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FGLMQDRPLMISSLIEHAAAFHGDTEIVSRLPEGPVRRTTWREINEHSKQVANALAELGIEQGDRVATLA WNSDRHLALYFGVSGSGAVMHTVNPRLFPEQIAYIVNHAEDRVLFFDITFAPLVAQLAGELGTVETFVAM TDRDHMPDIPQIPDGRLRCWDDFIGGQSTAFDWPEFDERSASSLCYTSGTTGNPKGVLYSHRSTMLHTLM IAARDAIDIHSGSVILLVVPMFHANAWGTPYTAAMVGAKLVMPGPHLDGQSVYELMKAEGVNQSQGVPTV WMMLFSYLDEHPEIDAHELGLRVAGTGGAALPLSMIERFHRDFGAESMQGWGMTETSPLCVVGRLLPKHE GLSDAEKNQIRLKQGRGVWGVDLKIVDDDGNRLPWDGKAFGEVWVRGPWIASGYFRGEGGEKLDAEGFFP TGDVATIDPDGYLQLVDRAKDVIKSGGEWVSSIDLENAALGHPAVAEAAVIGVPHPKWQERPLLIVVLRK GHHATREDILEYLAGEVVKWWLPDDVVFVDELPHTATGKVLKLKLREQYRDHRLSQPE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5172 | - | - | 100% (549) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_0905 | - | e-123 | 41.82% (550) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_4008 | - | 4e-52 | 30.56% (517) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1087 | fadD14 | 1e-139 | 45.94% (542) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_1585 | - | 0.0 | 87.07% (549) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv1058 | fadD14 | 1e-139 | 45.94% (542) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 2e-39 | 26.86% (525) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2080 | - | 1e-136 | 44.88% (537) | acyl-CoA synthetase |
| M. marinum M | MMAR_4412 | fadD14 | 1e-137 | 45.39% (542) | medium chain fatty-acid-CoA ligase FadD14 |
| M. avium 104 | MAV_1186 | - | 1e-136 | 45.74% (540) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5291 | - | 1e-143 | 47.03% (538) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2961 | - | 1e-137 | 43.83% (543) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_0229 | fadD14 | 1e-135 | 45.02% (542) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5172|M.vanbaalenii_PYR-1 ----------------------MFGLMQDRPLMISSLIEHAAAFHGDTEI
Mflv_1585|M.gilvum_PYR-GCK ----------------------MLGLMQDRPLMISSLIEHAAAFHGDTEI
Mb1087|M.bovis_AF2122/97 ----------------------MYGTMQDFPLTITAIMRHGCGVHGRRTV
Rv1058|M.tuberculosis_H37Rv ----------------------MYGTMQDFPLTITAIMRHGCGVHGRRTV
MMAR_4412|M.marinum_M ----------------------MYSTMQDFPLTITAIMRHGCGVHGSRQV
MUL_0229|M.ulcerans_Agy99 ----------------------MYSTMQDFPLTITAIMRHGCGVHGSRQV
MAV_1186|M.avium_104 ----------------------MDGTMQDFPLTITAIMRHGCSVHGARTV
TH_2961|M.thermoresistible__bu ----------------------MQSTMQPIPLTVAAIMRYAIEVHGDRTV
MSMEG_5291|M.smegmatis_MC2_155 --------------------------MQQWPLTITAILRHACGVNGDQTV
MAB_2080|M.abscessus_ATCC_1997 --------------------------MQNVPLTVSAIVQHAAAIHGDSEV
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
: * : : . * :
Mvan_5172|M.vanbaalenii_PYR-1 VSRLPEGP----------VRRTTWREINEHSKQVANALAELGIEQGDRVA
Mflv_1585|M.gilvum_PYR-GCK VSRLPEGP----------VRRTTWREIGERAKQVANALAELGVRHGDRVA
Mb1087|M.bovis_AF2122/97 TTATGEG-----------YRHSSYRDVGQRAGQLANALRRLGVTGDQRVA
Rv1058|M.tuberculosis_H37Rv TTATGEG-----------YRHSSYRDVGQRAGQLANALRRLGVTGDQRVA
MMAR_4412|M.marinum_M ITATGDA-----------YRQTTYREVGQRAAQLANALRGLGISGDQRVA
MUL_0229|M.ulcerans_Agy99 ITATGDA-----------YRQTTYREVGQRAAQLANALRGLGISGDQRVA
MAV_1186|M.avium_104 TTATGDG-----------YRRTSYRELGDRAAQLANALRGLGVTGDQRVA
TH_2961|M.thermoresistible__bu TTATGDGG----------YRHATYADLGREAARLANALRRLGITGDERVA
MSMEG_5291|M.smegmatis_MC2_155 TTATGQGG----------FRTTTYREVGERAAQLAHLLREVGITGDERVG
MAB_2080|M.abscessus_ATCC_1997 VTPTGNG-----------YRRTPYRIVLARVARLANALRSLGVTADQRVA
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
. .: : :*: * *: .: :.
Mvan_5172|M.vanbaalenii_PYR-1 TLAWNSDRHLALYFGVSGSGAVMHTVNPRLFPEQIAYIVNHAEDRVLFFD
Mflv_1585|M.gilvum_PYR-GCK TLAWNSDRHLALYFGVSGTGAVMHTVNPRLFPEQISYIVNHAEDRVLFFD
Mb1087|M.bovis_AF2122/97 TFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFPEQIAYVTNEAEDRVILVD
Rv1058|M.tuberculosis_H37Rv TFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFPEQIAYVTNEAEDRVILVD
MMAR_4412|M.marinum_M TFMWNNAEHLVAYLAVPSMGAVLHTLNIRLFAEQIAYVANEAEDQVVLVD
MUL_0229|M.ulcerans_Agy99 TFMWNNAEHLVTYLAVPSMGAVLHTLNIRLFAEQIAYVANEAEDQVVLVD
MAV_1186|M.avium_104 TFMWNNAEHLAAYLAVPSMGAVLHTLNIRLFPEQIAYVANEAGDQVVLVD
TH_2961|M.thermoresistible__bu TFQWNNQEHLATYVAVPSMGAVLHTLNIRLFPEQLQFIAYEAQDRVVIVD
MSMEG_5291|M.smegmatis_MC2_155 TFMWNNTEHLTAYLAIPAMGAVLHTLNIRLSPEQIGFIAREAEDRVIITD
MAB_2080|M.abscessus_ATCC_1997 TFQWSNQEHLEAYCAIPSMGAVLHTLNIRLAPEQLAYIANHASDQIVLVD
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
: . .: . . ** : :* .: *: : . :::: *
Mvan_5172|M.vanbaalenii_PYR-1 ITFAPLVAQLAGELGTVETFVAMTDRDHMPDIPQIPDGRLRCWDDFIGGQ
Mflv_1585|M.gilvum_PYR-GCK ITFAPLVSGLASSFDSVEYFVAMTDREHMPDVPGISADRLLCWEDVIGRQ
Mb1087|M.bovis_AF2122/97 LSLARLLAPVLPKLDTVHTVIAVGEGDTTP--LREAGKTVLRFAELIDAE
Rv1058|M.tuberculosis_H37Rv LSLARLLAPVLPKLDTVHTVIAVGEGDTTP--LREAGKTVLRFAELIDAE
MMAR_4412|M.marinum_M LSLTNLLAPVLPDLGTVHTVIAVGEGDTAP--LEESGKTVLRYDELLDGQ
MUL_0229|M.ulcerans_Agy99 LSLTNLLAPVLPNLDTVHTVIAVGEGDTAA--LEESGKTVLRYDELLDGQ
MAV_1186|M.avium_104 ASLVKLLAPVLPGLHTVHTVIVVGDGDTEP--LRASGKTVLRYADVIGAE
TH_2961|M.thermoresistible__bu ASLVPLLAPVLPTMETVHTVIVVGAGDLSP--LQVPGKQVLRYEEILAAE
MSMEG_5291|M.smegmatis_MC2_155 SSLIPLLAPVLPLVDSVHTVIVVGDGDLEP--LRGADRTVLRYDEAMAGR
MAB_2080|M.abscessus_ATCC_1997 ASVAPLLARALPAMASVHTVIVTGEGDLAP--LQGCGKTVLRYEEVLAGQ
MLBr_02546|M.leprae_Br4923 DEYTKVVSKAEPALGKLRALGVNPDEEEPP------GSTDETLAELIAR-
::: . .:. . . : . : :
Mvan_5172|M.vanbaalenii_PYR-1 STAFDWPEFDERSASSLCYTSGTTGNPKGVLYSHRSTMLHTLMIAARDAI
Mflv_1585|M.gilvum_PYR-GCK STHYEWPEFDECSASSLCYTSGTTGNPKGVLYSHRSTMLHTLMAAARDTI
Mb1087|M.bovis_AF2122/97 SPDFGWPQIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTTNGI
Rv1058|M.tuberculosis_H37Rv SPDFGWPQIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTTNGI
MMAR_4412|M.marinum_M PTEFDWPHIDENSAAAMCYTSGTTGHPKGVVYSHRSSFLHSMATCTANGI
MUL_0229|M.ulcerans_Agy99 STEFDWPHIDENSAAAMCYTSGTTGHPKGVVYSHRSSFLHSMATCTANGI
MAV_1186|M.avium_104 PAEFDWPRIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTANGI
TH_2961|M.thermoresistible__bu SDEFDWPELDENSAAAMCYTSGTTGHPKGVVYSHRSSYLHSTAVCSGNGL
MSMEG_5291|M.smegmatis_MC2_155 PTRFDWPDIDENSAAAMCYTSGTTGNPKGVVYSHRSSYLHSLNTCTANAL
MAB_2080|M.abscessus_ATCC_1997 EESFDWPRLDELSAAAMCYTSGTTGDPKGVVYSHRSTYLHSLTACTANAL
MLBr_02546|M.leprae_Br4923 SSSAPAPKVRKR-ASIIILTSGTTGTPKGANRNTPASLAPLGGILS--KV
* . : *: : ****** ***. . :: : :
Mvan_5172|M.vanbaalenii_PYR-1 DIHSGSVILLVVPMFHANAWGTPYTAAMVGAKLVMPGPHLDGQSVYELMK
Mflv_1585|M.gilvum_PYR-GCK DIHSGSVILLVVPMFHANAWGSPYTAAMVGAKLVMPGPHLDGESVYQLMK
Mb1087|M.bovis_AF2122/97 GVGSSDKVLPIVPMFHANGWGLPYAALMAGADLVLPDRHLDARSLIHMVE
Rv1058|M.tuberculosis_H37Rv GVGSSDKVLPIVPMFHANGWGLPYAALMAGADLVLPDRHLDARSLIHMVE
MMAR_4412|M.marinum_M GVGSNDRVLPIVPMFHANAWGLPYAALMAGADLVLPDRHLDARSLVHMVE
MUL_0229|M.ulcerans_Agy99 GLGSSDRVLPIVPMFHANAWGLPYAALMAGADLVLPDRHLDARSLVHMVE
MAV_1186|M.avium_104 GIGATDSLLPIVPMFHANAWGLPYAALMAGADLVLPDCHLDPRSLVRMVE
TH_2961|M.thermoresistible__bu GLGFEDRVLPIVPMFHANAWGLPYAALMAGADLVMPDRYLDAKSLVNLIE
MSMEG_5291|M.smegmatis_MC2_155 DVSCGDVVLPIVPMFHANAWGLPYAALMAGAGLVMPDRFLDGASLIELIE
MAB_2080|M.abscessus_ATCC_1997 SVSEADRVLAIVPMFHANAWGLIYAALMSGADLVLPDRYLQAEPLVSIIE
MLBr_02546|M.leprae_Br4923 PFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLR-RRFKPATVLEDIE
. . * .***** .: * : *: **: :. .: ::
Mvan_5172|M.vanbaalenii_PYR-1 AEGVNQSQGVPTVWMMLFSYLD-EHPEIDAHELGLRVAGTGGAALPLSMI
Mflv_1585|M.gilvum_PYR-GCK AEGVNQSQGVPTVWMMLFAYLD-EHPEIDAHELGLRYAGTGGAALPLSMI
Mb1087|M.bovis_AF2122/97 TLKPTLAGAVPTIWNDVMHYLE-KDPDHDMSSL--RLVACGGSAVPESLM
Rv1058|M.tuberculosis_H37Rv TLKPTLAGAVPTIWNDVMHYLE-KDPDHDMSSL--RLVACGGSAVPESLM
MMAR_4412|M.marinum_M NLRPTRAGAVPTIWNDVMHYLE-KNPGHDVSSL--GLVACGGSAVPESLM
MUL_0229|M.ulcerans_Agy99 NLRPTRAGAVPTIWNDVMHYLE-KNPGHDVSSL--GLVACGGSAVPESLM
MAV_1186|M.avium_104 DLRPTVTGAVPTIWNAVLHHLE-DDPDHDMSSL--RLVVCGGSAVPVSLM
TH_2961|M.thermoresistible__bu TQRPTVAGAVPTIWNDVLHHLD-SEPDHDISSL--RLVGCGGSAVPVSLM
MSMEG_5291|M.smegmatis_MC2_155 TQRPTLAGAVPTIWNDVLNCLE-KSPGHDISSL--RLVACGGSAVPLSLM
MAB_2080|M.abscessus_ATCC_1997 DTRPTVAGAVPTIWNDVDRYLD-SHPERDISSL--RLVACGGSAVPLSLM
MLBr_02546|M.leprae_Br4923 KHQATAMVVVPVMLSRILDTLENLETKSDLSSL--RVVFVSGSQLGAELA
. **.: : *: . * .* . .*: : .:
Mvan_5172|M.vanbaalenii_PYR-1 ERFHRDFGAESMQGWGMTETSPLCVVGRLLPKHEGLSDAEKNQIRLKQGR
Mflv_1585|M.gilvum_PYR-GCK ERFEKDFGAEAYQGWGMTETSPLCVVGRPLPKHDALDPADRRSLRLKQGR
Mb1087|M.bovis_AF2122/97 RTFEDKHDVQIRQLWGMTETSPLATMAWPPP---GTPDDQHWAFRITQGQ
Rv1058|M.tuberculosis_H37Rv RTFEDKHDVQIRQLWGMTETSPLATMAWPPP---GTPDDQHWAFRITQGQ
MMAR_4412|M.marinum_M RTFEEKYGVQIRQLWGMTETSPLATMAWPPP---GTPPDRHWAIRSTQGQ
MUL_0229|M.ulcerans_Agy99 RTFEEKYGVQIRQLWGMTETSPLATMAWPPP---GTPPDRHWAIRSTQGQ
MAV_1186|M.avium_104 RTFEEKHGVQIRQLWGMTETSPLATMAWPPP---GTPEDQHWAYRGTQGQ
TH_2961|M.thermoresistible__bu QSFEEKFGVQIRQLWGMTETSPVCTLAWPAP---NTPADRHWEVRGSQGR
MSMEG_5291|M.smegmatis_MC2_155 QAFQERHDVYIQQAWGMTETSPLATVAKPLP---GVTDERHWAMRITQGR
MAB_2080|M.abscessus_ATCC_1997 RAFEEKYNVPIVQAWGMTETSPLATVARPAH---RADATRRWEMRASQGR
MLBr_02546|M.leprae_Br4923 TRALEELGPVIYNMYGSTEIA-FATIAGPKD---------LQINSATVGP
. : :* ** : ...:. . *
Mvan_5172|M.vanbaalenii_PYR-1 GVWGVDLKIVDDDGNRLPWDGKAFGEVWVRGPWIASGYFRGEGGEKLDAE
Mflv_1585|M.gilvum_PYR-GCK GIWGVEIKIVDDDGNRLPWDGKAFGEVWVRGPWIASGYYRGEGGDKLDGE
Mb1087|M.bovis_AF2122/97 PVCGVETRIVDDDGQVLPNDGNAVGEVEVRGPWIAGSYYGGRDESKFDS-
Rv1058|M.tuberculosis_H37Rv PVCGVETRIVDDDGQVLPNDGNAVGEVEVRGPWIAGSYYGGRDESKFDS-
MMAR_4412|M.marinum_M PVCGVETRIVDDNGEALPNDGQAVGEVEVRGPWITGAYYLGYDQSKFDS-
MUL_0229|M.ulcerans_Agy99 PVCGVETRIVDDNGEALPNDGQAVGEVEVRGPWITGAYYLGYDQSEFDS-
MAV_1186|M.avium_104 PVCGVQMRIVDDDGRVLPNDGTAVGEVEVRGPWIAGSYYLGRDDSKFDS-
TH_2961|M.thermoresistible__bu PICGVEARIVDDEGNVLPRDNEAVGELEVRGPWITGSYYHDADPSKFEN-
MSMEG_5291|M.smegmatis_MC2_155 PMCGVEVRIVDDAGNPLPSDGKAVGELEVRGPWITGGYYLGRDAEKFDS-
MAB_2080|M.abscessus_ATCC_1997 PICGVEIRLRDDDGKDVPWDGQSVGEIQARGPWITGSYFGDNDTEKFDE-
MLBr_02546|M.leprae_Br4923 VVKGVKVKILDDSGKEVPRG--QVGRIFVGNAFPFEGYTGGGGKQIIDG-
: **. :: ** *. :* . .*.: . ..: .* . . . ::
Mvan_5172|M.vanbaalenii_PYR-1 GFFPTGDVATIDPDGYLQLVDRAKDVIKSGGEWVSSIDLENAALGHPAVA
Mflv_1585|M.gilvum_PYR-GCK GFFPTGDVATIDPDGYLQLVDRTKDVIKSGGEWVSSIDLENAAMGHPAIA
Mb1087|M.bovis_AF2122/97 GWLRTGDVGRIDEQGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVL
Rv1058|M.tuberculosis_H37Rv GWLRTGDVGRIDEQGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVL
MMAR_4412|M.marinum_M GWLRTGDVGRIDELGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVV
MUL_0229|M.ulcerans_Agy99 GWLRTGDVGRIDELGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVV
MAV_1186|M.avium_104 GWLRTGDVGRIDERGFVTLTDRAKDVIKSGGEWISSVELENCLIGHPDVV
TH_2961|M.thermoresistible__bu GWLRTGDVGRMDAQSYITLTDRAKDVIKSGGEWISSVELENHLIGHPKVR
MSMEG_5291|M.smegmatis_MC2_155 GWLRTGDVGVIDELGYVTLTDRAKDVIKSGGEWISSVELENHLIGHPAVL
MAB_2080|M.abscessus_ATCC_1997 GWLRTGDVGKIDAEGYLTLTDRSKDVIKSGGEWISSVELENTLIGHPAVY
MLBr_02546|M.leprae_Br4923 -LLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVV
: :***. :* . : : .* .::* **** : . ::*: .** :
Mvan_5172|M.vanbaalenii_PYR-1 EAAVIGVPHPKWQERPLLIVVLRKGHHATREDILEYLAGEVVKWWLPDDV
Mflv_1585|M.gilvum_PYR-GCK EAAVIGVPHPKWQERPLLVAVLRKGHSATREDILEFLAERVVRWWLPDDV
Mb1087|M.bovis_AF2122/97 EAAVVGVPDERWQERPLAVVVVREGATVSAGDLRAFLADKVVRWWLPERW
Rv1058|M.tuberculosis_H37Rv EAAVVGVPDERWQERPLAVVVVREGATVSAGDLRAFLADKVVRWWLPERW
MMAR_4412|M.marinum_M EAAVVGVPDERWQERPLAVVVRREGATVSAAELRKFLADRVVRWWLPERW
MUL_0229|M.ulcerans_Agy99 EAAVVGVPDERWQERPLAVVVRREGATVSAAELRKFLADRVVRWWLPERW
MAV_1186|M.avium_104 EAAVVGVPDERWEERPLAVVVVKDGASVDADQLRKFLADKVVRWWLPERW
TH_2961|M.thermoresistible__bu EAAVVGVPDDRWQERPLAAVVLHEGQQATPEELREFLSDKVVRWWLPERW
MSMEG_5291|M.smegmatis_MC2_155 EAAVVGVPDERWQERPLAVVVLHEGSSADPGELREFLADKVVRWWLPERW
MAB_2080|M.abscessus_ATCC_1997 EAAVVGVADDKWQERPLALVVVHPGTDVDIDQLRSFLADKVAKWWIPERW
MLBr_02546|M.leprae_Br4923 EATAIGVDDKEWGARLRAFVVKKQDATIDEDAIKAYVRDHLARYKVPREV
**:.:** . .* * .* : . : :: .:.:: :*
Mvan_5172|M.vanbaalenii_PYR-1 VFVDELPHTATGKVLKLKLREQYRDHRLSQPE---
Mflv_1585|M.gilvum_PYR-GCK VFVDELPHTATGKVLKITLREQYRDHELSQPE---
Mb1087|M.bovis_AF2122/97 AFVDEIPRTSVGKYDKKAIRSRYAEGAYQITEVHT
Rv1058|M.tuberculosis_H37Rv AFVDEIPRTSVGKYDKKAIRSRYAEGAYQITEVHT
MMAR_4412|M.marinum_M AFADQVPRTSVGKYDKKTIRAGYAEGVYQVTEVHN
MUL_0229|M.ulcerans_Agy99 AFADQVPRTSVGKYDKKTIRAGYAESVYQVTDVHN
MAV_1186|M.avium_104 TFVDEIPRTSVGKYDKKAVRSRYADGGYRVIEARD
TH_2961|M.thermoresistible__bu TFVEEIPRTSVGKYDKKTIRARYADGAYQVTHLGG
MSMEG_5291|M.smegmatis_MC2_155 AFVDQVPRTSVGKYDKKTIRARHAEGAYEVIHL--
MAB_2080|M.abscessus_ATCC_1997 SFVSDIPRTSVGKYDKKAIRARHSAGEYLIEIETS
MLBr_02546|M.leprae_Br4923 IFLEELPRNPTGKVLKRELRDFEVH----------
* .::*:...** * :*