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QRAIGVAVWGTGNMGSTAIRSTAAFPGLALAGVITSSADKAGRDAATFGGLEAPTGIAATTDVDAALAAC DAVAYMASGDIRPDDALADIERCLRAGRHVVTPSLYSLYDPASAPAEWIERLTAAAEEGRATLLVSGVDP GWGNDALAVTAASLCTRINTITCQEIFDYSTYDQPFAVKVSCGFGGSMDETPMMLLPSIPTMVWGGNVRL VGRGLGIEIDEITEEVERLPLEETVETVMGTFEKGTQGAFWLKVIGWSDGRQRIVIDHITRIHPSCAPHW PQPDQGDGEHRVVVDGDPQLTITSRADVPGGTRADGGNTTAANRLLGALNWLVEQKPGIYDGLAVPLRSA LPPEAEDARWA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0408 | - | - | 100% (362) | dihydrodipicolinate reductase |
| M. gilvum PYR-GCK | Mflv_1824 | - | 2e-67 | 40.75% (346) | dihydrodipicolinate reductase |
| M. gilvum PYR-GCK | Mflv_3282 | - | 1e-60 | 38.62% (347) | dihydrodipicolinate reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0949c | - | 1e-58 | 37.46% (347) | hypothetical protein Mb0949c |
| M. tuberculosis H37Rv | Rv0926c | - | 1e-58 | 37.46% (347) | hypothetical protein Rv0926c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4633 | - | 3e-59 | 36.92% (344) | hypothetical protein MAB_4633 |
| M. marinum M | MMAR_0386 | - | 9e-67 | 40.63% (347) | hypothetical protein MMAR_0386 |
| M. avium 104 | MAV_1045 | dapB | 8e-63 | 38.44% (346) | dihydrodipicolinate reductase N-terminus domain-containing |
| M. smegmatis MC2 155 | MSMEG_0407 | - | 1e-162 | 75.49% (359) | hypothetical protein MSMEG_0407 |
| M. thermoresistible (build 8) | TH_0599 | - | 5e-64 | 40.34% (357) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_4353 | - | 1e-20 | 26.47% (374) | hypothetical protein MUL_4353 |
| M. vanbaalenii PYR-1 | Mvan_0266 | - | 1e-176 | 80.11% (362) | dihydrodipicolinate reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0408|M.gilvum_PYR-GCK --MQRAIGVAVWGTGNMGSTAIRSTAAFPGLALAGVITSSADKAGRDAAT
Mvan_0266|M.vanbaalenii_PYR-1 --MGATTAVAVWGTGNMGATAIRSVTAFPGLHLAGLITSSEDKAGRDAAS
MSMEG_0407|M.smegmatis_MC2_155 --MRR---IAVWGTGNMGSTAIRSAVAFPGLELAAVITSSQDKVGRDAAM
Mb0949c|M.bovis_AF2122/97 ----MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDAAE
Rv0926c|M.tuberculosis_H37Rv ----MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDAAE
MAV_1045|M.avium_104 ----MPIPVVQLGTGNVGIHALRALITDPQFELTGVWVSSDAKAGKDAAE
TH_0599|M.thermoresistible__bu ----VTIRTAVVGTGNVGRHALAQVIADPRFDLTAVWVSSAAKAGLDAGE
MAB_4633|M.abscessus_ATCC_1997 ---MTKTRVAVWGTGNVGQHALAGVITDPSMELVGVWVSGSNKAGKDAGA
MMAR_0386|M.marinum_M ----MAIRVAHVGTGNVGRLALSELVTNPAFELTAVCVSTPEKVGRDAGD
MUL_4353|M.ulcerans_Agy99 MSGPAKLRVIQWATGGVGKAAIECILNHPQLELAGCWVHSAAKHGLDVGT
.**.:* :: * : *.. . * * *..
Mflv_0408|M.gilvum_PYR-GCK FGGLEAPTGIAATTDVDAALAAC-DAVAYMASGDIRPDDALADIERCLRA
Mvan_0266|M.vanbaalenii_PYR-1 FARLDAPTGISASTDVDAVLADC-HAVAYMASGDIRPDEAVADIERCLRA
MSMEG_0407|M.smegmatis_MC2_155 FAGLAEPTGVTATDDVDSALGAC-DAVAYMASGDIRPEEAIADIERCLRS
Mb0949c|M.bovis_AF2122/97 LAGLADSTGVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRRILAA
Rv0926c|M.tuberculosis_H37Rv LAGLADSTGVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRRILAA
MAV_1045|M.avium_104 LAGLAQPTGVLASTDLDAVLATGPRCAVYNALADNRLPEALDDYRRVLAA
TH_0599|M.thermoresistible__bu LAGLDVSTGIRATTDLDELLATGPECVVYTAMADNRLNEALDDYRRILAA
MAB_4633|M.abscessus_ATCC_1997 LAGLDILTGITATTDAAQILALRPDCVVYTAMTDNRLMEALKDLTDLLSA
MMAR_0386|M.marinum_M LAGVGIETGIAAINDLDAVLATAPECVVYCAMGDTRLPDAMADVMRILAA
MUL_4353|M.ulcerans_Agy99 IIGAAR-FGVTATNDVDELLALDADCVMYSPQVADE-----QDVKAILRS
: *: * * *. .. * . . * * :
Mflv_0408|M.gilvum_PYR-GCK GRHVVTPS-LYSLYDPASAPAEWIERLTAAAEEGRATLLVSGVDPGWGND
Mvan_0266|M.vanbaalenii_PYR-1 GVHVVTPS-LYSLYDPRSAPPEWVQRLTGAAEDGRAALLVSGVDPGWAND
MSMEG_0407|M.smegmatis_MC2_155 GKHVVTPA-LYSLYDPRSAPEHWVERLTDAATAGNATLLVSGVDPGWAND
Mb0949c|M.bovis_AF2122/97 GINIVGSGPVFLQYPWQVIPDEIIKPLQDAARAGNSSLYVNGIDPGFAND
Rv0926c|M.tuberculosis_H37Rv GINIVGSGPVFLQYPWQVIPDEIIKPLQDAARAGNSSLYVNGIDPGFAND
MAV_1045|M.avium_104 GINIVGSGPVFLQYPWQVIPDELIKPLEEAAQQGNSSLYVNGIDPGFAND
TH_0599|M.thermoresistible__bu GSNVVGSSAVFLQHPWQVLPAELIAPIEEAATAGNASLYVNGIDPGFAND
MAB_4633|M.abscessus_ATCC_1997 GINVAASAPVFLQYPWGVLPENMLTPIENAAREGNSSIFAGGIDPGFAND
MMAR_0386|M.marinum_M GSNVVGSSPGLLQYPWGVIPDKYIARVQRAAEQGNSSIFITGVDPGFIND
MUL_4353|M.ulcerans_Agy99 GKNVFTPVGWVYPD----LSKPRVKAVADAAVAGGVTLHGSGIHPGGITE
* :: . . : : ** * :: *:.** .:
Mflv_0408|M.gilvum_PYR-GCK ALAVTAASLCTRINTITCQEIFDYSTYDQPFAVKVSCGFG---GSMDETP
Mvan_0266|M.vanbaalenii_PYR-1 ALAVTAAGLCTRINTITCQEIFDYSTYDQPYAVRVSCGFG---GPMDETP
MSMEG_0407|M.smegmatis_MC2_155 ALAVTAAGLCTRIRSIRCQEIFDYSTYDQPYAVRVLCGFGTPMGPDDPVP
Mb0949c|M.bovis_AF2122/97 LLPMALAGTCESIEQIRCMEIVDYATYDSAVVMFDVMGFG---KPMDQIP
Rv0926c|M.tuberculosis_H37Rv LLPMALAGTCESIEQIRCMEIVDYATYDSAVVMFDVMGFG---KPMDQIP
MAV_1045|M.avium_104 LLPLALAGTCQSIQQIRCMEIVDYATYDSAAVMFDVMGFG---KPLDDVP
TH_0599|M.thermoresistible__bu QLPLALAGACQHIEQIRCLEIVDYATYDSATVLFDVMGFG---KPLDEIP
MAB_4633|M.abscessus_ATCC_1997 LLPLALMGTCQRIDQVRCIEIVDYATYDSATVMFDVMGFG---KPMEETP
MMAR_0386|M.marinum_M LLPFALAGTCQRIEQVRCMEIHDYASYDGAEVMH-YMGFG---RSLDEVP
MUL_4353|M.ulcerans_Agy99 RFPLMVSSLSSAITHVRAEEFSDIRTYNAPDVVRDIMGFG---VPHAQAM
:.. . . * : . *: * :*: . .: *** .
Mflv_0408|M.gilvum_PYR-GCK MMLLPSIPTMVWGGNVRLVGRGLGIEID-EITEEVERLPLEETVETVMGT
Mvan_0266|M.vanbaalenii_PYR-1 MMLLPTIPTMVWGGNIRLIGRGLGLEID-EITEEVERLPLADSVDTVMGR
MSMEG_0407|M.smegmatis_MC2_155 MMLLPTIPTMVWGGNVRMIGRGLGLQID-DITEKVERLPLAQACENVLGR
Mb0949c|M.bovis_AF2122/97 MLLQPGVLSLAWGSVVRQLAAGLGISLD-GVEEMYVREPAPEAFNIASGH
Rv0926c|M.tuberculosis_H37Rv MLLQPGVLSLAWGSVVRQLAAGLGISLD-GVEEMYVREPAPEAFNIASGH
MAV_1045|M.avium_104 MLLQPGVLSLAWGSVVRQLAAGLGVSLD-EVTQQHVRVPAPEDFDIASGH
TH_0599|M.thermoresistible__bu LLLQPGVLTMAWGSVVRQLAAGLGIELD-EVREQYVREPAPEDFDIAAGH
MAB_4633|M.abscessus_ATCC_1997 MLLQPGVLSLAWGSVVRQLAAGLGVELD-EVTEVYEKLSAPEDFDISSGH
MMAR_0386|M.marinum_M MLLQPGVLGIAWGTAIRQLAAGLGIEVD-EITESYQREPAPEDFEIAVGP
MUL_4353|M.ulcerans_Agy99 QGPMAALLESGFKMSVRMIANHMGFHIDPMIRATHEIAVATSDIASDVLP
. : : :* :. :*. :* : .
Mflv_0408|M.gilvum_PYR-GCK FEKGTQGAFWLKVIGWSDGRQRIVIDHITRI-HPSCAPHWPQPDQGDGEH
Mvan_0266|M.vanbaalenii_PYR-1 FDEGTQGAFFLRVIGWSGGRQRVIVEHITRI-DPSCAPHWPQPDQGVGDH
MSMEG_0407|M.smegmatis_MC2_155 FETGTQGAFRVQVIGWADGVERVVIDHITRI-DPACAPDWPQPDQGAGDH
Mb0949c|M.bovis_AF2122/97 IPKGSAAALRFEVLGLVDGVPAVVLEHVTRL-RADLCPEWPQPAQPGGSY
Rv0926c|M.tuberculosis_H37Rv IPKGSAAALRFEVLGLVDGVPAVVLEHVTRL-RADLCPEWPQPAQPGGSY
MAV_1045|M.avium_104 IAKGTAAALRFEVFGMVDGRPVVVLEHVTRL-REDLCPDWPQPAQHGGSY
TH_0599|M.thermoresistible__bu IPQGSAAALRFEVQGMVDGHPAVVLEHVTRL-RDDLRPDWPQPAQPGGSY
MAB_4633|M.abscessus_ATCC_1997 IPAGTMAALHFEVRGIKDGRAVTVLEHFTRL-REDLAPNWPQPAHEGGTY
MMAR_0386|M.marinum_M VAKGTQAVLQFEIRGMVDGQAAIVIEHITRL-RPDLRPDWPQPASGGGSY
MUL_4353|M.ulcerans_Agy99 IAADTVAGRKFRWQTLADGKPVITAAVNWLMGQADMHPDWSFGER-GERF
. .: . .. .* : *.*. .
Mflv_0408|M.gilvum_PYR-GCK RVVVDGDPQLTITSR----ADVPGGTRADGGNTTAANRLLGALNWLVEQK
Mvan_0266|M.vanbaalenii_PYR-1 RVIVDGDPQLTIVTR----ADVPGGTRADGGNTTAANRLLGAISWLAAQK
MSMEG_0407|M.smegmatis_MC2_155 RVLIDGDPQLSIVVR----ADVPGGTRADGGNTTAANRLLGAIAWLAEQK
Mb0949c|M.bovis_AF2122/97 RIEISGEPCYAMDIC----LSSRHGDHNHAGLVATAMRIVNAIPAVVAAE
Rv0926c|M.tuberculosis_H37Rv RIEISGEPCYAMDIC----LSSRHGDHNHAGLVATAMRIVNAIPAVVAAE
MAV_1045|M.avium_104 RIEVTGEPSYAMDIC----LSSRKGDHNHAGLVATAMRVVNAIPAVVAAP
TH_0599|M.thermoresistible__bu RVEVTGEPCYTLDLR----LSSPHGDHNHAGLVATAARVVNAIPPVVAAP
MAB_4633|M.abscessus_ATCC_1997 RVEITGEPSYLLDLG----SFSARGDHNYANLIATAMRVVNAVPAVVAAE
MMAR_0386|M.marinum_M RIEITGEPSYAVDIV----PSSRNGDHNHAAIVGAAGRIVNAIPAVLTAT
MUL_4353|M.ulcerans_Agy99 EIEITGNPSVSLVFKGLQPTSITEGLQRNPGVVATANHCANAIPVVCAAD
.: : *:* : * : :* : .*: :
Mflv_0408|M.gilvum_PYR-GCK PGIYDGLAVPLRSALPPEAEDARWA----
Mvan_0266|M.vanbaalenii_PYR-1 PGIYDGLDVPLHPPLAPELEATRWS----
MSMEG_0407|M.smegmatis_MC2_155 PGIYDGLDVPLHPPLSAEAEATRWA----
Mb0949c|M.bovis_AF2122/97 PGIRTTLDLPLITGEGRYAAA--------
Rv0926c|M.tuberculosis_H37Rv PGIRTTLDLPLITGEGRYAAA--------
MAV_1045|M.avium_104 PGIVTTLDLPLITGRGLYRPE--------
TH_0599|M.thermoresistible__bu AGIRTTLDLPWVSGTGRYLPPDRPEGTIR
MAB_4633|M.abscessus_ATCC_1997 AGIRTTLDLPLITGKGRAV----------
MMAR_0386|M.marinum_M PGIRTTLDLPLITGKGLYTPMVSN-----
MUL_4353|M.ulcerans_Agy99 PGIATYLDLPLFAGRPARASRGLER----
.** * :* .