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M. marinum M MMAR_3639 (fdhF)

annotation: formate dehydrogenase H FdhF
coordinates: 4478460 - 4482668
length: 1402

MAPNKDAVKTVCAYCGVGCGIVLQTTTDPQTGKRRVAKSTGDKSHPANLGRLCTKGTTTADLLAAPGRME
SAHLRAHRAGHLESIPIDDAITQCAMRLRAIIDEHGPDAVGVYVSGQMSIEAQYLANKLTKGFIGTNQIE
SNSRLCMAGASSGYKLSLGADGPPGSYQDFDHADVFLVIGANMADCHPILFLRMMERVKSGAKLIVVDPR
RTATADKADLFLQIAPGTDLALLNGLLHLIVENEQTDPQFISEFTEGWEVMPSFLEQFTPDRVSEITGIP
SEDIRTAARWIGTAANWMSCWTMGLNQSTHGTWNTNALCNLHLATGAICRPGSGPFSLTGQPNAMGGREM
GYMGPGLPGQRSVLSAPDREFVEEQWGLPGGALRTDVSGGVIDMFSRMADGEIKACWIICSNPVATVANR
KTVLAGLEKAELVISQDAFFETETNEYANVLLPAALWTESDGVMVNCERNMSLFPKAVDPVGDALPDWQI
IARIACEMGFSESFSYSSAAEVFEEIKRFSNPATGYDLRGISHDRLRETPLQWPCPPDGASNRSPIRYLN
DGVSQLQFVRADGTVPRLAFPTATGRAVFFARPHLVPDEMPDGDYPFLLNTGRLAHQWHTLTKTGKIAKL
NKLNPGPFVEVHPDDAADMQICEGDHIEIASRRGRAVLPVVITDRVRPGNCFAPFHWNDAFGEYLSINAV
TNDAVDPISRQPEYKACAVTLTKVARPQLQPEPGEPADTCADATAPKLLADTAQFSVTQVDALAELLGVA
NEPTPQFGPFARSYLAGLIAGLRSETGRRMAGVPTLPVSSPFDTGTRLWLDGLLAGMFARAETPPALPFP
QTPGAAAQSDNAAEAAVEQPPIVVLWASQTGTAEELAASVAAQLSAAELPVVLHGMDEFAVADLVSTQRL
LLVTSTTGDGEPPDNGAAFWRELCAATAPSLAGTRYSVLALGDSNYADFCGHGRALDHRLAELGASRVTD
RVDCEPDYEESAARWLQEVLDGLRRTAPPVITAAPVRAASIANRPQGYTKKRPLLTSVMRNTTLSRPRSA
KDVRQLVFRVPEQTVSYEAGDALGVWPRNAHQLVDEWLGVTQLDGHTEVEVAGHGTMSLRAALTDRFEIA
HLSPDLLRFVAQRTLDSNTANQLAELMRPENKAALADWTWGRQSVDLLAQSPVRASVDEWMSVLKPIQPR
LYSISSSPKEHPGEVHLTVSPVRYNFQGVPRRGVCSTYLADRSPSDQIAIYVRKSSNFRPPSDPRTPMIM
IGPGTGIAPFRGFLQERRALGHTGPNWLFFGEQHAATDFYYRDEIQAMHRDGLLTNLDLAFSRDQRDKVY
VQHLMQQRGAQLWQWLQDGAQVYVCGTADPMAKDVDRMLCQIVAEHGGLDPESATAFVHALSADKRYHRD
VY
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_3639fdhF-100% (1402)formate dehydrogenase H FdhF
M. marinum MMMAR_2605-2e-3324.45% (724) anaerobic dehydrogenase
M. marinum MMMAR_0437-9e-2926.67% (510) oxidoreductase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0203-7e-2725.54% (509) oxidoreductase
M. gilvum PYR-GCKMflv_3016-0.053.94% (1396) molybdopterin oxidoreductase
M. tuberculosis H37RvRv0197-1e-2625.54% (509) oxidoreductase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_2438-0.063.97% (730) oxidoreductase
M. avium 104MAV_2075-0.074.43% (1412) FdhF protein
M. smegmatis MC2 155MSMEG_2837-5e-9432.28% (728) nitrate reductase NarB
M. thermoresistible (build 8)TH_4553-5e-5558.89% (180) PUTATIVE sulfite reductase (NADPH) alpha subunit
M. ulcerans Agy99MUL_1474fdhF0.099.22% (1402) formate dehydrogenase H FdhF
M. vanbaalenii PYR-1Mvan_3491-0.054.80% (1396) molybdopterin oxidoreductase

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_3639|M.marinum_M               ------------------------------MAPNKDAVKTVCAYCGVGCG
MUL_1474|M.ulcerans_Agy99           ------------------------------MAPNKDAVKTVCAYCGVGCG
MAV_2075|M.avium_104                -------------------------------------MNTMCAYCGVGCG
MAB_2438|M.abscessus_ATCC_1997      --------------------------------------------------
Mflv_3016|M.gilvum_PYR-GCK          ------------------------------------MTRTACSYCGVGCG
Mvan_3491|M.vanbaalenii_PYR-1       ------------------------------------MTRTACSYCGVGCG
TH_4553|M.thermoresistible__bu      ---------------------------VATGRGGADCVRTACSYCGVGCG
MSMEG_2837|M.smegmatis_MC2_155      MARTDRISDPWGSRTPYAAGEPWPQRVDRYLTPGLTDDDVDRWVQSAAVL
Mb0203|M.bovis_AF2122/97            -------------------------------MTSSDWLPTACILCECNCG
Rv0197|M.tuberculosis_H37Rv         -------------------------------MTSSDWLPTACILCECNCG
                                                                                      

MMAR_3639|M.marinum_M               IVLQTTTDPQTGKRRVAKSTGDKSHPANLGRLCTKGTTTADLLAAP-GRM
MUL_1474|M.ulcerans_Agy99           IVLQTTTDPQTGKRRVAKSTGDKSHPANLGRLCTKGTTTADLLAAP-GRM
MAV_2075|M.avium_104                MVLQITTDPQTGRRHVAKSVGNKEHPANFGRLCTKGATTADLLAAP-GRM
MAB_2438|M.abscessus_ATCC_1997      ---MRTDAHAAGPVTVATVEGDVLHPSNQGRLCTKGATHAQLMAAD-GRM
Mflv_3016|M.gilvum_PYR-GCK          ISVETRTDPASGVPVIARVSGDKLHPTNFGRLCTKGATHAEMMAATDGRL
Mvan_3491|M.vanbaalenii_PYR-1       ISVETRTDPATGVPVIARVTGDKLHPSNFGRLCTKGATHAEMMAATDGRL
TH_4553|M.thermoresistible__bu      IEVRTTPGPAG--PVIAGVAGDPLHPTNRGRLCTKGATHAELMGSTKGRA
MSMEG_2837|M.smegmatis_MC2_155      HSNGDGLDIAVKDGRIVGVRGRADDRVNHGRLDPKDLFGWQANHAR-DRL
Mb0203|M.bovis_AF2122/97            IVVQVDD------RRLARIRGDKAHPGSAGYTCNKALRLDHYQNNR--AR
Rv0197|M.tuberculosis_H37Rv         IVVQVDD------RRLARIRGDKAHPGSAGYTCNKALRLDHYQNNR--AR
                                                   :.   *   .  . *    *     .         

MMAR_3639|M.marinum_M               ESAHLRAHRAGHLESIPIDDAITQCAMRLRAIIDEHGPDAVGVYVSGQMS
MUL_1474|M.ulcerans_Agy99           ESAHLRAHRAGHLESIPIDDAITQCAMRLRAIIDEHGPDAVGVYVSGQMS
MAV_2075|M.avium_104                DSAHARAGRGEPLEPIGTDQAITRCAKQLRAIIDEHGPDAFAMYVSGQMS
MAB_2438|M.abscessus_ATCC_1997      TTAHLRSIRGQQPIPAPLAAATAEAGRRLREILDNHGPDAIALYVSGQMT
Mflv_3016|M.gilvum_PYR-GCK          TTALVRPSRDADPVALDVDDAVAEAGSRLRAIVDEHGPDAVALYVSGQMS
Mvan_3491|M.vanbaalenii_PYR-1       TTALLRPSRDAEPVATDVDDALAEAGARLRAILDEHGPDAVALYVSGQMS
TH_4553|M.thermoresistible__bu      LTALIRPRRGEPPVPAPVDDAVAAAGQRLRAILDTHGPDAIALYVSGQLS
MSMEG_2837|M.smegmatis_MC2_155      RTPLIR--QDGVLVESDWDTAMDRIVARSRQLLDERGPNSIGFYTSGQLF
Mb0203|M.bovis_AF2122/97            LSSPMRRRADGTYEEIDWDTAIVEIAEGFKQIRDTHGGDKIFYYGGGGQ-
Rv0197|M.tuberculosis_H37Rv         LSSPMRRRADGTYEEIDWDTAIVEIAEGFKQIRDTHGGDKIFYYGGGGQ-
                                     :.  *              *        : : * :* : .  * .*   

MMAR_3639|M.marinum_M               IEAQYLANKLTKGFIGTNQIESNSRLCMAGASSGYKLSLGADGPPGSYQD
MUL_1474|M.ulcerans_Agy99           IEAQYLANKLTKGFIGTKQIESNSRLCMAGASSGYKLSLGADGPPGSYQD
MAV_2075|M.avium_104                LEAQYLANKLTKGFIGTNQIESNSRLCMASAGSGYKLSLGADGPPGSYQD
MAB_2438|M.abscessus_ATCC_1997      LEAQYLANKLAKGYIRTTHIESNSRLCMASAGTGYAQSLGADGPPGSYSD
Mflv_3016|M.gilvum_PYR-GCK          IEAQYLATKLAKGFLRTVHIESNSRLCMASAGTGYKQSLGSDGPPGSYTD
Mvan_3491|M.vanbaalenii_PYR-1       IEAQYLATKLAKGFLRTVHIESNSRLCMASAGTGFKQSLGADGPPGSYTD
TH_4553|M.thermoresistible__bu      LEAQYLATKLAKGFIRTAHLEANSRLCMASAASGYKQSLGADGPPGSYDD
MSMEG_2837|M.smegmatis_MC2_155      LEEYYTQCVIAHGAIGTNHVDGNTRLCTATAAEALKESFGCDGQPGSYTD
Mb0203|M.bovis_AF2122/97            --GNHLGGAYSGAFLKALGSRYRSNALAQEKTGEAWVDFQLYGG-HTRGE
Rv0197|M.tuberculosis_H37Rv         --GNHLGGAYSGAFLKALGSRYRSNALAQEKTGEAWVDFQLYGG-HTRGE
                                        :     : . : :     .:.            .:   *   :  :

MMAR_3639|M.marinum_M               FDHADVFLVIGAN--MADCHPILFLRMMERVKSG--AKLIVVDPRRTATA
MUL_1474|M.ulcerans_Agy99           FDHADVFLVIGAN--MADCHPILFLRMMERVKSG--AKLIVVDPRRTATA
MAV_2075|M.avium_104                FEHADVFFVIGAN--MADCHPILFLRMMDRVKAG--AKLIVVDPRRTATA
MAB_2438|M.abscessus_ATCC_1997      IEHSDLFFVIGAN--MADCHPILFLRMADRLSSG--ARLIVVDPRRTATA
Mflv_3016|M.gilvum_PYR-GCK          FDCTNLFFVIGSN--MADCHPILYLRMADRLKAG--ARLIVVDPRRTATA
Mvan_3491|M.vanbaalenii_PYR-1       FDCTDLFFVIGSN--MADCHPILYLRMADRLKAG--AKLIVVDPRRTATA
TH_4553|M.thermoresistible__bu      IDRADLFFVIGAN--MAPWP-----RSATSTRS--------VAPR-----
MSMEG_2837|M.smegmatis_MC2_155      VDHADVIALYGHN--VAETQTVLWMRMLDRLAGPNPPAIVCIDPRPTPVA
Mb0203|M.bovis_AF2122/97            FENAEVSVFVGKNPWMSQSFPRARVVLNEIAKDPG-RSMIVIDPVVTDTA
Rv0197|M.tuberculosis_H37Rv         FENAEVSVFVGKNPWMSQSFPRARVVLNEIAKDPG-RSMIVIDPVVTDTA
                                    .: :::  . * *  ::                        : *      

MMAR_3639|M.marinum_M               DKADLFLQIAPGTDLALLNGLLHLIVENEQTDPQFISEFTEGWEVMPSFL
MUL_1474|M.ulcerans_Agy99           DKADLFLQIAPGTDLALLNGLLHLIVENEQTDPQFISEFTEGWEVMPSFL
MAV_2075|M.avium_104                EKADLFLQIAPGTDLALLNGLLHLIVENGHTDGEFIAEFTEGWEVMPSFL
MAB_2438|M.abscessus_ATCC_1997      DRADLFLQITPGTDLALLNGLLHLLVENGAVDAEFIAQHTEGWDGMPEFL
Mflv_3016|M.gilvum_PYR-GCK          DKADLYLPIRPGTDLALLNGILRVLVQDGAIDEAFIAEHTEGWEAMPAFL
Mvan_3491|M.vanbaalenii_PYR-1       DKADLYLPIRPGTDLALLNGILHLLVENGAVDQEFIAEHTQGWESMPEFL
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      RHATVHLAPLPGTNVALMNGLLHEILDHDWMDHDYIEAHTVGFHELRKRV
Mb0203|M.bovis_AF2122/97            KMADFHLRVQPGCDAWCLAALAAVLVQENLCNEAFLAAHVHGVDTVRAAL
Rv0197|M.tuberculosis_H37Rv         KMADFHLRVQPGCDAWCLAALAAVLVQENLCNEAFLAAHVHGVDTVRAAL
                                                                                      

MMAR_3639|M.marinum_M               EQFTPDRVSEITGIPSEDIRTAARWIGTAANWMSCWTMGLNQSTHGTWNT
MUL_1474|M.ulcerans_Agy99           EQFTPDRVSEITGIPSEDIRTAARWIGTAANWMSCWTMGLNQSTHGTWNT
MAV_2075|M.avium_104                EQYTPDRVSEITGIPEQDIRAAAQLIGEADNFMSCWTMGLNQSTHGTWNT
MAB_2438|M.abscessus_ATCC_1997      AGYAPAVVAAITGLAEEDIRTAARWIGEAREWMTLWTMGLNQSTHGTWNT
Mflv_3016|M.gilvum_PYR-GCK          ADYPPSRVAEITGLAEADIRSAAAMIAEAGDWISCWTMGLNQSTHGTWNT
Mvan_3491|M.vanbaalenii_PYR-1       AGYPPDRVAAITGLSEADIRAAADMIAEAGDWLSCWTMGLNQSTHGTWNT
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      AEFPPERVADICGVDPDDVRRAGELIGTAERLLSTVLQGFYQSHQATAAA
Mb0203|M.bovis_AF2122/97            QEVPVADYAQRCGVDEELLRAAARRIGTAASVSVFEDLGIQQAPNSTVCS
Rv0197|M.tuberculosis_H37Rv         QEVPVADYAQRCGVDEELLRAAARRIGTAASVSVFEDLGIQQAPNSTVCS
                                                                                      

MMAR_3639|M.marinum_M               NALCNLHLATGAICRPGSGPFSLTGQPNAMGGREMGYMGPGLPGQRSVLS
MUL_1474|M.ulcerans_Agy99           NALCNLHLATGAICRPGSGPFSLTGQPNAMGGREMGYMGPGLPGQRSVLS
MAV_2075|M.avium_104                NAICNLHLATGAICKPGSGPFSLTGQPNAMGGREMGYMGPGLPGQRSVAS
MAB_2438|M.abscessus_ATCC_1997      NAICNLHLATGAICRPGSGPFSLTGQPNAMGGREMGYMGPGLPGQRSVKS
Mflv_3016|M.gilvum_PYR-GCK          NAICNLHLATGAICRPGAGPMSLTGQPNAMGGREMGYMGPGLPGQRAVLS
Mvan_3491|M.vanbaalenii_PYR-1       NAICNLHLATGAICRPGSGPMSLTGQPNAMGGREMGYMGPGLPGQRSVAS
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      VQVNNIHLVRGMLGRPGCGLLQMNGQPTAENTRECGADG-DLAGFRNWAN
Mb0203|M.bovis_AF2122/97            YLNKLLWILTGNFAKKGGQHLHSSFAPLFSQVSGRTPVTGAPIIAGLIPG
Rv0197|M.tuberculosis_H37Rv         YLNKLLWILTGNFAKKGGQHLHSSFAPLFSQVSGRTPVTGAPIIAGLIPG
                                                                                      

MMAR_3639|M.marinum_M               APDREFVEEQWGLPGGALRTDVS-GGVIDMFSRMADGEIKACWIICSNPV
MUL_1474|M.ulcerans_Agy99           APDREFVEEQWGLPGGALRTDVS-GGVIDMFSRMADGEIKACWIICSNPV
MAV_2075|M.avium_104                AADREFVEDVWGVPRGRLRTEVG-TGTIDMFSRMADGQIKACWIICTNPV
MAB_2438|M.abscessus_ATCC_1997      PADRDFVEKRWQLPPGSIRAEFG-TGTVDMFAQMAAGNIKACWIICTNPV
Mflv_3016|M.gilvum_PYR-GCK          AEDRSFVETQWDLEPGTVRTEVG-PGTVEMFRRIAGGDIKAVWIICTNPV
Mvan_3491|M.vanbaalenii_PYR-1       AADRAFVEEQWDLEPGTIRADIG-PGTVEMFRQMGSGDIKAAWIICTNPV
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      DSHIEELATLWNLDVTAIPHYAPPTHAMQMFRYAEEGSLRMLWVSATNPA
Mb0203|M.bovis_AF2122/97            NVVPEEILTEHPDRFRAMIVESGNPAHSLADSAACRAAFQALELMVVVDV
Rv0197|M.tuberculosis_H37Rv         NVVPEEILTEHPDRFRAMIVERGNPAHSLADSAACRAAFQALELMVVVDV
                                                                                      

MMAR_3639|M.marinum_M               ATVANRKTVLAGLEKAELVISQDAFFETETNEYANVLLPAALWTESDGVM
MUL_1474|M.ulcerans_Agy99           ATVANRKTVLAGLEKAELVISQDAFFETETNEYANVLLPAALWTESDGVM
MAV_2075|M.avium_104                ASVANRKTVLAGLERAELVIAQDAYLGTETSEYADVLLPAALWAETEGVM
MAB_2438|M.abscessus_ATCC_1997      ASVANRKNVVDGLRRAELVIAQDAFLATATNEYADILLPAALWAESDGVS
Mflv_3016|M.gilvum_PYR-GCK          ASVANRDTVITGLQSAELVITQDAYVDTATNRYADIMLPATLWAEADAVM
Mvan_3491|M.vanbaalenii_PYR-1       ASVANRDAVVAGLSTAELVITQDVYADTATNRYADIVLPATLWAETDAVM
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      VSLPELGRIRRILSQDRLFLVVQDLFLTETAQLADVVLPAAAWAEKTGTF
Mb0203|M.bovis_AF2122/97            AMTETARLAHYVLPAASQFEKPEATFFNFEFPRNGFQLRRPLFPPLPGTL
Rv0197|M.tuberculosis_H37Rv         AMTETARLAHYVLPAASQFEKPEATFFNFEFPRNGFQLRRPLFPPLPGTL
                                                                                      

MMAR_3639|M.marinum_M               VNCERNMSLFPKA-VDPVGDALPDWQIIARIACEMGFSESFS-----YSS
MUL_1474|M.ulcerans_Agy99           VNCERNMSLFPKA-VDPVGDALPDWQIIARIACEMGFSESFS-----YSS
MAV_2075|M.avium_104                VNSERNITLSQPA-VAAPGGAMPDWQIIARIACEMGFSEAFS-----YSC
MAB_2438|M.abscessus_ATCC_1997      INSERTATLTNRA-VEAPGDARPDWQLICDIATAMGFGDAFG-----YSS
Mflv_3016|M.gilvum_PYR-GCK          VNSGRTLTLLAQS-VPAAGDARPDWELICGVARHLGFGDAFD-----HKS
Mvan_3491|M.vanbaalenii_PYR-1       VNSDRNLTLLQQS-VPPVGDARPDWELICGVARHLGFGDAFD-----YKS
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      TNADRTVHISDKA-VDPPGQARSDFDIFLDYARRMDFRDRDGRPLPAWNT
Mb0203|M.bovis_AF2122/97            PEPEIWARLVRALGVVDEADLRPLREAAAQGRQAYTEAFLAAAATNPTVA
Rv0197|M.tuberculosis_H37Rv         PEPEIWARLVRALGVVDEADLRPLREAAAQGRQAYTEAFLAAAATNPTVA
                                                                                      

MMAR_3639|M.marinum_M               AAEVFEEIKRFSNPATGYDLRGISHDRLR-ETPLQWPCPPDGASNRSPIR
MUL_1474|M.ulcerans_Agy99           AAEVFEEIKRFSNPATGYDLRGISHDRLR-ETPLQWPCPPDGASNRSPIR
MAV_2075|M.avium_104                AEEVFEEIKRFWNPTTGYDLRGVSYERLR-RQPLQWPCPPQSTADRNPIR
MAB_2438|M.abscessus_ATCC_1997      SEEIFEEIRAFWNPRTGYDMRGMSYARLR-QGPVQWPCPPESEVDRNPIR
Mflv_3016|M.gilvum_PYR-GCK          SEEIFDEIRRFHNPRTGYDLRGVTYERLR-ATPVQWPCPSEDAPDRNPIR
Mvan_3491|M.vanbaalenii_PYR-1       SEQIFDEIRRFHNPGTGYDLRGITYERLR-DTPVQWPCASAEQSDRNPIR
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      PDEAFEAWKRCSAGRP-CDYTGLSYEKLRGSGGIQWPCNAEHPDGVERLY
Mb0203|M.bovis_AF2122/97            KLTAYVLYETLGPTLPDGLAGAAALWGLAQKTAMAYPDAVRRAGHADGNA
Rv0197|M.tuberculosis_H37Rv         KLTAYVLYETLGPTLPDGLAGAAALWGLAQKTAMAYPDAVRRAGHADGNA
                                                                                      

MMAR_3639|M.marinum_M               YLNDGVSQLQFVRADG---------TVPRLAFPTATGRAVFFARPHLVPD
MUL_1474|M.ulcerans_Agy99           YLNDGVSQLQFVRADG---------TVPRLAFPTATGRAVFFARPHLVPD
MAV_2075|M.avium_104                YLNDGVSQTQLVREDG---------TVPRLAFPTPSGRAVFFARPHLQPE
MAB_2438|M.abscessus_ATCC_1997      YLNDGISQHPHVDENG---------VVPRLAFPTPSRRAVFHARAHRDPA
Mflv_3016|M.gilvum_PYR-GCK          YLNDGVSQDLHIDDDG---------HIPRLAFATPSRRAVFHPRPHLDAA
Mvan_3491|M.vanbaalenii_PYR-1       YLNDGVSQDQYVGPDG---------HRPRLAFPTPSRRAVFHPRPHMDAA
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      AGGEFFAAPDYCEAYGKDLITGAPLEPTEYRAMNPFGKAIIKAAEYVPPH
Mb0203|M.bovis_AF2122/97            LFDAILERPSGVTFTVHN-------YEDDFALISHPDHKIALEIPEMLAE
Rv0197|M.tuberculosis_H37Rv         LFDAILERPSGVTFTVHN-------YEDDFALISHPDHKIALEIPEMLAE
                                                                                      

MMAR_3639|M.marinum_M               EMPDGDYPFLLNTGRLAHQWHTLTKTG-------KIAKLNKLNPGPFVEV
MUL_1474|M.ulcerans_Agy99           EMPDGDYPFLLNTGRLAHQWHTLTKTG-------KIAKLNKLNPGPFVEV
MAV_2075|M.avium_104                EMPDDDYPFLLNTGRLPHQWHTMTKTG-------KVAKLNKLNPGPFVEI
MAB_2438|M.abscessus_ATCC_1997      ELPGEGYPVVLNTGRLQHHWHTLTKTG-------RIKTLDRLHPSPFVEI
Mflv_3016|M.gilvum_PYR-GCK          ELPDDDYPFILNTGRLQHQWHTMTKTG-------RVAKLTKLNPAPFVEI
Mvan_3491|M.vanbaalenii_PYR-1       ELPDDDYPLVLNTGRLQHQWHTMTKTG-------KVAKLNKLNPGPFVEI
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      ERPSAEYPCVLITGRTVYHFHTRTKTG-------RTPQLQAAAPEVWVEL
Mb0203|M.bovis_AF2122/97            IRSLTQTPSRLTTPQLPIVLSVGERRAYTANDIFRDPSWRKRDANGALRV
Rv0197|M.tuberculosis_H37Rv         IRSLTQTPSRLTTPQLPIVLSVGERRAYTANDIFRDPSWRKRDANGALRV
                                                                                      

MMAR_3639|M.marinum_M               HPDDAADMQICEGDHIEIASRRGRAVLPVVITDRVRPGNCFAPFHWN---
MUL_1474|M.ulcerans_Agy99           HPDDAADMQICEGDHIEIASRRGRAVLPVVITDRVRPGNCFAPFHWN---
MAV_2075|M.avium_104                HPDDAARLGIGEHDRVEIASRRGRAVLPAVVSDRVRPGNCFAPFHWN---
MAB_2438|M.abscessus_ATCC_1997      HPHDATTLGISDGDIVEIASRRGTAELPALVSDRVKRGSCFAPFHWN---
Mflv_3016|M.gilvum_PYR-GCK          HPSDAAALGITDGQDLELRTRRGRAVLPAVLTERVRPGNTWAPFHWN---
Mvan_3491|M.vanbaalenii_PYR-1       HPDDAAALGISGGHDVELVTRRGRAVLPAVLTDRVQPGNTWVPFHWN---
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      ARADALRAGIVEGDLVEIRTVRGCVTAAARLTD-LRRGVVFLPFHYGYWD
Mb0203|M.bovis_AF2122/97            SVEDAQALGLADGCLARITTAAGSAEATVEVTETMLAGHAALPNGFG---
Rv0197|M.tuberculosis_H37Rv         SVEDAQALGLADGCLARITTAAGSAEATVEVTETMLAGHAALPNGFG---
                                                                                      

MMAR_3639|M.marinum_M               -----DAFGEYLSINAVTNDAVDPISRQPEYKACAVTLTKVARPQLQPEP
MUL_1474|M.ulcerans_Agy99           -----DAFGEYLSINAVTNDAVDPISRQPEYKACAVTLTKVARPQLQPEP
MAV_2075|M.avium_104                -----DAFGEYLSINAVTNDAVDPISNQPEFKACAVTLTKVAVSHPDSAI
MAB_2438|M.abscessus_ATCC_1997      -----DAHGPGLTINAVTNDAVDPDSLQPEFKVSAVALRPTGRTKADSMP
Mflv_3016|M.gilvum_PYR-GCK          -----DEHGENLTINALTNDAVDPDSLQPEFKVCAVRLTPVPAADGAPDL
Mvan_3491|M.vanbaalenii_PYR-1       -----DEHGDHLTVNALTNDAVDPDSLQPEFKVCAVRLAPVPAAG-APEF
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      TGDDGGKDGHHRAANELTLTDWDPVSKQPIFKTAAASVR-----------
Mb0203|M.bovis_AF2122/97            --LDYTGDDGRTVVAGVAPNALTSTRWRDPYAG-----------------
Rv0197|M.tuberculosis_H37Rv         --LDYTGDDGRTVVAGVAPNALTSTRWRDPYAG-----------------
                                                                                      

MMAR_3639|M.marinum_M               GEPADTCADATAPKLLADTAQFSVTQVDALAELLGVANEPTPQFGPFARS
MUL_1474|M.ulcerans_Agy99           GEPADACADATAPKLLADTAQFSVTQVDALAELLGVGNEPTPQFGPSARS
MAV_2075|M.avium_104                G-TGPSAGHDTPESAPTEVREISVSQVDALGELLGVATSFKPEFNELGRS
MAB_2438|M.abscessus_ATCC_1997      E-----------------------KQKEALGD------------------
Mflv_3016|M.gilvum_PYR-GCK          T------------------------------------------------D
Mvan_3491|M.vanbaalenii_PYR-1       T------------------------------------------------E
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      --------------------------------------------------
Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
                                                                                      

MMAR_3639|M.marinum_M               YLAGLIAGLRSETGRRMAGVPTLPVSSPFDTGTRLWLDGLLAGMFARAET
MUL_1474|M.ulcerans_Agy99           YLAGLIAGLRSETGRRMAGVSTLPISSPFDTGTRLWLDGLLAGMFARAET
MAV_2075|M.avium_104                YLAGMLTGLRSDVGRRAGGVPTLPPSAPFDSRTRLWVDGLLAGLFSRADA
MAB_2438|M.abscessus_ATCC_1997      --------------------------------------------------
Mflv_3016|M.gilvum_PYR-GCK          DEKLYIAGFLAGVDEGRPGVPVLPAGAPVGARARLWVDGLLAGRYSRLET
Mvan_3491|M.vanbaalenii_PYR-1       TEKLYLAGFFAGIEEGLPGVPVLPASAPVGPRARLWVDGLLAGRYSRSDT
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      --------------------------------------------------
Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
                                                                                      

MMAR_3639|M.marinum_M               PPALPFPQTPGAAAQSDNAAEA----AVEQPPIVVLWASQTGTAEELAAS
MUL_1474|M.ulcerans_Agy99           PPALPFPQTPGAAAQSDNAAEA----AVEQPPIVVLWASQTGTAEELAAS
MAV_2075|M.avium_104                SQQAALPEPPQPAAQQPPAAPAGATPAPERAPVVVLWASQTGNAEELAAD
MAB_2438|M.abscessus_ATCC_1997      --------------------------------VAILWTSQTGNAETAAVS
Mflv_3016|M.gilvum_PYR-GCK          AAPS----------------------ASPRGGPLVLWASQTGTAEEFAGS
Mvan_3491|M.vanbaalenii_PYR-1       VAET----------------------PATEG-PLVLWASQTGNAEEFAGR
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      ----------------------------------RIGAGMAATPEPVAHA
Mb0203|M.bovis_AF2122/97            ----------------------------------TPWHKHVPAAIRRADA
Rv0197|M.tuberculosis_H37Rv         ----------------------------------TPWHKHVPAAIRRADA
                                                                                      

MMAR_3639|M.marinum_M               VAAQLSAAELPVVLHGMDEFAVADLVSTQRLLLVTSTTGDGEPPDNGAAF
MUL_1474|M.ulcerans_Agy99           VAAQLSAAELPVVLHGMDEFAVADLVSTQRLLLVTSTTGDGEPPDNGAAF
MAV_2075|M.avium_104                VAAQLAAAELPVALHSMDDFPAAELAATRELLLITSTTGDGDAPDNGSGL
MAB_2438|M.abscessus_ATCC_1997      VHRLLHTAGISATITAMDECDPADLVGVNTAVVIASSFGEGGPPDNGARF
Mflv_3016|M.gilvum_PYR-GCK          LGERLAGARL----RAMDDTDLSELSDAGEVVIVTSTFGDGGPPDNGTAF
Mvan_3491|M.vanbaalenii_PYR-1       LGERLNGARL----RAMDDVELDDLSEAGEVVIVTSTFGDGGPPDNGAGF
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      VADEHL--------------------------------------------
Mb0203|M.bovis_AF2122/97            ESPIW---------------------------------------------
Rv0197|M.tuberculosis_H37Rv         ESPIWYPKWAILPARGVLA-------------------------------
                                                                                      

MMAR_3639|M.marinum_M               WRELCAATAPSLAGTRYSVLALGDSNYADFCGHGRALDHRLAELGASRVT
MUL_1474|M.ulcerans_Agy99           WRELCAPTAPSLAGTRYSVLALGDSNYADFCGHGRALDHRLAELGASRIT
MAV_2075|M.avium_104                WRALTGDAAPRLGNTRYAVLALGDSNYDDFCGHGRKLDARLAELGATRIA
MAB_2438|M.abscessus_ATCC_1997      WAALSGDTKP-LNHMRYAVLGFGDRAYADFCGHAKALDARLHELGASPLL
Mflv_3016|M.gilvum_PYR-GCK          WERLESADAPALDGVRYTVLGIGDRSYDNFCGHAKSLDTRLADLGATRML
Mvan_3491|M.vanbaalenii_PYR-1       WERLESPHAPSLDGVRYTVLGIGDRSYDNFCGHARSLDARLADLGATRML
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      --------------------------------------------------
Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
                                                                                      

MMAR_3639|M.marinum_M               DRVDCEPDYEESAARWLQEVLDGLRRTAPPV---------ITAAPVRAAS
MUL_1474|M.ulcerans_Agy99           DRVDCEPDYEESAARWLQEVLDGLRRTAPPV---------ITAEPVRAAS
MAV_2075|M.avium_104                ERVDCEPDYEQAAAKWVADVIEALTRTPTAVGGDGGATVSARTSPVAAPS
MAB_2438|M.abscessus_ATCC_1997      GRVDGEATDRTLVASWTADLLDAIGDGATAI---------VETVRKLRSE
Mflv_3016|M.gilvum_PYR-GCK          DRADCEAYDEQPMAAWADSVVGLMSTPVTPAP----------------TQ
Mvan_3491|M.vanbaalenii_PYR-1       DRVECEAYDAQPLARWADSVVELVAAPGTPP-------------------
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      --------------------------------------------------
Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
                                                                                      

MMAR_3639|M.marinum_M               IANR--PQGYTKKRPLLTSVMRNTTLSRPRSAKDVRQLVFRVPEQTVSYE
MUL_1474|M.ulcerans_Agy99           IASR--PQGYTKKRPLLTSVMRNTTLSRPRSAKDVRQLVFRVPEQTVSYE
MAV_2075|M.avium_104                RPNTPAPHTYSKKHPLITDMVRNTTLNGPKSTKDVRHLVFNLPEDAVSYE
MAB_2438|M.abscessus_ATCC_1997      GLRVAAPERFTRDAPILAALSHNELLSAPNSGKEVRRIEFDLTGHDVSYS
Mflv_3016|M.gilvum_PYR-GCK          PAVPAAPAPFTRGNPAQAPLCRNVRLTPDGAGKDVRQFGFDISGQDLAYS
Mvan_3491|M.vanbaalenii_PYR-1       AAPAQEPTLFTRAEPVAAPLCRNTRLTPQGAAKEVRQIGFDISAHDVTYS
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      --------------------------------------------------
Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
                                                                                      

MMAR_3639|M.marinum_M               AGDALGVWPRNAHQLVDEWLGVTQLDGHTEVEVAGHGTMSLRAALTDRFE
MUL_1474|M.ulcerans_Agy99           AGDALGVWPRNAHQLVDEWLGVTRLDGHTEVEVAGHGTMSLRAALTDRFE
MAV_2075|M.avium_104                AGDALGVWPRNSDELVDEWLAVTGLDGQTPVEVGEHGLMSLRSALTERIE
MAB_2438|M.abscessus_ATCC_1997      AGDALGIYPTNREEDVQRWLTTTGFDAQLPVTIDG-GELPLATALANHYD
Mflv_3016|M.gilvum_PYR-GCK          VGDSLGVWVVNSDAVVESWLSATGFHGAEAVIVDG-RQISLREALTRHYD
Mvan_3491|M.vanbaalenii_PYR-1       VGDSLGVCVVNSDFVVENWLAATDLRGDEAVVVDG-VQQALRDALTAHYD
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      --------------------------------------------------
Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
                                                                                      

MMAR_3639|M.marinum_M               IAHLSPDLLRFVAQRTLDSNTANQLAELMRPENKAALADWTWGRQSVDLL
MUL_1474|M.ulcerans_Agy99           IAHLSPDLLRFVAQRTLDSNTANQLAELMRPENKAALADWTWGRQSVDLL
MAV_2075|M.avium_104                IAHISRDLVRFVQERTGDA----KLAELLKPENKRALADWTWGRQSIDLL
MAB_2438|M.abscessus_ATCC_1997      ICRVTEDLLRFIAERRRDK----HSAKLLQGRDTQAREVWLRGRNALDVI
Mflv_3016|M.gilvum_PYR-GCK          VCKVTSNLVTFVAEHCPDA-----ATAKRLRNDRGALDTWLVDRNGLDLV
Mvan_3491|M.vanbaalenii_PYR-1       VCKVTSNLVKFVAEHCRDA-----ATAKRLRNDRGELDRWLVNRNGLDLV
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      --------------------------------------------------
Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
                                                                                      

MMAR_3639|M.marinum_M               AQSPVRASVDEWMSVLKPIQPRLYSISSSPKEHPGEVHLTVSPVRYN-FQ
MUL_1474|M.ulcerans_Agy99           AQSPVRASVDEWMSVLKPIQPRLYSISSSPKEHPGEVHLTVSPVRYN-FQ
MAV_2075|M.avium_104                AQLPVSASAHEWLRVLKRLQPRLYSISSSPKACPGEVHLTVSPVRYN-FQ
MAB_2438|M.abscessus_ATCC_1997      REFPIRAAIEEWQQVLIRLTPRQYSISSSPLVSPQAISLTVSIVRYQGPD
Mflv_3016|M.gilvum_PYR-GCK          REFGIRADPALWQEVLVRLTPRQYSISSSPLVSPHEVQLTVSVVRYRGAD
Mvan_3491|M.vanbaalenii_PYR-1       REFSVRADPQLWQEVLVRLTPRQYSISSSPLVSPNEVQLTVSVVRYRGAD
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      --------------------------------------------------
Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
                                                                                      

MMAR_3639|M.marinum_M               GVPRRGVCSTYLADRSPSDQIAIYVRKSSNFRPPSDPRTPMIMIGPGTGI
MUL_1474|M.ulcerans_Agy99           GVPRRGVCSTYLADRSPSDQIAIYVRKSSNFRPPSDPRTPMIMIGPGTGI
MAV_2075|M.avium_104                GVPRRGVCSTYLAARSPGDRVAVYLQPSSNFRPPSDPDTPMIMIGPGTGI
MAB_2438|M.abscessus_ATCC_1997      GSPRGGVGSTFLADRAQHLPVPIFLQRSPHFRPPRTSDTPMIMIGPGTGI
Mflv_3016|M.gilvum_PYR-GCK          GTPRGGVASTYLADLPDCTPVPVFLQRSPHFRPPEDPHTPMIMVGPGTGI
Mvan_3491|M.vanbaalenii_PYR-1       GGPRGGVASTYLADLPDGTAVPVFLQRSPHFRPPQDSHTPMIMVGPGTGI
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      --------------------------------------------------
Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
                                                                                      

MMAR_3639|M.marinum_M               APFRGFLQERRALGHTGPNWLFFGEQHAATDFYYRDEIQAMHRDGLLTNL
MUL_1474|M.ulcerans_Agy99           APFRGFLQERRALGHTGPNWLFFGEQHAATDFYYRDEIQAMHRDGLLTNL
MAV_2075|M.avium_104                APFRGFLQERRALGHRGPNWLFFGEQHAATDFYYRDELEQMREDGFLTEL
MAB_2438|M.abscessus_ATCC_1997      APFRGFLQERRALGHTGANWLFFGDQHRTEHFYYRDELDGFLRDGSLRRL
Mflv_3016|M.gilvum_PYR-GCK          APFRGFLQERRALGHRGANWLFFGDQHREQNFYYRDDLLDMVDDGFLNRL
Mvan_3491|M.vanbaalenii_PYR-1       APFRGFLQERRALGHRGPNWLFFGDQHRAQNFYYRDDLQDMVDDGFLNRL
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      --------------------------------------------------
Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
                                                                                      

MMAR_3639|M.marinum_M               DLAFSRDQRDKVYVQHLMQQRGAQLWQWLQDGAQVYVCGTADPMAKDVDR
MUL_1474|M.ulcerans_Agy99           DLAFSRDQRDKVYVQHLMQQRGAQLWQWLQDGAQVYVCGTADPMAKDVDR
MAV_2075|M.avium_104                DLAFSRDQQHKVYVQHLMRNRGKQLWSWLQDGAQLYVCGTADPMAKDVDR
MAB_2438|M.abscessus_ATCC_1997      DLAFSRDQAKRIYVQHRMMEQGAQLWRWLNEGAHLYVCGDASRMAKDVDG
Mflv_3016|M.gilvum_PYR-GCK          DLAFSRDQRQRIYVQHKMLDYGADVWRWLDDGAHFYVCGDATRMAKDVDD
Mvan_3491|M.vanbaalenii_PYR-1       DLAFSRDQARRVYVQHKMLDYGADVWRWLDDGAHFYVCGDATRMAGDVDD
TH_4553|M.thermoresistible__bu      --------------------------------------------------
MSMEG_2837|M.smegmatis_MC2_155      --------------------------------------------------
Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
                                                                                      

MMAR_3639|M.marinum_M               MLCQIVAEHGGLDPESATAFVHALSADKRYHRDVY
MUL_1474|M.ulcerans_Agy99           MLCQIVAEHGGLDPESATAFVHALSADKRYHRDVY
MAV_2075|M.avium_104                ALCDIAAEFGNLDPDAAKAYVQSLSADKRYHRDVY
MAB_2438|M.abscessus_ATCC_1997      ALLTIAQKHGKLSGEQALEFRKELVAEKRYVRDVY
Mflv_3016|M.gilvum_PYR-GCK          ALTEILRTHARMSSDAAREYKREMVAEKRYVRDVY
Mvan_3491|M.vanbaalenii_PYR-1       ALTEIIRTHGGMSADAARDYKREMVAEKRYVRDVY
TH_4553|M.thermoresistible__bu      -----------------------------------
MSMEG_2837|M.smegmatis_MC2_155      -----------------------------------
Mb0203|M.bovis_AF2122/97            -----------------------------------
Rv0197|M.tuberculosis_H37Rv         -----------------------------------