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SDTLASPSPETASGIPDYPMSRSAGCPFAPPPGVMALAAAKPLTRVRIWDGSTPWLITGYEQVRELFSDS RVSVDDRLPGFPHWNAGMLSTVHKRPRSVFTADGEEHTRFRRMLSKPFTFKRVEALRPTIQQITDEHIDA MLAGPQPADLVAKLALPVPSLVISQLLGVPYEDAEMFQHHANVGLARYATGADTVKGAMSLHKYLAELVE AKMANPAEDAVSDLAERVKAGELSVKEAAQLGTGLLIAGHETTANMIGLGVLALLVNPDQAGILRDAQDP KIVANAVEELLRYLSIIQNGQRRVAHEDIHIGGETIRAGEGIIIDLAPANWDAHAFTEPDRLYLHRAGAE RNVAFGYGRHQCVGQQLARAELQIVYRTLLQRIPTLTLATALEDVPFKDDRLAYGVYELPVTW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4762 | cyp105Q4 | - | 100% (414) | cytochrome P450 105Q4 Cyp105Q4 |
| M. marinum M | MMAR_3969 | cyp269A1 | 6e-49 | 33.41% (413) | cytochrome P450 269A1 Cyp269A1 |
| M. marinum M | MMAR_2768 | cyp140A5 | 9e-42 | 33.52% (355) | cytochrome P450 140A5 Cyp140A5 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1912c | cyp140 | 2e-38 | 33.43% (332) | cytochrome p450 140 CYP140 |
| M. gilvum PYR-GCK | Mflv_2418 | - | 1e-178 | 74.40% (414) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3121 | cyp141 | 8e-42 | 28.82% (406) | cytochrome P450 141 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-37 | 35.09% (322) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3961c | - | 4e-50 | 35.01% (377) | cytochrome P450 |
| M. avium 104 | MAV_2968 | - | 1e-170 | 70.49% (410) | cytochrome P450-SU2 |
| M. smegmatis MC2 155 | MSMEG_4856 | - | 1e-180 | 75.85% (414) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_4319 | - | 0.0 | 75.60% (414) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0333 | cyp105Q4 | 0.0 | 98.31% (414) | cytochrome P450 105Q4 Cyp105Q4 |
| M. vanbaalenii PYR-1 | Mvan_4234 | - | 1e-177 | 74.40% (414) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4762|M.marinum_M ---------MSDTLASPSPETASGIPDYPMSRSAGCPFAPPPGVMALAAA
MUL_0333|M.ulcerans_Agy99 ---------MSDTLASPSPETAAGIPDYPMSRSAGCPFAPPPGVMSLAAA
Mflv_2418|M.gilvum_PYR-GCK ---------MTETLA---QETVS-VPDYPMERSAGCPFAPPRQMLDMNAV
Mvan_4234|M.vanbaalenii_PYR-1 ---------MTETLA---QEAVS-VPEYPMERTAGCPFAPPQQMLEMNQV
MSMEG_4856|M.smegmatis_MC2_155 ---------MSETLT---QPSATDIPGYPMERAAACPFAPPPQMLDMNKA
TH_4319|M.thermoresistible__bu -------VNVSDTLTGTDADATAAIPEYPMERDGRCPFAPPPGVMELAAA
MAV_2968|M.avium_104 ---------MTQPST----DADTDIPDFPMTRAPGCPFAPPPKVLQLNAD
MAB_3961c|M.abscessus_ATCC_199 --------------------------------------MPAAQQRELQRA
Mb1912c|M.bovis_AF2122/97 ---------MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
Rv3121|M.tuberculosis_H37Rv -------------------MTSTSIPTFPFDRP--VPTEPSPMLSELRNS
MMAR_4762|M.marinum_M KPLTRVRIWDG-----------STPWLITGYEQVRELFSDSRVSVDDRLP
MUL_0333|M.ulcerans_Agy99 KPLTRVRIWDG-----------SAPWLITGYEQVRELFSGSRVSVDDRVP
Mflv_2418|M.gilvum_PYR-GCK KPLSRVRIWNG-----------TTPWLVTGHEAARTLFADPRVSVDDRIE
Mvan_4234|M.vanbaalenii_PYR-1 KPLSRVRIWNG-----------TTPWLVTGHEVARTLFADSRVSVDDRRE
MSMEG_4856|M.smegmatis_MC2_155 KGLSRVRIWDG-----------STPWLITGHEEARALFADSRVSVDDRRP
TH_4319|M.thermoresistible__bu KPLSRVRIWDG-----------STPWLVTGYETARALFADSRVSVDDRRP
MAV_2968|M.avium_104 KQLSRVRIWDG-----------STPWLVHGYQAIRALFADARTSVDDRLP
MAB_3961c|M.abscessus_ATCC_199 GTVHRVTTAVG-----------DPAWLITGYATVRQLFDDERVGRSHPEP
Mb1912c|M.bovis_AF2122/97 VPFYDEVRSHGALVRN------RANYLTVDHRLAHDLLRSDDFRVVSFGE
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
Rv3121|M.tuberculosis_H37Rv CPVAPIELPSG-----------HTAWLVTRFDDVKGVLSDKRFSCRAAAH
. * . : : : .
MMAR_4762|M.marinum_M GFPH------WNAGMLSTVHKRPRSVFTADGEEHTRFRRMLSKPFTFKRV
MUL_0333|M.ulcerans_Agy99 GFPH------WNAGMLSTVHKRPRSVFTADGEEHTRFRRMLSKPFTFKRV
Mflv_2418|M.gilvum_PYR-GCK GFPH------WNEHMLATVNKRPRSVFTSDAEEHTRFRRMLSKPFTFRRV
Mvan_4234|M.vanbaalenii_PYR-1 GFPH------WNEHMLSTVDKRPRSVFTSDAEEHTRFRRMLSKPFTFRRV
MSMEG_4856|M.smegmatis_MC2_155 GFPH------WNEHMLATVHKRPRSVFTSDAEEHTRFRRMLSKPFTFRRV
TH_4319|M.thermoresistible__bu GFPH------WNEMMRSTIYKRPRSVFTTDAEEHTKFRRMLSKPFTFKRV
MAV_2968|M.avium_104 GYPH------WNEGMLATVHKRPRSVFTSDAEEHTRFRRMLSKPFTFKRV
MAB_3961c|M.abscessus_ATCC_199 DTAA------RSG--DSAFFGGPIGSYETEREDHARGRRLMQPHFTPKQM
Mb1912c|M.bovis_AF2122/97 NLPPPLRWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTSRAV
MLBr_02088|M.leprae_Br4923 AIAA----------GAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVV
Rv3121|M.tuberculosis_H37Rv PSSP----------PFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFI
. . : :*: *: : : :
MMAR_4762|M.marinum_M EALRPTIQQITDEHIDAMLAGPQPADLVAKLALPVPSLVISQLLGVPYED
MUL_0333|M.ulcerans_Agy99 EALRPTIQQITDEHIDAMLAGPQPADLVAKLALPVPSLVISQLLGVPYED
Mflv_2418|M.gilvum_PYR-GCK EALRPVIQEVTDECIDEILAGPQPADLVAKLALPVPTRVISDMLGVPYDD
Mvan_4234|M.vanbaalenii_PYR-1 EALRPVIQQVTDECIDEILAGPQPADMVAKLALPVPTRVISDMLGVPYED
MSMEG_4856|M.smegmatis_MC2_155 EGLRPAIQKITDECIDAILAGPQPADIVDKLALPVPTVVISEMLGVPYED
TH_4319|M.thermoresistible__bu EGLRPAIQKITDDHIDKILAGPKPADLVTALALPVPSLVISEMLGVPYED
MAV_2968|M.avium_104 EALRPAVQKITDDHIDALLRGPNPGDIVSTVSLPVPSLVISELLGVPYED
MAB_3961c|M.abscessus_ATCC_199 RTLAGRVHELADELITAMIDRGSPADFYTAVAVPLPMMVLCELLGVPYAD
Mb1912c|M.bovis_AF2122/97 SALRDLVEQTAINLLDRFAEQPGIVDVVGRYCSQLPIVVISEILGVPEHD
MLBr_02088|M.leprae_Br4923 QALEGDIAALVDSLLDKGAA-AGQFDVIADLAFPLAVAVICRLLGVPYED
Rv3121|M.tuberculosis_H37Rv ARMRPVVQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKT
: : . . : *. . : ::. :***
MMAR_4762|M.marinum_M AEMFQHHANVGLARYA-----------TGADTVKGAMSLHKYLAELVEAK
MUL_0333|M.ulcerans_Agy99 AEMFQHHANVGLARYA-----------TGADTVKGAMSLHKYLAELVEAK
Mflv_2418|M.gilvum_PYR-GCK HEFFQEHANAGLARYA-----------AADAMQKGAMSLHQYLINLVEEK
Mvan_4234|M.vanbaalenii_PYR-1 HEFFQEHANAGLARYA-----------AADAMQKGAMSLHQYLINLVEEK
MSMEG_4856|M.smegmatis_MC2_155 HEFFQEHANAGLARYA-----------AADAMQKGAMSLHQYLIDLIEKK
TH_4319|M.thermoresistible__bu AEFFQEHANRGLDRYA-----------KAEDNMSKGMSLSQYLIKLVEAK
MAV_2968|M.avium_104 AEFFQTQAQRGMGRYA-----------TEEDTAQGAASLAKYLANLVRAK
MAB_3961c|M.abscessus_ATCC_199 RDEFREWT-VAASNTR-----------DRSRSEWGMGQLFVYGMQLVGRK
Mb1912c|M.bovis_AF2122/97 RPRVLEFGELAAPSLD--IGIPWRQYLRVQQGIRG---FDCWLEGHLQQL
MLBr_02088|M.leprae_Br4923 APEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCR
Rv3121|M.tuberculosis_H37Rv VHELAAHVDAAMSVCEIG----------DEEVSRRWSALCTMVIDILHRK
. : :
MMAR_4762|M.marinum_M MANPAEDAVSDLAERVKAGELS----VKEAAQLGTGLLIAGHETTANMIG
MUL_0333|M.ulcerans_Agy99 MANPAEDAVSDLAERVKAGELS----VKEAAQLGTGLLIAGHETTANMIG
Mflv_2418|M.gilvum_PYR-GCK QANPAEDAVSDLAERVTAGEIS----VKEAAQLGTGLLIAGHETTANMIG
Mvan_4234|M.vanbaalenii_PYR-1 QAHPAEDAVSDLAERVTAGEIS----VKEAAQLGTGLLIAGHETTANMIG
MSMEG_4856|M.smegmatis_MC2_155 QAEPAEDAVSDLAERVTAGELS----VKEAAQLGTGLLIAGHETTANMIG
TH_4319|M.thermoresistible__bu MQNPAEDAVSDLAERVKAGEID----VKEAAQLGTGLLIAGHETTANMIG
MAV_2968|M.avium_104 MQSPSEDLVSDLAERVNAEEIS----VREAAQLATGVLIAGHETTANMIS
MAB_3961c|M.abscessus_ATCC_199 RQQPGDDVISRLCT---IDGVA----DHEIASQSMALLLGGHETTVVQLG
Mb1912c|M.bovis_AF2122/97 RHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTVNLLG
MLBr_02088|M.leprae_Br4923 RGTPGEDLISRLIELDESGD---QLTEEEIIATCGLLLVAGHETTVNLIA
Rv3121|M.tuberculosis_H37Rv LAEPGDDLLSTIAQANRQQSTMT---DEQVVGMLLTVVIGGVDTPIAVIT
*.:* :* : : :::.* :*. :
MMAR_4762|M.marinum_M LGVLALLVNPDQAGILRDAQDPKIVANAVEELLRYLSIIQNGQRRVAHED
MUL_0333|M.ulcerans_Agy99 LGVLALLVNPDQAGILRDAHDPKIVANAVEELLRYLSIIQNGQRRVAHED
Mflv_2418|M.gilvum_PYR-GCK IGICALLENPEQAALLRDSEDPKFIANAVEELMRYLSIIQNGQRRVAIED
Mvan_4234|M.vanbaalenii_PYR-1 IGICALLENPEQAALLRDSDDPKFIANAVEELMRYLSIIQNGQRRVATED
MSMEG_4856|M.smegmatis_MC2_155 IGILALLENPEQADFLRNAEDPKVIANAVEELMRYLSIIQTGQRRVAVED
TH_4319|M.thermoresistible__bu LGVLALLEHPEQADFLRSAEDPKAIATAIEELMRYLSIIQNGQRRVAVED
MAV_2968|M.avium_104 LSVAALLEHPDQRALLCDTDDPKVIATAVEELMRYLSIIQTGQRRIAIED
MAB_3961c|M.abscessus_ATCC_199 LATLLLLANPEQWALLVS--QPDLVPNAVEETLRASRTGGGEIPRYARED
Mb1912c|M.bovis_AF2122/97 NGIRMLLDTPEHLATLRQ--HPELWPNTVEEILRLDSPVQLTAR-VACRD
MLBr_02088|M.leprae_Br4923 NAVLAMLRNPSQWKALSS--NPQRAPLVVEETLRYDPAIHLIGR-VAAKD
Rv3121|M.tuberculosis_H37Rv NGLASLLHHRDQYERLVE--DPGRVARAVEEIVRFNPATEIEHLRVVTED
. :* .: * . .* . .:** :* . .*
MMAR_4762|M.marinum_M IHIGGETIRAGEGIIIDLAPANWDAHAFTEPDRLYLHRAGAERNVAFGYG
MUL_0333|M.ulcerans_Agy99 IHIGGETIRAGEGIIIDLAPANWDAHAFTEPDRLYLHRAGAERNVAFGYG
Mflv_2418|M.gilvum_PYR-GCK IEIAGETIRAGEGIILDLAPANWDPQAYPEPDKLDLTRD-ANQQLGFGYG
Mvan_4234|M.vanbaalenii_PYR-1 IEIGGETIRAGEGIILDLAPANWDARAFPEPDKLDLTRD-ATQQLGFGYG
MSMEG_4856|M.smegmatis_MC2_155 IEIGGETIKAGEGIIIDLVPANWDAKAFPEPDKLDLTRD-AGQQLGFGYG
TH_4319|M.thermoresistible__bu IEIAGETIRAGEGIILDLAPANWDPATFPEPDRLDLQRS-DAPQLGFGYG
MAV_2968|M.avium_104 IEIGGETIRAGEGIILDVAPANWDARQFPNPDRLDLRRQ-DGPHVGFGYG
MAB_3961c|M.abscessus_ATCC_199 LEIDGVHIAAGELLLLDVGAANHDPAVFGCPDQLDVARK-HLAHVIFGYG
Mb1912c|M.bovis_AF2122/97 VEVAGVRIKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTG
MLBr_02088|M.leprae_Br4923 MTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS-RHLAFAVG
Rv3121|M.tuberculosis_H37Rv VVIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERN-PNEHIAFGYG
: : : *. . : .** *. : *..: * :: *. *
MMAR_4762|M.marinum_M RHQCVGQQLARAELQIVYRTLLQRIPTLTLATALEDVPFKDD-RLAYGVY
MUL_0333|M.ulcerans_Agy99 RHQCVGQQLARTELQIVYRTLLQRIPTLTLATALEDVPFKDD-RLAYGVY
Mflv_2418|M.gilvum_PYR-GCK RHQCVGQQLARAELQIVFHTLLRRIPTLKLAIPIDEVPFKHD-RLAYGVY
Mvan_4234|M.vanbaalenii_PYR-1 RHQCVGQQLARAELQIVFHTLLRRIPTMKPAIPLEEVPFKHD-RLAYGVY
MSMEG_4856|M.smegmatis_MC2_155 RHQCVGQQLARAELQIVFHTLLRRIPTLRLAIPLEEVPFKHD-RLAYGVY
TH_4319|M.thermoresistible__bu RHQCVGMQLARAELQIVFPTLLRRIPTLKLATTIDEIPFKHD-RLAYGVY
MAV_2968|M.avium_104 RHQCVGQQLARMELQIVLPTLLRRVPTLRLAAPLDELPFKHD-ALAYGLY
MAB_3961c|M.abscessus_ATCC_199 SRYCVGAPLARMQLTEVLGQLVERLPGLHLRRDISELTMRGD-LLTGGLR
Mb1912c|M.bovis_AF2122/97 RHFCLGAALARAEGEVGLRTFFDRFPDVRAAG---AGSRRDT-RVLRGWS
MLBr_02088|M.leprae_Br4923 SHFCLGAALARLEATVTLSAISARFPQVQLAG---ELVYKPN-VAMRGMS
Rv3121|M.tuberculosis_H37Rv PHACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIK
: * . :* : *.* : : *
MMAR_4762|M.marinum_M ELPVTW---------
MUL_0333|M.ulcerans_Agy99 ELPVTW---------
Mflv_2418|M.gilvum_PYR-GCK ELPVTW---------
Mvan_4234|M.vanbaalenii_PYR-1 ELPVTW---------
MSMEG_4856|M.smegmatis_MC2_155 ELPVAW---------
TH_4319|M.thermoresistible__bu ELPVTW---------
MAV_2968|M.avium_104 ELPVTW---------
MAB_3961c|M.abscessus_ATCC_199 EVPVGW---------
Mb1912c|M.bovis_AF2122/97 TLPVTLGPARSMVSP
MLBr_02088|M.leprae_Br4923 ALPVQV---------
Rv3121|M.tuberculosis_H37Rv ELLVTWPT-------
: *