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MGATTAVAVWGTGNMGATAIRSVTAFPGLHLAGLITSSEDKAGRDAASFARLDAPTGISASTDVDAVLAD CHAVAYMASGDIRPDEAVADIERCLRAGVHVVTPSLYSLYDPRSAPPEWVQRLTGAAEDGRAALLVSGVD PGWANDALAVTAAGLCTRINTITCQEIFDYSTYDQPYAVRVSCGFGGPMDETPMMLLPTIPTMVWGGNIR LIGRGLGLEIDEITEEVERLPLADSVDTVMGRFDEGTQGAFFLRVIGWSGGRQRVIVEHITRIDPSCAPH WPQPDQGVGDHRVIVDGDPQLTIVTRADVPGGTRADGGNTTAANRLLGAISWLAAQKPGIYDGLDVPLHP PLAPELEATRWS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0266 | - | - | 100% (362) | dihydrodipicolinate reductase |
| M. vanbaalenii PYR-1 | Mvan_4922 | - | 7e-64 | 39.07% (343) | dihydrodipicolinate reductase |
| M. vanbaalenii PYR-1 | Mvan_3001 | - | 4e-58 | 35.94% (345) | dihydrodipicolinate reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0949c | - | 5e-61 | 37.65% (340) | hypothetical protein Mb0949c |
| M. gilvum PYR-GCK | Mflv_0408 | - | 1e-176 | 80.11% (362) | dihydrodipicolinate reductase |
| M. tuberculosis H37Rv | Rv0926c | - | 5e-61 | 37.65% (340) | hypothetical protein Rv0926c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4633 | - | 1e-62 | 37.93% (348) | hypothetical protein MAB_4633 |
| M. marinum M | MMAR_0386 | - | 8e-63 | 37.79% (344) | hypothetical protein MMAR_0386 |
| M. avium 104 | MAV_1045 | dapB | 3e-65 | 39.41% (340) | dihydrodipicolinate reductase N-terminus domain-containing |
| M. smegmatis MC2 155 | MSMEG_0407 | - | 1e-168 | 77.44% (359) | hypothetical protein MSMEG_0407 |
| M. thermoresistible (build 8) | TH_0599 | - | 3e-64 | 40.46% (346) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3685 | - | 6e-22 | 26.30% (346) | hypothetical protein MUL_3685 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0266|M.vanbaalenii_PYR-1 --MGATTAVAVWGTGNMGATAIRSVTAFPGLHLAGLITSSEDKAGRDAAS
Mflv_0408|M.gilvum_PYR-GCK --MQRAIGVAVWGTGNMGSTAIRSTAAFPGLALAGVITSSADKAGRDAAT
MSMEG_0407|M.smegmatis_MC2_155 --MRR---IAVWGTGNMGSTAIRSAVAFPGLELAAVITSSQDKVGRDAAM
Mb0949c|M.bovis_AF2122/97 ----MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDAAE
Rv0926c|M.tuberculosis_H37Rv ----MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDAAE
MAV_1045|M.avium_104 ----MPIPVVQLGTGNVGIHALRALITDPQFELTGVWVSSDAKAGKDAAE
TH_0599|M.thermoresistible__bu ----VTIRTAVVGTGNVGRHALAQVIADPRFDLTAVWVSSAAKAGLDAGE
MAB_4633|M.abscessus_ATCC_1997 ---MTKTRVAVWGTGNVGQHALAGVITDPSMELVGVWVSGSNKAGKDAGA
MMAR_0386|M.marinum_M ----MAIRVAHVGTGNVGRLALSELVTNPAFELTAVCVSTPEKVGRDAGD
MUL_3685|M.ulcerans_Agy99 MSTARPLRVIQWTTGNIGRRSLHAIIGRPDLELVGVYAHGPDKVGVDAAE
***:* :: * : *..: . *.* **.
Mvan_0266|M.vanbaalenii_PYR-1 FARLDAPTGISASTDVDAVLADC-HAVAYMASGDIRPDEAVADIERCLRA
Mflv_0408|M.gilvum_PYR-GCK FGGLEAPTGIAATTDVDAALAAC-DAVAYMASGDIRPDDALADIERCLRA
MSMEG_0407|M.smegmatis_MC2_155 FAGLAEPTGVTATDDVDSALGAC-DAVAYMASGDIRPEEAIADIERCLRS
Mb0949c|M.bovis_AF2122/97 LAGLADSTGVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRRILAA
Rv0926c|M.tuberculosis_H37Rv LAGLADSTGVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRRILAA
MAV_1045|M.avium_104 LAGLAQPTGVLASTDLDAVLATGPRCAVYNALADNRLPEALDDYRRVLAA
TH_0599|M.thermoresistible__bu LAGLDVSTGIRATTDLDELLATGPECVVYTAMADNRLNEALDDYRRILAA
MAB_4633|M.abscessus_ATCC_1997 LAGLDILTGITATTDAAQILALRPDCVVYTAMTDNRLMEALKDLTDLLSA
MMAR_0386|M.marinum_M LAGVGIETGIAAINDLDAVLATAPECVVYCAMGDTRLPDAMADVMRILAA
MUL_3685|M.ulcerans_Agy99 LAGWPDPTGVRATSDIGALLALGADACCYNPLWPN-----IDELVGLLES
:. **: * * *. . * . : : * :
Mvan_0266|M.vanbaalenii_PYR-1 GVHVVTPSLYSLYDPR-SAPPEWVQRLTGAAEDGRAALLVSGVDPGWAND
Mflv_0408|M.gilvum_PYR-GCK GRHVVTPSLYSLYDPA-SAPAEWIERLTAAAEEGRATLLVSGVDPGWGND
MSMEG_0407|M.smegmatis_MC2_155 GKHVVTPALYSLYDPR-SAPEHWVERLTDAATAGNATLLVSGVDPGWAND
Mb0949c|M.bovis_AF2122/97 GINIVGSGPVFLQYPWQVIPDEIIKPLQDAARAGNSSLYVNGIDPGFAND
Rv0926c|M.tuberculosis_H37Rv GINIVGSGPVFLQYPWQVIPDEIIKPLQDAARAGNSSLYVNGIDPGFAND
MAV_1045|M.avium_104 GINIVGSGPVFLQYPWQVIPDELIKPLEEAAQQGNSSLYVNGIDPGFAND
TH_0599|M.thermoresistible__bu GSNVVGSSAVFLQHPWQVLPAELIAPIEEAATAGNASLYVNGIDPGFAND
MAB_4633|M.abscessus_ATCC_1997 GINVAASAPVFLQYPWGVLPENMLTPIENAAREGNSSIFAGGIDPGFAND
MMAR_0386|M.marinum_M GSNVVGSSPGLLQYPWGVIPDKYIARVQRAAEQGNSSIFITGVDPGFIND
MUL_3685|M.ulcerans_Agy99 GVNVCTSAAWITGGKQ---TPRDRERILAACERGGATIFGSDAHPGMTN-
* :: .. . . : *. * ::: . .** *
Mvan_0266|M.vanbaalenii_PYR-1 ALAVTAAGLCTRINTITCQEIFDYSTYDQPYAVRVSCGFG---GPMDETP
Mflv_0408|M.gilvum_PYR-GCK ALAVTAASLCTRINTITCQEIFDYSTYDQPFAVKVSCGFG---GSMDETP
MSMEG_0407|M.smegmatis_MC2_155 ALAVTAAGLCTRIRSIRCQEIFDYSTYDQPYAVRVLCGFGTPMGPDDPVP
Mb0949c|M.bovis_AF2122/97 LLPMALAGTCESIEQIRCMEIVDYATYDSAVVMFDVMGFG---KPMDQIP
Rv0926c|M.tuberculosis_H37Rv LLPMALAGTCESIEQIRCMEIVDYATYDSAVVMFDVMGFG---KPMDQIP
MAV_1045|M.avium_104 LLPLALAGTCQSIQQIRCMEIVDYATYDSAAVMFDVMGFG---KPLDDVP
TH_0599|M.thermoresistible__bu QLPLALAGACQHIEQIRCLEIVDYATYDSATVLFDVMGFG---KPLDEIP
MAB_4633|M.abscessus_ATCC_1997 LLPLALMGTCQRIDQVRCIEIVDYATYDSATVMFDVMGFG---KPMEETP
MMAR_0386|M.marinum_M LLPFALAGTCQRIEQVRCMEIHDYASYDGAEVMH-YMGFG---RSLDEVP
MUL_3685|M.ulcerans_Agy99 MVGMVLSGSCERVDEIRITESVDCSTYES-AATQTAMGFS---QHPDTPG
: .. . * : : * * ::*: . **. :
Mvan_0266|M.vanbaalenii_PYR-1 MMLLPTIPTMVWGGNIRLIGRGLGLEIDEITEEVERLPLADSVDTVMGRF
Mflv_0408|M.gilvum_PYR-GCK MMLLPSIPTMVWGGNVRLVGRGLGIEIDEITEEVERLPLEETVETVMGTF
MSMEG_0407|M.smegmatis_MC2_155 MMLLPTIPTMVWGGNVRMIGRGLGLQIDDITEKVERLPLAQACENVLGRF
Mb0949c|M.bovis_AF2122/97 MLLQPGVLSLAWGSVVRQLAAGLGISLDGVEEMYVREPAPEAFNIASGHI
Rv0926c|M.tuberculosis_H37Rv MLLQPGVLSLAWGSVVRQLAAGLGISLDGVEEMYVREPAPEAFNIASGHI
MAV_1045|M.avium_104 MLLQPGVLSLAWGSVVRQLAAGLGVSLDEVTQQHVRVPAPEDFDIASGHI
TH_0599|M.thermoresistible__bu LLLQPGVLTMAWGSVVRQLAAGLGIELDEVREQYVREPAPEDFDIAAGHI
MAB_4633|M.abscessus_ATCC_1997 MLLQPGVLSLAWGSVVRQLAAGLGVELDEVTEVYEKLSAPEDFDISSGHI
MMAR_0386|M.marinum_M MLLQPGVLGIAWGTAIRQLAAGLGIEVDEITESYQREPAPEDFEIAVGPV
MUL_3685|M.ulcerans_Agy99 LAESVRVESEVFAESAAMMADAIGATLDKMTFDVTFTAATADTDLGFMKI
: : .:. :. .:* :* : . : .
Mvan_0266|M.vanbaalenii_PYR-1 DEGTQGAFFLRVIGWSGGRQRVIVEHITRIDPSCAPHWPQPDQGVGDHRV
Mflv_0408|M.gilvum_PYR-GCK EKGTQGAFWLKVIGWSDGRQRIVIDHITRIHPSCAPHWPQPDQGDGEHRV
MSMEG_0407|M.smegmatis_MC2_155 ETGTQGAFRVQVIGWADGVERVVIDHITRIDPACAPDWPQPDQGAGDHRV
Mb0949c|M.bovis_AF2122/97 PKGSAAALRFEVLGLVDGVPAVVLEHVTRLRADLCPEWPQPAQPGGSYRI
Rv0926c|M.tuberculosis_H37Rv PKGSAAALRFEVLGLVDGVPAVVLEHVTRLRADLCPEWPQPAQPGGSYRI
MAV_1045|M.avium_104 AKGTAAALRFEVFGMVDGRPVVVLEHVTRLREDLCPDWPQPAQHGGSYRI
TH_0599|M.thermoresistible__bu PQGSAAALRFEVQGMVDGHPAVVLEHVTRLRDDLRPDWPQPAQPGGSYRV
MAB_4633|M.abscessus_ATCC_1997 PAGTMAALHFEVRGIKDGRAVTVLEHFTRLREDLAPNWPQPAHEGGTYRV
MMAR_0386|M.marinum_M AKGTQAVLQFEIRGMVDGQAAIVIEHITRLRPDLRPDWPQPASGGGSYRI
MUL_3685|M.ulcerans_Agy99 PAGTVGSVYGYHRGWVGDRNVVSVGFNWTMGNHVVP--PKPLKHG--HVI
*: . . * .. : . : * *:* : :
Mvan_0266|M.vanbaalenii_PYR-1 IVDGDPQLTIVTRADVPGGTRAD----GGNTTAANRLLGAISWLAAQKPG
Mflv_0408|M.gilvum_PYR-GCK VVDGDPQLTITSRADVPGGTRAD----GGNTTAANRLLGALNWLVEQKPG
MSMEG_0407|M.smegmatis_MC2_155 LIDGDPQLSIVVRADVPGGTRAD----GGNTTAANRLLGAIAWLAEQKPG
Mb0949c|M.bovis_AF2122/97 EISGEPCYAMDICLSSRHGDHNH----AGLVATAMRIVNAIPAVVAAEPG
Rv0926c|M.tuberculosis_H37Rv EISGEPCYAMDICLSSRHGDHNH----AGLVATAMRIVNAIPAVVAAEPG
MAV_1045|M.avium_104 EVTGEPSYAMDICLSSRKGDHNH----AGLVATAMRVVNAIPAVVAAPPG
TH_0599|M.thermoresistible__bu EVTGEPCYTLDLRLSSPHGDHNH----AGLVATAARVVNAIPPVVAAPAG
MAB_4633|M.abscessus_ATCC_1997 EITGEPSYLLDLGSFSARGDHNY----ANLIATAMRVVNAVPAVVAAEAG
MMAR_0386|M.marinum_M EITGEPSYAVDIVPSSRNGDHNH----AAIVGAAGRIVNAIPAVLTATPG
MUL_3685|M.ulcerans_Agy99 QVFGLPNMRTVLHCLPPKDWTESGFMGLGMIYTAMPVTNAVPAVVAAKPG
: * * . :* : .*: : .*
Mvan_0266|M.vanbaalenii_PYR-1 IYDGLDVPLHPPLAPELEATRWS----
Mflv_0408|M.gilvum_PYR-GCK IYDGLAVPLRSALPPEAEDARWA----
MSMEG_0407|M.smegmatis_MC2_155 IYDGLDVPLHPPLSAEAEATRWA----
Mb0949c|M.bovis_AF2122/97 IRTTLDLPLITGEGRYAAA--------
Rv0926c|M.tuberculosis_H37Rv IRTTLDLPLITGEGRYAAA--------
MAV_1045|M.avium_104 IVTTLDLPLITGRGLYRPE--------
TH_0599|M.thermoresistible__bu IRTTLDLPWVSGTGRYLPPDRPEGTIR
MAB_4633|M.abscessus_ATCC_1997 IRTTLDLPLITGKGRAV----------
MMAR_0386|M.marinum_M IRTTLDLPLITGKGLYTPMVSN-----
MUL_3685|M.ulcerans_Agy99 IVTLADLPPITGRAAL-----------
* :* .