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MRFGLTTALPRDGAAAREFAQRVEAAGIDVLTFADHLAPAVAPFSGATAAAAVTSRLHVGTLVLNNDFRH PVETAREAAGVATVSDGRFELGIGAGHMKSEYDSAGIPFDGGGTRVSRLVESVTVLRALLHGDAVDFDGD HYRVHAAAGEIVAAPVHRVPILIGGNGTRVLQLAGRIADIVGFAGISHNRDATRVRLSHFDGAGLADRIG VVREAAGERFAQIELNALIQAVVVTTDRQRAAAELAAAFGADPETLLCSPFVLLGTHEQMAEQLLARRRE FGIGYWTVFDELPGRESALPDISEVIALLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0757 | - | - | 100% (310) | luciferase family protein |
| M. vanbaalenii PYR-1 | Mvan_4930 | - | 3e-39 | 37.50% (288) | luciferase family protein |
| M. vanbaalenii PYR-1 | Mvan_0205 | - | 9e-35 | 33.81% (281) | luciferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2917 | - | 1e-123 | 71.06% (311) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1815 | - | 3e-40 | 39.30% (285) | luciferase family protein |
| M. tuberculosis H37Rv | Rv2893 | - | 1e-123 | 71.06% (311) | oxidoreductase |
| M. leprae Br4923 | MLBr_00269 | - | 7e-17 | 32.87% (216) | putative F420-dependent glucose-6-phosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0968c | - | 6e-23 | 31.15% (321) | luciferase-like hypothetical protein |
| M. marinum M | MMAR_2775 | - | 8e-39 | 37.86% (280) | oxidoreductase |
| M. avium 104 | MAV_1042 | - | 1e-31 | 31.19% (311) | hypothetical protein MAV_1042 |
| M. smegmatis MC2 155 | MSMEG_2516 | - | 1e-111 | 65.81% (310) | putative oxidoreductase |
| M. thermoresistible (build 8) | TH_2487 | - | 2e-22 | 33.99% (253) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2972 | - | 5e-38 | 38.30% (282) | oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2917|M.bovis_AF2122/97 ------------MTVASTAHHTRRLRFG-LAAPLPRAGTQMRAFAQAVEA
Rv2893|M.tuberculosis_H37Rv ------------MTVASTAHHTRRLRFG-LAAPLPRAGTQMRAFAQAVEA
Mvan_0757|M.vanbaalenii_PYR-1 ------------------------MRFG-LTTALPRDGAAAREFAQRVEA
MSMEG_2516|M.smegmatis_MC2_155 ------------------------MRFG-LHTALPR-GTDFAEFARGVED
Mflv_1815|M.gilvum_PYR-GCK -----MPLPPAVQTWTYDHDVAKEFRFG-VGVTRVSTRAKLEDDARRAEA
MAV_1042|M.avium_104 --------------------MAKDFRFG-MSMRFYKSREALLDKAKRAED
MMAR_2775|M.marinum_M MTLRLPRTRWLARLPAGSVTPVPEFRFS-FNVFRIDPVHTFIETCRRAEQ
MUL_2972|M.ulcerans_Agy99 ---------------------MPEFRFS-FNVFRIDPVHTFIETCRRAEQ
TH_2487|M.thermoresistible__bu -----------------MTDYGHDLLFGTFVTPSNHPPHHPVEQAVVADR
MAB_0968c|M.abscessus_ATCC_199 ------------------------MRFS-IWGQTNQSWADLLDIAQYADD
MLBr_00269|M.leprae_Br4923 ---------------------MAELRLGYKASAEQFAPRELVELGVAAEA
: :. .:
Mb2917|M.bovis_AF2122/97 AGFDVLAFPD----------HLVPSVSPFAGATAAAMATQRLHTGTLVLN
Rv2893|M.tuberculosis_H37Rv AGFDVLAFPD----------HLVPSVSPFAGATAAAMATQRLHTGTLVLN
Mvan_0757|M.vanbaalenii_PYR-1 AGIDVLTFAD----------HLAPAVAPFSGATAAAAVTSRLHVGTLVLN
MSMEG_2516|M.smegmatis_MC2_155 SGFDVLTVPD----------HIAPILSPFAGCAAAGAVTSRLHTGTLVLN
Mflv_1815|M.gilvum_PYR-GCK LGFDVLHVPD----------HLG-GSAPFPVMTAVAMATTSLRVGTFVLN
MAV_1042|M.avium_104 AGFDILCVPD----------HLG-AAAPFPTLTAVAMVTTTLRLSMYVLN
MMAR_2775|M.marinum_M WGYDAVFAAD----------HLG-IAAPFMTLVAAAAATDRMRVGTLVLN
MUL_2972|M.ulcerans_Agy99 WGYDAVFAAD----------HLG-IAAPFMTLVAAAAATDRMRVGILLLN
TH_2487|M.thermoresistible__bu AGLDLVTFQDH--------PYVAKYHDTWTLMSYAAARTQRVRLSANVAN
MAB_0968c|M.abscessus_ATCC_199 GTWRAFYAADHFMSHADTAEERTDFHEATALFAALAAATSRIRLAPLVLS
MLBr_00269|M.leprae_Br4923 HGMDSATVSDHFQPWR---HQGGHASFSLSWMTAVGERTNRILLGTSVLT
* . . * : . : .
Mb2917|M.bovis_AF2122/97 NDFRH-PVDTAREAAGVATLAEGRFELGLGAGHRRSEYDAAGI-TFDSGA
Rv2893|M.tuberculosis_H37Rv NDFRH-PVDTAREAAGVATLAEGRFELGLGAGHRRSEYDAAGI-TFDSGA
Mvan_0757|M.vanbaalenii_PYR-1 NDFRH-PVETAREAAGVATVSDGRFELGIGAGHMKSEYDSAGI-PFDGGG
MSMEG_2516|M.smegmatis_MC2_155 NDLRH-PVDVARESGTLAAMSGGRFELGLGAGHMKSEYDAVGV-KFDRGG
Mflv_1815|M.gilvum_PYR-GCK SAFYR-PALLARDVAALNDLSDGRVELGLGTGYVREEFDAAGI-PYPTAG
MAV_1042|M.avium_104 SAFYK-PALLSRDMQALDLLSDGRLEIGLGTGYVREEFEAAEI-PYPSAR
MMAR_2775|M.marinum_M APWWN-PALLARDIATTDVLTGGRLEVGLGAGHMKWEYDQADI-PFPSFT
MUL_2972|M.ulcerans_Agy99 APWWN-PALLARDIATTDVLTGGRLEVGLGAGHMKWEYDQADI-PFPSFT
TH_2487|M.thermoresistible__bu LPLRP-PAVLARSAAGLDLLSGGRVELGLGAGAFWDGVVAMGG-ERRSPG
MAB_0968c|M.abscessus_ATCC_199 MTFRH-PAVLANWAATVDHVSQGRFTLGLGAGWQENEHQRYGL-ELGKPG
MLBr_00269|M.leprae_Br4923 PTFRYNPAVIGQAFATMGCLYPNRVFLGVGTGEALNEVATGYQGAWPEFK
*. .. : .*. :*:*:*
Mb2917|M.bovis_AF2122/97 TRVARLIESAHLIRALLDAEPVDFDGQHYRVHAEAG----SLVAPPKVRV
Rv2893|M.tuberculosis_H37Rv TRVARLIESAHLIRALLDAEPVDFDGQHYRVHAEAG----SLVAPPKVRV
Mvan_0757|M.vanbaalenii_PYR-1 TRVSRLVESVTVLRALLHGDAVDFDGDHYRVHAAAG----EIVAAPVHRV
MSMEG_2516|M.smegmatis_MC2_155 VRVDRLVEAVSVIAPLLAGEAVDVDGSHYCVRGAAG----ELVAPPGVPV
Mflv_1815|M.gilvum_PYR-GCK ERVDHLKLTAAHIAEHLPDV------------------------------
MAV_1042|M.avium_104 ERVDYLEHMTKYLKEHHPST------------------------------
MMAR_2775|M.marinum_M TRTARLRQTIEELASRFAEEGFAQQAELREAHNIAVLRPTQRRGFGGYGP
MUL_2972|M.ulcerans_Agy99 TRTARLRQTIEELASRFAEDGFAQQAELREAHNIAVLRPTQRRGFGGYGP
TH_2487|M.thermoresistible__bu AAIKALEEAIAVIRGIWDVDAAGVLDVDGAHYRIRG---AKRGPAPAHRI
MAB_0968c|M.abscessus_ATCC_199 ARVDRFSEGLQVITGLLNEPVTTVDGQYYRLAEGICE-----PKPLQRPL
MLBr_00269|M.leprae_Br4923 ERFARLRESVRLMRELWRGDRVDFDGDYYQLKGASIY------DVPEGGV
: :
Mb2917|M.bovis_AF2122/97 PLLVGGNGTEVLRLGGRIADIVGLAGISHNRDATQVRFTHFDADGLADRI
Rv2893|M.tuberculosis_H37Rv PLLVGGNGTEVLRLGGRIADIVGLAGISHNRDATQVRFTHFDADGLADRI
Mvan_0757|M.vanbaalenii_PYR-1 PILIGGNGTRVLQLAGRIADIVGFAGISHNRDATRVRLSHFDGAGLADRI
MSMEG_2516|M.smegmatis_MC2_155 PLLIGGNGTRVLQLAGRVADIAGLAGFSHNHDATEIRLTHFGPAGLLDRI
Mflv_1815|M.gilvum_PYR-GCK PIMIAGNGDRVLRTAARFADIVGFTGGDRAATGDE--------DPLGDRI
MAV_1042|M.avium_104 PLIIAGNGDRVLTIAARNADIIGLTG--AKVRDVE--------DPFAERV
MMAR_2775|M.marinum_M PLLVGGTGDQVLRLAAQYADTVSIACLYQVKGRPPGTMRLATVAEIEQRV
MUL_2972|M.ulcerans_Agy99 PLLVGGTGDQVLRLAAQYADTVSIACLYQVKGRPPGTMRLAIVAEIEQRV
TH_2487|M.thermoresistible__bu SIWIGGYGPRMLGLVGRLADG---------------------------WL
MAB_0968c|M.abscessus_ATCC_199 PILIGATQPRMLALTARYAHEWNQWSSPGTFREVS--------GRLDAAA
MLBr_00269|M.leprae_Br4923 PIYIAAGGPEVAKYAGRAGEGFVCTSGKGEELYTEKLIP-----AVLEGA
.: :.. .: .: ..
Mb2917|M.bovis_AF2122/97 AVVRHAAGDRFEAIELNALIQA----------------VVCTNDRNAAAA
Rv2893|M.tuberculosis_H37Rv AVVRHAAGDRFEAIELNALIQA----------------VVCTNDRNAAAA
Mvan_0757|M.vanbaalenii_PYR-1 GVVREAAGERFAQIELNALIQA----------------VVVTTDRQRAAA
MSMEG_2516|M.smegmatis_MC2_155 GVVRDAAGARFEQIELNALIQF----------------VAHTEDPAAAAA
Mflv_1815|M.gilvum_PYR-GCK GFVRAAAGERFAALELNIAITA----------------IPLDSSGQPDLT
MAV_1042|M.avium_104 EFVRNAAGDRFDSLELNLAITA----------------MPRVGETEPDLK
MMAR_2775|M.marinum_M AYVRRCAGAARHPELHTLIQEV----------------VLTDDRRKVAGM
MUL_2972|M.ulcerans_Agy99 AYVRRCAGAARHPELHTLIQEV----------------VLTDDRREVAGM
TH_2487|M.thermoresistible__bu PSLQYLSGGVSDLTAMNQRIDD----------------AAVAAGRDPRQI
MAB_0968c|M.abscessus_ATCC_199 EKIGRDPATIWRSTQARVIVTD----------------GPQSEARAAETA
MLBr_00269|M.leprae_Br4923 AVAGRDADDIDKMIEIKMSYDPDPEQALSNIRFWAPLSLAAEQKHSIDDP
.
Mb2917|M.bovis_AF2122/97 ELAATLGGITPEQVLESPFLLLGTHEQMAEALAARQRRFGVSYWTVFDEW
Rv2893|M.tuberculosis_H37Rv ELAATLGGITPEQVLESPFLLLGTHEQMAEALAARQRRFGVSYWTVFDEW
Mvan_0757|M.vanbaalenii_PYR-1 ELAAAFG-ADPETLLCSPFVLLGTHEQMAEQLLARRREFGIGYWTVFDEL
MSMEG_2516|M.smegmatis_MC2_155 ELAGTLG-TEPSVLLESPFVLIGTYEQMAEALAERQRLYGVSYWTVIDAW
Mflv_1815|M.gilvum_PYR-GCK IPRISLPGLSDDELLRHPSVLSGSTTEIADRIHGYRDVYGISYVIVQMRH
MAV_1042|M.avium_104 LTRSYSPELTDEQILSMPSVLSGSPRDIADTLSAYRDKYGVSSFTVQDNH
MMAR_2775|M.marinum_M LAAKYGNLLTANEILQSPTLLIGTVEQIARQLRANRERYGFTHYTIPQPH
MUL_2972|M.ulcerans_Agy99 LAAKYGNLLTANEILQSPTLLIGTVEQIARQLRANRERYGFTHYTIPQPH
TH_2487|M.thermoresistible__bu RRLLNVGGQPSADELADIALSHG----ISAFILASDDTATTERFAAEVAP
MAB_0968c|M.abscessus_ATCC_199 AASPIPVLYGTAERIAEQMAPWTQEGVDEVILPDHLLGSGSARRDAYDAL
MLBr_00269|M.leprae_Br4923 IEMEKVADALPIEQVAKRWIVVSDPDEAVARVG-QYVTWGLNHLVFHAPG
: :
Mb2917|M.bovis_AF2122/97 AGRASAMRDIAEVIALLRYG--
Rv2893|M.tuberculosis_H37Rv AGRASAMRDIAEVIALLRYG--
Mvan_0757|M.vanbaalenii_PYR-1 PGRESALPDISEVIALLR----
MSMEG_2516|M.smegmatis_MC2_155 AGRESAMPHLAEVIKLLR----
Mflv_1815|M.gilvum_PYR-GCK ------AEAFGAVIDLLR----
MAV_1042|M.avium_104 ------IDNFAKVIAELR----
MMAR_2775|M.marinum_M ------VAAFAPVITVLGDLN-
MUL_2972|M.ulcerans_Agy99 ------VAAFAPVITVLGDLN-
TH_2487|M.thermoresistible__bu --------AVRELVTAQR----
MAB_0968c|M.abscessus_ATCC_199 ------AQALRPLSNETD----
MLBr_00269|M.leprae_Br4923 HNQRRFLELFEKDLAPRLRRLG
.