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TLDATPKPLTIVRGACPHDCPDTCAMLYHVEDGKLVDVQGDPNHPMTRGGLCVKVKNFHEHHYQPDRLLY PMRRVGAKGSGEFERITWDEALAEIKSRWTEIIDTYGSQAIMPHAYLGHQGVLNGLTSGDAFFNRLGSTV AEKTYCESGSSTAWHMTVGGSGGLDVESMAHSKYIIVWGMNMTSTNLHGWPFLLEARKNNGAKIVVIDPV KNRTARQADWHIPIRPGTDGALAMGMIQQIIAQGLVDTDYVERYTVGYDELAERAAQYPPERVEEITGIP ADDIRKLAYEYATSQPAAIRQGVALERSRGGGQAIRAITCLPALVGAWRHVGGGTMEMPIWEFPTKFDAI CKPEWIPEGTRVVNELDLGMALTGEMELDPPIKSLFVYNSNPVSQGPAQEKTMRGLMRDDLFTVVSEHFV TDTAKFADLLLPATMQAEQLDIMVTWGHLYISLNQPAIAPPGECVPNVELFRRLAHVMEFDDESMAYWNR TDREMLIDFHDWDAPALAGITYEKLEEVGWMRLAVGTPDVRAPHAEGNFPTPSGKCEFKSSLAEGGNFVV PVWRSMYEGMQPGGYVDPVPDYVPPFESPQSNPELAQRYPLSIISPKPHAFLNSQYGNAADKQKVQGGQR VFIHPADAAERGIAEGDVVRVFNDRGSFQGPAAYDDGLMAGLVMANVGHWQGKTSGTTVNAITADRHCGL GNAGVYGDNLVEVEKVAEEAFEDREAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5161 | - | - | 100% (728) | molybdopterin oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3016 | - | 3e-37 | 25.32% (695) | molybdopterin oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4342 | - | 2e-36 | 24.47% (711) | molydopterin dinucleotide-binding region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1477 | bisC | 5e-39 | 25.08% (658) | biotin sulfoxide reductase |
| M. tuberculosis H37Rv | Rv1442 | bisC | 5e-39 | 25.08% (658) | biotin sulfoxide reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3041 | - | 3e-40 | 25.77% (683) | putative biotin sulfoxide reductase BisC |
| M. marinum M | MMAR_3639 | fdhF | 1e-43 | 25.75% (730) | formate dehydrogenase H FdhF |
| M. avium 104 | MAV_2075 | - | 3e-45 | 26.40% (731) | FdhF protein |
| M. smegmatis MC2 155 | MSMEG_6816 | - | 0.0 | 94.38% (712) | molybdopterin oxidoreductase |
| M. thermoresistible (build 8) | TH_4041 | - | 2e-50 | 28.57% (714) | PUTATIVE Formate dehydrogenase |
| M. ulcerans Agy99 | MUL_1474 | fdhF | 5e-43 | 25.62% (730) | formate dehydrogenase H FdhF |
| M. vanbaalenii PYR-1 | Mvan_2438 | - | 1e-38 | 25.91% (656) | molybdopterin guanine dinucleotide-containing S/N-oxide |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5161|M.gilvum_PYR-GCK ----MTLDATPKPLTIVRGACPHDCPDTCAMLYHVEDGK--LVDVQGDPN
MSMEG_6816|M.smegmatis_MC2_155 ----------MQTLKIVRGACPHDCPDTCAMLYHVEDGK--LVDVQGDPN
MMAR_3639|M.marinum_M ------MAPNKDAVKTVCAYCGVGCGIVLQTTTDPQTGKRRVAKSTGDKS
MUL_1474|M.ulcerans_Agy99 ------MAPNKDAVKTVCAYCGVGCGIVLQTTTDPQTGKRRVAKSTGDKS
MAV_2075|M.avium_104 -------------MNTMCAYCGVGCGMVLQITTDPQTGRRHVAKSVGNKE
Mb1477|M.bovis_AF2122/97 --------------MQVYTSATHWGVFTARVHGGDIAAVAALASDTNPAP
Rv1442|M.tuberculosis_H37Rv --------------MQVYTSATHWGVFTARVHGGDIAAVAALASDTNPAP
MAB_3041|M.abscessus_ATCC_1997 MIRPAFSAVQVS--GSARLSHTHWGAFTPEVRDGEVIGVTPIETDLDPSP
Mvan_2438|M.vanbaalenii_PYR-1 MVGRGGRAVRLSSVSATQTSLTHWGAFSATVEAGEITAVAPVAGDDDPSV
TH_4041|M.thermoresistible__bu --------MATEQRVTYCRICEPLCGLIATVEDGR------LQSLRPDPD
:
Mflv_5161|M.gilvum_PYR-GCK HPMTRGGLCVKVKNFHEHHYQPDRLLYPMRRVGAKGSGEFERITWDEALA
MSMEG_6816|M.smegmatis_MC2_155 HPMTRGGLCVKVKNFHEHHYQPDRLLYPMRRVGAKGSGEFERITWDEALA
MMAR_3639|M.marinum_M HPANLGRLCTKGTTTADLLAAPGRMESAHLRAHR--AGHLESIPIDDAIT
MUL_1474|M.ulcerans_Agy99 HPANLGRLCTKGTTTADLLAAPGRMESAHLRAHR--AGHLESIPIDDAIT
MAV_2075|M.avium_104 HPANFGRLCTKGATTADLLAAPGRMDSAHARAGR--GEPLEPIGTDQAIT
Mb1477|M.bovis_AF2122/97 QLQNLPGAVRHRSRIANPAVRRGWLQHGPGPSSARGAEEFVEVSWDELIE
Rv1442|M.tuberculosis_H37Rv QLQNLPGAVRHRSRIANPAVRRGWLQHGPGPSSARGAEEFVEVSWDELIE
MAB_3041|M.abscessus_ATCC_1997 LLQNIPGSIRHQARVTAPAVRSGWLREGPGPSDKRGADEYVEVSWDELTE
Mvan_2438|M.vanbaalenii_PYR-1 ALGNLPGSVRHISRVTTPAVRRGWLDHGPGPDDSRGADDFVAVTWDELTE
TH_4041|M.thermoresistible__bu HPLSRGRACPKGIAFTEVQNDPDRVLYPLR---RRADGEFERVGWDEALD
. : . : : *:
Mflv_5161|M.gilvum_PYR-GCK EIKSRWTEIIDTYGSQAIMPHAY----LGHQGVLNGLTSGDAFFNRLGST
MSMEG_6816|M.smegmatis_MC2_155 EIKTRWTEIIDTHGAQAIMPHAY----LGHQGVLNGLTSGDAFFNRLGAT
MMAR_3639|M.marinum_M QCAMRLRAIIDEHGPDAVGVYVSGQMSIEAQYLANKLTKG---FIGTNQI
MUL_1474|M.ulcerans_Agy99 QCAMRLRAIIDEHGPDAVGVYVSGQMSIEAQYLANKLTKG---FIGTKQI
MAV_2075|M.avium_104 RCAKQLRAIIDEHGPDAFAMYVSGQMSLEAQYLANKLTKG---FIGTNQI
Mb1477|M.bovis_AF2122/97 LLASELRRTVDRYGNEAIYGSSYGWASAGRFHHAQSQVHR--FLNMLGGY
Rv1442|M.tuberculosis_H37Rv LLASELRRTVDRYGNEAIYGSSYGWASAGRFHHAQSQVHR--FLNMLGGY
MAB_3041|M.abscessus_ATCC_1997 LLADELRRVVDTHGNEAIYGGSYGWASAGRFHHAQSQVHR--FLKLLGGY
Mvan_2438|M.vanbaalenii_PYR-1 LLGDELRRVIDTHGNGAIYGGSYGWSSAGRFHHAQSQVHR--FLNCLGGY
TH_4041|M.thermoresistible__bu DIAARLTAIRDRHGGGAIGQYFG---NPVAFGYATALWSGMFVARLGSRH
. * :* *.
Mflv_5161|M.gilvum_PYR-GCK VAEKTYCESGSSTAWHMTVGGSGG-LDVES-------MAHSKYIIVWG--
MSMEG_6816|M.smegmatis_MC2_155 VAEKTYCESGSSTAWHMTVGGTGG-LDVES-------MAYSKYIIVWG--
MMAR_3639|M.marinum_M ESNSRLCMAGASSGYKLSLGADGPPGSYQD-------FDHADVFLVIG--
MUL_1474|M.ulcerans_Agy99 ESNSRLCMAGASSGYKLSLGADGPPGSYQD-------FDHADVFLVIG--
MAV_2075|M.avium_104 ESNSRLCMASAGSGYKLSLGADGPPGSYQD-------FEHADVFFVIG--
Mb1477|M.bovis_AF2122/97 TASRHSYSAGASEVIFPHIVGAALFEALAETTTWDVIVDHTALLVAFGGL
Rv1442|M.tuberculosis_H37Rv TASRHSYSAGASEVIFPHIVGAALFEALAETTTWDVIVDHTALLVAFGGL
MAB_3041|M.abscessus_ATCC_1997 TFSRHSYSLGATGVIMPHVIG-THDGLFKRSTSWDVIVENTDLLIAFGGI
Mvan_2438|M.vanbaalenii_PYR-1 TFSRHSYSLGATGVIMPRVVG-THDDLFKRSTQWDVIVEHTDLMVCFGGV
TH_4041|M.thermoresistible__bu QYSSGSQDINSRFVASKLLYGAASQIPFPD-------LPRTDFLFMLG--
. .: : . . : :. *
Mflv_5161|M.gilvum_PYR-GCK ------MNMTSTNLHGWPFLLEARKNNGAKIVVIDPVKNRT------ARQ
MSMEG_6816|M.smegmatis_MC2_155 ------MNMTSTNLHGWPFLLEARKNNGAKIVVIDPVRNRT------ARQ
MMAR_3639|M.marinum_M ------ANMADCHPILFLRMMERVKS-GAKLIVVDPRRTAT------ADK
MUL_1474|M.ulcerans_Agy99 ------ANMADCHPILFLRMMERVKS-GAKLIVVDPRRTAT------ADK
MAV_2075|M.avium_104 ------ANMADCHPILFLRMMDRVKA-GAKLIVVDPRRTAT------AEK
Mb1477|M.bovis_AF2122/97 PVKNTAVMPGGTTAHPDRDYVGRYRARGGRLVSVSPLRDDIAAIAGPLDD
Rv1442|M.tuberculosis_H37Rv PVKNTAVMPGGTTAHPDRDYVGRYRARGGRLVSVSPLRDDIAAIAGPLDD
MAB_3041|M.abscessus_ATCC_1997 ALKNTGVNHGGTTAHPARDALNRFRDRGGRIVSFSPLHDDI-------DG
Mvan_2438|M.vanbaalenii_PYR-1 ALKNTGVNHGGTTAHPARGALDRFRARGGHLVSFSPLRDDV-------DG
TH_4041|M.thermoresistible__bu -ANPFVSHGSALRAPRIKDDLTDITRRGGRVVVVDPRRTET-------AR
: *.::: ..* :
Mflv_5161|M.gilvum_PYR-GCK ADWHIPIRPGTDGALAMGMIQQIIAQGLVDTDYVERYTVGYDELAERAAQ
MSMEG_6816|M.smegmatis_MC2_155 ADWHIPIRPGTDGALALGMIHEIIAQGLVDTDYVERYTVGYDELAARAAN
MMAR_3639|M.marinum_M ADLFLQIAPGTDLALLNGLLHLIVENEQTDPQFISEFTEGWEVMPSFLEQ
MUL_1474|M.ulcerans_Agy99 ADLFLQIAPGTDLALLNGLLHLIVENEQTDPQFISEFTEGWEVMPSFLEQ
MAV_2075|M.avium_104 ADLFLQIAPGTDLALLNGLLHLIVENGHTDGEFIAEFTEGWEVMPSFLEQ
Mb1477|M.bovis_AF2122/97 RCRWLAPVPGTDVAIMLGLAYVLATESLADRAFLGRYCTGYERFERYLLG
Rv1442|M.tuberculosis_H37Rv RCRWLAPVPGTDVAIMLGLAYVLATESLADRAFLGRYCTGYERFERYLLG
MAB_3041|M.abscessus_ATCC_1997 ECEWHAPIPGTDVAVMLALAHVLAVEKLADLTFLSSYCTGYERFERYLLG
Mvan_2438|M.vanbaalenii_PYR-1 PCDWFAPVPGTDVAIMLALAHVLAAESLADRDFLATYCTGYDRFERYLLG
TH_4041|M.thermoresistible__bu AFEHIAVRPDSDAWLLLSMLQVIFAEGLEDTAAIARQTTGCSTLRGLVAG
*.:* : .: : : * : * . :
Mflv_5161|M.gilvum_PYR-GCK YP------PERVEEITGIPADDIRKLAYEYATSQPAAIRQGVALERSRGG
MSMEG_6816|M.smegmatis_MC2_155 YP------PERVEEITGIPADDVRKLAYEYATTQPAAIRQGVALERNRGG
MMAR_3639|M.marinum_M FT------PDRVSEITGIPSEDIRTAARWIGTAANWMSCWTMGLNQSTHG
MUL_1474|M.ulcerans_Agy99 FT------PDRVSEITGIPSEDIRTAARWIGTAANWMSCWTMGLNQSTHG
MAV_2075|M.avium_104 YT------PDRVSEITGIPEQDIRAAAQLIGEADNFMSCWTMGLNQSTHG
Mb1477|M.bovis_AF2122/97 LDDGIPKTPEWAAALSGLAAGDLRDLARRMAEHR-TLITTSLSLQRIEHG
Rv1442|M.tuberculosis_H37Rv LDDGIPKTPEWAAALSGLAAGDLRDLARRMAEHR-TLITTSLSLQRIEHG
MAB_3041|M.abscessus_ATCC_1997 VDDGVPKSPEWAAPISGLDAAELRTLARRMAAGR-TLVTVSWSLQRVRHG
Mvan_2438|M.vanbaalenii_PYR-1 VDDGTPKSPQWAAQICGLDADDLTALARRMAACR-TIVTVSWSLQRTRHG
TH_4041|M.thermoresistible__bu FP------PEATAARTGVPADVVRSLARDFAAAPTAAAYGRTGACLGRHG
*: . *: : * . . *
Mflv_5161|M.gilvum_PYR-GCK GQAIRAITCLPALVGAWRHVGGGTMEMP---------------------I
MSMEG_6816|M.smegmatis_MC2_155 GQAIRAITCLPALVGAWRHVGGGTMEMP---------------------I
MMAR_3639|M.marinum_M TWNTNALCNLHLATGAICRPGSGPFSLTGQPNAMGGREMGYMGPGLPGQR
MUL_1474|M.ulcerans_Agy99 TWNTNALCNLHLATGAICRPGSGPFSLTGQPNAMGGREMGYMGPGLPGQR
MAV_2075|M.avium_104 TWNTNAICNLHLATGAICKPGSGPFSLTGQPNAMGGREMGYMGPGLPGQR
Mb1477|M.bovis_AF2122/97 EQTVWMAATLAAMLGQIGLPGGGFGHGY-SSNGVGN-------PPLACGL
Rv1442|M.tuberculosis_H37Rv EQTVWMAATLAAMLGQIGLPGGGFGHGY-SSNGVGN-------PPLACGL
MAB_3041|M.abscessus_ATCC_1997 EQAPWMGLTLAAMLGQIGLPGGGFGHGYGSMNEPGL-------APVSCPL
Mvan_2438|M.vanbaalenii_PYR-1 EQAPWMGLTLAAMLGQIGLPGGGFGHGYGSMNEPGL-------APVRCGL
TH_4041|M.thermoresistible__bu TLVSFLLDALSIVTGNLDREGGLLMAHAVIPFEELG--------------
* * *.
Mflv_5161|M.gilvum_PYR-GCK WEFPTKFDAICKPEWIPEGTRVVNELDLGMALTGEMELDPPIKSLFVYNS
MSMEG_6816|M.smegmatis_MC2_155 WEFPTKFGEICRPDWIPEGTRVVNELDLGMALTGELDLDPPIKSLFVYNS
MMAR_3639|M.marinum_M SVLSAPDREFVEEQWGLPGGALRTDVSGGVIDMFSRMADGEIKACWIICS
MUL_1474|M.ulcerans_Agy99 SVLSAPDREFVEEQWGLPGGALRTDVSGGVIDMFSRMADGEIKACWIICS
MAV_2075|M.avium_104 SVASAADREFVEDVWGVPRGRLRTEVGTGTIDMFSRMADGQIKACWIICT
Mb1477|M.bovis_AF2122/97 PALPQGNNPVSTFIPVAAISELLQRPGQRLAYNGRLLELPDIKCVYWAGG
Rv1442|M.tuberculosis_H37Rv PALPQGNNPVSTFIPVAAISELLQRPGQRLAYNGRLLELPDIKCVYWAGG
MAB_3041|M.abscessus_ATCC_1997 PTFPQGPNPVETFIPVAAISELLLRPGQTLAYNGQTLTLPDIRCVYWAGG
Mvan_2438|M.vanbaalenii_PYR-1 PRLPQGINPVTTFIPVAAVSDMLLSPGEPFDYNGLRLHYPDIRLVYWAGG
TH_4041|M.thermoresistible__bu ERTGRLTYGTERSRIGGLPEVISTFPAALMADEINTPGDGQLRALFVTAG
: :: :
Mflv_5161|M.gilvum_PYR-GCK NPVSQGPAQEKTMRGLMRDDLFTVVSEHFVTDTAKFADLLLPATMQAEQL
MSMEG_6816|M.smegmatis_MC2_155 NPVSQGPAQEKTMRGLMRDDLFTVVSEHFITDTAKFADLLLPATMQAEQL
MMAR_3639|M.marinum_M NPVATVANRKTVLAGLEKAELVISQDAFFETETNEYANVLLPAALWTESD
MUL_1474|M.ulcerans_Agy99 NPVATVANRKTVLAGLEKAELVISQDAFFETETNEYANVLLPAALWTESD
MAV_2075|M.avium_104 NPVASVANRKTVLAGLERAELVIAQDAYLGTETSEYADVLLPAALWAETE
Mb1477|M.bovis_AF2122/97 NPFHHHQNLPRLRRALSRVDTIVVHEQYWT-AMAKHADIVVPTTTSFERD
Rv1442|M.tuberculosis_H37Rv NPFHHHQNLPRLRRALSRVDTIVVHEQYWT-AMAKHADIVVPTTTSFERD
MAB_3041|M.abscessus_ATCC_1997 NPFHHHQNLPRLRRALSRVDTVVVHDPVWT-AMAKHADIVVPSTTSLERD
Mvan_2438|M.vanbaalenii_PYR-1 NPFHHHQNIPRLRRALRRPDTVVVHDPYWT-PMAKHADIVVPSTTFAERH
TH_4041|M.thermoresistible__bu NPVLTVPNGPALEKVLGKLDLIVSLDFYVT-ETNRHAHYVLPATTFLERD
**. * : : . . ..*. ::*:: *
Mflv_5161|M.gilvum_PYR-GCK ----DIMVTWGHLYISLNQPAIAPPGECVPNVELFRRLAHVMEFDDESMA
MSMEG_6816|M.smegmatis_MC2_155 ----DIMVTWGHLYISLNQPAIEPPGECVPNVELFRRLARTMEFDEESMA
MMAR_3639|M.marinum_M ----GVMVNC-ERNMSLFPKAVDPVGDALPDWQIIARIACEMGFSESFSY
MUL_1474|M.ulcerans_Agy99 ----GVMVNC-ERNMSLFPKAVDPVGDALPDWQIIARIACEMGFSESFSY
MAV_2075|M.avium_104 ----GVMVNS-ERNITLSQPAVAAPGGAMPDWQIIARIACEMGFSEAFSY
Mb1477|M.bovis_AF2122/97 ----DFAASKTNPTLIAMPAMVPPYANARDDYHTFSALAHRLGFGKQFTE
Rv1442|M.tuberculosis_H37Rv ----DFAASKTNPTLIAMPAMVPPYANARDDYHTFSALAHRLGFGKQFTE
MAB_3041|M.abscessus_ATCC_1997 ----DFSGSRNDPLLVAMKAVAPPYANSRDDYTTFSALADRLGFGEQFSE
Mvan_2438|M.vanbaalenii_PYR-1 ----DFSGSRNDPVLMAMRRLAEPYAQARDDYDTFAALARRLGVADTFTE
TH_4041|M.thermoresistible__bu DYPYGFAANCPTVFIQSAEPVVGAYGEARNEWEVFDELARRMGLS-LFAT
.. . : . . . : : :* : .
Mflv_5161|M.gilvum_PYR-GCK YWNRTDREMLIDFHD-WDAPALAGITYEKLEEV---GWMR----------
MSMEG_6816|M.smegmatis_MC2_155 YWNRTDREMLIDFHD-WDAPALAGITYEKLEEV---GWMR----------
MMAR_3639|M.marinum_M SSAAEVFEEIKRFSNPATGYDLRGISHDRLRET---PLQWPCPPDGASNR
MUL_1474|M.ulcerans_Agy99 SSAAEVFEEIKRFSNPATGYDLRGISHDRLRET---PLQWPCPPDGASNR
MAV_2075|M.avium_104 SCAEEVFEEIKRFWNPTTGYDLRGVSYERLRRQ---PLQWPCPPQSTADR
Mb1477|M.bovis_AF2122/97 GRSAREWLEHM-YDKWSAELDFPVPSFAEFWRTGRLE-------------
Rv1442|M.tuberculosis_H37Rv GRSAREWLEHM-YDKWSAELDFPVPSFAEFWRTGRLE-------------
MAB_3041|M.abscessus_ATCC_1997 GRTAAQWLRHI-YTEWAGALNFSVPSFDEFWDRGYLE-------------
Mvan_2438|M.vanbaalenii_PYR-1 GRTSAQWLRHL-YEKWSATLDFEVPSFDEFWQVGQVR-------------
TH_4041|M.thermoresistible__bu GPLERLNPVLAWLDRRGVGRLTPRRLMELLLRLGPYGDRFG---------
:
Mflv_5161|M.gilvum_PYR-GCK -----LAVGTPDVRAPHAEG-----NFPTPSGKCEFKS------------
MSMEG_6816|M.smegmatis_MC2_155 -----LAVGAPDKRAPHAEG-----NFPTPSGKCEFKS------------
MMAR_3639|M.marinum_M SPIRYLNDGVSQLQFVRADGTVPRLAFPTATGRAVFFARPHLVPDEMPDG
MUL_1474|M.ulcerans_Agy99 SPIRYLNDGVSQLQFVRADGTVPRLAFPTATGRAVFFARPHLVPDEMPDG
MAV_2075|M.avium_104 NPIRYLNDGVSQTQLVREDGTVPRLAFPTPSGRAVFFARPHLQPEEMPDD
Mb1477|M.bovis_AF2122/97 -----LPTRTGLTWLADFRADPAAHPLGTPSGRIEIFS------------
Rv1442|M.tuberculosis_H37Rv -----LPTRTGLTWLADFRADPAAHPLGTPSGRIEIFS------------
MAB_3041|M.abscessus_ATCC_1997 -----LPTDAGLTLLSDFRENPAAHPLHTPSGRIEIFS------------
Mvan_2438|M.vanbaalenii_PYR-1 -----LPTDEGLTLFADFRADPSAHRLATPSGRIEIFS------------
TH_4041|M.thermoresistible__bu -----LRRGGLNPRRLRENPHGIVVADRVPTGVLGKVVR-----------
* ..:*
Mflv_5161|M.gilvum_PYR-GCK --SLAEGGNFVVPVWRSMYEG--------MQPGGYVDPVPDYVPPFESPQ
MSMEG_6816|M.smegmatis_MC2_155 --SLAEGGNFVVPVWRSMYEG--------MQPGGYVDPVPDYVPPFESPQ
MMAR_3639|M.marinum_M DYPFLLNTGRLAHQWHTLTKTGKIAKLNKLNPGPFVEVHPDDAADMQICE
MUL_1474|M.ulcerans_Agy99 DYPFLLNTGRLAHQWHTLTKTGKIAKLNKLNPGPFVEVHPDDAADMQICE
MAV_2075|M.avium_104 DYPFLLNTGRLPHQWHTMTKTGKVAKLNKLNPGPFVEIHPDDAARLGIGE
Mb1477|M.bovis_AF2122/97 ----------------------------DTVDAFALPDCAGHPTWYEPSE
Rv1442|M.tuberculosis_H37Rv ----------------------------DTVDAFALPDCAGHPTWYEPSE
MAB_3041|M.abscessus_ATCC_1997 ----------------------------ETIDGFGYSDCGGHPQWYEPTE
Mvan_2438|M.vanbaalenii_PYR-1 ----------------------------ADIAGFGYRDCVGHPAWFEPAE
TH_4041|M.thermoresistible__bu ------------------------------HRGGRVCLAPDEVVAEVHRL
. .
Mflv_5161|M.gilvum_PYR-GCK -SNPELAQRYPLSIISPKP---------------------HAFLNSQYGN
MSMEG_6816|M.smegmatis_MC2_155 -SNPELAQRYPLSIISPKP---------------------HAFLNSQYGN
MMAR_3639|M.marinum_M GDHIEIASRRGRAVLPVVITDRVRPGNCFAPFHWNDAFGEYLSINAVTND
MUL_1474|M.ulcerans_Agy99 GDHIEIASRRGRAVLPVVITDRVRPGNCFAPFHWNDAFGEYLSINAVTND
MAV_2075|M.avium_104 HDRVEIASRRGRAVLPAVVSDRVRPGNCFAPFHWNDAFGEYLSINAVTND
Mb1477|M.bovis_AF2122/97 WLGGPRAARYPLHLIANQP---------------------RTRLHSQLDH
Rv1442|M.tuberculosis_H37Rv WLGGPRAARYPLHLIANQP---------------------RTRLHSQLDH
MAB_3041|M.abscessus_ATCC_1997 WLGGERAQRFPLHLIANQP---------------------RTRLHSQLDF
Mvan_2438|M.vanbaalenii_PYR-1 WLGGPRAERYPLHLLANQP---------------------ASRLHSQLDG
TH_4041|M.thermoresistible__bu GQRHPDDPAYPLLAIGMREMR-----------------SQNTWMHNSPTL
: ::
Mflv_5161|M.gilvum_PYR-GCK AADKQKVQ-----------------------------GGQRVFIHPADAA
MSMEG_6816|M.smegmatis_MC2_155 AADKQKVQ-----------------------------GRQQVFIHPTDAA
MMAR_3639|M.marinum_M AVDPISRQPEYKACAVTLTKVARPQLQPEPGEPADTCADATAPKLLADTA
MUL_1474|M.ulcerans_Agy99 AVDPISRQPEYKACAVTLTKVARPQLQPEPGEPADACADATAPKLLADTA
MAV_2075|M.avium_104 AVDPISNQPEFKACAVTLTKVAVSHPDSAIG-TGPSAGHDTPESAPTEVR
Mb1477|M.bovis_AF2122/97 GGASMASK---------------------------IRGREPIRIHPDDAA
Rv1442|M.tuberculosis_H37Rv GGASMASK---------------------------IRGREPIRIHPDDAA
MAB_3041|M.abscessus_ATCC_1997 GGTSQGSK---------------------------VRGREPLRIHPQDAA
Mvan_2438|M.vanbaalenii_PYR-1 GATSQASK---------------------------VAGREPVRMHPDDAA
TH_4041|M.thermoresistible__bu MKGD---------------------------------RRHRARIHPADAA
:.
Mflv_5161|M.gilvum_PYR-GCK ERGIAEGDVVRVFNDRGSFQGPAAYDDG---LMAGLVMANVGHWQGKTSG
MSMEG_6816|M.smegmatis_MC2_155 ERGIAEGDMVRVFNDRGSFQGPAAYETG---LIPGLVMANVGHWQGKTSG
MMAR_3639|M.marinum_M QFSVTQVDALAELLGVANEPTPQFGPFAR-SYLAGLIAGLRSETGRRMAG
MUL_1474|M.ulcerans_Agy99 QFSVTQVDALAELLGVGNEPTPQFGPSAR-SYLAGLIAGLRSETGRRMAG
MAV_2075|M.avium_104 EISVSQVDALGELLGVATSFKPEFNELGR-SYLAGMLTGLRSDVGRRAGG
Mb1477|M.bovis_AF2122/97 ARELTDGDIVRVFNDRGACLAGVVIDDGLRPKVVQLSTGAWFDPADPRDP
Rv1442|M.tuberculosis_H37Rv ARELTDGDIVRVFNDRGACLAGVVIDDGLRPKVVQLSTGAWFDPADPRDP
MAB_3041|M.abscessus_ATCC_1997 TRGIADGDVVRVFNDRGACLAGAVLDEGLRRQVVQLSTGAWFDPIEPADP
Mvan_2438|M.vanbaalenii_PYR-1 ERGLAAGDVVRMFNDSGACLAGVVLDDRVRPRVVQLSTGAWFDPADPADP
TH_4041|M.thermoresistible__bu AAGVTHGGPVRIESPYGAIETEALCTDEMTPGTVAIPHGWGHNGGWRLAN
:: . : . : . .
Mflv_5161|M.gilvum_PYR-GCK TTVNAITADRHCG--LGNAGVYGDNLVEVEKVAEEAFEDREAS-------
MSMEG_6816|M.smegmatis_MC2_155 TTVNAITADRHCG--LGNAGVYGDNLVEVEKLDEHAVAQSA---------
MMAR_3639|M.marinum_M VPTLPVSSPFDTGTRLWLDGLLAGMFARAETPPALPFPQTPGAAAQSDNA
MUL_1474|M.ulcerans_Agy99 VSTLPISSPFDTGTRLWLDGLLAGMFARAETPPALPFPQTPGAAAQSDNA
MAV_2075|M.avium_104 VPTLPPSAPFDSRTRLWVDGLLAGLFSRADASQQAALPEPPQPAAQQPPA
Mb1477|M.bovis_AF2122/97 DSMCVHGNPNALSNDSGTSSLAHGSTGQHVLVQIERFTGELPPVRAHEPP
Rv1442|M.tuberculosis_H37Rv DSMCVHGNPNALSNDSGTSSLAHGSTGQHVLVQIERFTGELPPVRAHEPP
MAB_3041|M.abscessus_ATCC_1997 NSACAHGNPNVLTDDSGTSSLAQGCTGQHVLVQIERFEGTPPPVRAHTPP
Mvan_2438|M.vanbaalenii_PYR-1 DSMCVHGNPNMLTDDVGTSALAHGCTGAHALVQIEKYTAAPPPVRAHQPP
TH_4041|M.thermoresistible__bu RLAGANVNELTSNDSADLERLAGMSVLNGVPVRLVPVG------------
:
Mflv_5161|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6816|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3639|M.marinum_M AEA----AVEQPPIVVLWASQTGTAEELAASVAAQLSAAELPVVLHGMDE
MUL_1474|M.ulcerans_Agy99 AEA----AVEQPPIVVLWASQTGTAEELAASVAAQLSAAELPVVLHGMDE
MAV_2075|M.avium_104 APAGATPAPERAPVVVLWASQTGNAEELAADVAAQLAAAELPVALHSMDD
Mb1477|M.bovis_AF2122/97 RLA-----------------------------------------------
Rv1442|M.tuberculosis_H37Rv RLA-----------------------------------------------
MAB_3041|M.abscessus_ATCC_1997 RFVARD--------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1 VFAAR---------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
Mflv_5161|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6816|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3639|M.marinum_M FAVADLVSTQRLLLVTSTTGDGEPPDNGAAFWRELCAATAPSLAGTRYSV
MUL_1474|M.ulcerans_Agy99 FAVADLVSTQRLLLVTSTTGDGEPPDNGAAFWRELCAPTAPSLAGTRYSV
MAV_2075|M.avium_104 FPAAELAATRELLLITSTTGDGDAPDNGSGLWRALTGDAAPRLGNTRYAV
Mb1477|M.bovis_AF2122/97 --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
Mflv_5161|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6816|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3639|M.marinum_M LALGDSNYADFCGHGRALDHRLAELGASRVTDRVDCEPDYEESAARWLQE
MUL_1474|M.ulcerans_Agy99 LALGDSNYADFCGHGRALDHRLAELGASRITDRVDCEPDYEESAARWLQE
MAV_2075|M.avium_104 LALGDSNYDDFCGHGRKLDARLAELGATRIAERVDCEPDYEQAAAKWVAD
Mb1477|M.bovis_AF2122/97 --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
Mflv_5161|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6816|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3639|M.marinum_M VLDGLRRTAPPV---------ITAAPVRAASIANR--PQGYTKKRPLLTS
MUL_1474|M.ulcerans_Agy99 VLDGLRRTAPPV---------ITAEPVRAASIASR--PQGYTKKRPLLTS
MAV_2075|M.avium_104 VIEALTRTPTAVGGDGGATVSARTSPVAAPSRPNTPAPHTYSKKHPLITD
Mb1477|M.bovis_AF2122/97 --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
Mflv_5161|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6816|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3639|M.marinum_M VMRNTTLSRPRSAKDVRQLVFRVPEQTVSYEAGDALGVWPRNAHQLVDEW
MUL_1474|M.ulcerans_Agy99 VMRNTTLSRPRSAKDVRQLVFRVPEQTVSYEAGDALGVWPRNAHQLVDEW
MAV_2075|M.avium_104 MVRNTTLNGPKSTKDVRHLVFNLPEDAVSYEAGDALGVWPRNSDELVDEW
Mb1477|M.bovis_AF2122/97 --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
Mflv_5161|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6816|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3639|M.marinum_M LGVTQLDGHTEVEVAGHGTMSLRAALTDRFEIAHLSPDLLRFVAQRTLDS
MUL_1474|M.ulcerans_Agy99 LGVTRLDGHTEVEVAGHGTMSLRAALTDRFEIAHLSPDLLRFVAQRTLDS
MAV_2075|M.avium_104 LAVTGLDGQTPVEVGEHGLMSLRSALTERIEIAHISRDLVRFVQERTGDA
Mb1477|M.bovis_AF2122/97 --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
Mflv_5161|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6816|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3639|M.marinum_M NTANQLAELMRPENKAALADWTWGRQSVDLLAQSPVRASVDEWMSVLKPI
MUL_1474|M.ulcerans_Agy99 NTANQLAELMRPENKAALADWTWGRQSVDLLAQSPVRASVDEWMSVLKPI
MAV_2075|M.avium_104 ----KLAELLKPENKRALADWTWGRQSIDLLAQLPVSASAHEWLRVLKRL
Mb1477|M.bovis_AF2122/97 --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
Mflv_5161|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6816|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3639|M.marinum_M QPRLYSISSSPKEHPGEVHLTVSPVRYNFQGVPRRGVCSTYLADRSPSDQ
MUL_1474|M.ulcerans_Agy99 QPRLYSISSSPKEHPGEVHLTVSPVRYNFQGVPRRGVCSTYLADRSPSDQ
MAV_2075|M.avium_104 QPRLYSISSSPKACPGEVHLTVSPVRYNFQGVPRRGVCSTYLAARSPGDR
Mb1477|M.bovis_AF2122/97 --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
Mflv_5161|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6816|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3639|M.marinum_M IAIYVRKSSNFRPPSDPRTPMIMIGPGTGIAPFRGFLQERRALGHTGPNW
MUL_1474|M.ulcerans_Agy99 IAIYVRKSSNFRPPSDPRTPMIMIGPGTGIAPFRGFLQERRALGHTGPNW
MAV_2075|M.avium_104 VAVYLQPSSNFRPPSDPDTPMIMIGPGTGIAPFRGFLQERRALGHRGPNW
Mb1477|M.bovis_AF2122/97 --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
Mflv_5161|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6816|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3639|M.marinum_M LFFGEQHAATDFYYRDEIQAMHRDGLLTNLDLAFSRDQRDKVYVQHLMQQ
MUL_1474|M.ulcerans_Agy99 LFFGEQHAATDFYYRDEIQAMHRDGLLTNLDLAFSRDQRDKVYVQHLMQQ
MAV_2075|M.avium_104 LFFGEQHAATDFYYRDELEQMREDGFLTELDLAFSRDQQHKVYVQHLMRN
Mb1477|M.bovis_AF2122/97 --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
Mflv_5161|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6816|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3639|M.marinum_M RGAQLWQWLQDGAQVYVCGTADPMAKDVDRMLCQIVAEHGGLDPESATAF
MUL_1474|M.ulcerans_Agy99 RGAQLWQWLQDGAQVYVCGTADPMAKDVDRMLCQIVAEHGGLDPESATAF
MAV_2075|M.avium_104 RGKQLWSWLQDGAQLYVCGTADPMAKDVDRALCDIAAEFGNLDPDAAKAY
Mb1477|M.bovis_AF2122/97 --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4041|M.thermoresistible__bu --------------------------------------------------
Mflv_5161|M.gilvum_PYR-GCK ---------------
MSMEG_6816|M.smegmatis_MC2_155 ---------------
MMAR_3639|M.marinum_M VHALSADKRYHRDVY
MUL_1474|M.ulcerans_Agy99 VHALSADKRYHRDVY
MAV_2075|M.avium_104 VQSLSADKRYHRDVY
Mb1477|M.bovis_AF2122/97 ---------------
Rv1442|M.tuberculosis_H37Rv ---------------
MAB_3041|M.abscessus_ATCC_1997 ---------------
Mvan_2438|M.vanbaalenii_PYR-1 ---------------
TH_4041|M.thermoresistible__bu ---------------