For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
RSADDVWILGGYQSDFACNYHRDGRGFSELTAEVVESTLRDACVDARDIGVVHVANAFGELFAHQGHLGA MPATVVDGLWDTPATRHEAACASGSVAALAAIADLRSGAYRTALVVGVELEKTVPGDTATSILGAAAWTG HEGRDAKFMWPHMFNAVADEYDRRYGLDESHLRAIADLNFTNARANPLAQTRDWSVPSPPTADDTSNPVV DGRLRRLDCSQLTDGGAGLVLVSDAWLRDNPAARPLGRIDGWGHRTVGLGLRQKLDHSAGNPYVFPHVRS AVQDAFGRARVTLDEVDGFEVHDCFTPSEYLAIDHIGLTEPGQSWKAIEHGEIAIGGRLPVNPSGGLIGG GHPVGASGVRMLLDAARQVSDTAGDYQVEGAKTFGTLNFGGSTATTVSFVVGSTP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1808 | - | - | 100% (406) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_2505 | - | 1e-29 | 33.13% (326) | thiolase |
| M. gilvum PYR-GCK | Mflv_2025 | - | 1e-29 | 27.23% (404) | lipid-transfer protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0938c | - | 0.0 | 76.66% (407) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv0914c | - | 0.0 | 76.66% (407) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_02564 | fadA2 | 2e-09 | 21.34% (417) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_1864 | - | 6e-33 | 26.83% (410) | lipid-transfer protein |
| M. marinum M | MMAR_4613 | - | 1e-180 | 75.12% (402) | lipid carrier protein or keto acyl-CoA thiolase |
| M. avium 104 | MAV_5079 | - | 2e-37 | 34.46% (354) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_5608 | - | 0.0 | 76.88% (398) | acetyl-CoA acetyltransferase |
| M. thermoresistible (build 8) | TH_3699 | - | 3e-38 | 35.41% (353) | PUTATIVE thiolase |
| M. ulcerans Agy99 | MUL_2143 | ltp1 | 1e-29 | 25.94% (401) | lipid-transfer protein |
| M. vanbaalenii PYR-1 | Mvan_4939 | - | 0.0 | 84.16% (404) | acetyl-CoA acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1808|M.gilvum_PYR-GCK ------------------MRSADDVWILGGYQSDFACNYHRDGRGFSELT
Mvan_4939|M.vanbaalenii_PYR-1 -------------------MSSTGVWILGGYQSDFARNYDREGLDFAGLT
Mb0938c|M.bovis_AF2122/97 ------------------MD--DGVWILGGYQSDFARNLSKENRDFADLT
Rv0914c|M.tuberculosis_H37Rv ------------------MD--DGVWILGGYQSDFARNLSKENRDFADLT
MMAR_4613|M.marinum_M ------------------MDGTTGVWILGGYQSDFARNLTKENRDFADLT
MSMEG_5608|M.smegmatis_MC2_155 ------------------MEN---VWVLGGYQSDFARNLTRENLDFADLT
MAB_1864|M.abscessus_ATCC_1997 ----------------MKQQ--NKVFVVGVGMTKFEKPGRREGWDYPAMV
MUL_2143|M.ulcerans_Agy99 ----------------MPNNGSNRVFVIGVGMTKFEKPGRREGWDYPDMA
MAV_5079|M.avium_104 ---------------MPSNGIAGKVAVVAMGCSHFG---ERWDASTEDLI
TH_3699|M.thermoresistible__bu ---------------MASNGIAGKVAVVGMGCTRFG---ERWDASADDLI
MLBr_02564|M.leprae_Br4923 MLGETRRLQVAPASSVASDKTIQRTTFAKQRVAVLGGNRIPFARSNGAYA
. . : : .
Mflv_1808|M.gilvum_PYR-GCK AEVVESTLRDACVDARDIG---VVHVANAFGELFAHQGHLGAMPATVVDG
Mvan_4939|M.vanbaalenii_PYR-1 AEVVEATLEASGVDAADIG---VVHVANAFGGLFARQGHLGAMPATVNDG
Mb0938c|M.bovis_AF2122/97 REVVDGTLTAAKVDAADLAAAGVVHVANAFGEMFARQGHLGAMPATVCDD
Rv0914c|M.tuberculosis_H37Rv REVVDGTLTAAKVDAADLAAAGVVHVANAFGEMFARQGHLGAMPATVCDD
MMAR_4613|M.marinum_M AEVVPGTLAAAQIEAADIG---VVHVANAFGEMFAGQGHLGAMPATVSDG
MSMEG_5608|M.smegmatis_MC2_155 REVVENTLAHAKIDASDIG---VVHVANAFGELFARQGHLGAMPATVHEG
MAB_1864|M.abscessus_ATCC_1997 KEAGTKALEDAGVQYPEIEQ---AFIGNVYGDSCSGH------RALYELG
MUL_2143|M.ulcerans_Agy99 RESGTNALNDAGIEYREVEH---AYVGYVYGESTSGQ------RAVYELG
MAV_5079|M.avium_104 LEAYQECLDSVPNLGADDVD---AFWLGTLSSGLGGL------TLSRAIG
TH_3699|M.thermoresistible__bu LEAYAEALDSAG-ISRDDID---AYWLGTLSSGLGGL------TLSRAIG
MLBr_02564|M.leprae_Br4923 EASNQDMFSAALSGLVDRFGLAGERLDMVIGGAVLKHSRDFNLMRECVLG
: : . . .
Mflv_1808|M.gilvum_PYR-GCK LWD---TPATRHEAACASGSVAALAAIADLRSGAYRTALVVGVELEKTVP
Mvan_4939|M.vanbaalenii_PYR-1 LWG---TPAVRHEAACASGSVAALAAIADLRSGAYTSALVVGVELEKTVP
Mb0938c|M.bovis_AF2122/97 LWD---TPATRHEAACASGSVATLAAMADLRSGAYRVALVVGLELEKTVP
Rv0914c|M.tuberculosis_H37Rv LWD---TPATRHEAACASGSVATLAAMADLRSGAYRVALVVGLELEKTVP
MMAR_4613|M.marinum_M LWD---TPASRHEAACASGSVATLAAIADLRSGFYNSALVVGLELEKTVP
MSMEG_5608|M.smegmatis_MC2_155 LWD---TPSSRHEAACASGSVAALAAIADLRSGAYDTALVVGVELEKTVP
MAB_1864|M.abscessus_ATCC_1997 HTG---IPIYNVNSNCSTGSTALFMAANAIRSGQSDVVMAAGFEKMEPGS
MUL_2143|M.ulcerans_Agy99 MTG---IPVVNVNNNCSTGSTALFLAAQAIRGGLADCTVALGFEKMKPGS
MAV_5079|M.avium_104 NDD---KPVTRVENFCATGSEAFRNACYAVAAGAYDVAMALGVEKLKDSG
TH_3699|M.thermoresistible__bu SDD---KPVTRVENFCATGSEAFRNACYAVASGAYDIAMAVGVEKLKDSG
MLBr_02564|M.leprae_Br4923 SQLSPYTPAFDLQQACATGLQAAIVAADGIAAGRYEVAVAGGVDTTSDVP
* : *::* * * : .* .:. *.: .
Mflv_1808|M.gilvum_PYR-GCK G-------------DTATSILGAAAWTGHEGR--------DAKFMWPHMF
Mvan_4939|M.vanbaalenii_PYR-1 G-------------DEATSILGSAAWTGHEGQ--------QAKYMWPYMF
Mb0938c|M.bovis_AF2122/97 G-------------DTAAEHLSAAAWTGHEGA--------EARYLWPSMF
Rv0914c|M.tuberculosis_H37Rv G-------------DTAAEHLSAAAWTGHEGA--------EARYLWPSMF
MMAR_4613|M.marinum_M G-------------DTAAQYLGAAGWTGHEGA--------EARYLWPSVF
MSMEG_5608|M.smegmatis_MC2_155 G-------------DDAAANLGTAAWTGHEGA--------DATYMWPWMF
MAB_1864|M.abscessus_ATCC_1997 LGM--------KFSDRESPLQPHIMALGELSQ--------PQFPMTAWMF
MUL_2143|M.ulcerans_Agy99 LSS--------SYDDRTQPMDKHVKALAQIAE--------FAFPVAPWMF
MAV_5079|M.avium_104 YSG--------LLR-QDPPGDGTAPELSMTAP--------AAFSMLDPAY
TH_3699|M.thermoresistible__bu YSG--------LLR-QDPPGDGTAPEISMTAP--------AAFSMLDPAY
MLBr_02564|M.leprae_Br4923 ISLGDNLRRNLLKLRRSKSNVQRLKLVGALPANIGVEIPANSEPRTGLSM
.
Mflv_1808|M.gilvum_PYR-GCK NAVADEYDRRYGLDESHLRAIADLNFTNAR-------------------A
Mvan_4939|M.vanbaalenii_PYR-1 ETVAAEYDRRYGLDESHLHAIASLNFANAK-------------------T
Mb0938c|M.bovis_AF2122/97 AQVADEYDRRYGLDDTHLRAIAQLNFANAR-------------------R
Rv0914c|M.tuberculosis_H37Rv AQVADEYDRRYGLDDTHLRAIAQLNFANAR-------------------R
MMAR_4613|M.marinum_M TQVADEYDRRYGLDDTHLHSIAQLNYANAR-------------------R
MSMEG_5608|M.smegmatis_MC2_155 SKVADEYDRRYCLDPAHLRVIAAVNFANAR-------------------R
MAB_1864|M.abscessus_ATCC_1997 AAAAEEYMREYGLTAEQLAWIGYKNHKHSV-------------------N
MUL_2143|M.ulcerans_Agy99 GAAGREHMQQYGSTAEHFAKIGFKNHKHSV-------------------N
MAV_5079|M.avium_104 CARHGVHPDEMR---AAMTHVAWKNHDNGT-------------------R
TH_3699|M.thermoresistible__bu CARYGVHPDEMR---AAMTHVAWKNHDNGS-------------------R
MLBr_02564|M.leprae_Br4923 GEHAAITAKKMGIKRVDQDELAAASHRNMASAYDRGFFDDLVTPFLGLYR
. :. .. :
Mflv_1808|M.gilvum_PYR-GCK NPLAQTRDWSVPSPPTADDTSNPVVDGRLRRLDCSQLTDGGAGLVLVSDA
Mvan_4939|M.vanbaalenii_PYR-1 NPRAQTRTWAVPERVSADDTQNPVIEGRLRRLDCSQLTDGGAGVVLVSDD
Mb0938c|M.bovis_AF2122/97 NPNAQTRGWTIPDPITDDDATNPLTEGRLRRFDCSQMTDGGAGLVLVSDA
Rv0914c|M.tuberculosis_H37Rv NPNAQTRGWTIPDPITDDDATNPLTEGRLRRFDCSQMTDGGAGLVLVSDA
MMAR_4613|M.marinum_M NPNAQTRGWTIPDPITDDDATNPITEGRLRRLDCSQMTDGGAGLVLVNDA
MSMEG_5608|M.smegmatis_MC2_155 NPNAQTRTWNVPDPLTDDDATNPVVEGRIRRFDCSQMTDGGAGVVLVTDR
MAB_1864|M.abscessus_ATCC_1997 NPYSQFQDEYS----LEDILSSRTIVGPLTKLQCSPTSDGSAAAIVASEE
MUL_2143|M.ulcerans_Agy99 NPFAQFQEAYT----LDDILASRMIYEPLTKLRCSPTSDGSGAAILASES
MAV_5079|M.avium_104 NPKAQFRSPVS----RDTIDNAPKVAGRLGVFDCSGISDGAACALIVPAE
TH_3699|M.thermoresistible__bu NPKAQFRSGVS----KETIDKAVKVAGRLGVFDCSGVSDGAACAVIVPAD
MLBr_02564|M.leprae_Br4923 DDNLRPNSHVEKLATLRPVFGVQAGDATMTAGNSTSLTDGASVALLATEQ
: : . : .: :**.. ::.
Mflv_1808|M.gilvum_PYR-GCK WLRDNPAARPLGRIDGWGHRTVGLGLRQKLDH---SAGNPYVFPHVRSAV
Mvan_4939|M.vanbaalenii_PYR-1 WLRDHPTARPLGRIDGWGHRTVGLGLQQKLDH---SAGDPYVFPHVRAAV
Mb0938c|M.bovis_AF2122/97 YLRDHRDARPIGRIDGWGHRTVGLGLRQKLDRVAQGDSAPYLLPHVRATV
Rv0914c|M.tuberculosis_H37Rv YLRDHRDARPIGRIDGWGHRTVGLGLRQKLDRVAQGDSAPYLLPHVRATV
MMAR_4613|M.marinum_M YLRDHPGARPIGRIDGWGHCTVGLGLQQKLDRPAQGESGQYVLPHVRKAA
MSMEG_5608|M.smegmatis_MC2_155 WLRAHPGVTPQARIAGWGHRTVGLGLQQKIDR---ADADPYLLPHVRGAV
MAB_1864|M.abscessus_ATCC_1997 FVDTHGLADQAVEIVGQATVTDREDTFDGTAAG------IVGANMNKAAI
MUL_2143|M.ulcerans_Agy99 FVDSHGLAGRAVEIVGQAMTTDFASTFDGSAKN------LIGYDMNVQAA
MAV_5079|M.avium_104 RAREYTDTPMYVEALSLIAGSARASMDPGYDFT------TFPEVVKSAKD
TH_3699|M.thermoresistible__bu RAHEYTDTPMYVRALSLVSGSARGAVDAGYDYT------TFPEVVRSARD
MLBr_02564|M.leprae_Br4923 WVAAHSLTPFAYWVDAEIAAVDYVSGNDGLLMAP------------TYAV
. .
Mflv_1808|M.gilvum_PYR-GCK QDAFGRARVTLDEVDGFEVHDCFTPSEYLAIDHIGLTEPGQSWKAIEHGE
Mvan_4939|M.vanbaalenii_PYR-1 LDAFGRAEVTLDDVDGFEVHDCFTPSEYLAIDHIGLTAPGESWKAIEHGE
Mb0938c|M.bovis_AF2122/97 LDALRRARVTLDDLDGIEVHDCFTPSEYLAIDHIGLTGPGESWKAIENGE
Rv0914c|M.tuberculosis_H37Rv LDALRRARVTLDDLDGIEVHDCFTPSEYLAIDHIGLTGPGESWKAIENGE
MMAR_4613|M.marinum_M LDALRRAHVSLDDLNGYEVHDCFTPSEYLAIDHIGLTGPGESWKAIENGE
MSMEG_5608|M.smegmatis_MC2_155 QDAFGRAQVTLDDIDGFEVHDCFTPSEYLAIDHIGLTGPGESWKAIENGE
MAB_1864|M.abscessus_ATCC_1997 ASVYAQAQIGPDDLDVVELHDCFSANEILVYEALGFCEPGAAGKLIDNQD
MUL_2143|M.ulcerans_Agy99 RRVYQQSGLGPEDFQVIELHDCFSANELLLYEALGLCGQGEAPKLIDNGD
MAV_5079|M.avium_104 AYTQAGIEHPARELSLAEVHDCFTPTEIVLMEDLGFSVAGNAWKDVLSGE
TH_3699|M.thermoresistible__bu AYAQAGIDDPATQLSFAEVHDCFTPTEIVLMEDLGFTEPGRAYKDVLSGE
MLBr_02564|M.leprae_Br4923 PRLLARNGLSFQDFDFYEIHEAFASVVLAHLQAWESEEYCRQCLGLDTAL
:.. *:*:.*:. : :
Mflv_1808|M.gilvum_PYR-GCK IAIGGRLPVNPSGGLIGGGHPVGASGVRMLLDAARQVSDTAGDYQVEGAK
Mvan_4939|M.vanbaalenii_PYR-1 IALGGTLPINPSGGLIGGGHPVGASGVRMLLDAARQVSDTAGDYQVDGAK
Mb0938c|M.bovis_AF2122/97 IEIGGRLPINPSGGLIGGGHPVGASGVRMLLDAAKQVSGIAGDYQVENAE
Rv0914c|M.tuberculosis_H37Rv IEIGGRLPINPSGGLIGGGHPVGASGVRMLLDAAKQVSGIAGDYQVENAE
MMAR_4613|M.marinum_M IEIGGRLPINPSGGLIGGGHPVGASGVRMLLDAAKQVSGAAGDYQVENAT
MSMEG_5608|M.smegmatis_MC2_155 IEISGRLPINPSGGLIGGGHPVGASGVRMLLDATKQVSASAGEYQVEAAK
MAB_1864|M.abscessus_ATCC_1997 TTFGGKWVVNPSGGLISKGHPLGATGLAQCAELNWQLRGKADKRQVAGAA
MUL_2143|M.ulcerans_Agy99 TTYGGRWVVNPSGGLISKGHPLGATGLAQCCELTWQLRGTADRRQVDNVT
MAV_5079|M.avium_104 FDADGRLPVNPDGGLKSFGHPVGASGLRMLYEAWLQFGGRAGARQLSDPH
TH_3699|M.thermoresistible__bu FDADGRLPVNIDGGLKSFGHPVGASGLRMLYEAWLQFRGAAGERQLAEPH
MLBr_02564|M.leprae_Br4923 GPID-RSKLNVNGSSLAAGHPFAATGGRILVQTAKQLAEQKATQKGCGPM
. :* .*. . ***..*:* : *. :
Mflv_1808|M.gilvum_PYR-GCK ----TFGTLNFGGSTATTVSFVVGSTP------
Mvan_4939|M.vanbaalenii_PYR-1 ----TFGTLNFGGSTATTVSFVVGRTP------
Mb0938c|M.bovis_AF2122/97 ----AFGTLNFGGSTATTVSFVVSTTRGS----
Rv0914c|M.tuberculosis_H37Rv ----AFGTLNFGGSTATTVSFVVSTTRGS----
MMAR_4613|M.marinum_M ----KFGTLNFGGSTATTVSFVVSTTKDA----
MSMEG_5608|M.smegmatis_MC2_155 ----TFGTLNFGGSTATTVSFVVTAGKE-----
MAB_1864|M.abscessus_ATCC_1997 TKDGVALQHNIG--LGGSVVVTAYRPANR----
MUL_2143|M.ulcerans_Agy99 ----AALQHNIG--LGGAAVVTAYQRAER----
MAV_5079|M.avium_104 ----TALTHNLGGRPGGCVSFVSIVSRTRRKRV
TH_3699|M.thermoresistible__bu ----TALTHNLGGRPGGCVSFVSVVGRDR----
MLBr_02564|M.leprae_Br4923 R---ALISVCAAGGQGVAVILEA----------
. . . .