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VSDDIYILGGWQSDFAQKARDAQFFPLLRDATFGALDDARIEAADIDVIHVGNFAGEMFTGQGQLGGMAV SVHPDLAGKPASRHEAACASGSMAALAAMADLESGRYDCSLVVGAEVLRNVGGQEAGLRLGSAAWIGREI VDEPYPWPAMFGRIGEEYARRYGLDHAHLGRIAEINITNARRNPRAQTRDWSLTKESFYEDDLQNPPVAG PLRKQDCSRITDGSAAVVLATTRFAQDWARHRNVSLADVPRVLGWGHRTGTMLLEDKLAASRDAEYVFPH LRQAILDAYRRAGCSGPADLDAVETHDCFSISEYAAIDHFGITPPGKSWQAVEDGLIEPDGALPINPSGG LLGLGHPVGATGVRMLLDGARQVTGRAGDYQVPGARKVGLLNVGGSVTSAASFVVGI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0900 | - | - | 100% (407) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_4939 | - | e-112 | 52.83% (407) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2338 | - | 4e-33 | 28.75% (400) | lipid-transfer protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0938c | - | 1e-111 | 51.33% (413) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_1808 | - | 1e-111 | 52.58% (407) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv0914c | - | 1e-111 | 51.33% (413) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_01158 | fadA4 | 4e-05 | 26.01% (173) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_1864 | - | 2e-33 | 29.30% (413) | lipid-transfer protein |
| M. marinum M | MMAR_4613 | - | 1e-111 | 52.46% (406) | lipid carrier protein or keto acyl-CoA thiolase |
| M. avium 104 | MAV_5079 | - | 2e-38 | 31.47% (394) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_5608 | - | 1e-111 | 51.11% (405) | acetyl-CoA acetyltransferase |
| M. thermoresistible (build 8) | TH_3699 | - | 9e-40 | 32.40% (392) | PUTATIVE thiolase |
| M. ulcerans Agy99 | MUL_4955 | ltp1_1 | 1e-33 | 30.73% (410) | lipid-transfer protein Ltp1_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0938c|M.bovis_AF2122/97 MD--DGVWILGGYQSDFARNLSKENRDFADLTREVVDGTLTAAK-VDAAD
Rv0914c|M.tuberculosis_H37Rv MD--DGVWILGGYQSDFARNLSKENRDFADLTREVVDGTLTAAK-VDAAD
MMAR_4613|M.marinum_M MDGTTGVWILGGYQSDFARNLTKENRDFADLTAEVVPGTLAAAQ-IEAAD
MSMEG_5608|M.smegmatis_MC2_155 MEN---VWVLGGYQSDFARNLTRENLDFADLTREVVENTLAHAK-IDASD
Mflv_1808|M.gilvum_PYR-GCK MRSADDVWILGGYQSDFACNYHRDGRGFSELTAEVVESTLRDAC-VDARD
Mvan_0900|M.vanbaalenii_PYR-1 MS--DDIYILGGWQSDFAQKAR--DAQFFPLLRDATFGALDDAR-IEAAD
MAV_5079|M.avium_104 MPSNGIAGKVAVVAMGCSHFGERWDASTEDLILEAYQECLDSVPNLGADD
TH_3699|M.thermoresistible__bu MASNGIAGKVAVVGMGCTRFGERWDASADDLILEAYAEALDSAG-ISRDD
MAB_1864|M.abscessus_ATCC_1997 MKQQNKVFVVGVGMTKFEKPGRREGWDYPAMVKEAGTKALEDAG-VQYPE
MUL_4955|M.ulcerans_Agy99 MSASDEIWILGIRMTKFG---KHPDLDTVDLAAQAAMSALDDAG-VSMAD
MLBr_01158|M.leprae_Br4923 --MTTSVIVTGARTPIGKLMGSLKDFSASDLGAITIAAALKKAN-VAPSI
. . : . * . :
Mb0938c|M.bovis_AF2122/97 LAAAGVVHVANAFGEMFARQGHLGAMPATVCDDL-WDTPATRHEAACASG
Rv0914c|M.tuberculosis_H37Rv LAAAGVVHVANAFGEMFARQGHLGAMPATVCDDL-WDTPATRHEAACASG
MMAR_4613|M.marinum_M IG---VVHVANAFGEMFAGQGHLGAMPATVSDGL-WDTPASRHEAACASG
MSMEG_5608|M.smegmatis_MC2_155 IG---VVHVANAFGELFARQGHLGAMPATVHEGL-WDTPSSRHEAACASG
Mflv_1808|M.gilvum_PYR-GCK IG---VVHVANAFGELFAHQGHLGAMPATVVDGL-WDTPATRHEAACASG
Mvan_0900|M.vanbaalenii_PYR-1 ID---VIHVGNFAGEMFTGQGQLGGMAVSVHPDL-AGKPASRHEAACASG
MAV_5079|M.avium_104 VD-------AFWLGTLSSG---LGGLTLSRAIGN-DDKPVTRVENFCATG
TH_3699|M.thermoresistible__bu ID-------AYWLGTLSSG---LGGLTLSRAIGS-DDKPVTRVENFCATG
MAB_1864|M.abscessus_ATCC_1997 IE-------QAFIGNVYG-DSCSGHR-ALYELGH-TGIPIYNVNSNCSTG
MUL_4955|M.ulcerans_Agy99 IG-------VLAAGNLMAANAGIGQQ-LQKQIGQ-TGIPVYNVANACATG
MLBr_01158|M.leprae_Br4923 VQ------YVIIGQVLTAGAGQMPARQAAVAAGIGWDVPALTINKMCLSG
: : . . * * :*
Mb0938c|M.bovis_AF2122/97 SVATLAAMADLRSGAYRVALVVGLELEK-----------TVPGDTAAEHL
Rv0914c|M.tuberculosis_H37Rv SVATLAAMADLRSGAYRVALVVGLELEK-----------TVPGDTAAEHL
MMAR_4613|M.marinum_M SVATLAAIADLRSGFYNSALVVGLELEK-----------TVPGDTAAQYL
MSMEG_5608|M.smegmatis_MC2_155 SVAALAAIADLRSGAYDTALVVGVELEK-----------TVPGDDAAANL
Mflv_1808|M.gilvum_PYR-GCK SVAALAAIADLRSGAYRTALVVGVELEK-----------TVPGDTATSIL
Mvan_0900|M.vanbaalenii_PYR-1 SMAALAAMADLESGRYDCSLVVGAEVLR-----------NVGGQEAGLRL
MAV_5079|M.avium_104 SEAFRNACYAVAAGAYDVAMALGVEKLK-----------DSG---YSGLL
TH_3699|M.thermoresistible__bu SEAFRNACYAVASGAYDIAMAVGVEKLK-----------DSG---YSGLL
MAB_1864|M.abscessus_ATCC_1997 STALFMAANAIRSGQSDVVMAAGFEKME-PGSLG-----MKFSDRESPLQ
MUL_4955|M.ulcerans_Agy99 ATALRTAIMAVKAGEVDYGMAVGVEKLSGAGLLGGGGKKKSDADVWTPAG
MLBr_01158|M.leprae_Br4923 LDAIALADQLIRAGEFDVVVAGGQESMT-----------------KAPHL
* * : :* :. * *
Mb0938c|M.bovis_AF2122/97 SAAAWTGHEGAEARYLWPSMFAQVADEYDRRYGLDDTHLR----AIAQLN
Rv0914c|M.tuberculosis_H37Rv SAAAWTGHEGAEARYLWPSMFAQVADEYDRRYGLDDTHLR----AIAQLN
MMAR_4613|M.marinum_M GAAGWTGHEGAEARYLWPSVFTQVADEYDRRYGLDDTHLH----SIAQLN
MSMEG_5608|M.smegmatis_MC2_155 GTAAWTGHEGADATYMWPWMFSKVADEYDRRYCLDPAHLR----VIAAVN
Mflv_1808|M.gilvum_PYR-GCK GAAAWTGHEGRDAKFMWPHMFNAVADEYDRRYGLDESHLR----AIADLN
Mvan_0900|M.vanbaalenii_PYR-1 GSAAWIGREIVDEPYPWPAMFGRIGEEYARRYGLDHAHLG----RIAEIN
MAV_5079|M.avium_104 RQDPPGDGTAPELSMTAPAAFSMLDPAYCARHGVHPDEMRAAMTHVAWKN
TH_3699|M.thermoresistible__bu RQDPPGDGTAPEISMTAPAAFSMLDPAYCARYGVHPDEMRAAMTHVAWKN
MAB_1864|M.abscessus_ATCC_1997 PHIMALGELSQPQFPMTAWMFAAAAEEYMREYG-LTAEQLA---WIGYKN
MUL_4955|M.ulcerans_Agy99 RYGAVAPVDGRIGTETMPGVFAQIGTEYGHKYGGTSFELFA---KISEKN
MLBr_01158|M.leprae_Br4923 LMDSRSGYKYGDVTIVDHLAYDGLHDVFTNQPMGALTEQRNDVEKFTRQE
: : . . . :
Mb0938c|M.bovis_AF2122/97 FANARRNPNAQTRG---WTIP-DPITDDDATNPLTEGRLRRFDCSQMTDG
Rv0914c|M.tuberculosis_H37Rv FANARRNPNAQTRG---WTIP-DPITDDDATNPLTEGRLRRFDCSQMTDG
MMAR_4613|M.marinum_M YANARRNPNAQTRG---WTIP-DPITDDDATNPITEGRLRRLDCSQMTDG
MSMEG_5608|M.smegmatis_MC2_155 FANARRNPNAQTRT---WNVP-DPLTDDDATNPVVEGRIRRFDCSQMTDG
Mflv_1808|M.gilvum_PYR-GCK FTNARANPLAQTRD---WSVP-SPPTADDTSNPVVDGRLRRLDCSQLTDG
Mvan_0900|M.vanbaalenii_PYR-1 ITNARRNPRAQTRD---WSLTKESFYEDDLQNPPVAGPLRKQDCSRITDG
MAV_5079|M.avium_104 HDNGTRNPKAQFRSPVSR--------DTIDNAPKVAGRLGVFDCSGISDG
TH_3699|M.thermoresistible__bu HDNGSRNPKAQFRSGVSK--------ETIDKAVKVAGRLGVFDCSGVSDG
MAB_1864|M.abscessus_ATCC_1997 HKHSVNNPYSQFQD--------EYSLEDILSSRTIVGPLTKLQCSPTSDG
MUL_4955|M.ulcerans_Agy99 HAHSTLNPLAAYQK--------RFTLEQIMNDVMIAYPNTRPMCSANCDG
MLBr_01158|M.leprae_Br4923 QDEFAARSHQKAAA---------AWKDGVFADEVVPVSIPQSKGDSLQFT
. .. .
Mb0938c|M.bovis_AF2122/97 GAGLVLVSDAYLRDHRDAR-----PIGRIDGWGHRTVGLGLRQKLDRVAQ
Rv0914c|M.tuberculosis_H37Rv GAGLVLVSDAYLRDHRDAR-----PIGRIDGWGHRTVGLGLRQKLDRVAQ
MMAR_4613|M.marinum_M GAGLVLVNDAYLRDHPGAR-----PIGRIDGWGHCTVGLGLQQKLDRPAQ
MSMEG_5608|M.smegmatis_MC2_155 GAGVVLVTDRWLRAHPGVT-----PQARIAGWGHRTVGLGLQQKIDR---
Mflv_1808|M.gilvum_PYR-GCK GAGLVLVSDAWLRDNPAAR-----PLGRIDGWGHRTVGLGLRQKLDH---
Mvan_0900|M.vanbaalenii_PYR-1 SAAVVLATTRFAQDWARHRNVSLADVPRVLGWGHRTGTMLLEDKLAA---
MAV_5079|M.avium_104 AACALIVPAERAREYTDTP---------MYVEALSLIAGSARASMDPG--
TH_3699|M.thermoresistible__bu AACAVIVPADRAHEYTDTP---------MYVRALSLVSGSARGAVDAG--
MAB_1864|M.abscessus_ATCC_1997 SAAAIVASEEFVDTHGLAD-----------QAVEIVGQATVTDREDTFDG
MUL_4955|M.ulcerans_Agy99 AAAAIVCNGETLKSLSARQ-----------RRRAVKVSASVLTTDPYEPG
MLBr_01158|M.leprae_Br4923 EDEGIRANTSAESLAGLKP--------AFRCGGTITPGSASQISDGAATV
:
Mb0938c|M.bovis_AF2122/97 GDSAPYLLPHVRATVLDALRRARVT--LDDLDGIEVHDCFT---PSEYLA
Rv0914c|M.tuberculosis_H37Rv GDSAPYLLPHVRATVLDALRRARVT--LDDLDGIEVHDCFT---PSEYLA
MMAR_4613|M.marinum_M GESGQYVLPHVRKAALDALRRAHVS--LDDLNGYEVHDCFT---PSEYLA
MSMEG_5608|M.smegmatis_MC2_155 ADADPYLLPHVRGAVQDAFGRAQVT--LDDIDGFEVHDCFT---PSEYLA
Mflv_1808|M.gilvum_PYR-GCK SAGNPYVFPHVRSAVQDAFGRARVT--LDEVDGFEVHDCFT---PSEYLA
Mvan_0900|M.vanbaalenii_PYR-1 SRDAEYVFPHLRQAILDAYRRAGCSG-PADLDAVETHDCFS---ISEYAA
MAV_5079|M.avium_104 --YDFTTFPEVVKSAKDAYTQAGIEHPARELSLAEVHDCFT---PTEIVL
TH_3699|M.thermoresistible__bu --YDYTTFPEVVRSARDAYAQAGIDDPATQLSFAEVHDCFT---PTEIVL
MAB_1864|M.abscessus_ATCC_1997 TAAGIVGANMNKAAIASVYAQAQIG--PDDLDVVELHDCFS---ANEILV
MUL_4955|M.ulcerans_Agy99 CQVLPNVNTLTRNAAKTAYEQAGVG--PSDLDLVELHDCFA---TAELVH
MLBr_01158|M.leprae_Br4923 VVMNKEKAQQLGLTWLVEIGAHGVVAGPDSTLQSQPANAIKKAVDREGIS
: . : :.: *
Mb0938c|M.bovis_AF2122/97 IDHIGLTGPGESWKAIENGEIEIGGRLP--INPSGGLIGGGHPVGASGVR
Rv0914c|M.tuberculosis_H37Rv IDHIGLTGPGESWKAIENGEIEIGGRLP--INPSGGLIGGGHPVGASGVR
MMAR_4613|M.marinum_M IDHIGLTGPGESWKAIENGEIEIGGRLP--INPSGGLIGGGHPVGASGVR
MSMEG_5608|M.smegmatis_MC2_155 IDHIGLTGPGESWKAIENGEIEISGRLP--INPSGGLIGGGHPVGASGVR
Mflv_1808|M.gilvum_PYR-GCK IDHIGLTEPGQSWKAIEHGEIAIGGRLP--VNPSGGLIGGGHPVGASGVR
Mvan_0900|M.vanbaalenii_PYR-1 IDHFGITPPGKSWQAVEDGLIEPDGALP--INPSGGLLGLGHPVGATGVR
MAV_5079|M.avium_104 MEDLGFSVAGNAWKDVLSGEFDADGRLP--VNPDGGLKSFGHPVGASGLR
TH_3699|M.thermoresistible__bu MEDLGFTEPGRAYKDVLSGEFDADGRLP--VNIDGGLKSFGHPVGASGLR
MAB_1864|M.abscessus_ATCC_1997 YEALGFCEPGAAGKLIDNQDTTFGGKWV--VNPSGGLISKGHPLGATGLA
MUL_4955|M.ulcerans_Agy99 YDNLMLCEQGGAADFFESGAPWRHGSTP--VNVSGGLQSKGHPIAATGIA
MLBr_01158|M.leprae_Br4923 VEQLDVVEINEAFAAVALASARELGIAPELVNVNGGAIAVGHPLGMSGAR
: : . . : . * :* .** . ***:. :*
Mb0938c|M.bovis_AF2122/97 MLLDAAKQVSGIAGDYQVENAEAFGTLNFGGSTATTVSFVVSTTRGS---
Rv0914c|M.tuberculosis_H37Rv MLLDAAKQVSGIAGDYQVENAEAFGTLNFGGSTATTVSFVVSTTRGS---
MMAR_4613|M.marinum_M MLLDAAKQVSGAAGDYQVENATKFGTLNFGGSTATTVSFVVSTTKDA---
MSMEG_5608|M.smegmatis_MC2_155 MLLDATKQVSASAGEYQVEAAKTFGTLNFGGSTATTVSFVVTAGKE----
Mflv_1808|M.gilvum_PYR-GCK MLLDAARQVSDTAGDYQVEGAKTFGTLNFGGSTATTVSFVVGSTP-----
Mvan_0900|M.vanbaalenii_PYR-1 MLLDGARQVTGRAGDYQVPGARKVGLLNVGGSVTSAASFVVGI-------
MAV_5079|M.avium_104 MLYEAWLQFGGRAGARQLSDPHTALTHNLGGRPGGCVSFVSIVSRTRRKR
TH_3699|M.thermoresistible__bu MLYEAWLQFRGAAGERQLAEPHTALTHNLGGRPGGCVSFVSVVGRDR---
MAB_1864|M.abscessus_ATCC_1997 QCAELNWQLRGKADKRQVAGAATKDGVALQHNIGLGGSVVVTAYRPANR-
MUL_4955|M.ulcerans_Agy99 NVWEICHQLRGEAGDRQIDNAK----VGLAHVIGLGSACGVHILERSAA-
MLBr_01158|M.leprae_Br4923 ITLHVALELARRGSG--------YGVAALCGAGGQGDALILRAV------
. :. .. . :
Mb0938c|M.bovis_AF2122/97 -
Rv0914c|M.tuberculosis_H37Rv -
MMAR_4613|M.marinum_M -
MSMEG_5608|M.smegmatis_MC2_155 -
Mflv_1808|M.gilvum_PYR-GCK -
Mvan_0900|M.vanbaalenii_PYR-1 -
MAV_5079|M.avium_104 V
TH_3699|M.thermoresistible__bu -
MAB_1864|M.abscessus_ATCC_1997 -
MUL_4955|M.ulcerans_Agy99 -
MLBr_01158|M.leprae_Br4923 -