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HVPIPSRILPWAGRLRLPVIAAPMTSVSTPELVIGACRSGAIGSFPTHNAATTRELDAWLARAKSELAAE AAPVAPNLVVHRSNPRRDDDLAVLIHHKVELVITSVGSPAPVIEPLHNAGARVFADVASLEHAWRALDAG ADGLVLLTAGAGGQTGWANPFAFVRAVRENFDGPVVLAGGISDGRAILAAQILGADFAYLGTRFIATRQS AAGDDYRDALVAATLDDVRLSDRVGGVPASLLSCWLDAQSTPGADGAGSGFTQKQLLANREAWSAGHSVS GVHGVVDVADLVEELLTGYTVARRELKLVIGN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0347 | - | - | 100% (313) | 2-nitropropane dioxygenase, NPD |
| M. vanbaalenii PYR-1 | Mvan_5586 | - | 7e-22 | 32.64% (239) | 2-nitropropane dioxygenase, NPD |
| M. vanbaalenii PYR-1 | Mvan_5214 | - | 3e-18 | 30.04% (243) | 2-nitropropane dioxygenase, NPD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0021c | - | 2e-19 | 33.64% (217) | hypothetical protein Mb0021c |
| M. gilvum PYR-GCK | Mflv_1222 | - | 1e-22 | 33.61% (238) | 2-nitropropane dioxygenase, NPD |
| M. tuberculosis H37Rv | Rv0021c | - | 2e-19 | 33.64% (217) | hypothetical protein Rv0021c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4001c | - | 1e-19 | 30.91% (220) | putative 2-nitropropane dioxygenase, NPD |
| M. marinum M | MMAR_5042 | - | 6e-16 | 26.23% (244) | 2-nitropropane dioxygenase |
| M. avium 104 | MAV_2769 | - | 3e-20 | 29.21% (291) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. smegmatis MC2 155 | MSMEG_0332 | - | 1e-114 | 69.31% (303) | 2-nitropropane dioxygenase, NPD |
| M. thermoresistible (build 8) | TH_3584 | - | 4e-18 | 26.98% (215) | PUTATIVE 2-nitropropane dioxygenase, NPD |
| M. ulcerans Agy99 | MUL_4116 | - | 5e-16 | 26.23% (244) | 2-nitropropane dioxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5042|M.marinum_M --MRLRTPLTDLVG-VEHPVVQTGMGWVAGARLVSATANAGGLGILASAT
MUL_4116|M.ulcerans_Agy99 --MRLRTPLTDLVG-VEHPVVQTGMGWVAGARLVSATANAGGLGILASAT
Mflv_1222|M.gilvum_PYR-GCK ----MTNRIQDLLG-VEFPVVQAPMTYIARAELAAAVSDGGGLGMIETLT
MAV_2769|M.avium_104 ------------------------MTYIAGAQLAAAVSNAGALGIIETTS
MAB_4001c|M.abscessus_ATCC_199 ---MITNRVTELLG-VERPIVQAPMGWIARSQLASAVCNAGGLGIIETSS
TH_3584|M.thermoresistible__bu ---LIKTRFTEAFG-IEHPIVQGGMQWVGRAELVAAVANAGALGFITALT
Mb0021c|M.bovis_AF2122/97 --MVLSTAFSQMFG-IDYPIVSAPMDLIAGGELAAAVSGAGGLGLIGGGY
Rv0021c|M.tuberculosis_H37Rv --MVLSTAFSQMFG-IDYPIVSAPMDLIAGGELAAAVSGAGGLGLIGGGY
Mvan_0347|M.vanbaalenii_PYR-1 MHVPIPSRILPWAGRLRLPVIAAPMTSVSTPELVIGACRSGAIGSFPTHN
MSMEG_0332|M.smegmatis_MC2_155 -MNPLPT---AWSGRLVLPVIAAPMTSVSGPELVIAACRAGVIGSFPTHN
* :. .*. ... .* :* :
MMAR_5042|M.marinum_M MTL-DELATAIGKVK---ATTDKPFGVNIRADAADASDR----VELMIRE
MUL_4116|M.ulcerans_Agy99 MTL-DELATAIGKVK---ATTDKPFGVNIRADAADASDR----VELMIRE
Mflv_1222|M.gilvum_PYR-GCK ----DEGRADLLRVR---DLTDRPVAANLMIQGWKRDP---SIVDVLAAA
MAV_2769|M.avium_104 ----DQGRADLRRVR---ELTAGAVGANIALL-FNRDP---AMLDLLVAN
MAB_4001c|M.abscessus_ATCC_199 GEL-DAIKDEIRAMR---EFTDKPFGVNIAQA-FVRDP---SIAQFVVDQ
TH_3584|M.thermoresistible__bu QPTPEDLAKEIARCR---ELTDKPFGVNLTILPTINPPPYDEYRQVIVES
Mb0021c|M.bovis_AF2122/97 G----DRDWLARQFD---LAAGAPVGCGFITWSLARQPQ---LLDLALQY
Rv0021c|M.tuberculosis_H37Rv G----DRDWLARQFD---LAAGAPVGCGFITWSLARQPQ---LLDLALQY
Mvan_0347|M.vanbaalenii_PYR-1 AATTRELDAWLARAKSELAAEAAPVAPNLVVHRSNPRRD--DDLAVLIHH
MSMEG_0332|M.smegmatis_MC2_155 ATSPEELDSWLRRIT-AQAGGGAPVAPNLVVHRSNARLQ--ADLDCLIRH
... .:
MMAR_5042|M.marinum_M GVKVASFALAPKPELIARLKEAGAVVIPSIGAAKHARKVAGWGADAMIVQ
MUL_4116|M.ulcerans_Agy99 GVKVASFALAPKPELIARLKEAGAVVIPSIGAAKHARKVAGWGADAMIVQ
Mflv_1222|M.gilvum_PYR-GCK GVRHVFTSAGDPALFTDRLHDAGMTVVHVIGSLKGALKAADAGVDALVVE
MAV_2769|M.avium_104 DIRFVTTSAGDPALFTDRLHDAGITVFHVVGTLAAAKKAVDAGVDGLVVE
MAB_4001c|M.abscessus_ATCC_199 GVTFVTTSAGDPNKYTRVLKDNGLTVFHVVPTLAAALKAVDAGVDGLVVE
TH_3584|M.thermoresistible__bu GIKIVETAGSNPAPHLPMFHEHGVKVLHKCTSVRHAVKAQELGVDGISID
Mb0021c|M.bovis_AF2122/97 EPVAVMLSFGDPAVFADAIKSAGTRLVCQIQNRTQAERALQVGADVLVAQ
Rv0021c|M.tuberculosis_H37Rv EPVAVMLSFGDPAVFADAIKSAGTRLVCQIQNRTQAERALQVGADVLVAQ
Mvan_0347|M.vanbaalenii_PYR-1 KVELVITSVGSPAPVIEPLHNAGARVFADVASLEHAWRALDAGADGLVLL
MSMEG_0332|M.smegmatis_MC2_155 RVELVITSVGSPAAVVDRLHGIGAQLYADVASLRHAWAALDAGADGLVLL
. : . :: * : * . *.* :
MMAR_5042|M.marinum_M GGEGGGHTGPVATTLLLP---SVLDAVKGTGIPVIAAGGFFDGRGLAAAL
MUL_4116|M.ulcerans_Agy99 GGEGGGHTGPVATTLLLP---SVLDAVKGTGIPVIAAGGFFDGHGLAAAL
Mflv_1222|M.gilvum_PYR-GCK GVEGGGFKSALGASTMVL---LPLVAER-VDLPLICAGGICDARSAAAAV
MAV_2769|M.avium_104 GVEGGGFKNRFGASTMVL---LPLVAAH-VDVPIVAAGGICDARSMAAAF
MAB_4001c|M.abscessus_ATCC_199 GVEGGGFKDPKGASTMVL---LPLVRSH-VDIPIIAAGGICDGVSMAAAF
TH_3584|M.thermoresistible__bu GFECAGHPGEDDIPGLVL---IPAAAAK-ITVPMIASGGFADARGLVAAL
Mb0021c|M.bovis_AF2122/97 GTEAGGHGHGPRSTLTLVPEIVDLVTARGTDIPVIAAGGIADGRGLAAAL
Rv0021c|M.tuberculosis_H37Rv GTEAGGHGHGPRSTLTLVPEIVDLVTARGTDIPVIAAGGIADGRGLAAAL
Mvan_0347|M.vanbaalenii_PYR-1 TAGAGGQTGWANPFAFVR------AVRENFDGPVVLAGGISDGRAILAAQ
MSMEG_0332|M.smegmatis_MC2_155 TAGAGGQTGWANPLAFLS------AVRERFDGPLVLAGGIADGRSILAAQ
.* : . *:: :**: *. . **
MMAR_5042|M.marinum_M SYGAAGVAMGTRFLLTSDSTVPEAVKRRYLQAALDGTVVTTRVDGMPHRV
MUL_4116|M.ulcerans_Agy99 SYGAAGVAMGTRFLLTSDSTVPDAVKRRYLQAALDGTVVTTRVDGMPHRV
Mflv_1222|M.gilvum_PYR-GCK VLGAEGIQMGTRMLASAEALVHANFKDAIVAADDAGTILLDVPGNPTMRV
MAV_2769|M.avium_104 VLGAEAVQMGTRLLASADSPVHVNLKQAVVAADETATVLLPLDGKRMMRV
MAB_4001c|M.abscessus_ATCC_199 ALGAEGVQMGTRMMSAAESPIHHNWKAAVVAARETDTVLLNRLTKPGLRA
TH_3584|M.thermoresistible__bu ALGADGINMGSRFMCTVESPIHQKVKEAIVAGSELDTELIFRPLRNTGRV
Mb0021c|M.bovis_AF2122/97 MLGAAGVLVGTRFYATVEALSTPQARDPLLAATGDDMCRTTIYDQLRRYP
Rv0021c|M.tuberculosis_H37Rv MLGAAGVLVGTRFYATVEALSTPQARDPLLAATGDDMCRTTIYDQLRRYP
Mvan_0347|M.vanbaalenii_PYR-1 ILGADFAYLGTRFIATRQSAAGDDYRDALVAATLDDVRLSDRVGGVPASL
MSMEG_0332|M.smegmatis_MC2_155 AAGADLAYVGTRFIATSKSRASDEYRRAVVDSTLDDVKLSDRVGGIPASL
** :*:*: : .: : : .
MMAR_5042|M.marinum_M LRTGLVEKLEGGSRARGFTAAIRNAAKFKQMSQMSWASMIKDGLAMRHGK
MUL_4116|M.ulcerans_Agy99 LRTGLVEKLEGGSRARGFTAAIRNAAKFKQMSQMSWASMIKDGLAMRHGK
Mflv_1222|M.gilvum_PYR-GCK LRTGLAARIDEQDAD---------AKLLGRITDLYFG-------------
MAV_2769|M.avium_104 IRTPAAERLEAAGAAGE------GAAALQRVQRLYFE-------------
MAB_4001c|M.abscessus_ATCC_199 LRSARTEEMERRDLVS--------LLETGDPLDLYFG-------------
TH_3584|M.thermoresistible__bu ASNSVSREVVEILDKGGKFEDVAHLVSGKRGAKVYET-------------
Mb0021c|M.bovis_AF2122/97 WPQGHTMSVLSNALTDQFEDTELDILHREEAMARYWR-------------
Rv0021c|M.tuberculosis_H37Rv WPQGHTMSVLSNALTDQFEDTELDILHREEAMARYWR-------------
Mvan_0347|M.vanbaalenii_PYR-1 LSCWLDAQSTPGADGAGS----------GFTQKQLLA-------------
MSMEG_0332|M.smegmatis_MC2_155 LSAWLDRQADP--EGASD----------GFAQDRLLS-------------
MMAR_5042|M.marinum_M ELTWSQVVMAANTPMLLKAGLVDGNPEAGVLASGQVAGILDDLPSCAQLV
MUL_4116|M.ulcerans_Agy99 ELTWSQVLMAANTPMLLKAGLVDGNPEAGVLASGQVAGILDDLPSCAQLV
Mflv_1222|M.gilvum_PYR-GCK -----------------------GDLEASVANTGQVSSRITGLAPAAEIV
MAV_2769|M.avium_104 -----------------------GDLDASVANTGQVAGRIRDLPPAADII
MAB_4001c|M.abscessus_ATCC_199 -----------------------GNMETFVPLGGQVAGRIGGVESVKDIL
TH_3584|M.thermoresistible__bu -----------------------GDLEAGIWWIGTAMGLINDIPTVGELV
Mb0021c|M.bovis_AF2122/97 -------------------AVPARDYSIANVTAGQAAGLVNAVLPAADVI
Rv0021c|M.tuberculosis_H37Rv -------------------AVAARDYSIANVTAGQAAGLVNAVLPAADVI
Mvan_0347|M.vanbaalenii_PYR-1 --------------------------NREAWSAGHSVSGVHGVVDVADLV
MSMEG_0332|M.smegmatis_MC2_155 --------------------------NGDAWSAGHSVSGVHGVTTVEELV
. * . : : :::
MMAR_5042|M.marinum_M ESIVHDAIEHLRAAAALVE------
MUL_4116|M.ulcerans_Agy99 ESIVHDAIEHLRAAAALVE------
Mflv_1222|M.gilvum_PYR-GCK RQTWCEIQTVLDDTRARLG------
MAV_2769|M.avium_104 KQMWKGCREVLAATSARLDWADDA-
MAB_4001c|M.abscessus_ATCC_199 DATMDEFTAVIGKLAAQYV------
TH_3584|M.thermoresistible__bu SRMVSEAEEIINGRLAGALR-----
Mb0021c|M.bovis_AF2122/97 TGMAQQAARTLTAMRAV--------
Rv0021c|M.tuberculosis_H37Rv TGMAQQAARTLTAMRAV--------
Mvan_0347|M.vanbaalenii_PYR-1 EELLTGYTVARRELKLVIGN-----
MSMEG_0332|M.smegmatis_MC2_155 AELAGQYQAARAEFAALCEAGGPLR