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MTNSRTKLGLAIILVSLVVGGAIAVTRAAHELDRVHVVAYFDNSNGVFVGDDVRIKGVRVGRIEAIEPQP TQVRITFWFDAKYPVPADAKAVILSPTLVTSRAIQLTPGYTGGPTLQNNATIPRARTAVPVEFDEFRQQL ERLTALLQPTEPGEVSTLGSLVNTAADNLRGQGPAIRDAIIRLSQSVSALADHSPDIFTSVRNLSTLVSA LQDSTVLIRQLNQNLASVTGLLANEPTEVGDAVKNLNDVVGEVTAFVAANRDTIGATSDKLTSVSQALTD STDDIEQLLHIAPTTLSNAANLYQSAQGTLTGALNVANFSDPITFLCGAVQAASRLNNEQSAKLCVQYLA PIIKNRQYNFPPIGVNPFVGATVRPNEVTYSEDWMRPDYVPPQPTLPAATGADPDAPPPLTGPTLPAEAP VPMPDPSNRQTDPAAGLPGMMIPHGGGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0516 | - | - | 100% (448) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_4601 | - | e-157 | 60.61% (457) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0366 | - | e-149 | 60.71% (448) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0607 | mce2Da | 3e-78 | 40.20% (393) | hypothetical protein Mb0607 |
| M. gilvum PYR-GCK | Mflv_0649 | - | 0.0 | 100.00% (448) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1969 | mce3D | 1e-145 | 59.02% (449) | MCE-family protein MCE3D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 8e-77 | 37.81% (402) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4150c | - | 1e-69 | 33.62% (464) | MCE-family protein |
| M. marinum M | MMAR_4054 | mce3D_1 | 1e-163 | 63.13% (453) | MCE-family protein Mce3D_1 |
| M. avium 104 | MAV_2535 | - | 1e-158 | 64.25% (442) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_0349 | - | 1e-138 | 54.91% (448) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3918 | - | 1e-151 | 61.26% (444) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3921 | mce3D_1 | 1e-163 | 64.06% (448) | MCE-family protein Mce3D_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0607|M.bovis_AF2122/97 MSTIFDIRSLRLPKLSAKVVVVGGLVVVLAVVAAAAGARLYRKLTTTTVV
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
Mvan_0516|M.vanbaalenii_PYR-1 --MTNSRTKLGLAIILVS-LVVGGAIAVTRAAHELD---------RVHVV
Mflv_0649|M.gilvum_PYR-GCK --MTNSRTKLGLAIILVS-LVVGGAIAVTRAAHELD---------RVHVV
TH_3918|M.thermoresistible__bu ---MKALTRVGLAAVLVCTALTAGAHLGIDKARQGG---------RTDIV
MMAR_4054|M.marinum_M ---MIRRTKTWLAVLLVG-LLAAGVVVLLRTTEVVN---------RTNVV
MUL_3921|M.ulcerans_Agy99 ---MIRRTKTWLAVLLVG-LLAAGVVVLLRTTEVVN---------RTNVV
MAV_2535|M.avium_104 -----------MAIALTA-VLLGGIVTVVRSAAGVG---------RTTVV
Rv1969|M.tuberculosis_H37Rv ---MTTKLRRARSVLATALVLVAGVILAMRTADAAA---------RTTVV
MSMEG_0349|M.smegmatis_MC2_155 ---MRISKKQLTLAAGLVVVMVAGVLVGFRMTGPAA---------RTTIT
MAB_4150c|M.abscessus_ATCC_199 -MTTSKTWLKRGAFAMLSVALVGGLLYWVWPSRGTY-----------KIV
: .. :.
Mb0607|M.bovis_AF2122/97 AYFSEALALYPGDKVQIMGVRVGSIDKIEPAGDKMRVTLHYSNKYQVPAT
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
Mvan_0516|M.vanbaalenii_PYR-1 AYFDNSNGVFVGDDVRIKGVRVGRIEAIEPQPTQVRITFWFDAKYPVPAD
Mflv_0649|M.gilvum_PYR-GCK AYFDNSNGVFVGDDVRIKGVRVGRIEAIEPQPTQVRITFWFDAKYPVPAD
TH_3918|M.thermoresistible__bu AFFQNTKGLFVGDDVRIRGVNVGKITSIEPQPTQVKVTFWVGDGYDVPAD
MMAR_4054|M.marinum_M AYFENSNGVFTGDEVRILGVPVGKITSIEPQPESVKVSFWYDSKYKVPAD
MUL_3921|M.ulcerans_Agy99 AYFENSNGVFTGDEVRILGVPVGKITSIEPQPESVRVSFWYDSKYIVPAD
MAV_2535|M.avium_104 GYFANSTGLYNGDSVVILGVPVGKIEKIEPEPDRVRITFWLNDKYKVPAD
Rv1969|M.tuberculosis_H37Rv AYFDNSNGVFAGDDVLIRGVPVGKIVKIEPQPLRAKISFWFDRKYRVPAD
MSMEG_0349|M.smegmatis_MC2_155 AYFANSNGLFAGDDVLILGVPVGKVKEIEPLPERAKVTFWVDKEFQVPAD
MAB_4150c|M.abscessus_ATCC_199 GHFASAVGLYPGDDVRILGVKAGRISAVEPREGDVKVTMEMPDKFKVPEG
.* : .:: **.* * *: .* : : * :::: : **
Mb0607|M.bovis_AF2122/97 ATASILNPSLVASRTIQLSPPYTGGPVLQDGAVIPIERTQVPVEWDQLRD
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKGGPALGDNAVIPLERTQVPVEWDELRD
Mvan_0516|M.vanbaalenii_PYR-1 AKAVILSPTLVTSRAIQLTPGYTGGPTLQNNATIPRARTAVPVEFDEFRQ
Mflv_0649|M.gilvum_PYR-GCK AKAVILSPTLVTSRAIQLTPGYTGGPTLQNNATIPRARTAVPVEFDEFRQ
TH_3918|M.thermoresistible__bu VKAVILSPTLVTARAIQLTPPYRGGPTLASDAVIPLERTAVPVEWDDFRA
MMAR_4054|M.marinum_M AKAAILSPTLVTSRAIQLTPAYTGGPAMSDNAVIPRQRTAVPVEWDDVRA
MUL_3921|M.ulcerans_Agy99 AKAAILSPTLVTSRAIQLTPAYTGGPAMSDNAVIPRQRTAVPVEWDDVRA
MAV_2535|M.avium_104 VKAAILSPSLVTPRSIQLTPAYTGGPALADHAVIPQQRTAVPVEYDDFRQ
Rv1969|M.tuberculosis_H37Rv AAAAILSPQLVTGRAIQLTPPYAGGPTMADGTVIPQERTVVPVEWDDLRA
MSMEG_0349|M.smegmatis_MC2_155 ATAAILSPQLVTGRAIQLTPPYESGPELPDDAVIPIERTAVPVSWDDFRV
MAB_4150c|M.abscessus_ATCC_199 AQAIIMAPNLVTARFVQLTPAYTDGKALQDGASLGLDKTAVPIEWDEVKT
. * *: * **: * :** * * .* : . : : :* **:.:*:.:
Mb0607|M.bovis_AF2122/97 SINGILRQLGPTERQPKGPFGDLIESAADNLAGKGRQLNETLNSLSQALT
MLBr_02592|M.leprae_Br4923 SITKIISKLGPTKEQPKGPFGDVIESFADGLAGKGKQINATLDSLSRALT
Mvan_0516|M.vanbaalenii_PYR-1 QLERLTALLQPTEPGEVSTLGSLVNTAADNLRGQGPAIRDAIIRLSQSVS
Mflv_0649|M.gilvum_PYR-GCK QLERLTALLQPTEPGEVSTLGSLVNTAADNLRGQGPAIRDAIIRLSQSVS
TH_3918|M.thermoresistible__bu QFERLSQTLQPTEPGGVSTLGAFVNSAADNLRGQGPAIRDSVGKLSQALT
MMAR_4054|M.marinum_M QLAKLTKELQPTEPGGVSPLGSVINTAADNLRGEGANIRDTVIKLSQAFS
MUL_3921|M.ulcerans_Agy99 QLAKLTKELQPTEPGGVSPLGSVINTAADNLRGEGANIRDTVIKLSQAFS
MAV_2535|M.avium_104 QLEKLTQVLQPTAPGGTSTLGAFINTAADNLRGQGPDIRKTVIELSQAIS
Rv1969|M.tuberculosis_H37Rv QLQRLTALLQPTRPGGVSTLGALINTAADNLRGQGATIRDTIIKLSQAIS
MSMEG_0349|M.smegmatis_MC2_155 QLEKLTRTLQPETPGGTSALGNFINTAADNLRGEGDNIRDALVKLSKTVT
MAB_4150c|M.abscessus_ATCC_199 ELAKLSDSLGPQG-QSKGPVSDFINQAATTFDGNGDSFRNAVRELSQAAG
.: : * * .... .:: * : *:* :. :: **::
Mb0607|M.bovis_AF2122/97 ALNEGRGDFVAITRSLALFVSALYQNDQQFVALNENLAEFTDWFTKSDHD
MLBr_02592|M.leprae_Br4923 ALNEGRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLAHSDTD
Mvan_0516|M.vanbaalenii_PYR-1 ALADHSPDIFTSVRNLSTLVSALQDSTVLIRQLNQNLASVTGLLANEPTE
Mflv_0649|M.gilvum_PYR-GCK ALADHSPDIFTSVRNLSTLVSALQDSTVLIRQLNQNLASVTGLLANEPTE
TH_3918|M.thermoresistible__bu ALGEHSDDTFTSVKHLSTLVSALRDSTDVMRRLNENLASVTQLMVNDPGE
MMAR_4054|M.marinum_M ALGDHSTDIFSTVKNLAILVSALQDSTNFMRQLNQNLATVTGLLANDPNE
MUL_3921|M.ulcerans_Agy99 ALGDHSTDIFSTVKNLAILVSALQDSTNLMRQLNQNLATVTGLLANDPNE
MAV_2535|M.avium_104 ALGDHSNDLFSTVKNLSILVSALHDSSDLLQQLNQNLAEVTGLLANDPNE
Rv1969|M.tuberculosis_H37Rv ALGDHSKDIFSTVTNLSTLVTALHDSADLLERLNHNLAAVTSLLADGPDK
MSMEG_0349|M.smegmatis_MC2_155 TVSDHKDDVFSTLNNLATLVSALRDSTDVLAALNRNMAAVSALLADSPDE
MAB_4150c|M.abscessus_ATCC_199 RLGDSRTDLFGTIKNLQTLVDALANSNEQIVQFSTHLASVSKVLAASTEN
: : * . * :* ** . : :. ::* .: :. .
Mb0607|M.bovis_AF2122/97 LADTVERIDDVLGTVRKFVSDNRSVLAADVNNLADATTTLVQPEPRDGLE
MLBr_02592|M.leprae_Br4923 LSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPEPLNGVE
Mvan_0516|M.vanbaalenii_PYR-1 VGDAVKNLNDVVGEVTAFVAANRDTIGATSDKLTSVSQALT--DSTDDIE
Mflv_0649|M.gilvum_PYR-GCK VGDAVKNLNDVVGEVTAFVAANRDTIGATSDKLTSVSQALT--DSTDDIE
TH_3918|M.thermoresistible__bu VAEALEELASVVGDVKSFVAENRDSIGTASEKLASVSEALS--ESLGDVK
MMAR_4054|M.marinum_M VANAVRNLGDTVGEVQRFVADNREALGTTSDKLAGVSQALN--DSLDDVK
MUL_3921|M.ulcerans_Agy99 VANAVRNLGDTVGEVQRFVADNREALGTTSDKLAGVSQALN--DSLDDVK
MAV_2535|M.avium_104 VANAVRNLNDVVGDVRGFVAENRDALGTTSDKLASVTQAVT--DSLGDVK
Rv1969|M.tuberculosis_H37Rv IGQAAEDLNAVVADVGSFAAEHREAIGTASDKLASITTALV--DSLDDIK
MSMEG_0349|M.smegmatis_MC2_155 VGQAIADLNSLAVDVKSFVVENRDAVGTTSDVSASISTALV--QSLDDIK
MAB_4150c|M.abscessus_ATCC_199 LGATLGALNQALTDVRGFLGDTNSALIDQVNKLSDFVKIFS--DQSDDLE
:. : : * * .. : : : . : ..::
Mb0607|M.bovis_AF2122/97 TALHVLPTYASNFNNLYYPLHSSLVGQFVFPNFANPIQLICS-AIQAGSR
MLBr_02592|M.leprae_Br4923 TFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQFICS-AIQAGSR
Mvan_0516|M.vanbaalenii_PYR-1 QLLHIAPTTLSNAANLYQSAQGTLTGALNVANFSDPITFLCG-AVQAASR
Mflv_0649|M.gilvum_PYR-GCK QLLHIAPTTLSNAANLYQSAQGTLTGALNVANFSDPITFLCG-AVQAASR
TH_3918|M.thermoresistible__bu QLLHVAPTSLANVVNMYQPAQGTLSGVLAANNFSDPITFLCG-AVQAASR
MMAR_4054|M.marinum_M QFLHVAPNTLQNYVNIWQPAQGAVSAVPMLNNFANPISFLCG-AIQAASR
MUL_3921|M.ulcerans_Agy99 QFLHVAPNTLQNYVNIWQPAQGAVSAVPMLNNFANPISFLCG-AIQAASR
MAV_2535|M.avium_104 QLLHTAPTAFQNFLNIYQPAQGTLTGALAFNNFANTIQFLCG-AVEAASR
Rv1969|M.tuberculosis_H37Rv QTLHISPTVLQNFNNIFEPANGALTGALAGNNMANPIAFLCG-AIQAASR
MSMEG_0349|M.smegmatis_MC2_155 QSLHIFPTTLANFGNIYEPANGSLTGALAINNFSDPISFICG-AIEAASR
MAB_4150c|M.abscessus_ATCC_199 QILHVAPNGLANFYNIYNPAAGTLNGMLSIPNLANPVQFICGGVFETGTK
** *. * ::: . .:: . *:::.: ::*. ..::.::
Mb0607|M.bovis_AF2122/97 LGYQESAELCAQYLAPVLDALKFNYLPFGSNPFSSAATLPKEVAYSEERL
MLBr_02592|M.leprae_Br4923 LGYQESAELCAQYLSPVLDAIKFNYFPFGLNLFSTAEVLPKEVAYSEARL
Mvan_0516|M.vanbaalenii_PYR-1 LNNEQSAKLCVQYLAPIIKNRQYNFPPIGVNPFVGATVRPNEVTYSEDWM
Mflv_0649|M.gilvum_PYR-GCK LNNEQSAKLCVQYLAPIIKNRQYNFPPIGVNPFVGATVRPNEVTYSEDWM
TH_3918|M.thermoresistible__bu LGAEQSAKLCVQYLAPIVKNRQYNFPPLGVNPFVGAAARPNEITYSEDWL
MMAR_4054|M.marinum_M LGYEQSAKLCVQYLAPIIKNRQYNFLPFGQNLFVGASARPNELTYSEDWL
MUL_3921|M.ulcerans_Agy99 LGYEQSAKLCVQYLAPIIKNRQYNFLPFGQNLFVGASARPNELTYSEDWL
MAV_2535|M.avium_104 LGAKESAKLCVQYLAPIIKNRQVNFPPLGENLFVGAAARPNELTYSEDWL
Rv1969|M.tuberculosis_H37Rv LGGEQAAKLCVQYLAPIVKNRQYNYPPLGANLFVGAQARPNEVTYSEDWL
MSMEG_0349|M.smegmatis_MC2_155 LGAERSAKLCVQYLAPIVKNRQFNFPPFGENTFVGAQARPNEITFSEDWL
MAB_4150c|M.abscessus_ATCC_199 TEYLKRAEICRERMGPVLRRATFNYAPILLHPINQISAYKGQIIYDTPET
. *::* : :.*:: *: *: : : . :: :.
Mb0607|M.bovis_AF2122/97 RPPPGY-KDTTVPGIFSRDTPFSHGNHEPGWVVAPGMQGMQVQPFTANML
MLBr_02592|M.leprae_Br4923 QPPSGY-KDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQVGPITAALM
Mvan_0516|M.vanbaalenii_PYR-1 RP------DYVPPQPTLPAATGADPDAPPPLTGPTLPAEAP-VPMPDPSN
Mflv_0649|M.gilvum_PYR-GCK RP------DYVPPQPTLPAATGADPDAPPPLTGPTLPAEAP-VPMPDPSN
TH_3918|M.thermoresistible__bu RS------DSPSPQ----------------------------------SI
MMAR_4054|M.marinum_M RP------DYIPPQAIPPQAIPPQQAPPAAAPPAQAPPPAVGPPLPAEAP
MUL_3921|M.ulcerans_Agy99 RP------DYIPPQAIP-----PQQAPPAAAPPAQAPPPAVGLPLPAEAP
MAV_2535|M.avium_104 RP------DYVPPHPDSPPTGDAPAPPAAGATPAEAPPPAADAPPPAQAA
Rv1969|M.tuberculosis_H37Rv RP------DYVAPVADTPPD------PAAAV----------------TVD
MSMEG_0349|M.smegmatis_MC2_155 RP------DYIPPAQPVTQDLDPEVLPAEAA----------------PTD
MAB_4150c|M.abscessus_ATCC_199 EAKSQAPREDLVWVRPNGAPPPPKPSPQDLSALMLGPDEVNAPPPPGTEV
.. :
Mb0607|M.bovis_AF2122/97 TPESLAELLGGPDIAPPAAGNQLARTAECV--------------------
MLBr_02592|M.leprae_Br4923 TPDSLAELMGGPDIEPIQSNLQTPPGPPTAYDEHPVPPPIGLQASVPIPS
Mvan_0516|M.vanbaalenii_PYR-1 RQTDPAAGLPG-MMIPHGGGS-----------------------------
Mflv_0649|M.gilvum_PYR-GCK RQTDPAAGLPG-MMIPHGGGS-----------------------------
TH_3918|M.thermoresistible__bu STTDPASGLPG-MMAPPGGGG-----------------------------
MMAR_4054|M.marinum_M ATPDPAAGLRG-IMVPQGVGS-----------------------------
MUL_3921|M.ulcerans_Agy99 ATPDPAAGLRG-IMVPQGVGS-----------------------------
MAV_2535|M.avium_104 PT-NPAEGLRG-MMMPPGGGQ-----------------------------
Rv1969|M.tuberculosis_H37Rv ----PATGLRG-MMMPPGGGS-----------------------------
MSMEG_0349|M.smegmatis_MC2_155 GSADPSAGLPG-LMIPTEAGS-----------------------------
MAB_4150c|M.abscessus_ATCC_199 RPAEPGPVPPGFPVTADDAPPPAIPGAPR---------------------
. * : .
Mb0607|M.bovis_AF2122/97 ---------------------------------
MLBr_02592|M.leprae_Br4923 PRPDVVPGPVAPTPSPAANVGDPPLPAELGAGQ
Mvan_0516|M.vanbaalenii_PYR-1 ---------------------------------
Mflv_0649|M.gilvum_PYR-GCK ---------------------------------
TH_3918|M.thermoresistible__bu ---------------------------------
MMAR_4054|M.marinum_M ---------------------------------
MUL_3921|M.ulcerans_Agy99 ---------------------------------
MAV_2535|M.avium_104 ---------------------------------
Rv1969|M.tuberculosis_H37Rv ---------------------------------
MSMEG_0349|M.smegmatis_MC2_155 ---------------------------------
MAB_4150c|M.abscessus_ATCC_199 ---------------------------------