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MQNVPLTVSAIVQHAAAIHGDSEVVTPTGNGYRRTPYRIVLARVARLANALRSLGVTADQRVATFQWSNQ EHLEAYCAIPSMGAVLHTLNIRLAPEQLAYIANHASDQIVLVDASVAPLLARALPAMASVHTVIVTGEGD LAPLQGCGKTVLRYEEVLAGQEESFDWPRLDELSAAAMCYTSGTTGDPKGVVYSHRSTYLHSLTACTANA LSVSEADRVLAIVPMFHANAWGLIYAALMSGADLVLPDRYLQAEPLVSIIEDTRPTVAGAVPTIWNDVDR YLDSHPERDISSLRLVACGGSAVPLSLMRAFEEKYNVPIVQAWGMTETSPLATVARPAHRADATRRWEMR ASQGRPICGVEIRLRDDDGKDVPWDGQSVGEIQARGPWITGSYFGDNDTEKFDEGWLRTGDVGKIDAEGY LTLTDRSKDVIKSGGEWISSVELENTLIGHPAVYEAAVVGVADDKWQERPLALVVVHPGTDVDIDQLRSF LADKVAKWWIPERWSFVSDIPRTSVGKYDKKAIRARHSAGEYLIEIETS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_2080 | - | - | 100% (539) | acyl-CoA synthetase |
M. abscessus ATCC 19977 | MAB_4559 | - | 2e-58 | 31.44% (493) | putative long-chain-fatty-acid CoA ligase |
M. abscessus ATCC 19977 | MAB_3592c | - | 2e-53 | 31.55% (504) | putative medium-chain acyl-CoA ligase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1087 | fadD14 | 0.0 | 64.19% (539) | acyl-CoA synthetase |
M. gilvum PYR-GCK | Mflv_4589 | - | 0.0 | 63.25% (536) | acyl-CoA synthetase |
M. tuberculosis H37Rv | Rv1058 | fadD14 | 0.0 | 64.19% (539) | acyl-CoA synthetase |
M. leprae Br4923 | MLBr_02546 | fadD2 | 3e-40 | 27.96% (540) | acyl-CoA synthetase |
M. marinum M | MMAR_3133 | fadD14_1 | 0.0 | 85.05% (535) | medium chain fatty-acid-CoA ligase FadD14_1 |
M. avium 104 | MAV_1186 | - | 0.0 | 65.73% (534) | acyl-CoA synthetase |
M. smegmatis MC2 155 | MSMEG_5291 | - | 0.0 | 66.60% (533) | acyl-CoA synthetase |
M. thermoresistible (build 8) | TH_2961 | - | 0.0 | 67.85% (535) | PUTATIVE AMP-dependent synthetase and ligase |
M. ulcerans Agy99 | MUL_0229 | fadD14 | 0.0 | 64.79% (534) | acyl-CoA synthetase |
M. vanbaalenii PYR-1 | Mvan_5172 | - | 1e-136 | 44.88% (537) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment MAB_2080|M.abscessus_ATCC_1997 --------------------------MQNVPLTVSAIVQHAAAIHGDSEV MMAR_3133|M.marinum_M --------------------------MQDVQLTISAIVRHAASIHGNSEV Mb1087|M.bovis_AF2122/97 ----------------------MYGTMQDFPLTITAIMRHGCGVHGRRTV Rv1058|M.tuberculosis_H37Rv ----------------------MYGTMQDFPLTITAIMRHGCGVHGRRTV MUL_0229|M.ulcerans_Agy99 ----------------------MYSTMQDFPLTITAIMRHGCGVHGSRQV MAV_1186|M.avium_104 ----------------------MDGTMQDFPLTITAIMRHGCSVHGARTV TH_2961|M.thermoresistible__bu ----------------------MQSTMQPIPLTVAAIMRYAIEVHGDRTV MSMEG_5291|M.smegmatis_MC2_155 --------------------------MQQWPLTITAILRHACGVNGDQTV Mflv_4589|M.gilvum_PYR-GCK --------------------------MQDVALTVPAIVAHAAAVHGDREV Mvan_5172|M.vanbaalenii_PYR-1 ----------------------MFGLMQDRPLMISSLIEHAAAFHGDTEI MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM : : : . * : MAB_2080|M.abscessus_ATCC_1997 VTPTGNG-----------YRRTPYRIVLARVARLANALRSLGVTADQRVA MMAR_3133|M.marinum_M ITPDGIG-----------YRSMSYRSVLGRAGRLANALRGLGITADQRVA Mb1087|M.bovis_AF2122/97 TTATGEG-----------YRHSSYRDVGQRAGQLANALRRLGVTGDQRVA Rv1058|M.tuberculosis_H37Rv TTATGEG-----------YRHSSYRDVGQRAGQLANALRRLGVTGDQRVA MUL_0229|M.ulcerans_Agy99 ITATGDA-----------YRQTTYREVGQRAAQLANALRGLGISGDQRVA MAV_1186|M.avium_104 TTATGDG-----------YRRTSYRELGDRAAQLANALRGLGVTGDQRVA TH_2961|M.thermoresistible__bu TTATGDGG----------YRHATYADLGREAARLANALRRLGITGDERVA MSMEG_5291|M.smegmatis_MC2_155 TTATGQGG----------FRTTTYREVGERAAQLAHLLREVGITGDERVG Mflv_4589|M.gilvum_PYR-GCK LTARGPQQ----------ISGVSYHELGQRAARLANALREIGVRGDERVA Mvan_5172|M.vanbaalenii_PYR-1 VSRLPEGP----------VRRTTWREINEHSKQVANALAELGIEQGDRVA MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA . .: : :*: * *: .: :. MAB_2080|M.abscessus_ATCC_1997 TFQWSNQEHLEAYCAIPSMGAVLHTLNIRLAPEQLAYIANHASDQIVLVD MMAR_3133|M.marinum_M TFQWSNQEHLEAYCAVPSMGAVLHTLNIRLAPEQLAYIANHASDQIILVD Mb1087|M.bovis_AF2122/97 TFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFPEQIAYVTNEAEDRVILVD Rv1058|M.tuberculosis_H37Rv TFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFPEQIAYVTNEAEDRVILVD MUL_0229|M.ulcerans_Agy99 TFMWNNAEHLVTYLAVPSMGAVLHTLNIRLFAEQIAYVANEAEDQVVLVD MAV_1186|M.avium_104 TFMWNNAEHLAAYLAVPSMGAVLHTLNIRLFPEQIAYVANEAGDQVVLVD TH_2961|M.thermoresistible__bu TFQWNNQEHLATYVAVPSMGAVLHTLNIRLFPEQLQFIAYEAQDRVVIVD MSMEG_5291|M.smegmatis_MC2_155 TFMWNNTEHLTAYLAIPAMGAVLHTLNIRLSPEQIGFIAREAEDRVIITD Mflv_4589|M.gilvum_PYR-GCK TLQWSNQEHLDCYAAVPSMGAVLHTLNLRLPPEQLTWIANHAEDQVIIVD Mvan_5172|M.vanbaalenii_PYR-1 TLAWNSDRHLALYFGVSGSGAVMHTVNPRLFPEQIAYIVNHAEDRVLFFD MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD : . .: . . ** : :* .: *: : . :::: * MAB_2080|M.abscessus_ATCC_1997 ASVAPLLARALPAMASVHTVIVTGEGDLAP--LQGCGKTVLRYEEVLAGQ MMAR_3133|M.marinum_M ASVAPLLASALPAMESVHTVIATGGGDLAP--LQRCGKTVLRYEEILAQQ Mb1087|M.bovis_AF2122/97 LSLARLLAPVLPKLDTVHTVIAVGEGDTTP--LREAGKTVLRFAELIDAE Rv1058|M.tuberculosis_H37Rv LSLARLLAPVLPKLDTVHTVIAVGEGDTTP--LREAGKTVLRFAELIDAE MUL_0229|M.ulcerans_Agy99 LSLTNLLAPVLPNLDTVHTVIAVGEGDTAA--LEESGKTVLRYDELLDGQ MAV_1186|M.avium_104 ASLVKLLAPVLPGLHTVHTVIVVGDGDTEP--LRASGKTVLRYADVIGAE TH_2961|M.thermoresistible__bu ASLVPLLAPVLPTMETVHTVIVVGAGDLSP--LQVPGKQVLRYEEILAAE MSMEG_5291|M.smegmatis_MC2_155 SSLIPLLAPVLPLVDSVHTVIVVGDGDLEP--LRGADRTVLRYDEAMAGR Mflv_4589|M.gilvum_PYR-GCK GTVLNLLAGALPSMTSVHTVLVTGTGDLAA--VQGCGKDVLRYDDVVGAQ Mvan_5172|M.vanbaalenii_PYR-1 ITFAPLVAQLAGELGTVETFVAMTDRDHMPDIPQIPDGRLRCWDDFIGGQ MLBr_02546|M.leprae_Br4923 DEYTKVVSKAEPALGKLRALGVNPDEEEPP------GSTDETLAELIAR- ::: : .:.:. . : . . : : MAB_2080|M.abscessus_ATCC_1997 EESFDWPRLDELSAAAMCYTSGTTGDPKGVVYSHRSTYLHSLTACTANAL MMAR_3133|M.marinum_M PETFDWPEIDERSAAAMCYTSGTTGNPKGVVYSHRSTYLHALTACTSNAL Mb1087|M.bovis_AF2122/97 SPDFGWPQIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTTNGI Rv1058|M.tuberculosis_H37Rv SPDFGWPQIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTTNGI MUL_0229|M.ulcerans_Agy99 STEFDWPHIDENSAAAMCYTSGTTGHPKGVVYSHRSSFLHSMATCTANGI MAV_1186|M.avium_104 PAEFDWPRIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTANGI TH_2961|M.thermoresistible__bu SDEFDWPELDENSAAAMCYTSGTTGHPKGVVYSHRSSYLHSTAVCSGNGL MSMEG_5291|M.smegmatis_MC2_155 PTRFDWPDIDENSAAAMCYTSGTTGNPKGVVYSHRSSYLHSLNTCTANAL Mflv_4589|M.gilvum_PYR-GCK SSTFDWPDVDEQSAAAMCYTSGTTGRPKGVVYSHRSTWLHSQAACTSNAL Mvan_5172|M.vanbaalenii_PYR-1 STAFDWPEFDERSASSLCYTSGTTGNPKGVLYSHRSTMLHTLMIAARDAI MLBr_02546|M.leprae_Br4923 SSSAPAPKVRKR-ASIIILTSGTTGTPKGANRNTPASLAPLGGILS--KV * . : *: : ****** ***. . :: : : MAB_2080|M.abscessus_ATCC_1997 SVSEADRVLAIVPMFHANAWGLIYAALMSGADLVLPDRYLQAEPLVSIIE MMAR_3133|M.marinum_M AVSEADRILAIVPMFHANAWGLIYAALMSGADLVLPDRHLQAAPLVSIIE Mb1087|M.bovis_AF2122/97 GVGSSDKVLPIVPMFHANGWGLPYAALMAGADLVLPDRHLDARSLIHMVE Rv1058|M.tuberculosis_H37Rv GVGSSDKVLPIVPMFHANGWGLPYAALMAGADLVLPDRHLDARSLIHMVE MUL_0229|M.ulcerans_Agy99 GLGSSDRVLPIVPMFHANAWGLPYAALMAGADLVLPDRHLDARSLVHMVE MAV_1186|M.avium_104 GIGATDSLLPIVPMFHANAWGLPYAALMAGADLVLPDCHLDPRSLVRMVE TH_2961|M.thermoresistible__bu GLGFEDRVLPIVPMFHANAWGLPYAALMAGADLVMPDRYLDAKSLVNLIE MSMEG_5291|M.smegmatis_MC2_155 DVSCGDVVLPIVPMFHANAWGLPYAALMAGAGLVMPDRFLDGASLIELIE Mflv_4589|M.gilvum_PYR-GCK GIGHDDTVLAIVPMFHANAWGLPYAAMMAGAQLLLPDRFLQAGPLVEMIE Mvan_5172|M.vanbaalenii_PYR-1 DIHSGSVILLVVPMFHANAWGTPYTAAMVGAKLVMPGPHLDGQSVYELMK MLBr_02546|M.leprae_Br4923 PFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLR-RRFKPATVLEDIE . . * .***** .: * : *: *:: :. .: :: MAB_2080|M.abscessus_ATCC_1997 DTRPTVAGAVPTIWNDVDRYLD-SHPERDISSL--RLVACGGSAVPLSLM MMAR_3133|M.marinum_M ETQPTIAGAVPTIWNDVDRYLE-SNPARDISSL--RLVACGGSAVPVSLM Mb1087|M.bovis_AF2122/97 TLKPTLAGAVPTIWNDVMHYLE-KDPDHDMSSL--RLVACGGSAVPESLM Rv1058|M.tuberculosis_H37Rv TLKPTLAGAVPTIWNDVMHYLE-KDPDHDMSSL--RLVACGGSAVPESLM MUL_0229|M.ulcerans_Agy99 NLRPTRAGAVPTIWNDVMHYLE-KNPGHDVSSL--GLVACGGSAVPESLM MAV_1186|M.avium_104 DLRPTVTGAVPTIWNAVLHHLE-DDPDHDMSSL--RLVVCGGSAVPVSLM TH_2961|M.thermoresistible__bu TQRPTVAGAVPTIWNDVLHHLD-SEPDHDISSL--RLVGCGGSAVPVSLM MSMEG_5291|M.smegmatis_MC2_155 TQRPTLAGAVPTIWNDVLNCLE-KSPGHDISSL--RLVACGGSAVPLSLM Mflv_4589|M.gilvum_PYR-GCK AARPTMAGAVPTIWTDVLHYLR-DNPGHDLSSL--KMVACGGSAVPRSLM Mvan_5172|M.vanbaalenii_PYR-1 AEGVNQSQGVPTVWMMLFSYLD-EHPEIDAHELGLRVAGTGGAALPLSMI MLBr_02546|M.leprae_Br4923 KHQATAMVVVPVMLSRILDTLENLETKSDLSSL--RVVFVSGSQLGAELA . **.: : * . * .* :. .*: : .: MAB_2080|M.abscessus_ATCC_1997 RAFEEKYNVPIVQAWGMTETSPLATVARPAH---RADATRRWEMRASQGR MMAR_3133|M.marinum_M RAFEDKYNVPIVQAWGMTETSPLATVARAAH---GVGETRAWEMRESQGR Mb1087|M.bovis_AF2122/97 RTFEDKHDVQIRQLWGMTETSPLATMAWPPP---GTPDDQHWAFRITQGQ Rv1058|M.tuberculosis_H37Rv RTFEDKHDVQIRQLWGMTETSPLATMAWPPP---GTPDDQHWAFRITQGQ MUL_0229|M.ulcerans_Agy99 RTFEEKYGVQIRQLWGMTETSPLATMAWPPP---GTPPDRHWAIRSTQGQ MAV_1186|M.avium_104 RTFEEKHGVQIRQLWGMTETSPLATMAWPPP---GTPEDQHWAYRGTQGQ TH_2961|M.thermoresistible__bu QSFEEKFGVQIRQLWGMTETSPVCTLAWPAP---NTPADRHWEVRGSQGR MSMEG_5291|M.smegmatis_MC2_155 QAFQERHDVYIQQAWGMTETSPLATVAKPLP---GVTDERHWAMRITQGR Mflv_4589|M.gilvum_PYR-GCK TAYDELG-IRIVQAWGMTETSPLAAVALPRD---TDTPERSLYLRGTQGR Mvan_5172|M.vanbaalenii_PYR-1 ERFHRDFGAESMQGWGMTETSPLCVVGRLLPKHEGLSDAEKNQIRLKQGR MLBr_02546|M.leprae_Br4923 TRALEELGPVIYNMYGSTEIA-FATIAGPKD---------LQINSATVGP : :* ** : ...:. . * MAB_2080|M.abscessus_ATCC_1997 PICGVEIRLRDDDGKDVPWDGQSVGEIQARGPWITGSYFGDNDTEKFD-E MMAR_3133|M.marinum_M PMCGVEIRLRDDHKKTVPWDGRSAGEIQARGPWITGAYFGDDDPDKFD-G Mb1087|M.bovis_AF2122/97 PVCGVETRIVDDDGQVLPNDGNAVGEVEVRGPWIAGSYYGGRDESKFD-S Rv1058|M.tuberculosis_H37Rv PVCGVETRIVDDDGQVLPNDGNAVGEVEVRGPWIAGSYYGGRDESKFD-S MUL_0229|M.ulcerans_Agy99 PVCGVETRIVDDNGEALPNDGQAVGEVEVRGPWITGAYYLGYDQSEFD-S MAV_1186|M.avium_104 PVCGVQMRIVDDDGRVLPNDGTAVGEVEVRGPWIAGSYYLGRDDSKFD-S TH_2961|M.thermoresistible__bu PICGVEARIVDDEGNVLPRDNEAVGELEVRGPWITGSYYHDADPSKFE-N MSMEG_5291|M.smegmatis_MC2_155 PMCGVEVRIVDDAGNPLPSDGKAVGELEVRGPWITGGYYLGRDAEKFD-S Mflv_4589|M.gilvum_PYR-GCK VVAGVQARIVDDSGAEQPWDGKSVGEIQIRGPWITQSYYEYDSPAVSP-D Mvan_5172|M.vanbaalenii_PYR-1 GVWGVDLKIVDDDGNRLPWDGKAFGEVWVRGPWIASGYFRGEGGEKLDAE MLBr_02546|M.leprae_Br4923 VVKGVKVKILDDSGKEVPRG--QVGRIFVGNAFPFEGYTGGGGKQIID-- : **. :: ** * . *.: ..: .* . MAB_2080|M.abscessus_ATCC_1997 GWLRTGDVGKIDAEGYLTLTDRSKDVIKSGGEWISSVELENTLIGHPAVY MMAR_3133|M.marinum_M GWLRTGDVGRIDPDGYLTLTDRAKDVIKSGGEWISSVELENTLIGHPAIY Mb1087|M.bovis_AF2122/97 GWLRTGDVGRIDEQGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVL Rv1058|M.tuberculosis_H37Rv GWLRTGDVGRIDEQGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVL MUL_0229|M.ulcerans_Agy99 GWLRTGDVGRIDELGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVV MAV_1186|M.avium_104 GWLRTGDVGRIDERGFVTLTDRAKDVIKSGGEWISSVELENCLIGHPDVV TH_2961|M.thermoresistible__bu GWLRTGDVGRMDAQSYITLTDRAKDVIKSGGEWISSVELENHLIGHPKVR MSMEG_5291|M.smegmatis_MC2_155 GWLRTGDVGVIDELGYVTLTDRAKDVIKSGGEWISSVELENHLIGHPAVL Mflv_4589|M.gilvum_PYR-GCK GWLCTGDVGTISADAFITLTDRAKDVIKSGGEWISSVELENELAAHPAVR Mvan_5172|M.vanbaalenii_PYR-1 GFFPTGDVATIDPDGYLQLVDRAKDVIKSGGEWVSSIDLENAALGHPAVA MLBr_02546|M.leprae_Br4923 GLLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVV * : :***. :. : : .* .::* **** : . ::*: .** : MAB_2080|M.abscessus_ATCC_1997 EAAVVGVADDKWQERPLALVVVHPGTDVDIDQLRSFLADKVAKWWIPERW MMAR_3133|M.marinum_M EAAVVAVPDDKWQERPLALVVVHRGAEVDIDRLRAFLLDKVAKWWIPERW Mb1087|M.bovis_AF2122/97 EAAVVGVPDERWQERPLAVVVVREGATVSAGDLRAFLADKVVRWWLPERW Rv1058|M.tuberculosis_H37Rv EAAVVGVPDERWQERPLAVVVVREGATVSAGDLRAFLADKVVRWWLPERW MUL_0229|M.ulcerans_Agy99 EAAVVGVPDERWQERPLAVVVRREGATVSAAELRKFLADRVVRWWLPERW MAV_1186|M.avium_104 EAAVVGVPDERWEERPLAVVVVKDGASVDADQLRKFLADKVVRWWLPERW TH_2961|M.thermoresistible__bu EAAVVGVPDDRWQERPLAAVVLHEGQQATPEELREFLSDKVVRWWLPERW MSMEG_5291|M.smegmatis_MC2_155 EAAVVGVPDERWQERPLAVVVLHEGSSADPGELREFLADKVVRWWLPERW Mflv_4589|M.gilvum_PYR-GCK TATVIGVPDDKWQERPLAVVVLAADCTATAAELTEFLRARVAKWWLPERW Mvan_5172|M.vanbaalenii_PYR-1 EAAVIGVPHPKWQERPLLIVVLRKGHHATREDILEYLAGEVVKWWLPDDV MLBr_02546|M.leprae_Br4923 EATAIGVDDKEWGARLRAFVVKKQDATIDEDAIKAYVRDHLARYKVPREV *:.:.* . .* * ** . : :: .:.:: :* MAB_2080|M.abscessus_ATCC_1997 SFVSDIPRTSVGKYDKKAIRARHSAGEYLIEIETS MMAR_3133|M.marinum_M SFVSEIPRTSVGKYDKKAIRARHSAGEYQIETS-- Mb1087|M.bovis_AF2122/97 AFVDEIPRTSVGKYDKKAIRSRYAEGAYQITEVHT Rv1058|M.tuberculosis_H37Rv AFVDEIPRTSVGKYDKKAIRSRYAEGAYQITEVHT MUL_0229|M.ulcerans_Agy99 AFADQVPRTSVGKYDKKTIRAGYAESVYQVTDVHN MAV_1186|M.avium_104 TFVDEIPRTSVGKYDKKAVRSRYADGGYRVIEARD TH_2961|M.thermoresistible__bu TFVEEIPRTSVGKYDKKTIRARYADGAYQVTHLGG MSMEG_5291|M.smegmatis_MC2_155 AFVDQVPRTSVGKYDKKTIRARHAEGAYEVIHL-- Mflv_4589|M.gilvum_PYR-GCK AFVADVPLTSTGKFDKKKLRSQHADGDLAVETLA- Mvan_5172|M.vanbaalenii_PYR-1 VFVDELPHTATGKVLKLKLREQYRDHRLSQPE--- MLBr_02546|M.leprae_Br4923 IFLEELPRNPTGKVLKRELRDFEVH---------- * ::* ...** * :*