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MSISFETSESRADAELPVLPMPRAAHCPLAPPPEFVDWRQQPGLRRALFQGNPVWVVSRYHDIRAALVDP RLSAKTIPDSIMPTDADNKVPVMFARTDDPEHHRLRRMLTGNFTFRRCESMRPQIQDTVDHYLDRMVDGG VPADLVREFALPVPSLVIALLLGVPPEDLELFQFNTTKGLDQKSSDEEKGKAFGAMYAYIEELVQRKARE PGDDLISRLITEYVATGQLDHATTAMNSVIMMQAGHETTANMISLGTVALLGHPEIYARLGQTDDSAVVA NIVEELMRYLSIVHSQVDRVATEGLTIAGQLIRAGEFVVMNLPAGNWDTEFVDNPESFDADRNPRGHLGF GYGVHQCIGANLARVEMQVAFATLARRLPGLRLAVPPEQLKFKDANIYGMKELPVSW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2464 | - | - | 100% (407) | cytochrome P450 family protein |
| M. avium 104 | MAV_2968 | - | 1e-84 | 42.22% (405) | cytochrome P450-SU2 |
| M. avium 104 | MAV_1339 | - | 1e-48 | 34.26% (359) | cytochrome P450 superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0801 | cyp126 | 1e-35 | 31.34% (351) | cytochrome P450 126 |
| M. gilvum PYR-GCK | Mflv_2418 | - | 4e-81 | 41.35% (399) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3121 | cyp141 | 2e-42 | 28.64% (398) | cytochrome P450 141 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-38 | 32.00% (375) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3961c | - | 3e-47 | 32.13% (361) | cytochrome P450 |
| M. marinum M | MMAR_4762 | cyp105Q4 | 5e-77 | 40.75% (400) | cytochrome P450 105Q4 Cyp105Q4 |
| M. smegmatis MC2 155 | MSMEG_4856 | - | 3e-84 | 41.32% (409) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_4319 | - | 9e-83 | 41.52% (407) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0333 | cyp105Q4 | 7e-77 | 40.55% (402) | cytochrome P450 105Q4 Cyp105Q4 |
| M. vanbaalenii PYR-1 | Mvan_4234 | - | 6e-80 | 41.00% (400) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2418|M.gilvum_PYR-GCK ---------------MTETLA---QETVS-VPDYPMERSAGCPFAPPRQM
Mvan_4234|M.vanbaalenii_PYR-1 ---------------MTETLA---QEAVS-VPEYPMERTAGCPFAPPQQM
MSMEG_4856|M.smegmatis_MC2_155 ---------------MSETLT---QPSATDIPGYPMERAAACPFAPPPQM
TH_4319|M.thermoresistible__bu -------------VNVSDTLTGTDADATAAIPEYPMERDGRCPFAPPPGV
MMAR_4762|M.marinum_M ---------------MSDTLASPSPETASGIPDYPMSRSAGCPFAPPPGV
MUL_0333|M.ulcerans_Agy99 ---------------MSDTLASPSPETAAGIPDYPMSRSAGCPFAPPPGV
MAV_2464|M.avium_104 ---------------MSISFETSESRADAELPVLPMPRAAHCPLAPPPEF
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_3961c|M.abscessus_ATCC_199 --------------------------------------------MPAAQQ
Mb0801|M.bovis_AF2122/97 -------------------MTTAAGLSGIDLTDLDNFADGFPHHLFAIHR
Rv3121|M.tuberculosis_H37Rv -------------------------MTSTSIPTFPFDRP--VPTEPSPML
Mflv_2418|M.gilvum_PYR-GCK LDMNAVKPLSRVRIWNGTTPWLVTGHEAARTLFADPRVSVDDRIEGFPHW
Mvan_4234|M.vanbaalenii_PYR-1 LEMNQVKPLSRVRIWNGTTPWLVTGHEVARTLFADSRVSVDDRREGFPHW
MSMEG_4856|M.smegmatis_MC2_155 LDMNKAKGLSRVRIWDGSTPWLITGHEEARALFADSRVSVDDRRPGFPHW
TH_4319|M.thermoresistible__bu MELAAAKPLSRVRIWDGSTPWLVTGYETARALFADSRVSVDDRRPGFPHW
MMAR_4762|M.marinum_M MALAAAKPLTRVRIWDGSTPWLITGYEQVRELFSDSRVSVDDRLPGFPHW
MUL_0333|M.ulcerans_Agy99 MSLAAAKPLTRVRIWDGSAPWLITGYEQVRELFSGSRVSVDDRVPGFPHW
MAV_2464|M.avium_104 VDWRQQPGLRRA-LFQGNPVWVVSRYHDIRAALVDPRLSAKTIP------
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
MAB_3961c|M.abscessus_ATCC_199 RELQRAGTVHRVTTAVGDPAWLITGYATVRQLFDD-----ERVGRSHPEP
Mb0801|M.bovis_AF2122/97 REAPVYWHRPTEHTPDGEGFWSVATYAETLEVLRDPVTYSSVTGGQRRFG
Rv3121|M.tuberculosis_H37Rv SELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAHP----
* .: . :
Mflv_2418|M.gilvum_PYR-GCK NEHMLATVNKRPRSVFT-SDAEE--HTRFRRMLSKPFTFRRVEALRPVIQ
Mvan_4234|M.vanbaalenii_PYR-1 NEHMLSTVDKRPRSVFT-SDAEE--HTRFRRMLSKPFTFRRVEALRPVIQ
MSMEG_4856|M.smegmatis_MC2_155 NEHMLATVHKRPRSVFT-SDAEE--HTRFRRMLSKPFTFRRVEGLRPAIQ
TH_4319|M.thermoresistible__bu NEMMRSTIYKRPRSVFT-TDAEE--HTKFRRMLSKPFTFKRVEGLRPAIQ
MMAR_4762|M.marinum_M NAGMLSTVHKRPRSVFT-ADGEE--HTRFRRMLSKPFTFKRVEALRPTIQ
MUL_0333|M.ulcerans_Agy99 NAGMLSTVHKRPRSVFT-ADGEE--HTRFRRMLSKPFTFKRVEALRPTIQ
MAV_2464|M.avium_104 DSIMPTDADNKVPVMFARTDDPE--HHRLRRMLTGNFTFRRCESMRPQIQ
MLBr_02088|M.leprae_Br4923 AIAAGAEPRPFYASSFMFLDPP--DHTRLRKLVSKAFAPKVVQALEGDIA
MAB_3961c|M.abscessus_ATCC_199 DTAARSGDSAFFGGPIGSYETEREDHARGRRLMQPHFTPKQMRTLAGRVH
Mb0801|M.bovis_AF2122/97 GTVLQDLP--VAGQVLNMMDDPR--HTRIRRLVSSGLTPRMIRRVEDDLR
Rv3121|M.tuberculosis_H37Rv -SSPPFVPFVQLCPSLLSIDGPQ--HTAARRLLAQGLNPGFIARMRPVVQ
: : * *::: : : :
Mflv_2418|M.gilvum_PYR-GCK EVTDECIDEILAGPQPADLVAKLALPVPTRVISDMLGVPYDDHEFFQEHA
Mvan_4234|M.vanbaalenii_PYR-1 QVTDECIDEILAGPQPADMVAKLALPVPTRVISDMLGVPYEDHEFFQEHA
MSMEG_4856|M.smegmatis_MC2_155 KITDECIDAILAGPQPADIVDKLALPVPTVVISEMLGVPYEDHEFFQEHA
TH_4319|M.thermoresistible__bu KITDDHIDKILAGPKPADLVTALALPVPSLVISEMLGVPYEDAEFFQEHA
MMAR_4762|M.marinum_M QITDEHIDAMLAGPQPADLVAKLALPVPSLVISQLLGVPYEDAEMFQHHA
MUL_0333|M.ulcerans_Agy99 QITDEHIDAMLAGPQPADLVAKLALPVPSLVISQLLGVPYEDAEMFQHHA
MAV_2464|M.avium_104 DTVDHYLDRMVDGGVPADLVREFALPVPSLVIALLLGVPPEDLELFQFNT
MLBr_02088|M.leprae_Br4923 ALVDSLLDKGAAAG-QFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVS
MAB_3961c|M.abscessus_ATCC_199 ELADELITAMIDRGSPADFYTAVAVPLPMMVLCELLGVPYADRDEFREWT
Mb0801|M.bovis_AF2122/97 RRARGLLDG-VEPGAPFDFVVEIAAELPMQMICILLGVPETDRHWLFEAV
Rv3121|M.tuberculosis_H37Rv QIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAHV
. : *. .: : ::. :*** :
Mflv_2418|M.gilvum_PYR-GCK NAGLARYAAADAMQKGAMS-----------LHQYLINLVEEKQANPAEDA
Mvan_4234|M.vanbaalenii_PYR-1 NAGLARYAAADAMQKGAMS-----------LHQYLINLVEEKQAHPAEDA
MSMEG_4856|M.smegmatis_MC2_155 NAGLARYAAADAMQKGAMS-----------LHQYLIDLIEKKQAEPAEDA
TH_4319|M.thermoresistible__bu NRGLDRYAKAEDNMSKGMS-----------LSQYLIKLVEAKMQNPAEDA
MMAR_4762|M.marinum_M NVGLARYATGADTVKGAMS-----------LHKYLAELVEAKMANPAEDA
MUL_0333|M.ulcerans_Agy99 NVGLARYATGADTVKGAMS-----------LHKYLAELVEAKMANPAEDA
MAV_2464|M.avium_104 TKGLDQKSSDEEKGKAFGA-----------MYAYIEELVQRKAREPGDDL
MLBr_02088|M.leprae_Br4923 ALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGEDL
MAB_3961c|M.abscessus_ATCC_199 VAASNTRDRSRSEWGMG------------QLFVYGMQLVGRKRQQPGDDV
Mb0801|M.bovis_AF2122/97 EPGFDFRGSRRATMPRLNVEDAG-----SRLYTYALELIAGKRAEPADDM
Rv3121|M.tuberculosis_H37Rv DAAMSVCEIGDEEVSRRWS----------ALCTMVIDILHRKLAEPGDDL
: .:: : *.:*
Mflv_2418|M.gilvum_PYR-GCK VS-DLAERVT---AGEISVKEAAQLGTGLLIAGHETTANMIGIGICALLE
Mvan_4234|M.vanbaalenii_PYR-1 VS-DLAERVT---AGEISVKEAAQLGTGLLIAGHETTANMIGIGICALLE
MSMEG_4856|M.smegmatis_MC2_155 VS-DLAERVT---AGELSVKEAAQLGTGLLIAGHETTANMIGIGILALLE
TH_4319|M.thermoresistible__bu VS-DLAERVK---AGEIDVKEAAQLGTGLLIAGHETTANMIGLGVLALLE
MMAR_4762|M.marinum_M VS-DLAERVK---AGELSVKEAAQLGTGLLIAGHETTANMIGLGVLALLV
MUL_0333|M.ulcerans_Agy99 VS-DLAERVK---AGELSVKEAAQLGTGLLIAGHETTANMIGLGVLALLV
MAV_2464|M.avium_104 ISRLITEYVA---TGQLDHATTAMNSVIMMQAGHETTANMISLGTVALLG
MLBr_02088|M.leprae_Br4923 ISRLIELDES---GDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLR
MAB_3961c|M.abscessus_ATCC_199 ISRLCTIDG-------VADHEIASQSMALLLGGHETTVVQLGLATLLLLA
Mb0801|M.bovis_AF2122/97 LSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAE
Rv3121|M.tuberculosis_H37Rv LSTIAQANRQ---QSTMTDEQVVGMLLTVVIGGVDTPIAVITNGLASLLH
:* : :. .* :*. : . :
Mflv_2418|M.gilvum_PYR-GCK NPEQAALLRDSEDPKFIANAVEELMRYLSIIQNGQRRVAIEDIEIAGETI
Mvan_4234|M.vanbaalenii_PYR-1 NPEQAALLRDSDDPKFIANAVEELMRYLSIIQNGQRRVATEDIEIGGETI
MSMEG_4856|M.smegmatis_MC2_155 NPEQADFLRNAEDPKVIANAVEELMRYLSIIQTGQRRVAVEDIEIGGETI
TH_4319|M.thermoresistible__bu HPEQADFLRSAEDPKAIATAIEELMRYLSIIQNGQRRVAVEDIEIAGETI
MMAR_4762|M.marinum_M NPDQAGILRDAQDPKIVANAVEELLRYLSIIQNGQRRVAHEDIHIGGETI
MUL_0333|M.ulcerans_Agy99 NPDQAGILRDAHDPKIVANAVEELLRYLSIIQNGQRRVAHEDIHIGGETI
MAV_2464|M.avium_104 HPEIYARLGQTDDSAVVANIVEELMRYLSIVHSQVDRVATEGLTIAGQLI
MLBr_02088|M.leprae_Br4923 NPSQWKALSS--NPQRAPLVVEETLRYD-PAIHLIGRVAAKDMTIGQTTL
MAB_3961c|M.abscessus_ATCC_199 NPEQWALLVS--QPDLVPNAVEETLRASRTGGGEIPRYAREDLEIDGVHI
Mb0801|M.bovis_AF2122/97 NPDQLQTLRS--DFELLPTAIEEIVRWTSPSPSK-RRTASRAVSLGGQPI
Rv3121|M.tuberculosis_H37Rv HRDQYERLVE--DPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTAL
: . * . : . :** :* * . . : : :
Mflv_2418|M.gilvum_PYR-GCK RAGEGIILDLAPANWDPQAYPEPDKLDLTRD-ANQQLGFGYGRHQCVGQQ
Mvan_4234|M.vanbaalenii_PYR-1 RAGEGIILDLAPANWDARAFPEPDKLDLTRD-ATQQLGFGYGRHQCVGQQ
MSMEG_4856|M.smegmatis_MC2_155 KAGEGIIIDLVPANWDAKAFPEPDKLDLTRD-AGQQLGFGYGRHQCVGQQ
TH_4319|M.thermoresistible__bu RAGEGIILDLAPANWDPATFPEPDRLDLQRS-DAPQLGFGYGRHQCVGMQ
MMAR_4762|M.marinum_M RAGEGIIIDLAPANWDAHAFTEPDRLYLHRAGAERNVAFGYGRHQCVGQQ
MUL_0333|M.ulcerans_Agy99 RAGEGIIIDLAPANWDAHAFTEPDRLYLHRAGAERNVAFGYGRHQCVGQQ
MAV_2464|M.avium_104 RAGEFVVMNLPAGNWDTEFVDNPESFDADRN-PRGHLGFGYGVHQCIGAN
MLBr_02088|M.leprae_Br4923 TEGDTMVLLLAAANRDPAVYSRPDEFDPDRP-SSRHLAFAVGSHFCLGAA
MAB_3961c|M.abscessus_ATCC_199 AAGELLLLDVGAANHDPAVFGCPDQLDVARK-HLAHVIFGYGSRYCVGAP
Mb0801|M.bovis_AF2122/97 EAGQKVVVWEGSANRDPSVFDRADEFDITRK-PNPHLGFGQGVHYCLGAN
Rv3121|M.tuberculosis_H37Rv SAGSPAFTSITSANRDSDQFLDPDEFDVERN-PNEHIAFGYGPHACPASA
*. . ..* *. .: : * :: *. * : * .
Mflv_2418|M.gilvum_PYR-GCK LARAELQIVFHTLLRRIPTLKLAIPIDEVPFKHDRLAYG-VYELPVTW--
Mvan_4234|M.vanbaalenii_PYR-1 LARAELQIVFHTLLRRIPTMKPAIPLEEVPFKHDRLAYG-VYELPVTW--
MSMEG_4856|M.smegmatis_MC2_155 LARAELQIVFHTLLRRIPTLRLAIPLEEVPFKHDRLAYG-VYELPVAW--
TH_4319|M.thermoresistible__bu LARAELQIVFPTLLRRIPTLKLATTIDEIPFKHDRLAYG-VYELPVTW--
MMAR_4762|M.marinum_M LARAELQIVYRTLLQRIPTLTLATALEDVPFKDDRLAYG-VYELPVTW--
MUL_0333|M.ulcerans_Agy99 LARTELQIVYRTLLQRIPTLTLATALEDVPFKDDRLAYG-VYELPVTW--
MAV_2464|M.avium_104 LARVEMQVAFATLARRLPGLRLAVPPEQLKFK-DANIYG-MKELPVSW--
MLBr_02088|M.leprae_Br4923 LARLEATVTLSAISARFPQVQLAG---ELVYKPNVAMRG-MSALPVQV--
MAB_3961c|M.abscessus_ATCC_199 LARMQLTEVLGQLVERLPGLHLRRDISELTMRGDLLTGG-LREVPVGW--
Mb0801|M.bovis_AF2122/97 LARLELRVLFEELLSRFGSVRVVEPAEWTRSNRHTGIRH-LVVELRGG--
Rv3121|M.tuberculosis_H37Rv YSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT
:* : *: : . . :