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TTSFDLIELKRVLGGLWGAQDPTDSTMAALKRGVHGEEAMLIAGELVTASHGKTFDNVNPATGQVIGAVA DAGAADVDRAIDAARRAFDESSWPHDAEFRRHCLLQLHKAMAESADQFRATAVAEIGVAVRTTNTFHSDW PISSIPYWADMATNFEYEHTMPDRPWASGTRHVIRQEPIGVVAAITPWNFPLQTAMTKILPALAAGATVV LKPAFQTPWHATLLARLIAEKTDIPAGVINVVTPSDNAVAERLAVDPRVDLVHFTGSTAVGKKLMADASG RVARVALELGGKSANILLEDADFTQIVPQAAGVVCMNAGQGCVLPTRLLVPRSRYDEARELARITFEHMP FGDPTDPGTVQGPQISKVQQDRVLGLIAQGVAEGATLLTGGRIPDGFDGGFFVEPTLFADVDPHSTIAQR EIFGPVLAMIPYDNVEHAIDIANNTSYGLAGYVWGDEDAAVTVARRIRSGMVAVNGGFFYGHDVPSGGYK ESGLGRESGVEGFQEFLETKVIAVAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3387 | - | - | 100% (517) | aldehyde dehydrogenase (NAD) family protein |
| M. smegmatis MC2 155 | MSMEG_2552 | - | e-130 | 48.65% (481) | aldehyde dehydrogenase (NAD) family protein |
| M. smegmatis MC2 155 | MSMEG_5859 | - | e-121 | 48.23% (479) | aldehyde dehydrogenase (NAD) family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 1e-122 | 47.30% (482) | aldehyde dehydrogenase NAD dependant AldA |
| M. gilvum PYR-GCK | Mflv_4340 | - | 1e-132 | 50.40% (504) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0768 | aldA | 1e-122 | 47.30% (482) | aldehyde dehydrogenase NAD dependent AldA |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-48 | 30.82% (464) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1218 | - | 1e-122 | 47.63% (485) | aldehyde dehydrogenase AldA |
| M. marinum M | MMAR_4322 | aldA_2 | 1e-122 | 49.17% (484) | aldehyde dehydrogenase NAD dependent AldA_2 |
| M. avium 104 | MAV_1825 | - | 1e-137 | 51.42% (494) | aldehyde dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_3100 | - | 1e-133 | 50.00% (480) | PUTATIVE aldehyde dehydrogenase (NAD) family protein |
| M. ulcerans Agy99 | MUL_0477 | aldA | 1e-121 | 47.45% (491) | NAD-dependent aldehyde dehydrogenase, AldA |
| M. vanbaalenii PYR-1 | Mvan_0904 | - | 1e-139 | 53.24% (479) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0791|M.bovis_AF2122/97 -------------------MALWGDGI---------------SALLIDGK
Rv0768|M.tuberculosis_H37Rv -------------------MALWGDGI---------------SALLIDGK
MUL_0477|M.ulcerans_Agy99 -------------------MALLADGV---------------SSLFIDGK
MAB_1218|M.abscessus_ATCC_1997 -------------------MTVLSDGD---------------SELFIDGK
MSMEG_3387|M.smegmatis_MC2_155 MTTSFDLIELKRVLGGLWGAQDPTDSTMAALKRG----VHGEEAMLIAGE
Mvan_0904|M.vanbaalenii_PYR-1 -----------------------------------------MTGLLINGA
MAV_1825|M.avium_104 ------------------MTASSVAATTVQFNP--------ESRLYIAGR
TH_3100|M.thermoresistible__bu ------------------MTASPVATS-VQFNP--------ETRLYIDGE
Mflv_4340|M.gilvum_PYR-GCK ------------------MSATPTERTETSLEWGRRAAQRAENRMLIDGE
MMAR_4322|M.marinum_M -------------------MADTTEAVEV----------RFESKMMIDGK
MLBr_02573|M.leprae_Br4923 --------------------------------------------------
Mb0791|M.bovis_AF2122/97 LSDGRAG-TFPTVNPATEEVLGVAADADAEDMGRAIEAARRAFDSTDWSR
Rv0768|M.tuberculosis_H37Rv LSDGRAG-TFPTVNPATEEVLGVAADADAEDMGRAIEAARRAFDSTDWSR
MUL_0477|M.ulcerans_Agy99 RCEGAAG-TFATVNPATEETLGVAADAVAGDMDRAIEAARRAFDDTDWSR
MAB_1218|M.abscessus_ATCC_1997 LLPGGAG-RFPTVNPATEEVLGTAADADSDDMSDAIEAARRAFDDSGWSR
MSMEG_3387|M.smegmatis_MC2_155 LVTASHGKTFDNVNPATGQVIGAVADAGAADVDRAIDAARRAFDESSWPH
Mvan_0904|M.vanbaalenii_PYR-1 VRDSAGARTFPNINPATEQSIGSAPDADLSDLDAAVAAARRAFDDTDWSR
MAV_1825|M.avium_104 LRDSSTGKVAENINPATEEVLGTCADAGAEDMDEAIAAARRAFDTTDWST
TH_3100|M.thermoresistible__bu LRESRTGKTVDNINPATEEVLGTATDVGADDMEQAIAAARRAFDTTDWST
Mflv_4340|M.gilvum_PYR-GCK LVGAASGEMFDNLSPATGAVLGATAAAGADDMDRAIAAARRAFDTTDWST
MMAR_4322|M.marinum_M LVDGQAG-TFTNINPATEEPLGEVADASKTDMHRAIDAARRAFDETDWST
MLBr_02573|M.leprae_Br4923 -------MSIATINPATGETVKTFTPTTQDEVEDAIARAYARFDN---YR
.:.*** : . . :: *: * **
Mb0791|M.bovis_AF2122/97 NTELRVRCVRQLRDAMQQHVEELRELTISEVGAPRMLTASAQLEGPVGD-
Rv0768|M.tuberculosis_H37Rv NTELRVRCVRQLRDAMQQHVEELRELTISEVGAPRMLTASAQLEGPVGD-
MUL_0477|M.ulcerans_Agy99 NTELRVRCVRQLRDAMREHIEELRALTISEVGAPRMLTAAAQLEGPVND-
MAB_1218|M.abscessus_ATCC_1997 DVALRVHCIRQLRDGMKTHIEELRELTIAEVGAPRMLTAGAQLEGPVDD-
MSMEG_3387|M.smegmatis_MC2_155 DAEFRRHCLLQLHKAMAESADQFRATAVAEIGVAVRTTNTFHSDWPISSI
Mvan_0904|M.vanbaalenii_PYR-1 DHDFRAHCLRQLHEGLCAEQERLRDVLVMEAGVPVALTHSIWLDTILDSV
MAV_1825|M.avium_104 NREFRQHCLLQLHEALQEEKEDARAELIAEAGAPVGMTYIAQLDWPLADA
TH_3100|M.thermoresistible__bu NHEFRRRCLLQLHDALQEEKEDIRAELIAEVGATVGMTFIAQLEWPLADA
Mflv_4340|M.gilvum_PYR-GCK DKELRRRCLQQLQAAIESEKEDLRTELVAEVGCPVMTTESAQLDWPLAEA
MMAR_4322|M.marinum_M NRALRKRCLEQLQEAIEAEREELREELILEAGAPRAITFGPQLDAPLADA
MLBr_02573|M.leprae_Br4923 HTTFTQRAKWANATADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKG
. : :. . : : : .
Mb0791|M.bovis_AF2122/97 LSFAADTAESYPWKQDLGEAS--PLGIATRRTLAREAVGVVGAITPWNFP
Rv0768|M.tuberculosis_H37Rv LSFAADTAESYPWKQDLGEAS--PLGIATRRTLAREAVGVVGAITPWNFP
MUL_0477|M.ulcerans_Agy99 LAFSADTAESYSWKQDLGAAA--PMGIPTRRTVVREAVGVVGAITPWNFP
MAB_1218|M.abscessus_ATCC_1997 LQFAADTAESFDWTSDLGVAS--PMGIKTRRTLAREAVGVVGAVTPWNFP
MSMEG_3387|M.smegmatis_MC2_155 PYW-ADMATNFEYEHTMPDRP---WASGTRHVIRQEPIGVVAAITPWNFP
Mvan_0904|M.vanbaalenii_PYR-1 LYW-ADLATSYPYEVQLTARQTLAAVTSTRTVVR-EPVGVVAAITPWNYP
MAV_1825|M.avium_104 VRWPAQYISEFAWERQLDVD--AKMGEPYNRVVVKEPMGVVGAITPWNFP
TH_3100|M.thermoresistible__bu IRWPANYISEFAWERPLPDA--ALMGAPYHRKVVKEPVGVVGAITQWNFP
Mflv_4340|M.gilvum_PYR-GCK LRYPAGLIDDFEWERVLDAG--GLFGERNIRMVVKEAVGVVAAVTPSNFP
MMAR_4322|M.marinum_M LRYPVKLIDEYPWETDLGDVLVSITGQMTTRKVWREPVGVVGAIVPWNFP
MLBr_02573|M.leprae_Br4923 FRYYAEKAETLLADEPAEAAA----VGASKALARYQPLGVVLAVMPWNFP
: . :.:*** *: *:*
Mb0791|M.bovis_AF2122/97 HQINLAKLGPALAAGNTVVLKPAPDTPWCAAALGEIIVEHTDFPPGVVNI
Rv0768|M.tuberculosis_H37Rv HQINLAKLGPALAAGNTVVLKPAPDTPWCAAALGEIIVEHTDFPPGVVNI
MUL_0477|M.ulcerans_Agy99 HQINLAKLGPALAAGNTVVLKPAPDTPWCAAVLGELIADCTDIPPGVVNI
MAB_1218|M.abscessus_ATCC_1997 HQINLAKVGPALAAGNTLVLKPAPDTPWCAAVLGRIIAEHTDFPPGVVNI
MSMEG_3387|M.smegmatis_MC2_155 LQTAMTKILPALAAGATVVLKPAFQTPWHATLLARLIAEKTDIPAGVINV
Mvan_0904|M.vanbaalenii_PYR-1 LPLNIFKVAAALAAGCTVVLKPAPDTPWSGTELGRIILERTDIPAGVVNV
MAV_1825|M.avium_104 VEIIANKVGQILATGNTMVLKPAIETPWSALRWGRIIAEKTDIPAGVVNI
TH_3100|M.thermoresistible__bu FEIISNKLGQALATGNSVVLKPAMETPWSALRWCRIIAEKTDIPPGVVNI
Mflv_4340|M.gilvum_PYR-GCK LEVILNKLGPALAAGNTVVLKPDPHTPWNATRLGRLIAEKTDFPPGVVNV
MMAR_4322|M.marinum_M FEVTINKLGQALGTGNTVVLKPAPDTPFNATRLGRLIAEKTDIPPGVVSV
MLBr_02573|M.leprae_Br4923 LWQTVRFAAPALMAGNVGLLKHASNVPQCALYLADVIARG-GFPEDCFQT
* :* :** ..* . :* .:* . ..
Mb0791|M.bovis_AF2122/97 VTSSSHALGALLAKDPRVDMISFTGSTATGRAVMADAAATIKKVFLELGG
Rv0768|M.tuberculosis_H37Rv VTSSSHALGALLAKDPRVDMISFTGSTATGRAVMADAAATIKKVFLELGG
MUL_0477|M.ulcerans_Agy99 VTSSEHGLGALLAKDPRVDMVSFTGSTATGRSVMADGAATIKRMFLELGG
MAB_1218|M.abscessus_ATCC_1997 VTSSDHRIGAQLSTDPRVDMVSFTGSTATGRAVMTDAAATVKKVFLELGG
MSMEG_3387|M.smegmatis_MC2_155 VTPSDNAVAERLAVDPRVDLVHFTGSTAVGKKLMADASGRVARVALELGG
Mvan_0904|M.vanbaalenii_PYR-1 VTAADPLIGAALVADPRIDMVTFTGSTEVGKRIMAAAADNVTRVCLELGG
MAV_1825|M.avium_104 VPASDNDVAQRLVTDPRVDMVSFTGSTAVGKLIQRLSADMMKRNLLELGG
TH_3100|M.thermoresistible__bu VPTSDNSIAQVLATDPRVDMVSFTGSTAVGKLIQRLGADTMKRTMLELGG
Mflv_4340|M.gilvum_PYR-GCK VTTPSNAVAGLLGTDARVDLVSFTGSTAVGKLLMRQGADSMKRMFLELGG
MMAR_4322|M.marinum_M VTASDHLVGEELTLSPKVDLISFTGSTGVGKRIMEKGAATMKRLFLELGG
MLBr_02573|M.leprae_Br4923 LLISANGVEAILR-DPRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGG
: . : * ..:: :*** .*: : .. : *****
Mb0791|M.bovis_AF2122/97 KSAFVVLDD---ADLAAASAVSAFSACMHAGQGCAITTRLVVPRARYEEA
Rv0768|M.tuberculosis_H37Rv KSAFVVLDD---ADLAAASAVSAFSACMHAGQGCAITTRLVVPRARYEEA
MUL_0477|M.ulcerans_Agy99 KSAFIVLDD---ADLAAASSVSAFTASMHAGQGCAITTRLVVPRARYDEA
MAB_1218|M.abscessus_ATCC_1997 KSAFIVLDDLDEAALGSACSVAAFTAAMHAGQGCAITTRLVVPRERYDDA
MSMEG_3387|M.smegmatis_MC2_155 KSANILLED---ADFTQIVPQAAGVVCMNAGQGCVLPTRLLVPRSRYDEA
Mvan_0904|M.vanbaalenii_PYR-1 KSANIVLDD---ADLPALAADIAG-VCAHAGQGCALTTRLLLPRHRYDEG
MAV_1825|M.avium_104 KSVYLLLDD---ADLATTVPGCIG-ALMHSGQGCALTTRMLVPRERYDEA
TH_3100|M.thermoresistible__bu KSAYLVREG---ADLEAALPGCVG-ALMHSGQGCALATRMLVPRSIYDQA
Mflv_4340|M.gilvum_PYR-GCK KSAAIVLDD---ANPAVIVPTAVG-VCVHAGQACAATSRMLIHRSLYDQA
MMAR_4322|M.marinum_M KSATIVLED---AEFGLACAIGIA-PCMHAGQGCANPTRMLLPRSRYDEG
MLBr_02573|M.leprae_Br4923 SDPFIVMPS---ADLDAAVATAVTGRVQNNGQSCIAAKRFIAHADIYDEF
.. :: . * . : **.* ..*:: *::
Mb0791|M.bovis_AF2122/97 VAIAAATMSSIRPGDPNDPGTVCGPLISARQRDRVQGYLDLAVAEGGRFA
Rv0768|M.tuberculosis_H37Rv VAIAAATMSSIRPGDPNDPGTVCGPLISARQRDRVQGYLDLAVAEGGRFA
MUL_0477|M.ulcerans_Agy99 VAIAAGTMSSIKPGDPDDARTVCGPLISQRQRDRVEGYLDLAIAEGGTFA
MAB_1218|M.abscessus_ATCC_1997 VAAAAATMGSLKPGDPAKPGTICGPVISARQRDRVQSYLDLAVAEGGSFA
MSMEG_3387|M.smegmatis_MC2_155 RELARITFEHMPFGDPTDPGTVQGPQISKVQQDRVLGLIAQGVAEGATLL
Mvan_0904|M.vanbaalenii_PYR-1 IAVARAAFEQLRCGDPTDPAVVVGPVINARQRDRILRMIDVGKQE-ARLL
MAV_1825|M.avium_104 VELATATFASVTVGDPTDPANFCGPLVSAKQRDRVMDYIRIGKEEGARVT
TH_3100|M.thermoresistible__bu AEVASATFGSLAVGDPADPNTFCGPLVSARQRDRVLNYIEIAKREGGRIT
Mflv_4340|M.gilvum_PYR-GCK VADITMAYQYVPVGDPTDPGTLVGPVISAAQQERVLSAIEGARRDGAEIT
MMAR_4322|M.marinum_M VAILKSIYDNVMPGDPQDPATLCGPVISDKQRKRVLGYLNKGVEEGATCL
MLBr_02573|M.leprae_Br4923 VEKFVARMETLRVGDPTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIR
: *** .. ** . : :: : . .
Mb0791|M.bovis_AF2122/97 CGG----ARPADREVGFYIEPTVIAGLTNDARVAREEIFGPVLTVIAHDG
Rv0768|M.tuberculosis_H37Rv CGG----ARPADREVGFYIEPTVIAGLTNDARVAREEIFGPVLTVIAHDG
MUL_0477|M.ulcerans_Agy99 CGG----GRPAGRQVGYFIEPTVIAGLTTDARPAREEIFGPVLTVLAHDG
MAB_1218|M.abscessus_ATCC_1997 CGG----GRPEGKDRGFFIEPTVVAGLTNAARVAREEIFGPVLVVIAHDG
MSMEG_3387|M.smegmatis_MC2_155 TGG----RIPDGFDGGFFVEPTLFADVDPHSTIAQREIFGPVLAMIPYDN
Mvan_0904|M.vanbaalenii_PYR-1 VGG----GTPESLPVGYYVEPTLFCDVGPDAVIAQQEIFGPVLAIIPYED
MAV_1825|M.avium_104 IGG----GKPEGLDSGYFVAPTVFADVTPDMRIFQEEIFGPVITITPYDG
TH_3100|M.thermoresistible__bu VGG----GVPEGLDRGYFVAPTVVADVEPHHTIFQEEIFGPVLSITPYNG
Mflv_4340|M.gilvum_PYR-GCK AGGGLVAGLPDHLAGGHFVAPTVITGVDNSAAIAQQEVFGPVLVLLPFDD
MMAR_4322|M.marinum_M VGG---PDAPTGFDRGFYVRPTLFVDVDNSMTIAQEEIFGPVLSVIPFDT
MLBr_02573|M.leprae_Br4923 CGG----KRPD--RPGWFYPPTVITDITKDMALYTDEVFGPVASVYCATN
** * * : **:. .: *:**** :
Mb0791|M.bovis_AF2122/97 -DDDAVRIANDSPYGLSGTVYGADPQRAARIASRLRVGTVNVNGGVWYCA
Rv0768|M.tuberculosis_H37Rv -DDDAVRIANDSPYGLSGTVYGADPQRAARIASRLRVGTVNVNGGVWYCA
MUL_0477|M.ulcerans_Agy99 -DDDAVRIANDSPYGLSGTVYGGDPQRAADVAARLRVGAVNVNGGVWYCA
MAB_1218|M.abscessus_ATCC_1997 -DEDAVRIANDSPYGLSGTVFGDDDERSARVASRLRVGTVNVNGGVWYSA
MSMEG_3387|M.smegmatis_MC2_155 -VEHAIDIANNTSYGLAGYVWG-DEDAAVTVARRIRSGMVAVNGGFFYGH
Mvan_0904|M.vanbaalenii_PYR-1 -DDHAVQIANNSIYGLSAAVHSKDTDRAMGIARRLRTGTVGVNGGVWLAA
MAV_1825|M.avium_104 GDDGAIEMANNSMYGLAGTVLG-SKERAIAVGRRIRTGSVCVNSAIFYGA
TH_3100|M.thermoresistible__bu GDDAAVELANNSTYGLAGAVMG-PDDRAMAVARRIRTGSLMINNSLYYGA
Mflv_4340|M.gilvum_PYR-GCK -DDEAVRLANDSAFGLAGAVMSRSAERGMNIARRIRTGAFGVNGGMFYGA
MMAR_4322|M.marinum_M -EEDAIRIANDSVYGLAGNVMSGSLEHSLAVARRLRAGFIGVNGGAPYGA
MLBr_02573|M.leprae_Br4923 -IDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVAGQVFINGMTVSYP
: *: :** : :**.. . . . .: * . :*.
Mb0791|M.bovis_AF2122/97 DAPFGGYKQSGIGREMGLLGFEEYLEAKLIATAAN---
Rv0768|M.tuberculosis_H37Rv DAPFGGYKQSGIGREMGLLGFEEYLEAKLIATAAN---
MUL_0477|M.ulcerans_Agy99 DAPFGGYKQSGIGREMGLAGFEEYLETKLIATAAN---
MAB_1218|M.abscessus_ATCC_1997 DAPFGGYKQSGNGREMGVAGFEEYLETKVIATAVK---
MSMEG_3387|M.smegmatis_MC2_155 DVPSGGYKESGLGRESGVEGFQEFLETKVIAVAG----
Mvan_0904|M.vanbaalenii_PYR-1 DTPFGGYKQSGLGRELGIDGFAEFLETKSIALPC----
MAV_1825|M.avium_104 DAPFGGYKMSGIGRQNGIEGFEQHLQTKVIAYPID---
TH_3100|M.thermoresistible__bu DAPFGGYKMSGIGRQNGHEGFEQYLETKTIAYPLEAGQ
Mflv_4340|M.gilvum_PYR-GCK DAPFGGYKSSGVGRQCGIEGFSQYLETKTIARRERRKG
MMAR_4322|M.marinum_M DTPFGGYKDSGVGRQNGVAGFDQYTQIKSLGYPAG---
MLBr_02573|M.leprae_Br4923 ELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA-----
: * ** * ** **: . *: :. : * :