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PSNGIAGKVAVVAMGCSHFGERWDASTEDLILEAYQECLDSVPNLGADDVDAFWLGTLSSGLGGLTLSRA IGNDDKPVTRVENFCATGSEAFRNACYAVAAGAYDVAMALGVEKLKDSGYSGLLRQDPPGDGTAPELSMT APAAFSMLDPAYCARHGVHPDEMRAAMTHVAWKNHDNGTRNPKAQFRSPVSRDTIDNAPKVAGRLGVFDC SGISDGAACALIVPAERAREYTDTPMYVEALSLIAGSARASMDPGYDFTTFPEVVKSAKDAYTQAGIEHP ARELSLAEVHDCFTPTEIVLMEDLGFSVAGNAWKDVLSGEFDADGRLPVNPDGGLKSFGHPVGASGLRML YEAWLQFGGRAGARQLSDPHTALTHNLGGRPGGCVSFVSIVSRTRRKRV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5079 | - | - | 100% (400) | acetyl-CoA acetyltransferase |
| M. avium 104 | MAV_2557 | - | 2e-59 | 35.52% (397) | thiolase family protein |
| M. avium 104 | MAV_1817 | - | 2e-58 | 35.61% (396) | thiolase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0938c | - | 2e-40 | 34.76% (351) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_2505 | - | 9e-58 | 36.22% (381) | thiolase |
| M. tuberculosis H37Rv | Rv0914c | - | 2e-40 | 34.76% (351) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_01158 | fadA4 | 3e-07 | 21.07% (337) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_2951c | - | 2e-34 | 29.82% (399) | lipid-transfer protein |
| M. marinum M | MMAR_1918 | ltp1 | 5e-37 | 31.06% (396) | lipid-transfer protein Ltp1 |
| M. smegmatis MC2 155 | MSMEG_5608 | - | 1e-39 | 34.75% (354) | acetyl-CoA acetyltransferase |
| M. thermoresistible (build 8) | TH_3699 | - | 0.0 | 84.34% (396) | PUTATIVE thiolase |
| M. ulcerans Agy99 | MUL_2143 | ltp1 | 2e-36 | 30.81% (396) | lipid-transfer protein |
| M. vanbaalenii PYR-1 | Mvan_4153 | - | 2e-55 | 35.70% (381) | thiolase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0938c|M.bovis_AF2122/97 -----MDDGVWILGGYQSDFARNLSKE-----NRDFADLTREVVDGTLTA
Rv0914c|M.tuberculosis_H37Rv -----MDDGVWILGGYQSDFARNLSKE-----NRDFADLTREVVDGTLTA
MSMEG_5608|M.smegmatis_MC2_155 -----MEN-VWVLGGYQSDFARNLTRE-----NLDFADLTREVVENTLAH
MAV_5079|M.avium_104 MPSNGIAGKVAVVAMGCSHFGERWDAS--------TEDLILEAYQECLDS
TH_3699|M.thermoresistible__bu MASNGIAGKVAVVGMGCTRFGERWDAS--------ADDLILEAYAEALDS
Mflv_2505|M.gilvum_PYR-GCK ------MRRAAIVGAGMTPFAEHFALG--------IKDLIPMAFSACASS
Mvan_4153|M.vanbaalenii_PYR-1 ------MRRVAIVGAGMTPFGEHFALG--------MKDLLPMAFSECART
MMAR_1918|M.marinum_M -MPNNGSNRVFVIGVGMTKFEKPGRRE-----GWDYPDMARESGTNALND
MUL_2143|M.ulcerans_Agy99 -MPNNGSNRVFVIGVGMTKFEKPGRRE-----GWDYPDMARESGTNALND
MAB_2951c|M.abscessus_ATCC_199 -MAN----RVYVVGVGMTKFEKPGRRLNDDGSAWDYPDMARESGTKALAD
MLBr_01158|M.leprae_Br4923 ------MTTSVIVTGARTPIGKLMGSLK----DFSASDLGAITIAAALKK
:: : : . *:
Mb0938c|M.bovis_AF2122/97 AKVDAADLAAAGVVHVANAFGEMFARQGHLGAMPATVCDDL-WDTPATRH
Rv0914c|M.tuberculosis_H37Rv AKVDAADLAAAGVVHVANAFGEMFARQGHLGAMPATVCDDL-WDTPATRH
MSMEG_5608|M.smegmatis_MC2_155 AKIDASDIG---VVHVANAFGELFARQGHLGAMPATVHEGL-WDTPSSRH
MAV_5079|M.avium_104 VPN-LGADD------VDAFWLGTLSSGLGGLT--LSRAIGN-DDKPVTRV
TH_3699|M.thermoresistible__bu AG--ISRDD------IDAYWLGTLSSGLGGLT--LSRAIGS-DDKPVTRV
Mflv_2505|M.gilvum_PYR-GCK VDKGLAKDD------LQAAWIGAMGTADGFPSGILADTLGL-PNLPVTRV
Mvan_4153|M.vanbaalenii_PYR-1 VDKGLSKAD------LQAAWFGAMGTADGFPSGILADTLGL-PELPVTRV
MMAR_1918|M.marinum_M AG--IEYRE------VEHAYVGYVYGESTSGQR-AVYELGM-TGIPVVNV
MUL_2143|M.ulcerans_Agy99 AG--IEYRE------VEHAYVGYVYGESTSGQR-AVYELGM-TGIPVVNV
MAB_2951c|M.abscessus_ATCC_199 AG--IGYDL------VEQAYVGYVYGESTSGQR-AVYELGM-SGIPVVNV
MLBr_01158|M.leprae_Br4923 ANVAPSIVQ------YVIIGQVLTAGAGQMPARQAAVAAGIGWDVPALTI
. . *
Mb0938c|M.bovis_AF2122/97 EAACASGSVATLAAMADLRSGAYRVALVVGLELEKTVPGDTAAEH-----
Rv0914c|M.tuberculosis_H37Rv EAACASGSVATLAAMADLRSGAYRVALVVGLELEKTVPGDTAAEH-----
MSMEG_5608|M.smegmatis_MC2_155 EAACASGSVAALAAIADLRSGAYDTALVVGVELEKTVPGDDAAAN-----
MAV_5079|M.avium_104 ENFCATGSEAFRNACYAVAAGAYDVAMALGVEKLKDSGYSGLLRQ-DPPG
TH_3699|M.thermoresistible__bu ENFCATGSEAFRNACYAVASGAYDIAMAVGVEKLKDSGYSGLLRQ-DPPG
Mflv_2505|M.gilvum_PYR-GCK ENSCATGHDAIRNALFGVSSGAFDVALVIGADKLRDTTSAGMLWE-WEAM
Mvan_4153|M.vanbaalenii_PYR-1 ENSCATGHDAIRNALFGIASGAFDVALVMGADKLRDTTSAEMLWE-WEAM
MMAR_1918|M.marinum_M NNNCSTGSTALFLAAQAIRGGLADCTVALGFEKMKPGSLSSSYDDRTQPM
MUL_2143|M.ulcerans_Agy99 NNNCSTGSTALFLAAQAIRGGLADCTVALGFEKMKPGSLSSSYDDRTQPM
MAB_2951c|M.abscessus_ATCC_199 NNNCSTGSTALYLAAQSIRGGLADCALALGFEKMNPGSLGAMYDDRAQPM
MLBr_01158|M.leprae_Br4923 NKMCLSGLDAIALADQLIRAGEFDVVVAGGQESMTKAPHLLMDSR-----
: * :* * * : .* .:. * :
Mb0938c|M.bovis_AF2122/97 LSAAAWTGHEGAEARYLWPSMFAQVADEYDRRYGLDDTHLRAIAQLNFAN
Rv0914c|M.tuberculosis_H37Rv LSAAAWTGHEGAEARYLWPSMFAQVADEYDRRYGLDDTHLRAIAQLNFAN
MSMEG_5608|M.smegmatis_MC2_155 LGTAAWTGHEGADATYMWPWMFSKVADEYDRRYCLDPAHLRVIAAVNFAN
MAV_5079|M.avium_104 D---GTAPELSMTAPAAFSMLDPAYCARHGVHPDEMRAAMTHVAWKNHDN
TH_3699|M.thermoresistible__bu D---GTAPEISMTAPAAFSMLDPAYCARYGVHPDEMRAAMTHVAWKNHDN
Mflv_2505|M.gilvum_PYR-GCK ARDMAWDYPLGLVAPAGFALHVRRYLHES----PATEEHLAMVAVKNHRH
Mvan_4153|M.vanbaalenii_PYR-1 ARDMAWDYPLGLVAPAGFALHVRRYLHES----PATEEHLAMVAVKNHRH
MMAR_1918|M.marinum_M DKHVKALAQIAEFAFPVAPWMFGAAGREHMQQYGSTAEHFAKIGFKNHKH
MUL_2143|M.ulcerans_Agy99 DKHVKALAQIAEFAFPVAPWMFGAAGREHMQQYGSTAEHFAKIGFKNHKH
MAB_2951c|M.abscessus_ATCC_199 EKHILALAEISEVLFPPASWMFGAAGREHMQQYGSTAEHFAKIGHKNHKH
MLBr_01158|M.leprae_Br4923 --SGYKYGDVTIVDHLAYDGLHDVFTNQPMGALTEQRNDVEKFTRQEQDE
. . . : .
Mb0938c|M.bovis_AF2122/97 ARRNPNAQTRGWTIPDPITDDDATNPLTEGRLRRFDCSQMTDGGAGLVLV
Rv0914c|M.tuberculosis_H37Rv ARRNPNAQTRGWTIPDPITDDDATNPLTEGRLRRFDCSQMTDGGAGLVLV
MSMEG_5608|M.smegmatis_MC2_155 ARRNPNAQTRTWNVPDPLTDDDATNPVVEGRIRRFDCSQMTDGGAGVVLV
MAV_5079|M.avium_104 GTRNPKAQFR----SPVSRDTIDNAPKVAGRLGVFDCSGISDGAACALIV
TH_3699|M.thermoresistible__bu GSRNPKAQFR----SGVSKETIDKAVKVAGRLGVFDCSGVSDGAACAVIV
Mflv_2505|M.gilvum_PYR-GCK GVNNPKARLR----FEITMEQALNAPTVVTPFRLYDCAPQSDGAAALVIA
Mvan_4153|M.vanbaalenii_PYR-1 GVNNTKARLR----FEITMEQALNAPTVVTPFRLYDCAPQSDGAAALVIA
MMAR_1918|M.marinum_M SVNNPFAQFQ----EAYTLDDILASRMIYEPLTKLQCSPTSDGSGAAILA
MUL_2143|M.ulcerans_Agy99 SVNNPFAQFQ----EAYTLDDILASRMIYEPLTKLRCSPTSDGSGAAILA
MAB_2951c|M.abscessus_ATCC_199 SVNNPYAQFQ----DEYTLDDILNSRMIYDPLTKLQCSPTSDGSGAAILA
MLBr_01158|M.leprae_Br4923 FAARSHQKAAAAWKDGVFADEVVPVSIPQSKGDSLQFTEDEGIRANTSAE
.. : : : . .
Mb0938c|M.bovis_AF2122/97 SDAYLRDHRDARPIGRIDGWGHRTVGLGLRQKLDRVAQGDSAPYLLPHVR
Rv0914c|M.tuberculosis_H37Rv SDAYLRDHRDARPIGRIDGWGHRTVGLGLRQKLDRVAQGDSAPYLLPHVR
MSMEG_5608|M.smegmatis_MC2_155 TDRWLRAHPGVTPQARIAGWGHRTVGLGLQQKIDR---ADADPYLLPHVR
MAV_5079|M.avium_104 PAERAREY--TDTPMYVEALSLIAGSARASMDPGY----DFTTFPEVVKS
TH_3699|M.thermoresistible__bu PADRAHEY--TDTPMYVRALSLVSGSARGAVDAGY----DYTTFPEVVRS
Mflv_2505|M.gilvum_PYR-GCK SEDVVDKF--TDRPVWIRGVGLGLDSVMHQHKP------DLTTFPATTRA
Mvan_4153|M.vanbaalenii_PYR-1 ADDVVDRF--TDRPVWITGVGLGLDSVMHQHKP------DLTTFPATTRA
MMAR_1918|M.marinum_M SESFVDSHGLAGRAVEIVGQAMTTDFASTFDGSAK----NLIGYDMNVQA
MUL_2143|M.ulcerans_Agy99 SESFVDSHGLAGRAVEIVGQAMTTDFASTFDGSAK----NLIGYDMNVQA
MAB_2951c|M.abscessus_ATCC_199 SEAFVDRHGLASQAVEIVGQAMTTDFQNSFDGTCK----AIIGYHMNVSA
MLBr_01158|M.leprae_Br4923 SLAGLKPAFRCGGTITPGSASQISDGAATVVVMNK---EKAQQLGLTWLV
. . .
Mb0938c|M.bovis_AF2122/97 ATVLDALRRARVTLDDLDGIEVHDCFTPSEYLAIDHIGLTGPGESWKAIE
Rv0914c|M.tuberculosis_H37Rv ATVLDALRRARVTLDDLDGIEVHDCFTPSEYLAIDHIGLTGPGESWKAIE
MSMEG_5608|M.smegmatis_MC2_155 GAVQDAFGRAQVTLDDIDGFEVHDCFTPSEYLAIDHIGLTGPGESWKAIE
MAV_5079|M.avium_104 AKDAYTQAGIEHPARELSLAEVHDCFTPTEIVLMEDLGFSVAGNAWKDVL
TH_3699|M.thermoresistible__bu ARDAYAQAGIDDPATQLSFAEVHDCFTPTEIVLMEDLGFTEPGRAYKDVL
Mflv_2505|M.gilvum_PYR-GCK AKQAFAMAGMTP--SDVDVAEVHDFLTGIELMSYEDLGFAEKLGGYKLLE
Mvan_4153|M.vanbaalenii_PYR-1 AKQAFAMAGRSP--SDVDVAEVHDFLTGIELMSYEDLGFAERLGGYKLLE
MMAR_1918|M.marinum_M AQRVYQQSGLGP--EDFQVIELHDCFSANELLLYEALGLCGQGEAPKLID
MUL_2143|M.ulcerans_Agy99 ARRVYQQSGLGP--EDFQVIELHDCFSANELLLYEALGLCGQGEAPKLID
MAB_2951c|M.abscessus_ATCC_199 ARQVYDQSGLGA--EDFQVIELHDCFSANEFLLYEALGLCGEGEAGKLID
MLBr_01158|M.leprae_Br4923 EIGAHGVVAGPDSTLQSQPANAIKKAVDREGISVEQLDVVEINEAFAAVA
: . : . * : : :.. . :
Mb0938c|M.bovis_AF2122/97 NGEIEIGGRLP--INPSGGLIGGGHPVGASGVRMLLDAAKQVSGIAGDYQ
Rv0914c|M.tuberculosis_H37Rv NGEIEIGGRLP--INPSGGLIGGGHPVGASGVRMLLDAAKQVSGIAGDYQ
MSMEG_5608|M.smegmatis_MC2_155 NGEIEISGRLP--INPSGGLIGGGHPVGASGVRMLLDATKQVSASAGEYQ
MAV_5079|M.avium_104 SGEFDADGRLP--VNPDGGLKSFGHPVGASGLRMLYEAWLQFGGRAGARQ
TH_3699|M.thermoresistible__bu SGEFDADGRLP--VNIDGGLKSFGHPVGASGLRMLYEAWLQFRGAAGERQ
Mflv_2505|M.gilvum_PYR-GCK AEVTSVGGALP--VNPSGGLKAKGHPPGATGVAQCVELFAQLRGEAVN-Q
Mvan_4153|M.vanbaalenii_PYR-1 AEVTSLGGALP--VNPSGGLKAKGHPPGATGVAQCVELFAQLRGEAVN-Q
MMAR_1918|M.marinum_M NGDTTYGGRWV--VNPSGGLISKGHPLGATGLAQCCELTWQLRGTADRRQ
MUL_2143|M.ulcerans_Agy99 NGDTTYGGRWV--VNPSGGLISKGHPLGATGLAQCCELTWQLRGTADRRQ
MAB_2951c|M.abscessus_ATCC_199 NGDTTYGGRWV--VNPSGGLISKGHPLGATGLAQCAELTWQLRGAADKRQ
MLBr_01158|M.leprae_Br4923 LASARELGIAPELVNVNGGAIAVGHPLGMSGARITLHVALELARRGSGYG
* :* .** . *** * :* . :. .
Mb0938c|M.bovis_AF2122/97 VENAEAFGTLNFGGSTATTVSFVVSTTRGS----
Rv0914c|M.tuberculosis_H37Rv VENAEAFGTLNFGGSTATTVSFVVSTTRGS----
MSMEG_5608|M.smegmatis_MC2_155 VEAAKTFGTLNFGGSTATTVSFVVTAGKE-----
MAV_5079|M.avium_104 LSDPHTALTHNLGGRPGGCVSFVSIVSRTRRKRV
TH_3699|M.thermoresistible__bu LAEPHTALTHNLGGRPGGCVSFVSVVGRDR----
Mflv_2505|M.gilvum_PYR-GCK VDGARIGLAHNIGG--PTAVAAVTILEGPDGG--
Mvan_4153|M.vanbaalenii_PYR-1 VDGARIGLAHNIGG--PTAVSAVTILEGPSGN--
MMAR_1918|M.marinum_M VDDVTAALQHNIGLGGAAVVTAYQRAER------
MUL_2143|M.ulcerans_Agy99 VDNVTAALQHNIGLGGAAVVTAYQRAER------
MAB_2951c|M.abscessus_ATCC_199 VDRVDAALQHNIGLGGAAVITAYQRAER------
MLBr_01158|M.leprae_Br4923 VAALCGAG----GQGDALILRAV-----------
: * :