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MPIDPIAQKMLDDAKKSGRPNAHLLPVPTARQNFEDTFGALAKPQIHRVTDVEIPTRDGQTIPGRLYLPA EEAAALPLTVYYHGGGWLLGSIDSHDVATRLLANASGSAVLSVGYRRGPESRFPTAVDDAVDALIWAAGP ASGLGVDTTRLAVAGDSAGGNLAGAVALHVRHTGAPALRHQLLVYPVTTTDLEIGFDDEYQGVMLERDEM QWHQDNYLPSPEAATDARVSILGADLTGVPAATVILAECDPIRPQGELYAKALEAAGVPTATHLTPGMVH GFFGLDEVFPTATEAMTFAGKQLSEALAVVDR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0613 | - | - | 100% (312) | alpha/beta hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2672 | - | 1e-44 | 40.07% (282) | alpha/beta hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2888 | - | 3e-42 | 38.49% (291) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1434c | lipH | 1e-43 | 41.80% (244) | lipase LipH |
| M. gilvum PYR-GCK | Mflv_4552 | - | 2e-51 | 41.73% (278) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1399c | lipH | 1e-43 | 41.80% (244) | lipase LipH |
| M. leprae Br4923 | MLBr_00314 | - | 9e-13 | 26.01% (273) | putative esterase |
| M. abscessus ATCC 19977 | MAB_2039 | - | 2e-48 | 39.80% (304) | lipase LipH (carboxylesterase) |
| M. marinum M | MMAR_1746 | lipN | 3e-43 | 39.45% (289) | lipase/esterase LipN |
| M. avium 104 | MAV_3025 | - | 1e-42 | 43.95% (223) | esterase |
| M. smegmatis MC2 155 | MSMEG_3829 | - | 1e-139 | 77.67% (309) | esterase |
| M. thermoresistible (build 8) | TH_2802 | - | 7e-39 | 38.95% (267) | PUTATIVE esterase |
| M. ulcerans Agy99 | MUL_1989 | lipN | 3e-43 | 39.45% (289) | lipase/esterase LipN |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0613|M.vanbaalenii_PYR-1 ----------------------------------MPIDPIAQKMLDDAKK
MSMEG_3829|M.smegmatis_MC2_155 ----------------------------------MPIDPIAQKMLDDAKA
Mflv_4552|M.gilvum_PYR-GCK ----------------------------------MRLDPQIAALIDALDG
MAV_3025|M.avium_104 ----------------------------------MSLEPQIAAIIEQLDS
MMAR_1746|M.marinum_M MTNSLPGETDLHPETVHATMSWLSRVQNTVTVVGAKVIPWVPDVAKRLIT
MUL_1989|M.ulcerans_Agy99 MTNSLPGETDLHPETVHATMSWLSRVQNTVTVVGAKVIPWVPDVAKRLIT
TH_2802|M.thermoresistible__bu --------------------------------MNHPVPPLDPDAAARIAS
Mb1434c|M.bovis_AF2122/97 --------------------------MTEPTVARPDIDPVLKMLLD----
Rv1399c|M.tuberculosis_H37Rv --------------------------MTEPTVARPDIDPVLKMLLD----
MAB_2039|M.abscessus_ATCC_1997 --------------------------MTSP------VDPLLMSVLE----
MLBr_00314|M.leprae_Br4923 -----------------------MAISAGAPVEIVESGPSIAARLASLTS
*
Mvan_0613|M.vanbaalenii_PYR-1 SG----------RPNAHLLPVP----------------TARQNFEDTFGA
MSMEG_3829|M.smegmatis_MC2_155 SG----------RPNAHLLPVP----------------TARENFENTFAA
Mflv_4552|M.gilvum_PYR-GCK G-----------FPAVHTMTG----------------AQARATIRSRFTP
MAV_3025|M.avium_104 G-----------FPPVQQMSG----------------AEARALIRSRLVP
MMAR_1746|M.marinum_M RGRSVIIDGNTLDPALQLMLSGMRVVGLDGLVIDDDLAASRAHMREAMLG
MUL_1989|M.ulcerans_Agy99 RGRSVIIDGNTLDPALQLMLSGMRVVGLDGLVIDDDLAASRAHMREAMLG
TH_2802|M.thermoresistible__bu LG----------PPAPMRRRG---------------LQAVRDAIESAPLP
Mb1434c|M.bovis_AF2122/97 -----------TFP-VTFTAA-------------DGVEVARARLRQLKTP
Rv1399c|M.tuberculosis_H37Rv -----------TFP-VTFTAA-------------DGVEVARARLRQLKTP
MAB_2039|M.abscessus_ATCC_1997 -----------ASPAVQLDRP-------------EDLTLARESRRHAAPS
MLBr_00314|M.leprae_Br4923 RLT--------IRPILAVGSYVP-------------QLPWPFGLIDHAAR
*
Mvan_0613|M.vanbaalenii_PYR-1 LAKP-QIHRVTDVEIPTRDGQTIPGRLYLPAEE---AAALPLTVYYHGGG
MSMEG_3829|M.smegmatis_MC2_155 LQKP-DVHRVTDVAIETRDGAVIPGRLYVPAE----GDDLPLTVYYHGGG
Mflv_4552|M.gilvum_PYR-GCK AAEPEPVHSVHDMAVPVDDG-EVPVRVYRPAG----PAPLPALVFAHGGG
MAV_3025|M.avium_104 PAQPEPVAEVADRLVEGPGG-PLRIRVYRPEA----AAPLPALVYAHGGG
MMAR_1746|M.marinum_M FPGPQIHVDVEELTLPGPAG-DISARHYRPPG----DAAAPLLVFYHGGG
MUL_1989|M.ulcerans_Agy99 FPGPQIHVDVEELTLPGPAG-DISARHYRPPG----DAAAPLLVFYHGGG
TH_2802|M.thermoresistible__bu TDMP-AMASIVDRAVPGPGG-DIPVRIHRPER--GCGDPAPAVLYFHGGG
Mb1434c|M.bovis_AF2122/97 PELLPEL-RIEERTVGYDGLTDIPVRVYWPP--V-VRDNLPVVVYYHGGG
Rv1399c|M.tuberculosis_H37Rv PELLPEL-RIEERTVGYDGLTDIPVRVYWPP--V-VRDNLPVVVYYHGGG
MAB_2039|M.abscessus_ATCC_1997 DAQLPTVGRVKDTSIPVTDAPPIAVRIYWPAGFE-SAGELPLVLYYHGGG
MLBr_00314|M.leprae_Br4923 VLLPVTNAARAEVNLSNTSAQLVRAAGVRPAD-----GSGRIVLYLHGGA
: : : * :: ***.
Mvan_0613|M.vanbaalenii_PYR-1 WLLGSIDSHDVATRLLANASGSAVLSVGYRRGPESRFPTAVDDAVDALIW
MSMEG_3829|M.smegmatis_MC2_155 WLLGSVDSHDAATRLLAKASGSAVLSVGYRLAPESRFPTAVNDAIDAVEW
Mflv_4552|M.gilvum_PYR-GCK FVFCDLDSHDGLCRNLSNRLGAVVISVGYRLAPEHRWPTAAEDMYAVTRW
MAV_3025|M.avium_104 FVFCDLDSHDGLCRNLANLVPAVVVSVDYRLAPENAWPAAAEDVYAATCW
MMAR_1746|M.marinum_M WALGDLDTHDAVCRLTCRDAGIHVLAIDYRLSPEDRAPAAIDDAFAAFEW
MUL_1989|M.ulcerans_Agy99 WALGDLDTHDAVCRLTCRDAGIHVLAIDYRLSPEHRAPAAIDDAFAAFEW
TH_2802|M.thermoresistible__bu LVMGSNHSFEPLARGLAAASGAVVVAVDYRLAPEHPPPAQFDDAWATTRW
Mb1434c|M.bovis_AF2122/97 WSLGGLDTHDPVARAHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALRW
Rv1399c|M.tuberculosis_H37Rv WSLGGLDTHDPVARAHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALRW
MAB_2039|M.abscessus_ATCC_1997 FALGSIDTHDWVARSICAHIEAVVVSVDYRLAPENPYPAAVDDAFAALSW
MLBr_00314|M.leprae_Br4923 FLGCGANSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQW
. .:. . . :: :.** *: :* *
Mvan_0613|M.vanbaalenii_PYR-1 AAGPASGLGVDTTRLAVAGDSAGGNLAGAVALHVRHTGAPALRHQLLVYP
MSMEG_3829|M.smegmatis_MC2_155 ARAFGATLGVDTSRLAVAGDSAGGNLAAAVALHYRDAGEPVIRHQLLVYP
Mflv_4552|M.gilvum_PYR-GCK VSGDADALGVDPARIAVGGDSAGGNLAAVTALMARDRGGPALRAQLLLYP
MAV_3025|M.avium_104 ARDHADALGADPARLVVGGDSAGGNLAAVTTVMCRDRGGPAPAAQLLIYP
MMAR_1746|M.marinum_M AHAHAAELGALPGRVAVGGDSAGGNLAAVVSQLARDSGGPAPIFQWLIYP
MUL_1989|M.ulcerans_Agy99 AHAHAAELGALPGRVAVGGDSAGGNLAAVVSQLARDSGGPAPIFQWLIYP
TH_2802|M.thermoresistible__bu VAAHADELGLDTSRLAVAGDSAGGALAAAVALAARDRGGPELLAQLLMYP
Mb1434c|M.bovis_AF2122/97 VGENAAELGGDPSRIAVAGDSAGGNISAVMAQLARDVGGPPLVFQLLWYP
Rv1399c|M.tuberculosis_H37Rv VGENAAELGGDPSRIAVAGDSAGGNISAVMAQLARDVGGPPLVFQLLWYP
MAB_2039|M.abscessus_ATCC_1997 AAEHAPELGADPARIAVAGDSAGGNLATVAAQLAEIRGGPHLKFQLLWYP
MLBr_00314|M.leprae_Br4923 LRR----LGYDPEQIVLAGDSAGGYLALALAQRLQDVGEEPAALVAISPL
** . ::.:.****** :: . : . * :
Mvan_0613|M.vanbaalenii_PYR-1 VTTTDLEIG-FDDEYQGVMLERDEMQWHQDNYLPSP-EAATDARVSILGA
MSMEG_3829|M.smegmatis_MC2_155 VTTTDLTKG-MDPEYDGVMLERDELQWHQDNYLPGP-DAASDPRVNVLGA
Mflv_4552|M.gilvum_PYR-GCK VIAADFDTESYRLFGHGFYNPEPALRWYWDQYVP-ALSDRQHPYASPLHG
MAV_3025|M.avium_104 VIAADFDTESYRLFGQGYYNPAPALRWYWDCYVP-STRDRAHPYATPLNA
MMAR_1746|M.marinum_M RTDFAGRTRSASLFARGFLLTKRDIDWFHSQYLKGSGIEPTDPRVSPLRA
MUL_1989|M.ulcerans_Agy99 RTDFAGRTRSASLFARGFLLTKRDIDWFHSQYLKGSGIEPTDPRVSPLRA
TH_2802|M.thermoresistible__bu GLDRDLAAPSIVAMPEAPMLSRDDIVYLHELADLGAGTP-HDPYRVPAYA
Mb1434c|M.bovis_AF2122/97 TTMADLSLPSFTENADAPILDRDVIDAFLAWYVPGL-DISDHTMLPTTLA
Rv1399c|M.tuberculosis_H37Rv TTMADLSLPSFTENADAPILDRDVIDAFLAWYVPGL-DISDHTMLPTTLA
MAB_2039|M.abscessus_ATCC_1997 GTTSDLSLPSVVENADGPVLSRDIMRIFGQAYLGELSETADPTALPFTVA
MLBr_00314|M.leprae_Br4923 LQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDKPEELYE
:
Mvan_0613|M.vanbaalenii_PYR-1 D----LTGVPAATVILAECDPIRPQGELYAKALEAAGVPTATHLTPGMVH
MSMEG_3829|M.smegmatis_MC2_155 D----LHGLPEATVILAECDPIRPQGELYLQALKDAGVPVESHLTPGQVH
Mflv_4552|M.gilvum_PYR-GCK E----LTGLPPAVMVMTGHDPLRDEAVAYAQALTDAGVPVVRCEFDGAVH
MAV_3025|M.avium_104 D----LRGLPPAVVVVAGHDPLRDEGLAFGAALEAAGVPTVQLRYEGGIH
MMAR_1746|M.marinum_M ES---LAGLAPALIAVAGFDPLRDEGENYATALRAAGTPVDLRAMGSLTH
MUL_1989|M.ulcerans_Agy99 ES---LAGLAPALIAVAGFDPLRDEGENYATALRAAGTPVDLRAMGSLTH
TH_2802|M.thermoresistible__bu TD---LGGLPQTIIVTGACDPIRDWGERYAGRLRDAGVQTTVTRYPGMYH
Mb1434c|M.bovis_AF2122/97 PGNADLSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSVELSNEPTMVH
Rv1399c|M.tuberculosis_H37Rv PGNADLSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSVELSNEPTMVH
MAB_2039|M.abscessus_ATCC_1997 PVNGKLDGLPPAYIATAQHDPLRDDGKIYATRLADAGVPVQLRNADTLVH
MLBr_00314|M.leprae_Br4923 PLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVH
*:. : : : : . * .*. . *
Mvan_0613|M.vanbaalenii_PYR-1 GFFGLDEVFPTATEAMTFAGKQLSEALAVVDR------
MSMEG_3829|M.smegmatis_MC2_155 GFFGLDEIFPAATAAMTFAGQRLASALAVAGQSTR---
Mflv_4552|M.gilvum_PYR-GCK GFMT-MPMLDIAHEARRRSCQELTALLHG---------
MAV_3025|M.avium_104 GFMT-MPMLDIAHRARNEAAAALADLLRR---------
MMAR_1746|M.marinum_M GFLNLFPLGGGCAAATSELISALRAHLTRV--------
MUL_1989|M.ulcerans_Agy99 GFLNLFPLGGGCAAATSELISALRAHLTRV--------
TH_2802|M.thermoresistible__bu GFLMRYESTARGRLALAEIGALLRAKFANPLPF-----
Mb1434c|M.bovis_AF2122/97 GYVNFALVVPAAAEATGRGLAALKRALHA---------
Rv1399c|M.tuberculosis_H37Rv GYVNFALVVPAAAEATGRGLAALKRALHA---------
MAB_2039|M.abscessus_ATCC_1997 GYLDFARIVPAANEEFRLSLDACKTALQASPRPKAGP-
MLBr_00314|M.leprae_Br4923 VFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL
: