545) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4589|M.gilvum_PYR-GCK --------------------------MQDVALTVPAIVAHAAAVHGDREV
MMAR_3151|M.marinum_M ----------------------MRSTMQDVALTVPAIVAHASAVHGDREV
Mb1087|M.bovis_AF2122/97 ----------------------MYGTMQDFPLTITAIMRHGCGVHGRRTV
Rv1058|M.tuberculosis_H37Rv ----------------------MYGTMQDFPLTITAIMRHGCGVHGRRTV
MUL_0229|M.ulcerans_Agy99 ----------------------MYSTMQDFPLTITAIMRHGCGVHGSRQV
MAV_1186|M.avium_104 ----------------------MDGTMQDFPLTITAIMRHGCSVHGARTV
TH_2961|M.thermoresistible__bu ----------------------MQSTMQPIPLTVAAIMRYAIEVHGDRTV
MSMEG_5291|M.smegmatis_MC2_155 --------------------------MQQWPLTITAILRHACGVNGDQTV
MAB_2080|M.abscessus_ATCC_1997 --------------------------MQNVPLTVSAIVQHAAAIHGDSEV
Mvan_5172|M.vanbaalenii_PYR-1 ----------------------MFGLMQDRPLMISSLIEHAAAFHGDTEI
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
: . : : . * :
Mflv_4589|M.gilvum_PYR-GCK LTARGPQQ----------ISGVSYHELGQRAARLANALREIGVRGDERVA
MMAR_3151|M.marinum_M LTARGPRQ----------ISGVSYREVGERAARLANALRQIGIRGDERVA
Mb1087|M.bovis_AF2122/97 TTATGEG-----------YRHSSYRDVGQRAGQLANALRRLGVTGDQRVA
Rv1058|M.tuberculosis_H37Rv TTATGEG-----------YRHSSYRDVGQRAGQLANALRRLGVTGDQRVA
MUL_0229|M.ulcerans_Agy99 ITATGDA-----------YRQTTYREVGQRAAQLANALRGLGISGDQRVA
MAV_1186|M.avium_104 TTATGDG-----------YRRTSYRELGDRAAQLANALRGLGVTGDQRVA
TH_2961|M.thermoresistible__bu TTATGDGG----------YRHATYADLGREAARLANALRRLGITGDERVA
MSMEG_5291|M.smegmatis_MC2_155 TTATGQGG----------FRTTTYREVGERAAQLAHLLREVGITGDERVG
MAB_2080|M.abscessus_ATCC_1997 VTPTGNG-----------YRRTPYRIVLARVARLANALRSLGVTADQRVA
Mvan_5172|M.vanbaalenii_PYR-1 VSRLPEGP----------VRRTTWREINEHSKQVANALAELGIEQGDRVA
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
. .: : :*: * *: .: :.
Mflv_4589|M.gilvum_PYR-GCK TLQWSNQEHLDCYAAVPSMGAVLHTLNLRLPPEQLTWIANHAEDQVIIVD
MMAR_3151|M.marinum_M TLQWSNQEHLDCYAAVPSMGAVLHTLNLRLPPEQLTWIANHAEDRVIIVD
Mb1087|M.bovis_AF2122/97 TFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFPEQIAYVTNEAEDRVILVD
Rv1058|M.tuberculosis_H37Rv TFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFPEQIAYVTNEAEDRVILVD
MUL_0229|M.ulcerans_Agy99 TFMWNNAEHLVTYLAVPSMGAVLHTLNIRLFAEQIAYVANEAEDQVVLVD
MAV_1186|M.avium_104 TFMWNNAEHLAAYLAVPSMGAVLHTLNIRLFPEQIAYVANEAGDQVVLVD
TH_2961|M.thermoresistible__bu TFQWNNQEHLATYVAVPSMGAVLHTLNIRLFPEQLQFIAYEAQDRVVIVD
MSMEG_5291|M.smegmatis_MC2_155 TFMWNNTEHLTAYLAIPAMGAVLHTLNIRLSPEQIGFIAREAEDRVIITD
MAB_2080|M.abscessus_ATCC_1997 TFQWSNQEHLEAYCAIPSMGAVLHTLNIRLAPEQLAYIANHASDQIVLVD
Mvan_5172|M.vanbaalenii_PYR-1 TLAWNSDRHLALYFGVSGSGAVMHTVNPRLFPEQIAYIVNHAEDRVLFFD
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
: . .: . . ** : :* .: *: : . :::: *
Mflv_4589|M.gilvum_PYR-GCK GTVLNLLAGALPSMTSVHTVLVTGTGDLAA--VQGCGKDVLRYDDVVGAQ
MMAR_3151|M.marinum_M STVLALLAAALPSMTSVRTVLVTGTGDLAA--VEGCGKDVLRYDDVVAAQ
Mb1087|M.bovis_AF2122/97 LSLARLLAPVLPKLDTVHTVIAVGEGDTTP--LREAGKTVLRFAELIDAE
Rv1058|M.tuberculosis_H37Rv LSLARLLAPVLPKLDTVHTVIAVGEGDTTP--LREAGKTVLRFAELIDAE
MUL_0229|M.ulcerans_Agy99 LSLTNLLAPVLPNLDTVHTVIAVGEGDTAA--LEESGKTVLRYDELLDGQ
MAV_1186|M.avium_104 ASLVKLLAPVLPGLHTVHTVIVVGDGDTEP--LRASGKTVLRYADVIGAE
TH_2961|M.thermoresistible__bu ASLVPLLAPVLPTMETVHTVIVVGAGDLSP--LQVPGKQVLRYEEILAAE
MSMEG_5291|M.smegmatis_MC2_155 SSLIPLLAPVLPLVDSVHTVIVVGDGDLEP--LRGADRTVLRYDEAMAGR
MAB_2080|M.abscessus_ATCC_1997 ASVAPLLARALPAMASVHTVIVTGEGDLAP--LQGCGKTVLRYEEVLAGQ
Mvan_5172|M.vanbaalenii_PYR-1 ITFAPLVAQLAGELGTVETFVAMTDRDHMPDIPQIPDGRLRCWDDFIGGQ
MLBr_02546|M.leprae_Br4923 DEYTKVVSKAEPALGKLRALGVNPDEEEPP------GSTDETLAELIAR-
::: : .:.:. . : . . : :
Mflv_4589|M.gilvum_PYR-GCK SSTFDWPDVDEQSAAAMCYTSGTTGRPKGVVYSHRSTWLHSQAACTSNAL
MMAR_3151|M.marinum_M SSTFEWPDVDERSAAAMCYTSGTTGHPKGVVYSHRSTWLHSQAACTSNAL
Mb1087|M.bovis_AF2122/97 SPDFGWPQIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTTNGI
Rv1058|M.tuberculosis_H37Rv SPDFGWPQIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTTNGI
MUL_0229|M.ulcerans_Agy99 STEFDWPHIDENSAAAMCYTSGTTGHPKGVVYSHRSSFLHSMATCTANGI
MAV_1186|M.avium_104 PAEFDWPRIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTANGI
TH_2961|M.thermoresistible__bu SDEFDWPELDENSAAAMCYTSGTTGHPKGVVYSHRSSYLHSTAVCSGNGL
MSMEG_5291|M.smegmatis_MC2_155 PTRFDWPDIDENSAAAMCYTSGTTGNPKGVVYSHRSSYLHSLNTCTANAL
MAB_2080|M.abscessus_ATCC_1997 EESFDWPRLDELSAAAMCYTSGTTGDPKGVVYSHRSTYLHSLTACTANAL
Mvan_5172|M.vanbaalenii_PYR-1 STAFDWPEFDERSASSLCYTSGTTGNPKGVLYSHRSTMLHTLMIAARDAI
MLBr_02546|M.leprae_Br4923 SSSAPAPKVRKR-ASIIILTSGTTGTPKGANRNTPASLAPLGGILS--KV
* . : *: : ****** ***. . :: : :
Mflv_4589|M.gilvum_PYR-GCK GIGHDDTVLAIVPMFHANAWGLPYAAMMAGAQLLLPDRFLQAGPLVEMIE
MMAR_3151|M.marinum_M GIGHDDTVLAIVPMFHANAWGLPYAAMMAGAQLLLPDRFLQAGPLVEMIE
Mb1087|M.bovis_AF2122/97 GVGSSDKVLPIVPMFHANGWGLPYAALMAGADLVLPDRHLDARSLIHMVE
Rv1058|M.tuberculosis_H37Rv GVGSSDKVLPIVPMFHANGWGLPYAALMAGADLVLPDRHLDARSLIHMVE
MUL_0229|M.ulcerans_Agy99 GLGSSDRVLPIVPMFHANAWGLPYAALMAGADLVLPDRHLDARSLVHMVE
MAV_1186|M.avium_104 GIGATDSLLPIVPMFHANAWGLPYAALMAGADLVLPDCHLDPRSLVRMVE
TH_2961|M.thermoresistible__bu GLGFEDRVLPIVPMFHANAWGLPYAALMAGADLVMPDRYLDAKSLVNLIE
MSMEG_5291|M.smegmatis_MC2_155 DVSCGDVVLPIVPMFHANAWGLPYAALMAGAGLVMPDRFLDGASLIELIE
MAB_2080|M.abscessus_ATCC_1997 SVSEADRVLAIVPMFHANAWGLIYAALMSGADLVLPDRYLQAEPLVSIIE
Mvan_5172|M.vanbaalenii_PYR-1 DIHSGSVILLVVPMFHANAWGTPYTAAMVGAKLVMPGPHLDGQSVYELMK
MLBr_02546|M.leprae_Br4923 PFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKP-ATVLEDIE
. . * .***** .: * : *: *:: . .: ::
Mflv_4589|M.gilvum_PYR-GCK AARPTMAGAVPTIWTDVLHYLR-DNPGHDLSSL--KMVACGGSAVPRSLM
MMAR_3151|M.marinum_M AVRPTMAGAVPTIWTDVLHYLR-DNPGHDVSSL--KMVACGGSAVPRSLM
Mb1087|M.bovis_AF2122/97 TLKPTLAGAVPTIWNDVMHYLE-KDPDHDMSSL--RLVACGGSAVPESLM
Rv1058|M.tuberculosis_H37Rv TLKPTLAGAVPTIWNDVMHYLE-KDPDHDMSSL--RLVACGGSAVPESLM
MUL_0229|M.ulcerans_Agy99 NLRPTRAGAVPTIWNDVMHYLE-KNPGHDVSSL--GLVACGGSAVPESLM
MAV_1186|M.avium_104 DLRPTVTGAVPTIWNAVLHHLE-DDPDHDMSSL--RLVVCGGSAVPVSLM
TH_2961|M.thermoresistible__bu TQRPTVAGAVPTIWNDVLHHLD-SEPDHDISSL--RLVGCGGSAVPVSLM
MSMEG_5291|M.smegmatis_MC2_155 TQRPTLAGAVPTIWNDVLNCLE-KSPGHDISSL--RLVACGGSAVPLSLM
MAB_2080|M.abscessus_ATCC_1997 DTRPTVAGAVPTIWNDVDRYLD-SHPERDISSL--RLVACGGSAVPLSLM
Mvan_5172|M.vanbaalenii_PYR-1 AEGVNQSQGVPTVWMMLFSYLD-EHPEIDAHELGLRVAGTGGAALPLSMI
MLBr_02546|M.leprae_Br4923 KHQATAMVVVPVMLSRILDTLENLETKSDLSSL--RVVFVSGSQLGAELA
. **.: : * . * .* :. .*: : .:
Mflv_4589|M.gilvum_PYR-GCK TAYDELG-IRIVQAWGMTETSPLAAVALPRDTDT---PERSLYLRGTQGR
MMAR_3151|M.marinum_M TAYDELG-IRIVQAWGMTETSPLASVALPRSSDT---PERSLHLRATQGR
Mb1087|M.bovis_AF2122/97 RTFEDKHDVQIRQLWGMTETSPLATMAWPPPGTP---DDQHWAFRITQGQ
Rv1058|M.tuberculosis_H37Rv RTFEDKHDVQIRQLWGMTETSPLATMAWPPPGTP---DDQHWAFRITQGQ
MUL_0229|M.ulcerans_Agy99 RTFEEKYGVQIRQLWGMTETSPLATMAWPPPGTP---PDRHWAIRSTQGQ
MAV_1186|M.avium_104 RTFEEKHGVQIRQLWGMTETSPLATMAWPPPGTP---EDQHWAYRGTQGQ
TH_2961|M.thermoresistible__bu QSFEEKFGVQIRQLWGMTETSPVCTLAWPAPNTP---ADRHWEVRGSQGR
MSMEG_5291|M.smegmatis_MC2_155 QAFQERHDVYIQQAWGMTETSPLATVAKPLPGVT---DERHWAMRITQGR
MAB_2080|M.abscessus_ATCC_1997 RAFEEKYNVPIVQAWGMTETSPLATVARPAHRAD---ATRRWEMRASQGR
Mvan_5172|M.vanbaalenii_PYR-1 ERFHRDFGAESMQGWGMTETSPLCVVGRLLPKHEGLSDAEKNQIRLKQGR
MLBr_02546|M.leprae_Br4923 TRALEELGPVIYNMYGSTEIAFATIAGPKDLQIN----------SATVGP
: :* ** : . . *
Mflv_4589|M.gilvum_PYR-GCK VVAGVQARIVDDSGAEQPWDGKSVGEIQIRGPWITQSYYEYDSPAVSP-D
MMAR_3151|M.marinum_M VVAGVQARIVDDSGAEQPWDGKSVGEIQVRGPWITQSYYENDSPAASP-D
Mb1087|M.bovis_AF2122/97 PVCGVETRIVDDDGQVLPNDGNAVGEVEVRGPWIAGSYYGGRDESKFD-S
Rv1058|M.tuberculosis_H37Rv PVCGVETRIVDDDGQVLPNDGNAVGEVEVRGPWIAGSYYGGRDESKFD-S
MUL_0229|M.ulcerans_Agy99 PVCGVETRIVDDNGEALPNDGQAVGEVEVRGPWITGAYYLGYDQSEFD-S
MAV_1186|M.avium_104 PVCGVQMRIVDDDGRVLPNDGTAVGEVEVRGPWIAGSYYLGRDDSKFD-S
TH_2961|M.thermoresistible__bu PICGVEARIVDDEGNVLPRDNEAVGELEVRGPWITGSYYHDADPSKFE-N
MSMEG_5291|M.smegmatis_MC2_155 PMCGVEVRIVDDAGNPLPSDGKAVGELEVRGPWITGGYYLGRDAEKFD-S
MAB_2080|M.abscessus_ATCC_1997 PICGVEIRLRDDDGKDVPWDGQSVGEIQARGPWITGSYFGDNDTEKFD-E
Mvan_5172|M.vanbaalenii_PYR-1 GVWGVDLKIVDDDGNRLPWDGKAFGEVWVRGPWIASGYFRGEGGEKLDAE
MLBr_02546|M.leprae_Br4923 VVKGVKVKILDDSGKEVPRG--QVGRIFVGNAFPFEGYTGGGGKQIID--
: **. :: ** * * . .*.: ..: .* .
Mflv_4589|M.gilvum_PYR-GCK GWLCTGDVGTISADAFITLTDRAKDVIKSGGEWISSVELENELAAHPAVR
MMAR_3151|M.marinum_M GWLRTGDVGTISADALIALTDRSKDVIKSGGEWISSVELENELAAHPAVR
Mb1087|M.bovis_AF2122/97 GWLRTGDVGRIDEQGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVL
Rv1058|M.tuberculosis_H37Rv GWLRTGDVGRIDEQGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVL
MUL_0229|M.ulcerans_Agy99 GWLRTGDVGRIDELGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVV
MAV_1186|M.avium_104 GWLRTGDVGRIDERGFVTLTDRAKDVIKSGGEWISSVELENCLIGHPDVV
TH_2961|M.thermoresistible__bu GWLRTGDVGRMDAQSYITLTDRAKDVIKSGGEWISSVELENHLIGHPKVR
MSMEG_5291|M.smegmatis_MC2_155 GWLRTGDVGVIDELGYVTLTDRAKDVIKSGGEWISSVELENHLIGHPAVL
MAB_2080|M.abscessus_ATCC_1997 GWLRTGDVGKIDAEGYLTLTDRSKDVIKSGGEWISSVELENTLIGHPAVY
Mvan_5172|M.vanbaalenii_PYR-1 GFFPTGDVATIDPDGYLQLVDRAKDVIKSGGEWVSSIDLENAALGHPAVA
MLBr_02546|M.leprae_Br4923 GLLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVV
* : :***. :. : : .* .::* **** : . ::*: .** *
Mflv_4589|M.gilvum_PYR-GCK TATVIGVPDDKWQERPLAVVVLAADCTATAAELTEFLRARVAKWWLPERW
MMAR_3151|M.marinum_M TATVIGVPDDKWQERPLAVVVLAADRTATAAELTEFLRARVAKWWLPERW
Mb1087|M.bovis_AF2122/97 EAAVVGVPDERWQERPLAVVVVREGATVSAGDLRAFLADKVVRWWLPERW
Rv1058|M.tuberculosis_H37Rv EAAVVGVPDERWQERPLAVVVVREGATVSAGDLRAFLADKVVRWWLPERW
MUL_0229|M.ulcerans_Agy99 EAAVVGVPDERWQERPLAVVVRREGATVSAAELRKFLADRVVRWWLPERW
MAV_1186|M.avium_104 EAAVVGVPDERWEERPLAVVVVKDGASVDADQLRKFLADKVVRWWLPERW
TH_2961|M.thermoresistible__bu EAAVVGVPDDRWQERPLAAVVLHEGQQATPEELREFLSDKVVRWWLPERW
MSMEG_5291|M.smegmatis_MC2_155 EAAVVGVPDERWQERPLAVVVLHEGSSADPGELREFLADKVVRWWLPERW
MAB_2080|M.abscessus_ATCC_1997 EAAVVGVADDKWQERPLALVVVHPGTDVDIDQLRSFLADKVAKWWIPERW
Mvan_5172|M.vanbaalenii_PYR-1 EAAVIGVPHPKWQERPLLIVVLRKGHHATREDILEYLAGEVVKWWLPDDV
MLBr_02546|M.leprae_Br4923 EATAIGVDDKEWGARLRAFVVKKQDATIDEDAIKAYVRDHLARYKVPREV
*:.:** . .* * ** . : :: .:.:: :*
Mflv_4589|M.gilvum_PYR-GCK AFVADVPLTSTGKFDKKKLRSQHADGDLAVETLA-
MMAR_3151|M.marinum_M AFVTDIPLTSTGKFDKKKLRRQFADGDLIIETLA-
Mb1087|M.bovis_AF2122/97 AFVDEIPRTSVGKYDKKAIRSRYAEGAYQITEVHT
Rv1058|M.tuberculosis_H37Rv AFVDEIPRTSVGKYDKKAIRSRYAEGAYQITEVHT
MUL_0229|M.ulcerans_Agy99 AFADQVPRTSVGKYDKKTIRAGYAESVYQVTDVHN
MAV_1186|M.avium_104 TFVDEIPRTSVGKYDKKAVRSRYADGGYRVIEARD
TH_2961|M.thermoresistible__bu TFVEEIPRTSVGKYDKKTIRARYADGAYQVTHLGG
MSMEG_5291|M.smegmatis_MC2_155 AFVDQVPRTSVGKYDKKTIRARHAEGAYEVIHL--
MAB_2080|M.abscessus_ATCC_1997 SFVSDIPRTSVGKYDKKAIRARHSAGEYLIEIETS
Mvan_5172|M.vanbaalenii_PYR-1 VFVDELPHTATGKVLKLKLREQYRDHRLSQPE---
MLBr_02546|M.leprae_Br4923 IFLEELPRNPTGKVLKRELRDFEVH----------
* ::* ...** * :*