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MAPNKDAVKTVCAYCGVGCGIVLQTTTDPQTGKRRVAKSTGDKSHPANLGRLCTKGTTTADLLAAPGRME SAHLRAHRAGHLESIPIDDAITQCAMRLRAIIDEHGPDAVGVYVSGQMSIEAQYLANKLTKGFIGTNQIE SNSRLCMAGASSGYKLSLGADGPPGSYQDFDHADVFLVIGANMADCHPILFLRMMERVKSGAKLIVVDPR RTATADKADLFLQIAPGTDLALLNGLLHLIVENEQTDPQFISEFTEGWEVMPSFLEQFTPDRVSEITGIP SEDIRTAARWIGTAANWMSCWTMGLNQSTHGTWNTNALCNLHLATGAICRPGSGPFSLTGQPNAMGGREM GYMGPGLPGQRSVLSAPDREFVEEQWGLPGGALRTDVSGGVIDMFSRMADGEIKACWIICSNPVATVANR KTVLAGLEKAELVISQDAFFETETNEYANVLLPAALWTESDGVMVNCERNMSLFPKAVDPVGDALPDWQI IARIACEMGFSESFSYSSAAEVFEEIKRFSNPATGYDLRGISHDRLRETPLQWPCPPDGASNRSPIRYLN DGVSQLQFVRADGTVPRLAFPTATGRAVFFARPHLVPDEMPDGDYPFLLNTGRLAHQWHTLTKTGKIAKL NKLNPGPFVEVHPDDAADMQICEGDHIEIASRRGRAVLPVVITDRVRPGNCFAPFHWNDAFGEYLSINAV TNDAVDPISRQPEYKACAVTLTKVARPQLQPEPGEPADTCADATAPKLLADTAQFSVTQVDALAELLGVA NEPTPQFGPFARSYLAGLIAGLRSETGRRMAGVPTLPVSSPFDTGTRLWLDGLLAGMFARAETPPALPFP QTPGAAAQSDNAAEAAVEQPPIVVLWASQTGTAEELAASVAAQLSAAELPVVLHGMDEFAVADLVSTQRL LLVTSTTGDGEPPDNGAAFWRELCAATAPSLAGTRYSVLALGDSNYADFCGHGRALDHRLAELGASRVTD RVDCEPDYEESAARWLQEVLDGLRRTAPPVITAAPVRAASIANRPQGYTKKRPLLTSVMRNTTLSRPRSA KDVRQLVFRVPEQTVSYEAGDALGVWPRNAHQLVDEWLGVTQLDGHTEVEVAGHGTMSLRAALTDRFEIA HLSPDLLRFVAQRTLDSNTANQLAELMRPENKAALADWTWGRQSVDLLAQSPVRASVDEWMSVLKPIQPR LYSISSSPKEHPGEVHLTVSPVRYNFQGVPRRGVCSTYLADRSPSDQIAIYVRKSSNFRPPSDPRTPMIM IGPGTGIAPFRGFLQERRALGHTGPNWLFFGEQHAATDFYYRDEIQAMHRDGLLTNLDLAFSRDQRDKVY VQHLMQQRGAQLWQWLQDGAQVYVCGTADPMAKDVDRMLCQIVAEHGGLDPESATAFVHALSADKRYHRD VY
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_3639 | fdhF | - | 100% (1402) | formate dehydrogenase H FdhF |
M. marinum M | MMAR_2605 | - | 2e-33 | 24.45% (724) | anaerobic dehydrogenase |
M. marinum M | MMAR_0437 | - | 9e-29 | 26.67% (510) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0203 | - | 7e-27 | 25.54% (509) | oxidoreductase |
M. gilvum PYR-GCK | Mflv_3016 | - | 0.0 | 53.94% (1396) | molybdopterin oxidoreductase |
M. tuberculosis H37Rv | Rv0197 | - | 1e-26 | 25.54% (509) | oxidoreductase |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_2438 | - | 0.0 | 63.97% (730) | oxidoreductase |
M. avium 104 | MAV_2075 | - | 0.0 | 74.43% (1412) | FdhF protein |
M. smegmatis MC2 155 | MSMEG_2837 | - | 5e-94 | 32.28% (728) | nitrate reductase NarB |
M. thermoresistible (build 8) | TH_4553 | - | 5e-55 | 58.89% (180) | PUTATIVE sulfite reductase (NADPH) alpha subunit |
M. ulcerans Agy99 | MUL_1474 | fdhF | 0.0 | 99.22% (1402) | formate dehydrogenase H FdhF |
M. vanbaalenii PYR-1 | Mvan_3491 | - | 0.0 | 54.80% (1396) | molybdopterin oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_3639|M.marinum_M ------------------------------MAPNKDAVKTVCAYCGVGCG MUL_1474|M.ulcerans_Agy99 ------------------------------MAPNKDAVKTVCAYCGVGCG MAV_2075|M.avium_104 -------------------------------------MNTMCAYCGVGCG MAB_2438|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3016|M.gilvum_PYR-GCK ------------------------------------MTRTACSYCGVGCG Mvan_3491|M.vanbaalenii_PYR-1 ------------------------------------MTRTACSYCGVGCG TH_4553|M.thermoresistible__bu ---------------------------VATGRGGADCVRTACSYCGVGCG MSMEG_2837|M.smegmatis_MC2_155 MARTDRISDPWGSRTPYAAGEPWPQRVDRYLTPGLTDDDVDRWVQSAAVL Mb0203|M.bovis_AF2122/97 -------------------------------MTSSDWLPTACILCECNCG Rv0197|M.tuberculosis_H37Rv -------------------------------MTSSDWLPTACILCECNCG MMAR_3639|M.marinum_M IVLQTTTDPQTGKRRVAKSTGDKSHPANLGRLCTKGTTTADLLAAP-GRM MUL_1474|M.ulcerans_Agy99 IVLQTTTDPQTGKRRVAKSTGDKSHPANLGRLCTKGTTTADLLAAP-GRM MAV_2075|M.avium_104 MVLQITTDPQTGRRHVAKSVGNKEHPANFGRLCTKGATTADLLAAP-GRM MAB_2438|M.abscessus_ATCC_1997 ---MRTDAHAAGPVTVATVEGDVLHPSNQGRLCTKGATHAQLMAAD-GRM Mflv_3016|M.gilvum_PYR-GCK ISVETRTDPASGVPVIARVSGDKLHPTNFGRLCTKGATHAEMMAATDGRL Mvan_3491|M.vanbaalenii_PYR-1 ISVETRTDPATGVPVIARVTGDKLHPSNFGRLCTKGATHAEMMAATDGRL TH_4553|M.thermoresistible__bu IEVRTTPGPAG--PVIAGVAGDPLHPTNRGRLCTKGATHAELMGSTKGRA MSMEG_2837|M.smegmatis_MC2_155 HSNGDGLDIAVKDGRIVGVRGRADDRVNHGRLDPKDLFGWQANHAR-DRL Mb0203|M.bovis_AF2122/97 IVVQVDD------RRLARIRGDKAHPGSAGYTCNKALRLDHYQNNR--AR Rv0197|M.tuberculosis_H37Rv IVVQVDD------RRLARIRGDKAHPGSAGYTCNKALRLDHYQNNR--AR :. * . . * * . MMAR_3639|M.marinum_M ESAHLRAHRAGHLESIPIDDAITQCAMRLRAIIDEHGPDAVGVYVSGQMS MUL_1474|M.ulcerans_Agy99 ESAHLRAHRAGHLESIPIDDAITQCAMRLRAIIDEHGPDAVGVYVSGQMS MAV_2075|M.avium_104 DSAHARAGRGEPLEPIGTDQAITRCAKQLRAIIDEHGPDAFAMYVSGQMS MAB_2438|M.abscessus_ATCC_1997 TTAHLRSIRGQQPIPAPLAAATAEAGRRLREILDNHGPDAIALYVSGQMT Mflv_3016|M.gilvum_PYR-GCK TTALVRPSRDADPVALDVDDAVAEAGSRLRAIVDEHGPDAVALYVSGQMS Mvan_3491|M.vanbaalenii_PYR-1 TTALLRPSRDAEPVATDVDDALAEAGARLRAILDEHGPDAVALYVSGQMS TH_4553|M.thermoresistible__bu LTALIRPRRGEPPVPAPVDDAVAAAGQRLRAILDTHGPDAIALYVSGQLS MSMEG_2837|M.smegmatis_MC2_155 RTPLIR--QDGVLVESDWDTAMDRIVARSRQLLDERGPNSIGFYTSGQLF Mb0203|M.bovis_AF2122/97 LSSPMRRRADGTYEEIDWDTAIVEIAEGFKQIRDTHGGDKIFYYGGGGQ- Rv0197|M.tuberculosis_H37Rv LSSPMRRRADGTYEEIDWDTAIVEIAEGFKQIRDTHGGDKIFYYGGGGQ- :. * * : : * :* : . * .* MMAR_3639|M.marinum_M IEAQYLANKLTKGFIGTNQIESNSRLCMAGASSGYKLSLGADGPPGSYQD MUL_1474|M.ulcerans_Agy99 IEAQYLANKLTKGFIGTKQIESNSRLCMAGASSGYKLSLGADGPPGSYQD MAV_2075|M.avium_104 LEAQYLANKLTKGFIGTNQIESNSRLCMASAGSGYKLSLGADGPPGSYQD MAB_2438|M.abscessus_ATCC_1997 LEAQYLANKLAKGYIRTTHIESNSRLCMASAGTGYAQSLGADGPPGSYSD Mflv_3016|M.gilvum_PYR-GCK IEAQYLATKLAKGFLRTVHIESNSRLCMASAGTGYKQSLGSDGPPGSYTD Mvan_3491|M.vanbaalenii_PYR-1 IEAQYLATKLAKGFLRTVHIESNSRLCMASAGTGFKQSLGADGPPGSYTD TH_4553|M.thermoresistible__bu LEAQYLATKLAKGFIRTAHLEANSRLCMASAASGYKQSLGADGPPGSYDD MSMEG_2837|M.smegmatis_MC2_155 LEEYYTQCVIAHGAIGTNHVDGNTRLCTATAAEALKESFGCDGQPGSYTD Mb0203|M.bovis_AF2122/97 --GNHLGGAYSGAFLKALGSRYRSNALAQEKTGEAWVDFQLYGG-HTRGE Rv0197|M.tuberculosis_H37Rv --GNHLGGAYSGAFLKALGSRYRSNALAQEKTGEAWVDFQLYGG-HTRGE : : . : : .:. .: * : : MMAR_3639|M.marinum_M FDHADVFLVIGAN--MADCHPILFLRMMERVKSG--AKLIVVDPRRTATA MUL_1474|M.ulcerans_Agy99 FDHADVFLVIGAN--MADCHPILFLRMMERVKSG--AKLIVVDPRRTATA MAV_2075|M.avium_104 FEHADVFFVIGAN--MADCHPILFLRMMDRVKAG--AKLIVVDPRRTATA MAB_2438|M.abscessus_ATCC_1997 IEHSDLFFVIGAN--MADCHPILFLRMADRLSSG--ARLIVVDPRRTATA Mflv_3016|M.gilvum_PYR-GCK FDCTNLFFVIGSN--MADCHPILYLRMADRLKAG--ARLIVVDPRRTATA Mvan_3491|M.vanbaalenii_PYR-1 FDCTDLFFVIGSN--MADCHPILYLRMADRLKAG--AKLIVVDPRRTATA TH_4553|M.thermoresistible__bu IDRADLFFVIGAN--MAPWP-----RSATSTRS--------VAPR----- MSMEG_2837|M.smegmatis_MC2_155 VDHADVIALYGHN--VAETQTVLWMRMLDRLAGPNPPAIVCIDPRPTPVA Mb0203|M.bovis_AF2122/97 FENAEVSVFVGKNPWMSQSFPRARVVLNEIAKDPG-RSMIVIDPVVTDTA Rv0197|M.tuberculosis_H37Rv FENAEVSVFVGKNPWMSQSFPRARVVLNEIAKDPG-RSMIVIDPVVTDTA .: ::: . * * :: : * MMAR_3639|M.marinum_M DKADLFLQIAPGTDLALLNGLLHLIVENEQTDPQFISEFTEGWEVMPSFL MUL_1474|M.ulcerans_Agy99 DKADLFLQIAPGTDLALLNGLLHLIVENEQTDPQFISEFTEGWEVMPSFL MAV_2075|M.avium_104 EKADLFLQIAPGTDLALLNGLLHLIVENGHTDGEFIAEFTEGWEVMPSFL MAB_2438|M.abscessus_ATCC_1997 DRADLFLQITPGTDLALLNGLLHLLVENGAVDAEFIAQHTEGWDGMPEFL Mflv_3016|M.gilvum_PYR-GCK DKADLYLPIRPGTDLALLNGILRVLVQDGAIDEAFIAEHTEGWEAMPAFL Mvan_3491|M.vanbaalenii_PYR-1 DKADLYLPIRPGTDLALLNGILHLLVENGAVDQEFIAEHTQGWESMPEFL TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 RHATVHLAPLPGTNVALMNGLLHEILDHDWMDHDYIEAHTVGFHELRKRV Mb0203|M.bovis_AF2122/97 KMADFHLRVQPGCDAWCLAALAAVLVQENLCNEAFLAAHVHGVDTVRAAL Rv0197|M.tuberculosis_H37Rv KMADFHLRVQPGCDAWCLAALAAVLVQENLCNEAFLAAHVHGVDTVRAAL MMAR_3639|M.marinum_M EQFTPDRVSEITGIPSEDIRTAARWIGTAANWMSCWTMGLNQSTHGTWNT MUL_1474|M.ulcerans_Agy99 EQFTPDRVSEITGIPSEDIRTAARWIGTAANWMSCWTMGLNQSTHGTWNT MAV_2075|M.avium_104 EQYTPDRVSEITGIPEQDIRAAAQLIGEADNFMSCWTMGLNQSTHGTWNT MAB_2438|M.abscessus_ATCC_1997 AGYAPAVVAAITGLAEEDIRTAARWIGEAREWMTLWTMGLNQSTHGTWNT Mflv_3016|M.gilvum_PYR-GCK ADYPPSRVAEITGLAEADIRSAAAMIAEAGDWISCWTMGLNQSTHGTWNT Mvan_3491|M.vanbaalenii_PYR-1 AGYPPDRVAAITGLSEADIRAAADMIAEAGDWLSCWTMGLNQSTHGTWNT TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 AEFPPERVADICGVDPDDVRRAGELIGTAERLLSTVLQGFYQSHQATAAA Mb0203|M.bovis_AF2122/97 QEVPVADYAQRCGVDEELLRAAARRIGTAASVSVFEDLGIQQAPNSTVCS Rv0197|M.tuberculosis_H37Rv QEVPVADYAQRCGVDEELLRAAARRIGTAASVSVFEDLGIQQAPNSTVCS MMAR_3639|M.marinum_M NALCNLHLATGAICRPGSGPFSLTGQPNAMGGREMGYMGPGLPGQRSVLS MUL_1474|M.ulcerans_Agy99 NALCNLHLATGAICRPGSGPFSLTGQPNAMGGREMGYMGPGLPGQRSVLS MAV_2075|M.avium_104 NAICNLHLATGAICKPGSGPFSLTGQPNAMGGREMGYMGPGLPGQRSVAS MAB_2438|M.abscessus_ATCC_1997 NAICNLHLATGAICRPGSGPFSLTGQPNAMGGREMGYMGPGLPGQRSVKS Mflv_3016|M.gilvum_PYR-GCK NAICNLHLATGAICRPGAGPMSLTGQPNAMGGREMGYMGPGLPGQRAVLS Mvan_3491|M.vanbaalenii_PYR-1 NAICNLHLATGAICRPGSGPMSLTGQPNAMGGREMGYMGPGLPGQRSVAS TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 VQVNNIHLVRGMLGRPGCGLLQMNGQPTAENTRECGADG-DLAGFRNWAN Mb0203|M.bovis_AF2122/97 YLNKLLWILTGNFAKKGGQHLHSSFAPLFSQVSGRTPVTGAPIIAGLIPG Rv0197|M.tuberculosis_H37Rv YLNKLLWILTGNFAKKGGQHLHSSFAPLFSQVSGRTPVTGAPIIAGLIPG MMAR_3639|M.marinum_M APDREFVEEQWGLPGGALRTDVS-GGVIDMFSRMADGEIKACWIICSNPV MUL_1474|M.ulcerans_Agy99 APDREFVEEQWGLPGGALRTDVS-GGVIDMFSRMADGEIKACWIICSNPV MAV_2075|M.avium_104 AADREFVEDVWGVPRGRLRTEVG-TGTIDMFSRMADGQIKACWIICTNPV MAB_2438|M.abscessus_ATCC_1997 PADRDFVEKRWQLPPGSIRAEFG-TGTVDMFAQMAAGNIKACWIICTNPV Mflv_3016|M.gilvum_PYR-GCK AEDRSFVETQWDLEPGTVRTEVG-PGTVEMFRRIAGGDIKAVWIICTNPV Mvan_3491|M.vanbaalenii_PYR-1 AADRAFVEEQWDLEPGTIRADIG-PGTVEMFRQMGSGDIKAAWIICTNPV TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 DSHIEELATLWNLDVTAIPHYAPPTHAMQMFRYAEEGSLRMLWVSATNPA Mb0203|M.bovis_AF2122/97 NVVPEEILTEHPDRFRAMIVESGNPAHSLADSAACRAAFQALELMVVVDV Rv0197|M.tuberculosis_H37Rv NVVPEEILTEHPDRFRAMIVERGNPAHSLADSAACRAAFQALELMVVVDV MMAR_3639|M.marinum_M ATVANRKTVLAGLEKAELVISQDAFFETETNEYANVLLPAALWTESDGVM MUL_1474|M.ulcerans_Agy99 ATVANRKTVLAGLEKAELVISQDAFFETETNEYANVLLPAALWTESDGVM MAV_2075|M.avium_104 ASVANRKTVLAGLERAELVIAQDAYLGTETSEYADVLLPAALWAETEGVM MAB_2438|M.abscessus_ATCC_1997 ASVANRKNVVDGLRRAELVIAQDAFLATATNEYADILLPAALWAESDGVS Mflv_3016|M.gilvum_PYR-GCK ASVANRDTVITGLQSAELVITQDAYVDTATNRYADIMLPATLWAEADAVM Mvan_3491|M.vanbaalenii_PYR-1 ASVANRDAVVAGLSTAELVITQDVYADTATNRYADIVLPATLWAETDAVM TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 VSLPELGRIRRILSQDRLFLVVQDLFLTETAQLADVVLPAAAWAEKTGTF Mb0203|M.bovis_AF2122/97 AMTETARLAHYVLPAASQFEKPEATFFNFEFPRNGFQLRRPLFPPLPGTL Rv0197|M.tuberculosis_H37Rv AMTETARLAHYVLPAASQFEKPEATFFNFEFPRNGFQLRRPLFPPLPGTL MMAR_3639|M.marinum_M VNCERNMSLFPKA-VDPVGDALPDWQIIARIACEMGFSESFS-----YSS MUL_1474|M.ulcerans_Agy99 VNCERNMSLFPKA-VDPVGDALPDWQIIARIACEMGFSESFS-----YSS MAV_2075|M.avium_104 VNSERNITLSQPA-VAAPGGAMPDWQIIARIACEMGFSEAFS-----YSC MAB_2438|M.abscessus_ATCC_1997 INSERTATLTNRA-VEAPGDARPDWQLICDIATAMGFGDAFG-----YSS Mflv_3016|M.gilvum_PYR-GCK VNSGRTLTLLAQS-VPAAGDARPDWELICGVARHLGFGDAFD-----HKS Mvan_3491|M.vanbaalenii_PYR-1 VNSDRNLTLLQQS-VPPVGDARPDWELICGVARHLGFGDAFD-----YKS TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 TNADRTVHISDKA-VDPPGQARSDFDIFLDYARRMDFRDRDGRPLPAWNT Mb0203|M.bovis_AF2122/97 PEPEIWARLVRALGVVDEADLRPLREAAAQGRQAYTEAFLAAAATNPTVA Rv0197|M.tuberculosis_H37Rv PEPEIWARLVRALGVVDEADLRPLREAAAQGRQAYTEAFLAAAATNPTVA MMAR_3639|M.marinum_M AAEVFEEIKRFSNPATGYDLRGISHDRLR-ETPLQWPCPPDGASNRSPIR MUL_1474|M.ulcerans_Agy99 AAEVFEEIKRFSNPATGYDLRGISHDRLR-ETPLQWPCPPDGASNRSPIR MAV_2075|M.avium_104 AEEVFEEIKRFWNPTTGYDLRGVSYERLR-RQPLQWPCPPQSTADRNPIR MAB_2438|M.abscessus_ATCC_1997 SEEIFEEIRAFWNPRTGYDMRGMSYARLR-QGPVQWPCPPESEVDRNPIR Mflv_3016|M.gilvum_PYR-GCK SEEIFDEIRRFHNPRTGYDLRGVTYERLR-ATPVQWPCPSEDAPDRNPIR Mvan_3491|M.vanbaalenii_PYR-1 SEQIFDEIRRFHNPGTGYDLRGITYERLR-DTPVQWPCASAEQSDRNPIR TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 PDEAFEAWKRCSAGRP-CDYTGLSYEKLRGSGGIQWPCNAEHPDGVERLY Mb0203|M.bovis_AF2122/97 KLTAYVLYETLGPTLPDGLAGAAALWGLAQKTAMAYPDAVRRAGHADGNA Rv0197|M.tuberculosis_H37Rv KLTAYVLYETLGPTLPDGLAGAAALWGLAQKTAMAYPDAVRRAGHADGNA MMAR_3639|M.marinum_M YLNDGVSQLQFVRADG---------TVPRLAFPTATGRAVFFARPHLVPD MUL_1474|M.ulcerans_Agy99 YLNDGVSQLQFVRADG---------TVPRLAFPTATGRAVFFARPHLVPD MAV_2075|M.avium_104 YLNDGVSQTQLVREDG---------TVPRLAFPTPSGRAVFFARPHLQPE MAB_2438|M.abscessus_ATCC_1997 YLNDGISQHPHVDENG---------VVPRLAFPTPSRRAVFHARAHRDPA Mflv_3016|M.gilvum_PYR-GCK YLNDGVSQDLHIDDDG---------HIPRLAFATPSRRAVFHPRPHLDAA Mvan_3491|M.vanbaalenii_PYR-1 YLNDGVSQDQYVGPDG---------HRPRLAFPTPSRRAVFHPRPHMDAA TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 AGGEFFAAPDYCEAYGKDLITGAPLEPTEYRAMNPFGKAIIKAAEYVPPH Mb0203|M.bovis_AF2122/97 LFDAILERPSGVTFTVHN-------YEDDFALISHPDHKIALEIPEMLAE Rv0197|M.tuberculosis_H37Rv LFDAILERPSGVTFTVHN-------YEDDFALISHPDHKIALEIPEMLAE MMAR_3639|M.marinum_M EMPDGDYPFLLNTGRLAHQWHTLTKTG-------KIAKLNKLNPGPFVEV MUL_1474|M.ulcerans_Agy99 EMPDGDYPFLLNTGRLAHQWHTLTKTG-------KIAKLNKLNPGPFVEV MAV_2075|M.avium_104 EMPDDDYPFLLNTGRLPHQWHTMTKTG-------KVAKLNKLNPGPFVEI MAB_2438|M.abscessus_ATCC_1997 ELPGEGYPVVLNTGRLQHHWHTLTKTG-------RIKTLDRLHPSPFVEI Mflv_3016|M.gilvum_PYR-GCK ELPDDDYPFILNTGRLQHQWHTMTKTG-------RVAKLTKLNPAPFVEI Mvan_3491|M.vanbaalenii_PYR-1 ELPDDDYPLVLNTGRLQHQWHTMTKTG-------KVAKLNKLNPGPFVEI TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 ERPSAEYPCVLITGRTVYHFHTRTKTG-------RTPQLQAAAPEVWVEL Mb0203|M.bovis_AF2122/97 IRSLTQTPSRLTTPQLPIVLSVGERRAYTANDIFRDPSWRKRDANGALRV Rv0197|M.tuberculosis_H37Rv IRSLTQTPSRLTTPQLPIVLSVGERRAYTANDIFRDPSWRKRDANGALRV MMAR_3639|M.marinum_M HPDDAADMQICEGDHIEIASRRGRAVLPVVITDRVRPGNCFAPFHWN--- MUL_1474|M.ulcerans_Agy99 HPDDAADMQICEGDHIEIASRRGRAVLPVVITDRVRPGNCFAPFHWN--- MAV_2075|M.avium_104 HPDDAARLGIGEHDRVEIASRRGRAVLPAVVSDRVRPGNCFAPFHWN--- MAB_2438|M.abscessus_ATCC_1997 HPHDATTLGISDGDIVEIASRRGTAELPALVSDRVKRGSCFAPFHWN--- Mflv_3016|M.gilvum_PYR-GCK HPSDAAALGITDGQDLELRTRRGRAVLPAVLTERVRPGNTWAPFHWN--- Mvan_3491|M.vanbaalenii_PYR-1 HPDDAAALGISGGHDVELVTRRGRAVLPAVLTDRVQPGNTWVPFHWN--- TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 ARADALRAGIVEGDLVEIRTVRGCVTAAARLTD-LRRGVVFLPFHYGYWD Mb0203|M.bovis_AF2122/97 SVEDAQALGLADGCLARITTAAGSAEATVEVTETMLAGHAALPNGFG--- Rv0197|M.tuberculosis_H37Rv SVEDAQALGLADGCLARITTAAGSAEATVEVTETMLAGHAALPNGFG--- MMAR_3639|M.marinum_M -----DAFGEYLSINAVTNDAVDPISRQPEYKACAVTLTKVARPQLQPEP MUL_1474|M.ulcerans_Agy99 -----DAFGEYLSINAVTNDAVDPISRQPEYKACAVTLTKVARPQLQPEP MAV_2075|M.avium_104 -----DAFGEYLSINAVTNDAVDPISNQPEFKACAVTLTKVAVSHPDSAI MAB_2438|M.abscessus_ATCC_1997 -----DAHGPGLTINAVTNDAVDPDSLQPEFKVSAVALRPTGRTKADSMP Mflv_3016|M.gilvum_PYR-GCK -----DEHGENLTINALTNDAVDPDSLQPEFKVCAVRLTPVPAADGAPDL Mvan_3491|M.vanbaalenii_PYR-1 -----DEHGDHLTVNALTNDAVDPDSLQPEFKVCAVRLAPVPAAG-APEF TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 TGDDGGKDGHHRAANELTLTDWDPVSKQPIFKTAAASVR----------- Mb0203|M.bovis_AF2122/97 --LDYTGDDGRTVVAGVAPNALTSTRWRDPYAG----------------- Rv0197|M.tuberculosis_H37Rv --LDYTGDDGRTVVAGVAPNALTSTRWRDPYAG----------------- MMAR_3639|M.marinum_M GEPADTCADATAPKLLADTAQFSVTQVDALAELLGVANEPTPQFGPFARS MUL_1474|M.ulcerans_Agy99 GEPADACADATAPKLLADTAQFSVTQVDALAELLGVGNEPTPQFGPSARS MAV_2075|M.avium_104 G-TGPSAGHDTPESAPTEVREISVSQVDALGELLGVATSFKPEFNELGRS MAB_2438|M.abscessus_ATCC_1997 E-----------------------KQKEALGD------------------ Mflv_3016|M.gilvum_PYR-GCK T------------------------------------------------D Mvan_3491|M.vanbaalenii_PYR-1 T------------------------------------------------E TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 -------------------------------------------------- Mb0203|M.bovis_AF2122/97 -------------------------------------------------- Rv0197|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_3639|M.marinum_M YLAGLIAGLRSETGRRMAGVPTLPVSSPFDTGTRLWLDGLLAGMFARAET MUL_1474|M.ulcerans_Agy99 YLAGLIAGLRSETGRRMAGVSTLPISSPFDTGTRLWLDGLLAGMFARAET MAV_2075|M.avium_104 YLAGMLTGLRSDVGRRAGGVPTLPPSAPFDSRTRLWVDGLLAGLFSRADA MAB_2438|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3016|M.gilvum_PYR-GCK DEKLYIAGFLAGVDEGRPGVPVLPAGAPVGARARLWVDGLLAGRYSRLET Mvan_3491|M.vanbaalenii_PYR-1 TEKLYLAGFFAGIEEGLPGVPVLPASAPVGPRARLWVDGLLAGRYSRSDT TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 -------------------------------------------------- Mb0203|M.bovis_AF2122/97 -------------------------------------------------- Rv0197|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_3639|M.marinum_M PPALPFPQTPGAAAQSDNAAEA----AVEQPPIVVLWASQTGTAEELAAS MUL_1474|M.ulcerans_Agy99 PPALPFPQTPGAAAQSDNAAEA----AVEQPPIVVLWASQTGTAEELAAS MAV_2075|M.avium_104 SQQAALPEPPQPAAQQPPAAPAGATPAPERAPVVVLWASQTGNAEELAAD MAB_2438|M.abscessus_ATCC_1997 --------------------------------VAILWTSQTGNAETAAVS Mflv_3016|M.gilvum_PYR-GCK AAPS----------------------ASPRGGPLVLWASQTGTAEEFAGS Mvan_3491|M.vanbaalenii_PYR-1 VAET----------------------PATEG-PLVLWASQTGNAEEFAGR TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 ----------------------------------RIGAGMAATPEPVAHA Mb0203|M.bovis_AF2122/97 ----------------------------------TPWHKHVPAAIRRADA Rv0197|M.tuberculosis_H37Rv ----------------------------------TPWHKHVPAAIRRADA MMAR_3639|M.marinum_M VAAQLSAAELPVVLHGMDEFAVADLVSTQRLLLVTSTTGDGEPPDNGAAF MUL_1474|M.ulcerans_Agy99 VAAQLSAAELPVVLHGMDEFAVADLVSTQRLLLVTSTTGDGEPPDNGAAF MAV_2075|M.avium_104 VAAQLAAAELPVALHSMDDFPAAELAATRELLLITSTTGDGDAPDNGSGL MAB_2438|M.abscessus_ATCC_1997 VHRLLHTAGISATITAMDECDPADLVGVNTAVVIASSFGEGGPPDNGARF Mflv_3016|M.gilvum_PYR-GCK LGERLAGARL----RAMDDTDLSELSDAGEVVIVTSTFGDGGPPDNGTAF Mvan_3491|M.vanbaalenii_PYR-1 LGERLNGARL----RAMDDVELDDLSEAGEVVIVTSTFGDGGPPDNGAGF TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 VADEHL-------------------------------------------- Mb0203|M.bovis_AF2122/97 ESPIW--------------------------------------------- Rv0197|M.tuberculosis_H37Rv ESPIWYPKWAILPARGVLA------------------------------- MMAR_3639|M.marinum_M WRELCAATAPSLAGTRYSVLALGDSNYADFCGHGRALDHRLAELGASRVT MUL_1474|M.ulcerans_Agy99 WRELCAPTAPSLAGTRYSVLALGDSNYADFCGHGRALDHRLAELGASRIT MAV_2075|M.avium_104 WRALTGDAAPRLGNTRYAVLALGDSNYDDFCGHGRKLDARLAELGATRIA MAB_2438|M.abscessus_ATCC_1997 WAALSGDTKP-LNHMRYAVLGFGDRAYADFCGHAKALDARLHELGASPLL Mflv_3016|M.gilvum_PYR-GCK WERLESADAPALDGVRYTVLGIGDRSYDNFCGHAKSLDTRLADLGATRML Mvan_3491|M.vanbaalenii_PYR-1 WERLESPHAPSLDGVRYTVLGIGDRSYDNFCGHARSLDARLADLGATRML TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 -------------------------------------------------- Mb0203|M.bovis_AF2122/97 -------------------------------------------------- Rv0197|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_3639|M.marinum_M DRVDCEPDYEESAARWLQEVLDGLRRTAPPV---------ITAAPVRAAS MUL_1474|M.ulcerans_Agy99 DRVDCEPDYEESAARWLQEVLDGLRRTAPPV---------ITAEPVRAAS MAV_2075|M.avium_104 ERVDCEPDYEQAAAKWVADVIEALTRTPTAVGGDGGATVSARTSPVAAPS MAB_2438|M.abscessus_ATCC_1997 GRVDGEATDRTLVASWTADLLDAIGDGATAI---------VETVRKLRSE Mflv_3016|M.gilvum_PYR-GCK DRADCEAYDEQPMAAWADSVVGLMSTPVTPAP----------------TQ Mvan_3491|M.vanbaalenii_PYR-1 DRVECEAYDAQPLARWADSVVELVAAPGTPP------------------- TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 -------------------------------------------------- Mb0203|M.bovis_AF2122/97 -------------------------------------------------- Rv0197|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_3639|M.marinum_M IANR--PQGYTKKRPLLTSVMRNTTLSRPRSAKDVRQLVFRVPEQTVSYE MUL_1474|M.ulcerans_Agy99 IASR--PQGYTKKRPLLTSVMRNTTLSRPRSAKDVRQLVFRVPEQTVSYE MAV_2075|M.avium_104 RPNTPAPHTYSKKHPLITDMVRNTTLNGPKSTKDVRHLVFNLPEDAVSYE MAB_2438|M.abscessus_ATCC_1997 GLRVAAPERFTRDAPILAALSHNELLSAPNSGKEVRRIEFDLTGHDVSYS Mflv_3016|M.gilvum_PYR-GCK PAVPAAPAPFTRGNPAQAPLCRNVRLTPDGAGKDVRQFGFDISGQDLAYS Mvan_3491|M.vanbaalenii_PYR-1 AAPAQEPTLFTRAEPVAAPLCRNTRLTPQGAAKEVRQIGFDISAHDVTYS TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 -------------------------------------------------- Mb0203|M.bovis_AF2122/97 -------------------------------------------------- Rv0197|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_3639|M.marinum_M AGDALGVWPRNAHQLVDEWLGVTQLDGHTEVEVAGHGTMSLRAALTDRFE MUL_1474|M.ulcerans_Agy99 AGDALGVWPRNAHQLVDEWLGVTRLDGHTEVEVAGHGTMSLRAALTDRFE MAV_2075|M.avium_104 AGDALGVWPRNSDELVDEWLAVTGLDGQTPVEVGEHGLMSLRSALTERIE MAB_2438|M.abscessus_ATCC_1997 AGDALGIYPTNREEDVQRWLTTTGFDAQLPVTIDG-GELPLATALANHYD Mflv_3016|M.gilvum_PYR-GCK VGDSLGVWVVNSDAVVESWLSATGFHGAEAVIVDG-RQISLREALTRHYD Mvan_3491|M.vanbaalenii_PYR-1 VGDSLGVCVVNSDFVVENWLAATDLRGDEAVVVDG-VQQALRDALTAHYD TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 -------------------------------------------------- Mb0203|M.bovis_AF2122/97 -------------------------------------------------- Rv0197|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_3639|M.marinum_M IAHLSPDLLRFVAQRTLDSNTANQLAELMRPENKAALADWTWGRQSVDLL MUL_1474|M.ulcerans_Agy99 IAHLSPDLLRFVAQRTLDSNTANQLAELMRPENKAALADWTWGRQSVDLL MAV_2075|M.avium_104 IAHISRDLVRFVQERTGDA----KLAELLKPENKRALADWTWGRQSIDLL MAB_2438|M.abscessus_ATCC_1997 ICRVTEDLLRFIAERRRDK----HSAKLLQGRDTQAREVWLRGRNALDVI Mflv_3016|M.gilvum_PYR-GCK VCKVTSNLVTFVAEHCPDA-----ATAKRLRNDRGALDTWLVDRNGLDLV Mvan_3491|M.vanbaalenii_PYR-1 VCKVTSNLVKFVAEHCRDA-----ATAKRLRNDRGELDRWLVNRNGLDLV TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 -------------------------------------------------- Mb0203|M.bovis_AF2122/97 -------------------------------------------------- Rv0197|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_3639|M.marinum_M AQSPVRASVDEWMSVLKPIQPRLYSISSSPKEHPGEVHLTVSPVRYN-FQ MUL_1474|M.ulcerans_Agy99 AQSPVRASVDEWMSVLKPIQPRLYSISSSPKEHPGEVHLTVSPVRYN-FQ MAV_2075|M.avium_104 AQLPVSASAHEWLRVLKRLQPRLYSISSSPKACPGEVHLTVSPVRYN-FQ MAB_2438|M.abscessus_ATCC_1997 REFPIRAAIEEWQQVLIRLTPRQYSISSSPLVSPQAISLTVSIVRYQGPD Mflv_3016|M.gilvum_PYR-GCK REFGIRADPALWQEVLVRLTPRQYSISSSPLVSPHEVQLTVSVVRYRGAD Mvan_3491|M.vanbaalenii_PYR-1 REFSVRADPQLWQEVLVRLTPRQYSISSSPLVSPNEVQLTVSVVRYRGAD TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 -------------------------------------------------- Mb0203|M.bovis_AF2122/97 -------------------------------------------------- Rv0197|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_3639|M.marinum_M GVPRRGVCSTYLADRSPSDQIAIYVRKSSNFRPPSDPRTPMIMIGPGTGI MUL_1474|M.ulcerans_Agy99 GVPRRGVCSTYLADRSPSDQIAIYVRKSSNFRPPSDPRTPMIMIGPGTGI MAV_2075|M.avium_104 GVPRRGVCSTYLAARSPGDRVAVYLQPSSNFRPPSDPDTPMIMIGPGTGI MAB_2438|M.abscessus_ATCC_1997 GSPRGGVGSTFLADRAQHLPVPIFLQRSPHFRPPRTSDTPMIMIGPGTGI Mflv_3016|M.gilvum_PYR-GCK GTPRGGVASTYLADLPDCTPVPVFLQRSPHFRPPEDPHTPMIMVGPGTGI Mvan_3491|M.vanbaalenii_PYR-1 GGPRGGVASTYLADLPDGTAVPVFLQRSPHFRPPQDSHTPMIMVGPGTGI TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 -------------------------------------------------- Mb0203|M.bovis_AF2122/97 -------------------------------------------------- Rv0197|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_3639|M.marinum_M APFRGFLQERRALGHTGPNWLFFGEQHAATDFYYRDEIQAMHRDGLLTNL MUL_1474|M.ulcerans_Agy99 APFRGFLQERRALGHTGPNWLFFGEQHAATDFYYRDEIQAMHRDGLLTNL MAV_2075|M.avium_104 APFRGFLQERRALGHRGPNWLFFGEQHAATDFYYRDELEQMREDGFLTEL MAB_2438|M.abscessus_ATCC_1997 APFRGFLQERRALGHTGANWLFFGDQHRTEHFYYRDELDGFLRDGSLRRL Mflv_3016|M.gilvum_PYR-GCK APFRGFLQERRALGHRGANWLFFGDQHREQNFYYRDDLLDMVDDGFLNRL Mvan_3491|M.vanbaalenii_PYR-1 APFRGFLQERRALGHRGPNWLFFGDQHRAQNFYYRDDLQDMVDDGFLNRL TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 -------------------------------------------------- Mb0203|M.bovis_AF2122/97 -------------------------------------------------- Rv0197|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_3639|M.marinum_M DLAFSRDQRDKVYVQHLMQQRGAQLWQWLQDGAQVYVCGTADPMAKDVDR MUL_1474|M.ulcerans_Agy99 DLAFSRDQRDKVYVQHLMQQRGAQLWQWLQDGAQVYVCGTADPMAKDVDR MAV_2075|M.avium_104 DLAFSRDQQHKVYVQHLMRNRGKQLWSWLQDGAQLYVCGTADPMAKDVDR MAB_2438|M.abscessus_ATCC_1997 DLAFSRDQAKRIYVQHRMMEQGAQLWRWLNEGAHLYVCGDASRMAKDVDG Mflv_3016|M.gilvum_PYR-GCK DLAFSRDQRQRIYVQHKMLDYGADVWRWLDDGAHFYVCGDATRMAKDVDD Mvan_3491|M.vanbaalenii_PYR-1 DLAFSRDQARRVYVQHKMLDYGADVWRWLDDGAHFYVCGDATRMAGDVDD TH_4553|M.thermoresistible__bu -------------------------------------------------- MSMEG_2837|M.smegmatis_MC2_155 -------------------------------------------------- Mb0203|M.bovis_AF2122/97 -------------------------------------------------- Rv0197|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_3639|M.marinum_M MLCQIVAEHGGLDPESATAFVHALSADKRYHRDVY MUL_1474|M.ulcerans_Agy99 MLCQIVAEHGGLDPESATAFVHALSADKRYHRDVY MAV_2075|M.avium_104 ALCDIAAEFGNLDPDAAKAYVQSLSADKRYHRDVY MAB_2438|M.abscessus_ATCC_1997 ALLTIAQKHGKLSGEQALEFRKELVAEKRYVRDVY Mflv_3016|M.gilvum_PYR-GCK ALTEILRTHARMSSDAAREYKREMVAEKRYVRDVY Mvan_3491|M.vanbaalenii_PYR-1 ALTEIIRTHGGMSADAARDYKREMVAEKRYVRDVY TH_4553|M.thermoresistible__bu ----------------------------------- MSMEG_2837|M.smegmatis_MC2_155 ----------------------------------- Mb0203|M.bovis_AF2122/97 ----------------------------------- Rv0197|M.tuberculosis_H37Rv -----------------------------------