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VNLLWRSRSLLSVLLATILVGGLVVVVGAGGRTSQNVVVAYFENSNGLFPGDDVRVLGVPVGRVLEIEPQ PDRAKVTFGYDRAIQIPADAKAAILSPQLVTGRAIQLTPAYTGGPVMADGAVIDQSRTVVPVEWDDFRDQ LERLTELLKPTEPGGVSTLGAFVNTAADNMRGQGGAIRDTVVKLSQTLSTLGDHSDDIFATFTNLSTVVT ALHDSSGALEALNGNLAQVSTLLADNPDKVGLAVEALNAAAIEVKTFAEENRDVIGTTSDKLTSISSTLV GSLDDIKQTLHIAPTTIGNFANIYEPANGALTGALAVNNFSNPIEFLCGAVQAASRLNGEQSAKLCAQYM APIFKNRQYNFPPLGFNFFVGAQARPNEITYSEPWMRPDYVPPAVPPAPEPVAAEPGPLPAEAGSEPAPV PTDPAQGLTGLMVPHGGGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0366 | - | - | 100% (439) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_3979 | - | e-160 | 64.60% (435) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0516 | - | e-149 | 60.71% (448) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0607 | mce2Da | 9e-78 | 37.79% (434) | hypothetical protein Mb0607 |
| M. gilvum PYR-GCK | Mflv_0649 | - | 1e-149 | 60.71% (448) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1969 | mce3D | 1e-163 | 65.14% (436) | MCE-family protein MCE3D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 7e-78 | 36.24% (436) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4150c | - | 3e-71 | 34.46% (444) | MCE-family protein |
| M. marinum M | MMAR_2885 | mce3D | 1e-166 | 66.21% (435) | MCE-family protein Mce3D |
| M. avium 104 | MAV_2535 | - | 1e-149 | 59.13% (438) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_0349 | - | 1e-152 | 62.00% (429) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_4580 | - | 1e-150 | 60.79% (431) | PUTATIVE putative transcriptional regulator, AraC family |
| M. ulcerans Agy99 | MUL_2867 | mce3D | 1e-163 | 65.29% (435) | MCE-family protein Mce3D |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0607|M.bovis_AF2122/97 MSTIFDIRSLRLPKLSAKVVVVGGLVVVLAVVAAAAGARLYRKLTTTTVV
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
Mvan_0366|M.vanbaalenii_PYR-1 -----------MNLLWRSRSLLSVLLATILVGGLVVVVGAGGRTSQNVVV
MSMEG_0349|M.smegmatis_MC2_155 ------------MRISKKQLTLAAGLVVVMVAGVLVGFRMTGPAARTTIT
MMAR_2885|M.marinum_M ----------MTTRLRRTRSVLATTLILVLVAGVIAAMRTAGDATRTLVV
MUL_2867|M.ulcerans_Agy99 ----------MTTRLRRTRSVLATTLILVLVAGVIAAMRTAGDATRTLVV
Rv1969|M.tuberculosis_H37Rv ----------MTTKLRRARSVLAT--ALVLVAGVILAMRTADAAARTTVV
TH_4580|M.thermoresistible__bu ---------------------VAVALIVVLFAGIVGTVRLAQQGSRMTVV
Mflv_0649|M.gilvum_PYR-GCK ------------MTNSRTKLGLAIILVSLVVGGAIAVTRAAHELDRVHVV
MAV_2535|M.avium_104 ---------------------MAIALTAVLLGGIVTVVRSAAGVGRTTVV
MAB_4150c|M.abscessus_ATCC_199 ------------MTTSKTWLKRGAFAMLSVALVGGLLYWVWPSRGTYKIV
. :.
Mb0607|M.bovis_AF2122/97 AYFSEALALYPGDKVQIMGVRVGSIDKIEPAGDKMRVTLHYSNKYQVPAT
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
Mvan_0366|M.vanbaalenii_PYR-1 AYFENSNGLFPGDDVRVLGVPVGRVLEIEPQPDRAKVTFGYDRAIQIPAD
MSMEG_0349|M.smegmatis_MC2_155 AYFANSNGLFAGDDVLILGVPVGKVKEIEPLPERAKVTFWVDKEFQVPAD
MMAR_2885|M.marinum_M AYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQPLRSKISFWFDRKYKVPAD
MUL_2867|M.ulcerans_Agy99 AYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQPLRSKISFWFDRKYKVPAD
Rv1969|M.tuberculosis_H37Rv AYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQPLRAKISFWFDRKYRVPAD
TH_4580|M.thermoresistible__bu AYFENTTGVFPGDDVRILGVRVGQISAIEPQPDRVKVTFWVDERYPVPAE
Mflv_0649|M.gilvum_PYR-GCK AYFDNSNGVFVGDDVRIKGVRVGRIEAIEPQPTQVRITFWFDAKYPVPAD
MAV_2535|M.avium_104 GYFANSTGLYNGDSVVILGVPVGKIEKIEPEPDRVRITFWLNDKYKVPAD
MAB_4150c|M.abscessus_ATCC_199 GHFASAVGLYPGDDVRILGVKAGRISAVEPREGDVKVTMEMPDKFKVPEG
:* : .:: **.* : *: .* : : * :::: :*
Mb0607|M.bovis_AF2122/97 ATASILNPSLVASRTIQLSPPYTGGPVLQDGAVIPIERTQVPVEWDQLRD
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKGGPALGDNAVIPLERTQVPVEWDELRD
Mvan_0366|M.vanbaalenii_PYR-1 AKAAILSPQLVTGRAIQLTPAYTGGPVMADGAVIDQSRTVVPVEWDDFRD
MSMEG_0349|M.smegmatis_MC2_155 ATAAILSPQLVTGRAIQLTPPYESGPELPDDAVIPIERTAVPVSWDDFRV
MMAR_2885|M.marinum_M AKAAILSPQLVTGRAIQLTPPYSGGPTMASGAIISQQRTAVPVEWDDLRN
MUL_2867|M.ulcerans_Agy99 AKAAILSPQLVTGRAIQLTPPYSGGPTTASGAIISQQRTAVPVEWDDLRN
Rv1969|M.tuberculosis_H37Rv AAAAILSPQLVTGRAIQLTPPYAGGPTMADGTVIPQERTVVPVEWDDLRA
TH_4580|M.thermoresistible__bu VNAVILSPQLVTGRAIQLTPAYTSGPMLADGAEIPLARTAVPVEWDDVRE
Mflv_0649|M.gilvum_PYR-GCK AKAVILSPTLVTSRAIQLTPGYTGGPTLQNNATIPRARTAVPVEFDEFRQ
MAV_2535|M.avium_104 VKAAILSPSLVTPRSIQLTPAYTGGPALADHAVIPQQRTAVPVEYDDFRQ
MAB_4150c|M.abscessus_ATCC_199 AQAIIMAPNLVTARFVQLTPAYTDGKALQDGASLGLDKTAVPIEWDEVKT
. * *: * **: * :** * * .* . : : :* **:.:*:.:
Mb0607|M.bovis_AF2122/97 SINGILRQLGPTERQPKGPFGDLIESAADNLAGKGRQLNETLNSLSQALT
MLBr_02592|M.leprae_Br4923 SITKIISKLGPTKEQPKGPFGDVIESFADGLAGKGKQINATLDSLSRALT
Mvan_0366|M.vanbaalenii_PYR-1 QLERLTELLKPTEPGGVSTLGAFVNTAADNMRGQGGAIRDTVVKLSQTLS
MSMEG_0349|M.smegmatis_MC2_155 QLEKLTRTLQPETPGGTSALGNFINTAADNLRGEGDNIRDALVKLSKTVT
MMAR_2885|M.marinum_M QLQRLTELLKPTEPGGVSTLGALINTAADNLRGQGSTIRDAIVELSQTVS
MUL_2867|M.ulcerans_Agy99 QLQRLTELLKPTEPGGVSTLGALINTAADNLRGQGSTIRDAIVELSQTVS
Rv1969|M.tuberculosis_H37Rv QLQRLTALLQPTRPGGVSTLGALINTAADNLRGQGATIRDTIIKLSQAIS
TH_4580|M.thermoresistible__bu QLARVTQLLQPTAPGEPSTLGRAIDTAADNLRGQGPTIRDTIVRLSRAMS
Mflv_0649|M.gilvum_PYR-GCK QLERLTALLQPTEPGEVSTLGSLVNTAADNLRGQGPAIRDAIIRLSQSVS
MAV_2535|M.avium_104 QLEKLTQVLQPTAPGGTSTLGAFINTAADNLRGQGPDIRKTVIELSQAIS
MAB_4150c|M.abscessus_ATCC_199 ELAKLSDSLGPQG-QSKGPVSDFINQAATTFDGNGDSFRNAVRELSQAAG
.: : * * .... :: * : *:* :. :: **::
Mb0607|M.bovis_AF2122/97 ALNEGRGDFVAITRSLALFVSALYQNDQQFVALNENLAEFTDWFTKSDHD
MLBr_02592|M.leprae_Br4923 ALNEGRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLAHSDTD
Mvan_0366|M.vanbaalenii_PYR-1 TLGDHSDDIFATFTNLSTVVTALHDSSGALEALNGNLAQVSTLLADNPDK
MSMEG_0349|M.smegmatis_MC2_155 TVSDHKDDVFSTLNNLATLVSALRDSTDVLAALNRNMAAVSALLADSPDE
MMAR_2885|M.marinum_M TLSDHRNDIFSTVRNLSTLVSALHDSADLLEQLNHNLAAVSSLLATDPNK
MUL_2867|M.ulcerans_Agy99 TLSDHRNDIFSTVRNLSTLVSALHDSADLLEQLNHNLAAVSSLLATDPNK
Rv1969|M.tuberculosis_H37Rv ALGDHSKDIFSTVTNLSTLVTALHDSADLLERLNHNLAAVTSLLADGPDK
TH_4580|M.thermoresistible__bu ALGDHSQDVFGSLRNLSTLVSALHDSTGLLEQLNHNMAAVSALLAEDPDK
Mflv_0649|M.gilvum_PYR-GCK ALADHSPDIFTSVRNLSTLVSALQDSTVLIRQLNQNLASVTGLLANEPTE
MAV_2535|M.avium_104 ALGDHSNDLFSTVKNLSILVSALHDSSDLLQQLNQNLAEVTGLLANDPNE
MAB_4150c|M.abscessus_ATCC_199 RLGDSRTDLFGTIKNLQTLVDALANSNEQIVQFSTHLASVSKVLAASTEN
: : *.. .* .* ** . : :. ::* .: :: .
Mb0607|M.bovis_AF2122/97 LADTVERIDDVLGTVRKFVSDNRSVLAADVNNLADATTTLVQPEPRDGLE
MLBr_02592|M.leprae_Br4923 LSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPEPLNGVE
Mvan_0366|M.vanbaalenii_PYR-1 VGLAVEALNAAAIEVKTFAEENRDVIGTTSDKLTSISSTLVGS--LDDIK
MSMEG_0349|M.smegmatis_MC2_155 VGQAIADLNSLAVDVKSFVVENRDAVGTTSDVSASISTALVQS--LDDIK
MMAR_2885|M.marinum_M VGQAVEDINAVVADVQSFAAENREAVGTASDKLASISNALVAS--LDDIK
MUL_2867|M.ulcerans_Agy99 VGQAVKDINAVVADVQSFAAEYREAVGTASDKLASISNALVAS--LDDIK
Rv1969|M.tuberculosis_H37Rv IGQAAEDLNAVVADVGSFAAEHREAIGTASDKLASITTALVDS--LDDIK
TH_4580|M.thermoresistible__bu VGRVVADLHALVGDLQQFVADNREPLEIASTRLDSVGTALVDS--IDDIK
Mflv_0649|M.gilvum_PYR-GCK VGDAVKNLNDVVGEVTAFVAANRDTIGATSDKLTSVSQALTDS--TDDIE
MAV_2535|M.avium_104 VANAVRNLNDVVGDVRGFVAENRDALGTTSDKLASVTQAVTDS--LGDVK
MAB_4150c|M.abscessus_ATCC_199 LGATLGALNQALTDVRGFLGDTNSALIDQVNKLSDFVKIFSDQ--SDDLE
:. . :. : * .. : . ..::
Mb0607|M.bovis_AF2122/97 TALHVLPTYASNFNNLYYPLHSSLVGQFVFPNFANPIQLICS-AIQAGSR
MLBr_02592|M.leprae_Br4923 TFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQFICS-AIQAGSR
Mvan_0366|M.vanbaalenii_PYR-1 QTLHIAPTTIGNFANIYEPANGALTGALAVNNFSNPIEFLCG-AVQAASR
MSMEG_0349|M.smegmatis_MC2_155 QSLHIFPTTLANFGNIYEPANGSLTGALAINNFSDPISFICG-AIEAASR
MMAR_2885|M.marinum_M QTLHIGPTVLQNFNNIFEPANGALTGALAANDFANPISFLCG-AIQSASR
MUL_2867|M.ulcerans_Agy99 QTLHIGPTVLQNLNNIFEPANGALTGALAANDFANPISFLCG-AIQSASR
Rv1969|M.tuberculosis_H37Rv QTLHISPTVLQNFNNIFEPANGALTGALAGNNMANPIAFLCG-AIQAASR
TH_4580|M.thermoresistible__bu QALHVAPTVLQNFSNIYEAANGSFTGALAANNFANPIQFLCG-AVQAASR
Mflv_0649|M.gilvum_PYR-GCK QLLHIAPTTLSNAANLYQSAQGTLTGALNVANFSDPITFLCG-AVQAASR
MAV_2535|M.avium_104 QLLHTAPTAFQNFLNIYQPAQGTLTGALAFNNFANTIQFLCG-AVEAASR
MAB_4150c|M.abscessus_ATCC_199 QILHVAPNGLANFYNIYNPAAGTLNGMLSIPNLANPVQFICGGVFETGTK
** *. * ::: . .:. * ::::.: ::*. ..::.::
Mb0607|M.bovis_AF2122/97 LGYQESAELCAQYLAPVLDALKFNYLPFGSNPFSSAATLPKEVAYS--EE
MLBr_02592|M.leprae_Br4923 LGYQESAELCAQYLSPVLDAIKFNYFPFGLNLFSTAEVLPKEVAYS--EA
Mvan_0366|M.vanbaalenii_PYR-1 LNGEQSAKLCAQYMAPIFKNRQYNFPPLGFNFFVGAQARPNEITYS--EP
MSMEG_0349|M.smegmatis_MC2_155 LGAERSAKLCVQYLAPIVKNRQFNFPPFGENTFVGAQARPNEITFS--ED
MMAR_2885|M.marinum_M LGGEQAAKLCVQYLAPILKNRQYNFPPLGENLFVGAQARPNEVTYS--ED
MUL_2867|M.ulcerans_Agy99 LGGEQAAKLCVQYLAPILKNRQYNFPPLGENLFVGAQARPNEVTYG--ED
Rv1969|M.tuberculosis_H37Rv LGGEQAAKLCVQYLAPIVKNRQYNYPPLGANLFVGAQARPNEVTYS--ED
TH_4580|M.thermoresistible__bu LGAEQAAKLCVQYLAPIVKNRQYNFPPLGLNLFVGAQARPNEVTYS--EP
Mflv_0649|M.gilvum_PYR-GCK LNNEQSAKLCVQYLAPIIKNRQYNFPPIGVNPFVGATVRPNEVTYS--ED
MAV_2535|M.avium_104 LGAKESAKLCVQYLAPIIKNRQVNFPPLGENLFVGAAARPNELTYS--ED
MAB_4150c|M.abscessus_ATCC_199 TEYLKRAEICRERMGPVLRRATFNYAPILLHPINQISAYKGQIIYDTPET
. *::* : :.*:. *: *: : : . :: :. *
Mb0607|M.bovis_AF2122/97 RLRPPPGYKDTTVPGIFSRDTPFSHGNHEPGWVVAPGMQGMQVQPFTANM
MLBr_02592|M.leprae_Br4923 RLQPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQVGPITAAL
Mvan_0366|M.vanbaalenii_PYR-1 WMRP-----DYVPPAVPPAPEP----------VAAEPGPLPAEAGSEPAP
MSMEG_0349|M.smegmatis_MC2_155 WLRP-----DYIPPAQPVTQD-------------LDPEVLPAEAAPTDG-
MMAR_2885|M.marinum_M WMRP-----DYVPPQP----------------------DMPPAERPADVT
MUL_2867|M.ulcerans_Agy99 WMRP-----DYVPPQP----------------------DMPPAEPPADVT
Rv1969|M.tuberculosis_H37Rv WLRP-----DYVAPVA----------------------DTPP-DPAAAVT
TH_4580|M.thermoresistible__bu WMRP-----DYVPPLP---------------------AEAAPAASPHGTT
Mflv_0649|M.gilvum_PYR-GCK WMRP-----DYVPPQPTLPAATGADPDAPPPLTGPTLPAEAPVPMPDPSN
MAV_2535|M.avium_104 WLRP-----DYVPPHPDSPPTGDAPAPPAAGATPAEAPPPAADAPPPAQA
MAB_4150c|M.abscessus_ATCC_199 EAKSQAPREDLVWVRPNGAPPPPKPSPQDLSALMLGPDEVNAPPPPGTEV
:. *
Mb0607|M.bovis_AF2122/97 LTPESLAELLGGPDIAPPAAGNQLARTAECV-------------------
MLBr_02592|M.leprae_Br4923 MTPDSLAELMGGPDIEPIQSNLQTPPGPPTAYDEHPVPPPIGLQASVPIP
Mvan_0366|M.vanbaalenii_PYR-1 VPTDPAQGLTG--LMVPHGGGS----------------------------
MSMEG_0349|M.smegmatis_MC2_155 -SADPSAGLPG--LMIPTEAGS----------------------------
MMAR_2885|M.marinum_M VEPDPAAGLRG--MMVPPGGG-----------------------------
MUL_2867|M.ulcerans_Agy99 VEPDPAAGLRG--MMVPPGGG-----------------------------
Rv1969|M.tuberculosis_H37Rv VDP--ATGLRG--MMMPPGGGS----------------------------
TH_4580|M.thermoresistible__bu VAADPAAGLPG--LLLPHGGDR----------------------------
Mflv_0649|M.gilvum_PYR-GCK RQTDPAAGLPG--MMIPHGGGS----------------------------
MAV_2535|M.avium_104 APTNPAEGLRG--MMMPPGGGQ----------------------------
MAB_4150c|M.abscessus_ATCC_199 RPAEPGPVPPGFPVTADDAPPPAIPGAPR---------------------
. *
Mb0607|M.bovis_AF2122/97 ----------------------------------
MLBr_02592|M.leprae_Br4923 SPRPDVVPGPVAPTPSPAANVGDPPLPAELGAGQ
Mvan_0366|M.vanbaalenii_PYR-1 ----------------------------------
MSMEG_0349|M.smegmatis_MC2_155 ----------------------------------
MMAR_2885|M.marinum_M ----------------------------------
MUL_2867|M.ulcerans_Agy99 ----------------------------------
Rv1969|M.tuberculosis_H37Rv ----------------------------------
TH_4580|M.thermoresistible__bu ----------------------------------
Mflv_0649|M.gilvum_PYR-GCK ----------------------------------
MAV_2535|M.avium_104 ----------------------------------
MAB_4150c|M.abscessus_ATCC_199 ----------------------------------