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MAIRVALIGTGNCGSLALRQLIEDPRFALTGVWVSSQEKVGRDAGELARLDVTTGVAAVDDMAAIIDAKP DCAVYCAMGDVRPKEALADVRGLLEAGINVVGSSPGFLAYPWGVIPDRAIERVESAARQGNTSLFITGVD PGFVTDLLPLALASTCQSVSQVRTMEIADYATYDGATVMFDVMGFGNEIGDLPFLYQPGMLSAAWGVGVR QLAAGLGVEVDEIRDSVEQEPAPEDFDVAVGTIKKGTVAAVRFLIEGLVDGAPAIVVEHITRLRGDLRPD WAQPAQEGGSYRVEITGEPSYVMDICPTSNNGDHNYAAILAAAGRIVNAIPDVVAAEPGIRSTLDLPFGT GRGTYRAP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3001 | - | - | 100% (358) | dihydrodipicolinate reductase |
| M. vanbaalenii PYR-1 | Mvan_4922 | - | e-122 | 58.10% (358) | dihydrodipicolinate reductase |
| M. vanbaalenii PYR-1 | Mvan_4970 | - | 6e-59 | 40.00% (350) | dihydrodipicolinate reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0949c | - | 1e-126 | 61.62% (357) | hypothetical protein Mb0949c |
| M. gilvum PYR-GCK | Mflv_3282 | - | 0.0 | 87.64% (356) | dihydrodipicolinate reductase |
| M. tuberculosis H37Rv | Rv0926c | - | 1e-126 | 61.62% (357) | hypothetical protein Rv0926c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4633 | - | 1e-119 | 59.43% (350) | hypothetical protein MAB_4633 |
| M. marinum M | MMAR_0386 | - | 1e-135 | 65.07% (355) | hypothetical protein MMAR_0386 |
| M. avium 104 | MAV_5137 | - | 1e-134 | 66.02% (359) | homoserine dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5586 | - | 1e-129 | 61.06% (357) | hypothetical protein MSMEG_5586 |
| M. thermoresistible (build 8) | TH_0599 | - | 1e-124 | 59.22% (358) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_4353 | - | 2e-37 | 32.22% (360) | hypothetical protein MUL_4353 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3001|M.vanbaalenii_PYR-1 ----MAIRVALIGTGNCGSLALRQLIEDPRFALTGVWVSSQEKVGRDAGE
Mflv_3282|M.gilvum_PYR-GCK ----MAIRVALIGTGNCGSLALRQLIEDARFDLVGVWVSTPAKVGKDAGE
MMAR_0386|M.marinum_M ----MAIRVAHVGTGNVGRLALSELVTNPAFELTAVCVSTPEKVGRDAGD
MAV_5137|M.avium_104 ----MAIRVAHVGTGNVGGLALAELITNPRYELTGVCVSTPEKVGKDAGE
MSMEG_5586|M.smegmatis_MC2_155 ----MAIRVAAIGTGNVGRHALRQLITNPAYELTAVWVSSPEKAGKDAGD
TH_0599|M.thermoresistible__bu ----VTIRTAVVGTGNVGRHALAQVIADPRFDLTAVWVSSAAKAGLDAGE
Mb0949c|M.bovis_AF2122/97 ----MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDAAE
Rv0926c|M.tuberculosis_H37Rv ----MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDAAE
MAB_4633|M.abscessus_ATCC_1997 ---MTKTRVAVWGTGNVGQHALAGVITDPSMELVGVWVSGSNKAGKDAGA
MUL_4353|M.ulcerans_Agy99 MSGPAKLRVIQWATGGVGKAAIECILNHPQLELAGCWVHSAAKHGLDVGT
. .**. * :: :: .. *.. * * * *..
Mvan_3001|M.vanbaalenii_PYR-1 LARLDVTT----GVAAVDDMAAIIDAKPDCAVYCAMGDVRPKEALADVRG
Mflv_3282|M.gilvum_PYR-GCK LARLDVTT----GIAATDDLDALVATRPDCVVYCAMGDVRPREALADVRK
MMAR_0386|M.marinum_M LAGVGIET----GIAAINDLDAVLATAPECVVYCAMGDTRLPDAMADVMR
MAV_5137|M.avium_104 LCGVGLDAGVVTGVAAVGDLDAVIAAKPECVVYCAMADTRLPEAMADVMR
MSMEG_5586|M.smegmatis_MC2_155 LAGLEVTT----GIKATDSLDEVLATEPECAVYTAMADNRLPDALEDYRR
TH_0599|M.thermoresistible__bu LAGLDVST----GIRATTDLDELLATGPECVVYTAMADNRLNEALDDYRR
Mb0949c|M.bovis_AF2122/97 LAGLADST----GVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRR
Rv0926c|M.tuberculosis_H37Rv LAGLADST----GVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRR
MAB_4633|M.abscessus_ATCC_1997 LAGLDILT----GITATTDAAQILALRPDCVVYTAMTDNRLMEALKDLTD
MUL_4353|M.ulcerans_Agy99 IIGAARFG-----VTATNDVDELLALDADCVMYSPQVADE-----QDVKA
: : * . :: . *.:* . . *
Mvan_3001|M.vanbaalenii_PYR-1 LLEAGINVVGSSPGFLAYPWGVIPDRAIERVESAARQGNTSLFITGVDPG
Mflv_3282|M.gilvum_PYR-GCK LLEAGINVVGSSPGFLSYPWGVIGDHTIEKVQAAARQGNSSLFITGVDPG
MMAR_0386|M.marinum_M ILAAGSNVVGSSPGLLQYPWGVIPDKYIARVQRAAEQGNSSIFITGVDPG
MAV_5137|M.avium_104 ILAAGINVVGSSPGLLQYPWGVMPEKYIARVEDAARQGNSSIFISGVDPG
MSMEG_5586|M.smegmatis_MC2_155 ILAAGVNVVGSSAVFLQYPWQVLPEELVKPIEDAAHAGGASLFVNGIDPG
TH_0599|M.thermoresistible__bu ILAAGSNVVGSSAVFLQHPWQVLPAELIAPIEEAATAGNASLYVNGIDPG
Mb0949c|M.bovis_AF2122/97 ILAAGINIVGSGPVFLQYPWQVIPDEIIKPLQDAARAGNSSLYVNGIDPG
Rv0926c|M.tuberculosis_H37Rv ILAAGINIVGSGPVFLQYPWQVIPDEIIKPLQDAARAGNSSLYVNGIDPG
MAB_4633|M.abscessus_ATCC_1997 LLSAGINVAASAPVFLQYPWGVLPENMLTPIENAAREGNSSIFAGGIDPG
MUL_4353|M.ulcerans_Agy99 ILRSGKNVFTP----VGWVYPDLSKPRVKAVADAAVAGGVTLHGSGIHPG
:* :* *: . : : : : : ** *. ::. *:.**
Mvan_3001|M.vanbaalenii_PYR-1 FVTDLLPLALASTCQSVSQVRTMEIADYATYDGATVMFDVMGFGNEIGDL
Mflv_3282|M.gilvum_PYR-GCK FVTDLLPLALASTCQHIEQIRTMEIADYATYDGATVMFDVMGFGNEIGDL
MMAR_0386|M.marinum_M FINDLLPFALAGTCQRIEQVRCMEIHDYASYDGAEVMH-YMGFGRSLDEV
MAV_5137|M.avium_104 FANDLIPLALAGTCQRVEQVRCMEIHDYASYNGAEVMG-YMGFGRPLDEI
MSMEG_5586|M.smegmatis_MC2_155 FANDLLPLALAGTCQQIEQIRCMEIVDYATYDSATVMLDVMGFGKSLDET
TH_0599|M.thermoresistible__bu FANDQLPLALAGACQHIEQIRCLEIVDYATYDSATVLFDVMGFGKPLDEI
Mb0949c|M.bovis_AF2122/97 FANDLLPMALAGTCESIEQIRCMEIVDYATYDSAVVMFDVMGFGKPMDQI
Rv0926c|M.tuberculosis_H37Rv FANDLLPMALAGTCESIEQIRCMEIVDYATYDSAVVMFDVMGFGKPMDQI
MAB_4633|M.abscessus_ATCC_1997 FANDLLPLALMGTCQRIDQVRCIEIVDYATYDSATVMFDVMGFGKPMEET
MUL_4353|M.ulcerans_Agy99 GITERFPLMVSSLSSAITHVRAEEFSDIRTYNAPDVVRDIMGFGVPHAQA
.: :*: : . .. : ::* *: * :*:.. *: **** :
Mvan_3001|M.vanbaalenii_PYR-1 PFLYQPGMLSAAWGVGVRQLAAGLGVEVD-EIRDSVEQEPAPEDFDVAVG
Mflv_3282|M.gilvum_PYR-GCK PFLYQPGMLSAAWGVGIRQLAAGLGVEVE-EIRDSVEQEPAPEDFEVAVG
MMAR_0386|M.marinum_M PMLLQPGVLGIAWGTAIRQLAAGLGIEVD-EITESYQREPAPEDFEIAVG
MAV_5137|M.avium_104 PMLLQPGVLSIAWGTAIRQLAAGLGIQVD-EITESYQREPAPEDFDIAVG
MSMEG_5586|M.smegmatis_MC2_155 PMLLQPGVLSLAWGSVVRQLAAGLGIELD-AVTEEHTRVPAPEDFDIAAG
TH_0599|M.thermoresistible__bu PLLLQPGVLTMAWGSVVRQLAAGLGIELD-EVREQYVREPAPEDFDIAAG
Mb0949c|M.bovis_AF2122/97 PMLLQPGVLSLAWGSVVRQLAAGLGISLD-GVEEMYVREPAPEAFNIASG
Rv0926c|M.tuberculosis_H37Rv PMLLQPGVLSLAWGSVVRQLAAGLGISLD-GVEEMYVREPAPEAFNIASG
MAB_4633|M.abscessus_ATCC_1997 PMLLQPGVLSLAWGSVVRQLAAGLGVELD-EVTEVYEKLSAPEDFDISSG
MUL_4353|M.ulcerans_Agy99 MQGPMAALLESGFKMSVRMIANHMGFHIDPMIRATHEIAVATSDIASDVL
..:* .: :* :* :*. :: : *.. :
Mvan_3001|M.vanbaalenii_PYR-1 TIKKGTVAAVRFLIEGLVDGAPAIVVEHITRL-RGDLRPDWAQPAQEGGS
Mflv_3282|M.gilvum_PYR-GCK TIRKGTVAAVRFLIEGLVDGRPAIVVEHITRL-RGDLRPDWAQPAQEGGS
MMAR_0386|M.marinum_M PVAKGTQAVLQFEIRGMVDGQAAIVIEHITRL-RPDLRPDWPQPASGGGS
MAV_5137|M.avium_104 RVAKGTLAVLQFEIRGMVNGHPAIVIEHVTRL-RPDLRPDLPQPAAGDGS
MSMEG_5586|M.smegmatis_MC2_155 HISEGTTAAMRFEVRGMVDGKPAVVLEHVTRL-RDDLCPEWPQPAQEGGS
TH_0599|M.thermoresistible__bu HIPQGSAAALRFEVQGMVDGHPAVVLEHVTRL-RDDLRPDWPQPAQPGGS
Mb0949c|M.bovis_AF2122/97 HIPKGSAAALRFEVLGLVDGVPAVVLEHVTRL-RADLCPEWPQPAQPGGS
Rv0926c|M.tuberculosis_H37Rv HIPKGSAAALRFEVLGLVDGVPAVVLEHVTRL-RADLCPEWPQPAQPGGS
MAB_4633|M.abscessus_ATCC_1997 HIPAGTMAALHFEVRGIKDGRAVTVLEHFTRL-REDLAPNWPQPAHEGGT
MUL_4353|M.ulcerans_Agy99 PIAADTVAGRKFRWQTLADGKPVITAAVNWLMGQADMHPDWSFGER-GER
: .: * :* : :* .. . : : *: *: . .
Mvan_3001|M.vanbaalenii_PYR-1 YRVEITGEPSYVMDIC----PTSNNGDHNYAAILAAAGRIVNAIPDVVAA
Mflv_3282|M.gilvum_PYR-GCK YRVEITGEPSYVMDIR----PTSRNGDHNYAAILAAAGRIVNAIPEVVAA
MMAR_0386|M.marinum_M YRIEITGEPSYAVDIV----PSSRNGDHNHAAIVGAAGRIVNAIPAVLTA
MAV_5137|M.avium_104 YRVEITGEPSYAVDIV----PSSRKGDHNHAAIAGAAGRIVNAIPAVIAA
MSMEG_5586|M.smegmatis_MC2_155 YRVEVTGEPSYALDLC----LSSPYGDHNHAGLVATAARVVNAIPAVFAA
TH_0599|M.thermoresistible__bu YRVEVTGEPCYTLDLR----LSSPHGDHNHAGLVATAARVVNAIPPVVAA
Mb0949c|M.bovis_AF2122/97 YRIEISGEPCYAMDIC----LSSRHGDHNHAGLVATAMRIVNAIPAVVAA
Rv0926c|M.tuberculosis_H37Rv YRIEISGEPCYAMDIC----LSSRHGDHNHAGLVATAMRIVNAIPAVVAA
MAB_4633|M.abscessus_ATCC_1997 YRVEITGEPSYLLDLG----SFSARGDHNYANLIATAMRVVNAVPAVVAA
MUL_4353|M.ulcerans_Agy99 FEIEITGNPSVSLVFKGLQPTSITEGLQRNPGVVATANHCANAIPVVCAA
:.:*::*:*. : : * :. . : .:* : .**:* * :*
Mvan_3001|M.vanbaalenii_PYR-1 EPGIRSTLDLPFGTGRGTYRAP--------
Mflv_3282|M.gilvum_PYR-GCK EAGIRTTLDLPLVTGNGTYRPA--------
MMAR_0386|M.marinum_M TPGIRTTLDLPLITGKGLYTP--MVSN---
MAV_5137|M.avium_104 PPGIRTTLDLPLVTGKGLYAPSTLVTT---
MSMEG_5586|M.smegmatis_MC2_155 PPGIRTTLDMPLITGKGLYAAR--------
TH_0599|M.thermoresistible__bu PAGIRTTLDLPWVSGTGRYLPPDRPEGTIR
Mb0949c|M.bovis_AF2122/97 EPGIRTTLDLPLITGEGRYAAA--------
Rv0926c|M.tuberculosis_H37Rv EPGIRTTLDLPLITGEGRYAAA--------
MAB_4633|M.abscessus_ATCC_1997 EAGIRTTLDLPLITGKGRAV----------
MUL_4353|M.ulcerans_Agy99 DPGIATYLDLPLFAGRPARASRGLER----
.** : **:* :*