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M. abscessus ATCC 19977 MAB_2080 (-)

annotation: acyl-CoA synthetase
coordinates: 2079985 - 2081604
length: 539

MQNVPLTVSAIVQHAAAIHGDSEVVTPTGNGYRRTPYRIVLARVARLANALRSLGVTADQRVATFQWSNQ
EHLEAYCAIPSMGAVLHTLNIRLAPEQLAYIANHASDQIVLVDASVAPLLARALPAMASVHTVIVTGEGD
LAPLQGCGKTVLRYEEVLAGQEESFDWPRLDELSAAAMCYTSGTTGDPKGVVYSHRSTYLHSLTACTANA
LSVSEADRVLAIVPMFHANAWGLIYAALMSGADLVLPDRYLQAEPLVSIIEDTRPTVAGAVPTIWNDVDR
YLDSHPERDISSLRLVACGGSAVPLSLMRAFEEKYNVPIVQAWGMTETSPLATVARPAHRADATRRWEMR
ASQGRPICGVEIRLRDDDGKDVPWDGQSVGEIQARGPWITGSYFGDNDTEKFDEGWLRTGDVGKIDAEGY
LTLTDRSKDVIKSGGEWISSVELENTLIGHPAVYEAAVVGVADDKWQERPLALVVVHPGTDVDIDQLRSF
LADKVAKWWIPERWSFVSDIPRTSVGKYDKKAIRARHSAGEYLIEIETS
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. abscessus ATCC 19977MAB_2080--100% (539)acyl-CoA synthetase
M. abscessus ATCC 19977MAB_4559-2e-5831.44% (493) putative long-chain-fatty-acid CoA ligase
M. abscessus ATCC 19977MAB_3592c-2e-5331.55% (504) putative medium-chain acyl-CoA ligase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1087fadD140.064.19% (539) acyl-CoA synthetase
M. gilvum PYR-GCKMflv_4589-0.063.25% (536) acyl-CoA synthetase
M. tuberculosis H37RvRv1058fadD140.064.19% (539) acyl-CoA synthetase
M. leprae Br4923MLBr_02546fadD23e-4027.96% (540) acyl-CoA synthetase
M. marinum MMMAR_3133fadD14_10.085.05% (535) medium chain fatty-acid-CoA ligase FadD14_1
M. avium 104MAV_1186-0.065.73% (534) acyl-CoA synthetase
M. smegmatis MC2 155MSMEG_5291-0.066.60% (533) acyl-CoA synthetase
M. thermoresistible (build 8)TH_2961-0.067.85% (535) PUTATIVE AMP-dependent synthetase and ligase
M. ulcerans Agy99MUL_0229fadD140.064.79% (534) acyl-CoA synthetase
M. vanbaalenii PYR-1Mvan_5172-1e-13644.88% (537) AMP-dependent synthetase and ligase

CLUSTAL 2.0.9 multiple sequence alignment


MAB_2080|M.abscessus_ATCC_1997      --------------------------MQNVPLTVSAIVQHAAAIHGDSEV
MMAR_3133|M.marinum_M               --------------------------MQDVQLTISAIVRHAASIHGNSEV
Mb1087|M.bovis_AF2122/97            ----------------------MYGTMQDFPLTITAIMRHGCGVHGRRTV
Rv1058|M.tuberculosis_H37Rv         ----------------------MYGTMQDFPLTITAIMRHGCGVHGRRTV
MUL_0229|M.ulcerans_Agy99           ----------------------MYSTMQDFPLTITAIMRHGCGVHGSRQV
MAV_1186|M.avium_104                ----------------------MDGTMQDFPLTITAIMRHGCSVHGARTV
TH_2961|M.thermoresistible__bu      ----------------------MQSTMQPIPLTVAAIMRYAIEVHGDRTV
MSMEG_5291|M.smegmatis_MC2_155      --------------------------MQQWPLTITAILRHACGVNGDQTV
Mflv_4589|M.gilvum_PYR-GCK          --------------------------MQDVALTVPAIVAHAAAVHGDREV
Mvan_5172|M.vanbaalenii_PYR-1       ----------------------MFGLMQDRPLMISSLIEHAAAFHGDTEI
MLBr_02546|M.leprae_Br4923          MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
                                                              :        : :  .    *   :

MAB_2080|M.abscessus_ATCC_1997      VTPTGNG-----------YRRTPYRIVLARVARLANALRSLGVTADQRVA
MMAR_3133|M.marinum_M               ITPDGIG-----------YRSMSYRSVLGRAGRLANALRGLGITADQRVA
Mb1087|M.bovis_AF2122/97            TTATGEG-----------YRHSSYRDVGQRAGQLANALRRLGVTGDQRVA
Rv1058|M.tuberculosis_H37Rv         TTATGEG-----------YRHSSYRDVGQRAGQLANALRRLGVTGDQRVA
MUL_0229|M.ulcerans_Agy99           ITATGDA-----------YRQTTYREVGQRAAQLANALRGLGISGDQRVA
MAV_1186|M.avium_104                TTATGDG-----------YRRTSYRELGDRAAQLANALRGLGVTGDQRVA
TH_2961|M.thermoresistible__bu      TTATGDGG----------YRHATYADLGREAARLANALRRLGITGDERVA
MSMEG_5291|M.smegmatis_MC2_155      TTATGQGG----------FRTTTYREVGERAAQLAHLLREVGITGDERVG
Mflv_4589|M.gilvum_PYR-GCK          LTARGPQQ----------ISGVSYHELGQRAARLANALREIGVRGDERVA
Mvan_5172|M.vanbaalenii_PYR-1       VSRLPEGP----------VRRTTWREINEHSKQVANALAELGIEQGDRVA
MLBr_02546|M.leprae_Br4923          LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
                                     .                    .:  :      :*: *   *:  .: :.

MAB_2080|M.abscessus_ATCC_1997      TFQWSNQEHLEAYCAIPSMGAVLHTLNIRLAPEQLAYIANHASDQIVLVD
MMAR_3133|M.marinum_M               TFQWSNQEHLEAYCAVPSMGAVLHTLNIRLAPEQLAYIANHASDQIILVD
Mb1087|M.bovis_AF2122/97            TFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFPEQIAYVTNEAEDRVILVD
Rv1058|M.tuberculosis_H37Rv         TFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFPEQIAYVTNEAEDRVILVD
MUL_0229|M.ulcerans_Agy99           TFMWNNAEHLVTYLAVPSMGAVLHTLNIRLFAEQIAYVANEAEDQVVLVD
MAV_1186|M.avium_104                TFMWNNAEHLAAYLAVPSMGAVLHTLNIRLFPEQIAYVANEAGDQVVLVD
TH_2961|M.thermoresistible__bu      TFQWNNQEHLATYVAVPSMGAVLHTLNIRLFPEQLQFIAYEAQDRVVIVD
MSMEG_5291|M.smegmatis_MC2_155      TFMWNNTEHLTAYLAIPAMGAVLHTLNIRLSPEQIGFIAREAEDRVIITD
Mflv_4589|M.gilvum_PYR-GCK          TLQWSNQEHLDCYAAVPSMGAVLHTLNLRLPPEQLTWIANHAEDQVIIVD
Mvan_5172|M.vanbaalenii_PYR-1       TLAWNSDRHLALYFGVSGSGAVMHTVNPRLFPEQIAYIVNHAEDRVLFFD
MLBr_02546|M.leprae_Br4923          ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
                                     :  .   .:    . .  ** :  :* .:   *:  :  .   :::: *

MAB_2080|M.abscessus_ATCC_1997      ASVAPLLARALPAMASVHTVIVTGEGDLAP--LQGCGKTVLRYEEVLAGQ
MMAR_3133|M.marinum_M               ASVAPLLASALPAMESVHTVIATGGGDLAP--LQRCGKTVLRYEEILAQQ
Mb1087|M.bovis_AF2122/97            LSLARLLAPVLPKLDTVHTVIAVGEGDTTP--LREAGKTVLRFAELIDAE
Rv1058|M.tuberculosis_H37Rv         LSLARLLAPVLPKLDTVHTVIAVGEGDTTP--LREAGKTVLRFAELIDAE
MUL_0229|M.ulcerans_Agy99           LSLTNLLAPVLPNLDTVHTVIAVGEGDTAA--LEESGKTVLRYDELLDGQ
MAV_1186|M.avium_104                ASLVKLLAPVLPGLHTVHTVIVVGDGDTEP--LRASGKTVLRYADVIGAE
TH_2961|M.thermoresistible__bu      ASLVPLLAPVLPTMETVHTVIVVGAGDLSP--LQVPGKQVLRYEEILAAE
MSMEG_5291|M.smegmatis_MC2_155      SSLIPLLAPVLPLVDSVHTVIVVGDGDLEP--LRGADRTVLRYDEAMAGR
Mflv_4589|M.gilvum_PYR-GCK          GTVLNLLAGALPSMTSVHTVLVTGTGDLAA--VQGCGKDVLRYDDVVGAQ
Mvan_5172|M.vanbaalenii_PYR-1       ITFAPLVAQLAGELGTVETFVAMTDRDHMPDIPQIPDGRLRCWDDFIGGQ
MLBr_02546|M.leprae_Br4923          DEYTKVVSKAEPALGKLRALGVNPDEEEPP------GSTDETLAELIAR-
                                         :::     : .:.:. .    :  .      .       : :   

MAB_2080|M.abscessus_ATCC_1997      EESFDWPRLDELSAAAMCYTSGTTGDPKGVVYSHRSTYLHSLTACTANAL
MMAR_3133|M.marinum_M               PETFDWPEIDERSAAAMCYTSGTTGNPKGVVYSHRSTYLHALTACTSNAL
Mb1087|M.bovis_AF2122/97            SPDFGWPQIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTTNGI
Rv1058|M.tuberculosis_H37Rv         SPDFGWPQIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTTNGI
MUL_0229|M.ulcerans_Agy99           STEFDWPHIDENSAAAMCYTSGTTGHPKGVVYSHRSSFLHSMATCTANGI
MAV_1186|M.avium_104                PAEFDWPRIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTANGI
TH_2961|M.thermoresistible__bu      SDEFDWPELDENSAAAMCYTSGTTGHPKGVVYSHRSSYLHSTAVCSGNGL
MSMEG_5291|M.smegmatis_MC2_155      PTRFDWPDIDENSAAAMCYTSGTTGNPKGVVYSHRSSYLHSLNTCTANAL
Mflv_4589|M.gilvum_PYR-GCK          SSTFDWPDVDEQSAAAMCYTSGTTGRPKGVVYSHRSTWLHSQAACTSNAL
Mvan_5172|M.vanbaalenii_PYR-1       STAFDWPEFDERSASSLCYTSGTTGNPKGVLYSHRSTMLHTLMIAARDAI
MLBr_02546|M.leprae_Br4923          SSSAPAPKVRKR-ASIIILTSGTTGTPKGANRNTPASLAPLGGILS--KV
                                          * . :  *: :  ****** ***.  .  ::        :   :

MAB_2080|M.abscessus_ATCC_1997      SVSEADRVLAIVPMFHANAWGLIYAALMSGADLVLPDRYLQAEPLVSIIE
MMAR_3133|M.marinum_M               AVSEADRILAIVPMFHANAWGLIYAALMSGADLVLPDRHLQAAPLVSIIE
Mb1087|M.bovis_AF2122/97            GVGSSDKVLPIVPMFHANGWGLPYAALMAGADLVLPDRHLDARSLIHMVE
Rv1058|M.tuberculosis_H37Rv         GVGSSDKVLPIVPMFHANGWGLPYAALMAGADLVLPDRHLDARSLIHMVE
MUL_0229|M.ulcerans_Agy99           GLGSSDRVLPIVPMFHANAWGLPYAALMAGADLVLPDRHLDARSLVHMVE
MAV_1186|M.avium_104                GIGATDSLLPIVPMFHANAWGLPYAALMAGADLVLPDCHLDPRSLVRMVE
TH_2961|M.thermoresistible__bu      GLGFEDRVLPIVPMFHANAWGLPYAALMAGADLVMPDRYLDAKSLVNLIE
MSMEG_5291|M.smegmatis_MC2_155      DVSCGDVVLPIVPMFHANAWGLPYAALMAGAGLVMPDRFLDGASLIELIE
Mflv_4589|M.gilvum_PYR-GCK          GIGHDDTVLAIVPMFHANAWGLPYAAMMAGAQLLLPDRFLQAGPLVEMIE
Mvan_5172|M.vanbaalenii_PYR-1       DIHSGSVILLVVPMFHANAWGTPYTAAMVGAKLVMPGPHLDGQSVYELMK
MLBr_02546|M.leprae_Br4923          PFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLR-RRFKPATVLEDIE
                                     .   .  *  .***** .:     * : *: *::    :.  .:   ::

MAB_2080|M.abscessus_ATCC_1997      DTRPTVAGAVPTIWNDVDRYLD-SHPERDISSL--RLVACGGSAVPLSLM
MMAR_3133|M.marinum_M               ETQPTIAGAVPTIWNDVDRYLE-SNPARDISSL--RLVACGGSAVPVSLM
Mb1087|M.bovis_AF2122/97            TLKPTLAGAVPTIWNDVMHYLE-KDPDHDMSSL--RLVACGGSAVPESLM
Rv1058|M.tuberculosis_H37Rv         TLKPTLAGAVPTIWNDVMHYLE-KDPDHDMSSL--RLVACGGSAVPESLM
MUL_0229|M.ulcerans_Agy99           NLRPTRAGAVPTIWNDVMHYLE-KNPGHDVSSL--GLVACGGSAVPESLM
MAV_1186|M.avium_104                DLRPTVTGAVPTIWNAVLHHLE-DDPDHDMSSL--RLVVCGGSAVPVSLM
TH_2961|M.thermoresistible__bu      TQRPTVAGAVPTIWNDVLHHLD-SEPDHDISSL--RLVGCGGSAVPVSLM
MSMEG_5291|M.smegmatis_MC2_155      TQRPTLAGAVPTIWNDVLNCLE-KSPGHDISSL--RLVACGGSAVPLSLM
Mflv_4589|M.gilvum_PYR-GCK          AARPTMAGAVPTIWTDVLHYLR-DNPGHDLSSL--KMVACGGSAVPRSLM
Mvan_5172|M.vanbaalenii_PYR-1       AEGVNQSQGVPTVWMMLFSYLD-EHPEIDAHELGLRVAGTGGAALPLSMI
MLBr_02546|M.leprae_Br4923          KHQATAMVVVPVMLSRILDTLENLETKSDLSSL--RVVFVSGSQLGAELA
                                        .    **.:   :   *    .  *  .*   :.  .*: :  .: 

MAB_2080|M.abscessus_ATCC_1997      RAFEEKYNVPIVQAWGMTETSPLATVARPAH---RADATRRWEMRASQGR
MMAR_3133|M.marinum_M               RAFEDKYNVPIVQAWGMTETSPLATVARAAH---GVGETRAWEMRESQGR
Mb1087|M.bovis_AF2122/97            RTFEDKHDVQIRQLWGMTETSPLATMAWPPP---GTPDDQHWAFRITQGQ
Rv1058|M.tuberculosis_H37Rv         RTFEDKHDVQIRQLWGMTETSPLATMAWPPP---GTPDDQHWAFRITQGQ
MUL_0229|M.ulcerans_Agy99           RTFEEKYGVQIRQLWGMTETSPLATMAWPPP---GTPPDRHWAIRSTQGQ
MAV_1186|M.avium_104                RTFEEKHGVQIRQLWGMTETSPLATMAWPPP---GTPEDQHWAYRGTQGQ
TH_2961|M.thermoresistible__bu      QSFEEKFGVQIRQLWGMTETSPVCTLAWPAP---NTPADRHWEVRGSQGR
MSMEG_5291|M.smegmatis_MC2_155      QAFQERHDVYIQQAWGMTETSPLATVAKPLP---GVTDERHWAMRITQGR
Mflv_4589|M.gilvum_PYR-GCK          TAYDELG-IRIVQAWGMTETSPLAAVALPRD---TDTPERSLYLRGTQGR
Mvan_5172|M.vanbaalenii_PYR-1       ERFHRDFGAESMQGWGMTETSPLCVVGRLLPKHEGLSDAEKNQIRLKQGR
MLBr_02546|M.leprae_Br4923          TRALEELGPVIYNMYGSTEIA-FATIAGPKD---------LQINSATVGP
                                                : :* ** : ...:.                   . * 

MAB_2080|M.abscessus_ATCC_1997      PICGVEIRLRDDDGKDVPWDGQSVGEIQARGPWITGSYFGDNDTEKFD-E
MMAR_3133|M.marinum_M               PMCGVEIRLRDDHKKTVPWDGRSAGEIQARGPWITGAYFGDDDPDKFD-G
Mb1087|M.bovis_AF2122/97            PVCGVETRIVDDDGQVLPNDGNAVGEVEVRGPWIAGSYYGGRDESKFD-S
Rv1058|M.tuberculosis_H37Rv         PVCGVETRIVDDDGQVLPNDGNAVGEVEVRGPWIAGSYYGGRDESKFD-S
MUL_0229|M.ulcerans_Agy99           PVCGVETRIVDDNGEALPNDGQAVGEVEVRGPWITGAYYLGYDQSEFD-S
MAV_1186|M.avium_104                PVCGVQMRIVDDDGRVLPNDGTAVGEVEVRGPWIAGSYYLGRDDSKFD-S
TH_2961|M.thermoresistible__bu      PICGVEARIVDDEGNVLPRDNEAVGELEVRGPWITGSYYHDADPSKFE-N
MSMEG_5291|M.smegmatis_MC2_155      PMCGVEVRIVDDAGNPLPSDGKAVGELEVRGPWITGGYYLGRDAEKFD-S
Mflv_4589|M.gilvum_PYR-GCK          VVAGVQARIVDDSGAEQPWDGKSVGEIQIRGPWITQSYYEYDSPAVSP-D
Mvan_5172|M.vanbaalenii_PYR-1       GVWGVDLKIVDDDGNRLPWDGKAFGEVWVRGPWIASGYFRGEGGEKLDAE
MLBr_02546|M.leprae_Br4923          VVKGVKVKILDDSGKEVPRG--QVGRIFVGNAFPFEGYTGGGGKQIID--
                                     : **. :: **     * .    *.:   ..:   .*    .       

MAB_2080|M.abscessus_ATCC_1997      GWLRTGDVGKIDAEGYLTLTDRSKDVIKSGGEWISSVELENTLIGHPAVY
MMAR_3133|M.marinum_M               GWLRTGDVGRIDPDGYLTLTDRAKDVIKSGGEWISSVELENTLIGHPAIY
Mb1087|M.bovis_AF2122/97            GWLRTGDVGRIDEQGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVL
Rv1058|M.tuberculosis_H37Rv         GWLRTGDVGRIDEQGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVL
MUL_0229|M.ulcerans_Agy99           GWLRTGDVGRIDELGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVV
MAV_1186|M.avium_104                GWLRTGDVGRIDERGFVTLTDRAKDVIKSGGEWISSVELENCLIGHPDVV
TH_2961|M.thermoresistible__bu      GWLRTGDVGRMDAQSYITLTDRAKDVIKSGGEWISSVELENHLIGHPKVR
MSMEG_5291|M.smegmatis_MC2_155      GWLRTGDVGVIDELGYVTLTDRAKDVIKSGGEWISSVELENHLIGHPAVL
Mflv_4589|M.gilvum_PYR-GCK          GWLCTGDVGTISADAFITLTDRAKDVIKSGGEWISSVELENELAAHPAVR
Mvan_5172|M.vanbaalenii_PYR-1       GFFPTGDVATIDPDGYLQLVDRAKDVIKSGGEWVSSIDLENAALGHPAVA
MLBr_02546|M.leprae_Br4923          GLLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVV
                                    * : :***. :.    : : .* .::* **** : . ::*:   .** : 

MAB_2080|M.abscessus_ATCC_1997      EAAVVGVADDKWQERPLALVVVHPGTDVDIDQLRSFLADKVAKWWIPERW
MMAR_3133|M.marinum_M               EAAVVAVPDDKWQERPLALVVVHRGAEVDIDRLRAFLLDKVAKWWIPERW
Mb1087|M.bovis_AF2122/97            EAAVVGVPDERWQERPLAVVVVREGATVSAGDLRAFLADKVVRWWLPERW
Rv1058|M.tuberculosis_H37Rv         EAAVVGVPDERWQERPLAVVVVREGATVSAGDLRAFLADKVVRWWLPERW
MUL_0229|M.ulcerans_Agy99           EAAVVGVPDERWQERPLAVVVRREGATVSAAELRKFLADRVVRWWLPERW
MAV_1186|M.avium_104                EAAVVGVPDERWEERPLAVVVVKDGASVDADQLRKFLADKVVRWWLPERW
TH_2961|M.thermoresistible__bu      EAAVVGVPDDRWQERPLAAVVLHEGQQATPEELREFLSDKVVRWWLPERW
MSMEG_5291|M.smegmatis_MC2_155      EAAVVGVPDERWQERPLAVVVLHEGSSADPGELREFLADKVVRWWLPERW
Mflv_4589|M.gilvum_PYR-GCK          TATVIGVPDDKWQERPLAVVVLAADCTATAAELTEFLRARVAKWWLPERW
Mvan_5172|M.vanbaalenii_PYR-1       EAAVIGVPHPKWQERPLLIVVLRKGHHATREDILEYLAGEVVKWWLPDDV
MLBr_02546|M.leprae_Br4923          EATAIGVDDKEWGARLRAFVVKKQDATIDEDAIKAYVRDHLARYKVPREV
                                     *:.:.* . .*  *    **   .       :  ::  .:.:: :*   

MAB_2080|M.abscessus_ATCC_1997      SFVSDIPRTSVGKYDKKAIRARHSAGEYLIEIETS
MMAR_3133|M.marinum_M               SFVSEIPRTSVGKYDKKAIRARHSAGEYQIETS--
Mb1087|M.bovis_AF2122/97            AFVDEIPRTSVGKYDKKAIRSRYAEGAYQITEVHT
Rv1058|M.tuberculosis_H37Rv         AFVDEIPRTSVGKYDKKAIRSRYAEGAYQITEVHT
MUL_0229|M.ulcerans_Agy99           AFADQVPRTSVGKYDKKTIRAGYAESVYQVTDVHN
MAV_1186|M.avium_104                TFVDEIPRTSVGKYDKKAVRSRYADGGYRVIEARD
TH_2961|M.thermoresistible__bu      TFVEEIPRTSVGKYDKKTIRARYADGAYQVTHLGG
MSMEG_5291|M.smegmatis_MC2_155      AFVDQVPRTSVGKYDKKTIRARHAEGAYEVIHL--
Mflv_4589|M.gilvum_PYR-GCK          AFVADVPLTSTGKFDKKKLRSQHADGDLAVETLA-
Mvan_5172|M.vanbaalenii_PYR-1       VFVDELPHTATGKVLKLKLREQYRDHRLSQPE---
MLBr_02546|M.leprae_Br4923          IFLEELPRNPTGKVLKRELRDFEVH----------
                                     *  ::* ...**  *  :*