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RFGLHTALPRGTDFAEFARGVEDSGFDVLTVPDHIAPILSPFAGCAAAGAVTSRLHTGTLVLNNDLRHPV DVARESGTLAAMSGGRFELGLGAGHMKSEYDAVGVKFDRGGVRVDRLVEAVSVIAPLLAGEAVDVDGSHY CVRGAAGELVAPPGVPVPLLIGGNGTRVLQLAGRVADIAGLAGFSHNHDATEIRLTHFGPAGLLDRIGVV RDAAGARFEQIELNALIQFVAHTEDPAAAAAELAGTLGTEPSVLLESPFVLIGTYEQMAEALAERQRLYG VSYWTVIDAWAGRESAMPHLAEVIKLLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2516 | - | - | 100% (309) | putative oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_5592 | - | 2e-25 | 30.79% (302) | hypothetical protein MSMEG_5592 |
| M. smegmatis MC2 155 | MSMEG_3977 | - | 1e-23 | 28.88% (277) | hypothetical protein MSMEG_3977 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2917 | - | 1e-109 | 65.27% (311) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1815 | - | 4e-31 | 34.48% (290) | luciferase family protein |
| M. tuberculosis H37Rv | Rv2893 | - | 1e-109 | 65.27% (311) | oxidoreductase |
| M. leprae Br4923 | MLBr_00269 | - | 2e-11 | 28.81% (177) | putative F420-dependent glucose-6-phosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2431c | - | 1e-20 | 28.75% (313) | luciferase-like oxidoreductase |
| M. marinum M | MMAR_2775 | - | 2e-33 | 35.11% (282) | oxidoreductase |
| M. avium 104 | MAV_1042 | - | 1e-26 | 30.13% (312) | hypothetical protein MAV_1042 |
| M. thermoresistible (build 8) | TH_4285 | - | 5e-19 | 34.55% (191) | PUTATIVE luciferase family protein |
| M. ulcerans Agy99 | MUL_2972 | - | 7e-32 | 34.04% (282) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0757 | - | 1e-111 | 65.81% (310) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2917|M.bovis_AF2122/97 ------------MTVASTAHHTRRLRFGLAAPLPRAGTQ-MRAFAQAVEA
Rv2893|M.tuberculosis_H37Rv ------------MTVASTAHHTRRLRFGLAAPLPRAGTQ-MRAFAQAVEA
Mvan_0757|M.vanbaalenii_PYR-1 ------------------------MRFGLTTALPRDGAA-AREFAQRVEA
MSMEG_2516|M.smegmatis_MC2_155 ------------------------MRFGLHTALPR-GTD-FAEFARGVED
MMAR_2775|M.marinum_M MTLRLPRTRWLARLPAGSVTPVPEFRFSFNVFRIDPVHT-FIETCRRAEQ
MUL_2972|M.ulcerans_Agy99 ---------------------MPEFRFSFNVFRIDPVHT-FIETCRRAEQ
Mflv_1815|M.gilvum_PYR-GCK -----MPLPPAVQTWTYDHDVAKEFRFGVGVTRVSTRAK-LEDDARRAEA
MAV_1042|M.avium_104 --------------------MAKDFRFGMSMRFYKSREA-LLDKAKRAED
MAB_2431c|M.abscessus_ATCC_199 ---------------MTIRLGYQIPNFSYGTGVAELFPT-VVKQVREAEA
TH_4285|M.thermoresistible__bu -----------------MQFGFKTS--PQNTTWQDMLS--VWRAADDIDV
MLBr_00269|M.leprae_Br4923 ---------------------MAELRLGYKASAEQFAPRELVELGVAAEA
:
Mb2917|M.bovis_AF2122/97 AGFDVLAFPDHLVP----------SVSPFAGATAAAMATQRLHTGTLVLN
Rv2893|M.tuberculosis_H37Rv AGFDVLAFPDHLVP----------SVSPFAGATAAAMATQRLHTGTLVLN
Mvan_0757|M.vanbaalenii_PYR-1 AGIDVLTFADHLAP----------AVAPFSGATAAAAVTSRLHVGTLVLN
MSMEG_2516|M.smegmatis_MC2_155 SGFDVLTVPDHIAP----------ILSPFAGCAAAGAVTSRLHTGTLVLN
MMAR_2775|M.marinum_M WGYDAVFAADHLG-----------IAAPFMTLVAAAAATDRMRVGTLVLN
MUL_2972|M.ulcerans_Agy99 WGYDAVFAADHLG-----------IAAPFMTLVAAAAATDRMRVGILLLN
Mflv_1815|M.gilvum_PYR-GCK LGFDVLHVPDHLG-----------GSAPFPVMTAVAMATTSLRVGTFVLN
MAV_1042|M.avium_104 AGFDILCVPDHLG-----------AAAPFPTLTAVAMVTTTLRLSMYVLN
MAB_2431c|M.abscessus_ATCC_199 SGFDTVFVMDHFYQLPMIGTPDQPMLEAYTALGALASATSTIQLSTLVTG
TH_4285|M.thermoresistible__bu --FESGWTFDHFY--PIFSDPTGPCLEGWTTLTALAQATTRLRVGVLVTG
MLBr_00269|M.leprae_Br4923 HGMDSATVSDHFQPWRHQG---GHASFSLSWMTAVGERTNRILLGTSVLT
: **: * . * : . :
Mb2917|M.bovis_AF2122/97 NDFRH-PVDTAREAAGVATLAEGRFELGLGAGHRRSEYD-AAGITFDSGA
Rv2893|M.tuberculosis_H37Rv NDFRH-PVDTAREAAGVATLAEGRFELGLGAGHRRSEYD-AAGITFDSGA
Mvan_0757|M.vanbaalenii_PYR-1 NDFRH-PVETAREAAGVATVSDGRFELGIGAGHMKSEYD-SAGIPFDGGG
MSMEG_2516|M.smegmatis_MC2_155 NDLRH-PVDVARESGTLAAMSGGRFELGLGAGHMKSEYD-AVGVKFDRGG
MMAR_2775|M.marinum_M APWWN-PALLARDIATTDVLTGGRLEVGLGAGHMKWEYD-QADIPFPSFT
MUL_2972|M.ulcerans_Agy99 APWWN-PALLARDIATTDVLTGGRLEVGLGAGHMKWEYD-QADIPFPSFT
Mflv_1815|M.gilvum_PYR-GCK SAFYR-PALLARDVAALNDLSDGRVELGLGTGYVREEFD-AAGIPYPTAG
MAV_1042|M.avium_104 SAFYK-PALLSRDMQALDLLSDGRLEIGLGTGYVREEFE-AAEIPYPSAR
MAB_2431c|M.abscessus_ATCC_199 NTYRN-PALLAKAVTTLDVVSGGRAILGIGAGWFELEHQ-QLGFEFGTFT
TH_4285|M.thermoresistible__bu IHYRH-PAVLANMASALDIISAGRLELGIGAGWNEEESG-AYGIELGTLK
MLBr_00269|M.leprae_Br4923 PTFRYNPAVIGQAFATMGCLYPNRVFLGVGTGEALNEVATGYQGAWPEFK
*. .. : .* :*:*:* *
Mb2917|M.bovis_AF2122/97 TRVARLIESAHLIRALLDAEPVDFDGQHYRVHAEAG----SLVAPPKVRV
Rv2893|M.tuberculosis_H37Rv TRVARLIESAHLIRALLDAEPVDFDGQHYRVHAEAG----SLVAPPKVRV
Mvan_0757|M.vanbaalenii_PYR-1 TRVSRLVESVTVLRALLHGDAVDFDGDHYRVHAAAG----EIVAAPVHRV
MSMEG_2516|M.smegmatis_MC2_155 VRVDRLVEAVSVIAPLLAGEAVDVDGSHYCVRGAAG----ELVAPPGVPV
MMAR_2775|M.marinum_M TRTARLRQTIEELASRFAEEGFAQQAELREAHNIAVLRPTQRRGFGGYGP
MUL_2972|M.ulcerans_Agy99 TRTARLRQTIEELASRFAEDGFAQQAELREAHNIAVLRPTQRRGFGGYGP
Mflv_1815|M.gilvum_PYR-GCK ERVDHLKLTAAHIAEHLPDV------------------------------
MAV_1042|M.avium_104 ERVDYLEHMTKYLKEHHPST------------------------------
MAB_2431c|M.abscessus_ATCC_199 DRFERLTEALEIIPPMLRGERPTFEGKYYRTESALN----EPR--LRPNI
TH_4285|M.thermoresistible__bu ERFDRFEEACQVLISLLSQETTDFDGAYYRLKSARN----EPKGPQQPHP
MLBr_00269|M.leprae_Br4923 ERFARLRESVRLMRELWRGDRVDFDGDYYQLKGASIY------DVPEGGV
* : :
Mb2917|M.bovis_AF2122/97 PLLVGGNGTE-VLRLGGRIAD-IVGLAGISHNRDATQVRFTHFDADGLA-
Rv2893|M.tuberculosis_H37Rv PLLVGGNGTE-VLRLGGRIAD-IVGLAGISHNRDATQVRFTHFDADGLA-
Mvan_0757|M.vanbaalenii_PYR-1 PILIGGNGTR-VLQLAGRIAD-IVGFAGISHNRDATRVRLSHFDGAGLA-
MSMEG_2516|M.smegmatis_MC2_155 PLLIGGNGTR-VLQLAGRVAD-IAGLAGFSHNHDATEIRLTHFGPAGLL-
MMAR_2775|M.marinum_M PLLVGGTGDQ-VLRLAAQYAD-TVSIACLYQVKGRPPGTMRLATVAEIE-
MUL_2972|M.ulcerans_Agy99 PLLVGGTGDQ-VLRLAAQYAD-TVSIACLYQVKGRPPGTMRLAIVAEIE-
Mflv_1815|M.gilvum_PYR-GCK PIMIAGNGDR-VLRTAARFAD-IVGFTGGDRAATG--------DEDPLG-
MAV_1042|M.avium_104 PLIIAGNGDR-VLTIAARNAD-IIGLTG--AKVRD--------VEDPFA-
MAB_2431c|M.abscessus_ATCC_199 PIMIGGSGEKKTFGLAVKYAD-HLNLLS-SLDEIPHKLTVLRQRCEEAG-
TH_4285|M.thermoresistible__bu PICIGGSGEKRTLRITAKYAD-HWNFVGGPPEEFARKRDVLAAHCADVG-
MLBr_00269|M.leprae_Br4923 PIYIAAGGPE-VAKYAGRAGEGFVCTSGKGEELYTEKLIPAVLEGAAVAG
*: :.. * . . : .:
Mb2917|M.bovis_AF2122/97 ------DRIAVVRHAAGDRFEAIELNALIQA---VVCTNDRNAAAAELAA
Rv2893|M.tuberculosis_H37Rv ------DRIAVVRHAAGDRFEAIELNALIQA---VVCTNDRNAAAAELAA
Mvan_0757|M.vanbaalenii_PYR-1 ------DRIGVVREAAGERFAQIELNALIQA---VVVTTDRQRAAAELAA
MSMEG_2516|M.smegmatis_MC2_155 ------DRIGVVRDAAGARFEQIELNALIQF---VAHTEDPAAAAAELAG
MMAR_2775|M.marinum_M ------QRVAYVRRCAGAARHPELHTLIQEV---VLTDDRRKVAGMLAAK
MUL_2972|M.ulcerans_Agy99 ------QRVAYVRRCAGAARHPELHTLIQEV---VLTDDRREVAGMLAAK
Mflv_1815|M.gilvum_PYR-GCK ------DRIGFVRAAAGERFAALELNIAITA---IPLDSSGQPDLTIPRI
MAV_1042|M.avium_104 ------ERVEFVRNAAGDRFDSLELNLAITA---MPRVGETEPDLKLTRS
MAB_2431c|M.abscessus_ATCC_199 ------RDPSTLETSAFFSVFIDDDSATAWK---LAASQLSQNGIDLDT-
TH_4285|M.thermoresistible__bu ------RDPREIRLSAHVRLGEDGDCRKVVD---EAAALAS-EGLDLAIV
MLBr_00269|M.leprae_Br4923 RDADDIDKMIEIKMSYDPDPEQALSNIRFWAPLSLAAEQKHSIDDPIEME
:. .
Mb2917|M.bovis_AF2122/97 TLGGITPEQVLESPFLLLGTHEQMAEALAARQRRFGVSYWTVFDEWAGRA
Rv2893|M.tuberculosis_H37Rv TLGGITPEQVLESPFLLLGTHEQMAEALAARQRRFGVSYWTVFDEWAGRA
Mvan_0757|M.vanbaalenii_PYR-1 AFG-ADPETLLCSPFVLLGTHEQMAEQLLARRREFGIGYWTVFDELPGRE
MSMEG_2516|M.smegmatis_MC2_155 TLG-TEPSVLLESPFVLIGTYEQMAEALAERQRLYGVSYWTVIDAWAGRE
MMAR_2775|M.marinum_M YGNLLTANEILQSPTLLIGTVEQIARQLRANRERYGFTHYTIPQPH----
MUL_2972|M.ulcerans_Agy99 YGNLLTANEILQSPTLLIGTVEQIARQLRANRERYGFTHYTIPQPH----
Mflv_1815|M.gilvum_PYR-GCK SLPGLSDDELLRHPSVLSGSTTEIADRIHGYRDVYGISYVIVQMRH----
MAV_1042|M.avium_104 YSPELTDEQILSMPSVLSGSPRDIADTLSAYRDKYGVSSFTVQDNH----
MAB_2431c|M.abscessus_ATCC_199 -LPDEARAQVLGR--TLVGNPEEIAEQVQTRVLDQGIDSVTLNAPATGHL
TH_4285|M.thermoresistible__bu YLPTPHTPAVL----------EPLAEAIR----DSGLPAR----------
MLBr_00269|M.leprae_Br4923 KVADALPIEQVAKRWIVVSDPDEAVARVG-QYVTWGLNHLVFHAPGHNQR
: . : *.
Mb2917|M.bovis_AF2122/97 SAMRDIAEVIALLRYG--
Rv2893|M.tuberculosis_H37Rv SAMRDIAEVIALLRYG--
Mvan_0757|M.vanbaalenii_PYR-1 SALPDISEVIALLR----
MSMEG_2516|M.smegmatis_MC2_155 SAMPHLAEVIKLLR----
MMAR_2775|M.marinum_M --VAAFAPVITVLGDLN-
MUL_2972|M.ulcerans_Agy99 --VAAFAPVITVLGDLN-
Mflv_1815|M.gilvum_PYR-GCK --AEAFGAVIDLLR----
MAV_1042|M.avium_104 --IDNFAKVIAELR----
MAB_2431c|M.abscessus_ATCC_199 PGVVELIGNTLRPLFKN-
TH_4285|M.thermoresistible__bu ------------------
MLBr_00269|M.leprae_Br4923 RFLELFEKDLAPRLRRLG