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M. thermoresistible (build 8) TH_4041 (-)

annotation: Formate dehydrogenase
coordinates: 621218 - 623392
length: 725

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4041--100% (725)Formate dehydrogenase
M. thermoresistible (build 8)TH_4483-e-10936.32% (680) PUTATIVE Formate dehydrogenase
M. thermoresistible (build 8)TH_4553-2e-0726.26% (179) PUTATIVE sulfite reductase (NADPH) alpha subunit

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0203-3e-6429.04% (730) oxidoreductase
M. gilvum PYR-GCKMflv_4342-0.051.93% (726) molydopterin dinucleotide-binding region
M. tuberculosis H37RvRv0197-5e-6429.04% (730) oxidoreductase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_3870c-0.050.42% (716) molybdopterin oxidoreductase
M. marinum MMMAR_2605-1e-11535.84% (745) anaerobic dehydrogenase
M. avium 104MAV_4983-2e-6328.47% (720) molybdopterin oxidoreductase Fe4S4 subunit
M. smegmatis MC2 155MSMEG_2237-0.052.17% (736) anaerobic dehydrogenase, typically
M. ulcerans Agy99MUL_1474fdhF1e-3925.67% (744) formate dehydrogenase H FdhF
M. vanbaalenii PYR-1Mvan_2003-0.053.90% (731) molybdopterin oxidoreductase

CLUSTAL 2.0.9 multiple sequence alignment


Mb0203|M.bovis_AF2122/97            -------MTSSDWLPTACILCECNCGIVVQVDDR------RLARIRGDKA
Rv0197|M.tuberculosis_H37Rv         -------MTSSDWLPTACILCECNCGIVVQVDDR------RLARIRGDKA
MAV_4983|M.avium_104                -------MTG-EWQPSACILCECNCGIVVQVEDR------RLARIRGDKA
Mflv_4342|M.gilvum_PYR-GCK          ------MVTHTEHKATFCRICEPLCGMIATVEDG------KLVALRPDKD
Mvan_2003|M.vanbaalenii_PYR-1       -------MSDVVQKSTFCRICEPLCGMIATVEDG------RLTALRPDKE
MSMEG_2237|M.smegmatis_MC2_155      MVIESGAGHKPEHKVTFCRICEPLCGMIATVEDG------RLTALRPDRD
MAB_3870c|M.abscessus_ATCC_199      --------------------------MVATVEGG------KLLSLRPDKD
TH_4041|M.thermoresistible__bu      --------MATEQRVTYCRICEPLCGLIATVEDG------RLQSLRPDPD
MMAR_2605|M.marinum_M               -----MATVDDGRHLHTCPLCEAMCGLEIRVADGPSGG--RVVGIRGNRD
MUL_1474|M.ulcerans_Agy99           ------MAPNKDAVKTVCAYCGVGCGIVLQTTTDPQTGKRRVAKSTGDKS
                                                              :   .         ::     :  

Mb0203|M.bovis_AF2122/97            HPGSAGYTCNKALRLDHYQNNRARLSSPMRR-----------RADGTYEE
Rv0197|M.tuberculosis_H37Rv         HPGSAGYTCNKALRLDHYQNNRARLSSPMRR-----------RADGTYEE
MAV_4983|M.avium_104                HPASQGYTCNKVLRLDHYQNSRARLTSPLRR-----------RPDGSYEE
Mflv_4342|M.gilvum_PYR-GCK          HPLSAGFACQKGIAFTEVVNDPDRVTTPMRR------------TADGFEP
Mvan_2003|M.vanbaalenii_PYR-1       HPLSAGFACQKGIAFTEVVNDPDRVTTPMRR------------TPDGFVP
MSMEG_2237|M.smegmatis_MC2_155      HPLSAGFACQKGIAFAEVVNDPDRITTPLRRRADAKRPGNRTDVLDGFEP
MAB_3870c|M.abscessus_ATCC_199      NPASSGFSCQKGIAFADVHNDPDRLTTPMRR-----------TVSGEFEP
TH_4041|M.thermoresistible__bu      HPLSRGRACPKGIAFTEVQNDPDRVLYPLRR-----------RADGEFER
MMAR_2605|M.marinum_M               DVWSRGHICPKGASLGALHDDPDRIRHPMIK------------IDGQWHE
MUL_1474|M.ulcerans_Agy99           HPANLGRLCTKGTTTADLLAAPGRMESAHLR----------AHRAGHLES
                                    .  . *  * *            *:  .  :              .    

Mb0203|M.bovis_AF2122/97            IDWDTAIVEIAEGFKQIRDTHG-GDKIFYYGGGGQGNHLGGAYSGAFLKA
Rv0197|M.tuberculosis_H37Rv         IDWDTAIVEIAEGFKQIRDTHG-GDKIFYYGGGGQGNHLGGAYSGAFLKA
MAV_4983|M.avium_104                IDWDTAIVEIAEGFKRIRDSYG-GDKIFYYGGGGQGNHLGGAYSGAFLKA
Mflv_4342|M.gilvum_PYR-GCK          VSWDEAMSDIATRLSGVLHRHGPGAVGWYMGNPGAFSYAHVMAIMAFIKG
Mvan_2003|M.vanbaalenii_PYR-1       VSWDEALTDITARLAAVLRERGSGAVGWYMGNPGAFSYSHVLSILAFIKG
MSMEG_2237|M.smegmatis_MC2_155      VGWDEALDDIAHRLSGIHRRHGSGAVAWYMGNPAAFSYSHLFAAMAFAKG
MAB_3870c|M.abscessus_ATCC_199      VEWDTAMADIAERVRAIHRMHGSGAIGWYFGNPGAFSYSHVLWLLLLSMG
TH_4041|M.thermoresistible__bu      VGWDEALDDIAARLTAIRDRHGGGAIGQYFGNPVAFGYATALWSGMFVAR
MMAR_2605|M.marinum_M               VSWDAAFRRCTELLAPVIDTYGIGAVTAYTGNPLAHSFSLARYAGVLLG-
MUL_1474|M.ulcerans_Agy99           IPIDDAITQCAMRLRAIIDEHGPDAVGVYVSG--QMSIEAQYLANKLTKG
                                    :  * *:   :  .  :    * .    * ..    .         :   

Mb0203|M.bovis_AF2122/97            LGSRYRSNALAQEKTGEAWVDFQLYGGHTR-----GEFENAEVSVFVGKN
Rv0197|M.tuberculosis_H37Rv         LGSRYRSNALAQEKTGEAWVDFQLYGGHTR-----GEFENAEVSVFVGKN
MAV_4983|M.avium_104                LGSRYRSNALAQEKTGESWIDGQLYGGHTR-----GEFEHAEVAVFVGKN
Mflv_4342|M.gilvum_PYR-GCK          IGSGTHFYTASSQDTNCRLMASQLLYGTPTSV-PIPDLARTDLLVVIGAN
Mvan_2003|M.vanbaalenii_PYR-1       LGRHTHFYTASSQDTNSRLMASQLLYGTPTSV-PIPDLTRTDFLVVMGAN
MSMEG_2237|M.smegmatis_MC2_155      IGGDSHFFSSSTQDTSSRLLANQFLYGAPFPV-PIPDVMRTDLLVMIGAN
MAB_3870c|M.abscessus_ATCC_199      FGSRLHLFTAGSQDINSRFVASQLLYGNSATM-PVPDIPRTDLLVVIGAN
TH_4041|M.thermoresistible__bu      LGSR-HQYSSGSQDINSRFVASKLLYGAASQI-PFPDLPRTDFLFMLGAN
MMAR_2605|M.marinum_M               MSGMPVTYSPGTVDQWPKNLSSHLMYGGWWTF-PVPDIERTDLLVIMGAN
MUL_1474|M.ulcerans_Agy99           FIGTKQIESNSRLCMAGASSGYKLSLGADGPPGSYQDFDHADVFLVIGAN
                                    :       : .           ::  *         :. .::. ..:* *

Mb0203|M.bovis_AF2122/97            PWMSQS----FPRARVVLNEIAKDPGRSMIVIDPVVTDTAKMADFHLRVQ
Rv0197|M.tuberculosis_H37Rv         PWMSQS----FPRARVVLNEIAKDPGRSMIVIDPVVTDTAKMADFHLRVQ
MAV_4983|M.avium_104                PWMSQS----FPRARVVLNEIAKDPARSMIVIDPVVTDTAKMADFHLRVR
Mflv_4342|M.gilvum_PYR-GCK          PVVSHGSFLTAPRIKDRMHDIVKRGGR-VVVIDPRKTETAAQFEWCG-IV
Mvan_2003|M.vanbaalenii_PYR-1       PVVSHGSFLTAPRIKDRMHDIVRRGGR-VVVIDPRKTETAAQFEWCG-IV
MSMEG_2237|M.smegmatis_MC2_155      PVVSHGSFLTAPRLKDRMHDIVKRGGR-VVVVDPRRSETAAQFEWLG-IV
MAB_3870c|M.abscessus_ATCC_199      PVVSHGSGVTMPRIREHMKAVVKRGGR-VLVIDPRKTETAADFEWLG-IA
TH_4041|M.thermoresistible__bu      PFVSHGSALRAPRIKDDLTDITRRGGR-VVVVDPRRTETARAFEHIA-VR
MMAR_2605|M.marinum_M               PAASQGSLLAAPDVMGLIDAIRQRGKV-IVIDPVRTVTAARADEWLP-IV
MUL_1474|M.ulcerans_Agy99           MADCHP------ILFLRMMERVKSGAK-LIVVDPRRTATADKADLFLQIA
                                       .:            :    :     :::       :*   :    : 

Mb0203|M.bovis_AF2122/97            PGCDAWCLAALAAVLVQENLCNEAFLAAHVHGVDTVRAALQEVPVADYAQ
Rv0197|M.tuberculosis_H37Rv         PGCDAWCLAALAAVLVQENLCNEAFLAAHVHGVDTVRAALQEVPVADYAQ
MAV_4983|M.avium_104                PGTDAWCLAALAAVLVQENLCDEAFLAEHVRCADAVRHALRDVAVSEYAA
Mflv_4342|M.gilvum_PYR-GCK          PDTDALLLLSLLQVMFSEGLAHTREIESVADGVDWLRAQVAPFTPEATQP
Mvan_2003|M.vanbaalenii_PYR-1       PDTDALLLLSLLQVMFAEELAHTGEIAAQTAGLDWLRSQAAPFPPEATAA
MSMEG_2237|M.smegmatis_MC2_155      PDTDAYFLLSLLQVMFDENLVAP-RAATQADGLDWLRRQSAPFTPESTRA
MAB_3870c|M.abscessus_ATCC_199      PDGDAFLLLSLLQVMFTENLVDRALVAQHARGVAWLEGLVRPFTPESTQA
TH_4041|M.thermoresistible__bu      PDSDAWLLLSMLQVIFAEGLEDTAAIARQTTGCSTLRGLVAGFPPEATAA
MMAR_2605|M.marinum_M               PGTDAALLLAVAHTLFDEDLVNP---GPHVDGVDTMRRVAADWPPARVSA
MUL_1474|M.ulcerans_Agy99           PGTDLALLNGLLHLIVENEQTDPQFISEFTEGWEVMPSFLEQFTPDRVSE
                                    *. *   * .:   :. :           .     :       .      

Mb0203|M.bovis_AF2122/97            RCGVDEELLRAAARRIGTAASVSVFEDLGIQQAPNSTVCSYLNKLLWILT
Rv0197|M.tuberculosis_H37Rv         RCGVDEELLRAAARRIGTAASVSVFEDLGIQQAPNSTVCSYLNKLLWILT
MAV_4983|M.avium_104                HCGVDEELLRTAARRIGTADSVAVFEDLGVQQAPNSTLCSYLNKLLWILT
Mflv_4342|M.gilvum_PYR-GCK          HTGIDPDTVRALARDLATTPRAAVYGRLGTCVGRYGTLTSYLLDVVNLVA
Mvan_2003|M.vanbaalenii_PYR-1       RTGIDPEVVRALARDLATTPRAAIYGRLGTCVGRHGTLTSYLIDVVNLVA
MSMEG_2237|M.smegmatis_MC2_155      HTGVEPETLRALARDLAGTARAAVYGRLGTCVGRHGTLTTYLIDAVNIVA
MAB_3870c|M.abscessus_ATCC_199      QTGVDPGVVRQLARDLAGADRAVVYGRVGTCLGQNGTLTTYLLDVVNLVA
TH_4041|M.thermoresistible__bu      RTGVPADVVRSLARDFAAAPTAAAYGRTGACLGRHGTLVSFLLDALSIVT
MMAR_2605|M.marinum_M               VTGIEEERIRRLARELAGTHKSVVYGRIGLCNQEFGSLASWLVDVINILT
MUL_1474|M.ulcerans_Agy99           ITGIPSEDIRTAARWIGTAANWMSCWTMGLNQSTHGTWNTNALCNLHLAT
                                      *:    :*  ** :. :         *      .:  :     : : :

Mb0203|M.bovis_AF2122/97            GNFAKKGGQHLHSSFAP-------------LFSQVSGRTPVTG-------
Rv0197|M.tuberculosis_H37Rv         GNFAKKGGQHLHSSFAP-------------LFSQVSGRTPVTG-------
MAV_4983|M.avium_104                GNFAKRGGQHLHSSFAP-------------LFGQFSGRTPVTG-------
Mflv_4342|M.gilvum_PYR-GCK          GNLDVPGGSVIAGLGMPAQRVVNIGMGAALRRTYRRGRSRIGG-------
Mvan_2003|M.vanbaalenii_PYR-1       GNLDTPGGSVIGGMGLPGQRWVNVGMGALLRRIYRRRRSRIGG-------
MSMEG_2237|M.smegmatis_MC2_155      GNLDVPGGSVFSTLGMPGQRWGSMAMGASLRRSYRTRRTRVGG-------
MAB_3870c|M.abscessus_ATCC_199      GHLGRVGGSMFGSFGIPGERFAMKAVGALLGAVYRRRRSRVGG-------
TH_4041|M.thermoresistible__bu      GNLDREGGLLMAHAVIPFEELGERTG----RLTYGTERSRIGG-------
MMAR_2605|M.marinum_M               GHFDTPGGAMFPRPAAWSITTQPLPGLEGGVAEFGRWHTRVRG-------
MUL_1474|M.ulcerans_Agy99           GAICRPGSGPFSLTGQPNAMGGREMGYMGPGLPGQRSVLSAPDREFVEEQ
                                    * :   *.  :                               .       

Mb0203|M.bovis_AF2122/97            ---APIIAGLIPGNVVPEEILTEHPDRFRAMIVESGNPAHSLADSAACRA
Rv0197|M.tuberculosis_H37Rv         ---APIIAGLIPGNVVPEEILTEHPDRFRAMIVERGNPAHSLADSAACRA
MAV_4983|M.avium_104                ---APIISGLVPSNVVPEEILTDHPDRFRAMIVESSNPAHSLANSAACRE
Mflv_4342|M.gilvum_PYR-GCK          ---FRAIIGSEPAAVMAKEMTTPGQRQIRAMFISAGNPVLSVPNGEELES
Mvan_2003|M.vanbaalenii_PYR-1       ---FRAVIGSEPAALMAKEMTTPGERQIRAMFVSAGNPVLSVPNGDELAS
MSMEG_2237|M.smegmatis_MC2_155      ---FKSVIGAEPAALMAKEITTPGRRQVKAMFIGAGNPVLSVPNGPELAE
MAB_3870c|M.abscessus_ATCC_199      ---FPSVLGSEPAGIMAKEITTPGRGQIRALFVGAGNPVLSVPNGDELEA
TH_4041|M.thermoresistible__bu      ---LPEVISTFPAALMADEINTPGDGQLRALFVTAGNPVLTVPNGPALEK
MMAR_2605|M.marinum_M               ---AKEVLGQAPVSCLAEEIATPGDGQLRALITIAGNPVLSTPGGDKLDE
MUL_1474|M.ulcerans_Agy99           WGLPGGALRTDVSGGVIDMFSRMADGEIKACWIICSNPVATVANRKTVLA
                                                   : . :      ..:*     .**. : ..      

Mb0203|M.bovis_AF2122/97            AFQALELMVVVDVAMTETARLAHYVLPAASQFEKPEATFFNFEFPRNGFQ
Rv0197|M.tuberculosis_H37Rv         AFQALELMVVVDVAMTETARLAHYVLPAASQFEKPEATFFNFEFPRNGFQ
MAV_4983|M.avium_104                AFASLELMVVIDVAMTETARLAHYVLPAASQFEKPEATFFNLEFPRNTFQ
Mflv_4342|M.gilvum_PYR-GCK          ALDSLDLAVGLDFYLTETTAHCDYVLPVTTMYERDDFPLVFQQFQATPFR
Mvan_2003|M.vanbaalenii_PYR-1       ALDSLDLSVALDFYLTETSARCDYVLPVTTMYERDDFPLTFQPFQATPFR
MSMEG_2237|M.smegmatis_MC2_155      ALDAAELTVGLDLYVNETTAHCDYVLPVTTMYERDDFAVTFQMFQATPFR
MAB_3870c|M.abscessus_ATCC_199      ACEQLDLMVGIDLYLNETLAHCHYVLPATTMYERDDFMIPFATLRPAPYR
TH_4041|M.thermoresistible__bu      VLGKLDLIVSLDFYVTETNRHAHYVLPATTFLERDDYPYGFAANCPTVFI
MMAR_2605|M.marinum_M               ALSSLEAMISVDLWLNETTRHADVILPGLSPLEQPHHDDLVLQFAIRSFA
MUL_1474|M.ulcerans_Agy99           GLEKAELVISQDAFFETETNEYANVLLPAALWTESDGVMVNCERNMSLFP
                                         :  :  *  .         :*   :   . .            : 

Mb0203|M.bovis_AF2122/97            LR-RPLFPPLPGTLPEPEIWARLVRALGVVDEADLRPLREAAAQGRQAYT
Rv0197|M.tuberculosis_H37Rv         LR-RPLFPPLPGTLPEPEIWARLVRALGVVDEADLRPLREAAAQGRQAYT
MAV_4983|M.avium_104                LR-RPLLTPLPGTLPEPEIWARLVRALGVVTEADLRPLHDAARRGRHAYT
Mflv_4342|M.gilvum_PYR-GCK          QVTEAVIAPVGQARQEWEIIGELITRMAG--------------------E
Mvan_2003|M.vanbaalenii_PYR-1       QATEAVIEPVGQARPEWEIVGGLLQRLSG--------------------Q
MSMEG_2237|M.smegmatis_MC2_155      QATEAMVAPRGQARTEWDIVVDLIGRMSV--------------------R
MAB_3870c|M.abscessus_ATCC_199      QATEAVVAPAGQARQEWQIIEDLTSRLWN--------------------L
TH_4041|M.thermoresistible__bu      QSAEPVVGAYGEARNEWEVFDELARRMGLS-----------------LFA
MMAR_2605|M.marinum_M               NYSAPVFDP-GDRPHEWEILIRLTGLCTGT-----------------PAE
MUL_1474|M.ulcerans_Agy99           KA----VDPVGDALPDWQIIARIACEMGFSESFSYSSAAEVFEEIKRFSN
                                          . .      : ::   :                           

Mb0203|M.bovis_AF2122/97            EAFLAAAATNPTVAKLTAYVLYETLGPTLPDGLAGAAALWGLAQKTAMAY
Rv0197|M.tuberculosis_H37Rv         EAFLAAAATNPTVAKLTAYVLYETLGPTLPDGLAGAAALWGLAQKTAMAY
MAV_4983|M.avium_104                EAFLTAVSTNPTVAQLLPFVLYETLGPTLPDGLRGAAALWGLAQKTALTY
Mflv_4342|M.gilvum_PYR-GCK          SRVFAGLTA---------------AGKALRRIGA-PFTPRMFADLVIRSS
Mvan_2003|M.vanbaalenii_PYR-1       SRVFAVLTG---------------AGRGLTRLGV-PFTPRRLADGIIRVC
MSMEG_2237|M.smegmatis_MC2_155      TPVFAMLRC---------------AQKLAGRRGR-RLNPRPLIDGMIRMA
MAB_3870c|M.abscessus_ATCC_199      TPGLRFIEG---------------LRRTVALFGA-RLQPRLLADALIRMS
TH_4041|M.thermoresistible__bu      TGPLERLNP---------------VLAWLDRRGVGRLTPRRLMELLLRLG
MMAR_2605|M.marinum_M               DVDVAAIDDGFFDYLAFTKGFDGAAIRKRYEHDGWAGGPERILDLTLRTG
MUL_1474|M.ulcerans_Agy99           PATGYDLRGISHDRLRETPLQWPCPPDGASNRSPIRYLNDGVSQLQFVRA
                                                                             . :      

Mb0203|M.bovis_AF2122/97            P------------------------------DAVRRAGHADGNALFDAIL
Rv0197|M.tuberculosis_H37Rv         P------------------------------DAVRRAGHADGNALFDAIL
MAV_4983|M.avium_104                P------------------------------EAVRRAGHADGNALFDAIL
Mflv_4342|M.gilvum_PYR-GCK          A------------------------------GGDRFGLRRGGLSFGRLSR
Mvan_2003|M.vanbaalenii_PYR-1       A------------------------------GGDRFGLRRGGLTFARLTR
MSMEG_2237|M.smegmatis_MC2_155      D------------------------------GGDRFGLRRDGLTFRKLAE
MAB_3870c|M.abscessus_ATCC_199      A------------------------------GGDLFRLRRQGLTFDRLTR
TH_4041|M.thermoresistible__bu      P------------------------------YGDRFGLRRGGLNPRRLR-
MMAR_2605|M.marinum_M               P------------------------------FGDRYGQNPGGLTLDMLK-
MUL_1474|M.ulcerans_Agy99           DGTVPRLAFPTATGRAVFFARPHLVPDEMPDGDYPFLLNTGRLAHQWHTL
                                                                          .           

Mb0203|M.bovis_AF2122/97            ERPSGVTFTVHNYEDDFALIS-HPDHKIALEIPEMLAEIRSLT-------
Rv0197|M.tuberculosis_H37Rv         ERPSGVTFTVHNYEDDFALIS-HPDHKIALEIPEMLAEIRSLT-------
MAV_4983|M.avium_104                DNPSGVTFTVHDYADDFTLIG-HPDHKIALEIPAMLQELAKLS-------
Mflv_4342|M.gilvum_PYR-GCK          DHAHGKVLSPNLATGVLKDAIAYLRGRIRLVHEDIEAEIAMLL-------
Mvan_2003|M.vanbaalenii_PYR-1       DHPHGAVIAPHLRTGVLKEAISYLNGRIQLAHHDIASEIAALR-------
MSMEG_2237|M.smegmatis_MC2_155      EHPHGVIVAPHVRTGVLGEVVVYPKGRVRLEHADIATEITALT-------
MAB_3870c|M.abscessus_ATCC_199      DYPHGKVLAEHLPEVPLSRSVSYLDGRMRLEHKDIESEVASLA-------
TH_4041|M.thermoresistible__bu      ENPHGIVVADRVPTGVLGKVVRHRGGRVCLAPDEVVAEVHRLG-------
MMAR_2605|M.marinum_M               ANPNGIDFGPMVSQ--LPDILGTPEKKIRLAPQYLLDDLPRLA-------
MUL_1474|M.ulcerans_Agy99           TKTGKIAKLNKLNPGPFVEVHPDDAADMQICEGDHIEIASRRGRAVLPVV
                                      .             :          : :                    

Mb0203|M.bovis_AF2122/97            -------------------------------------QTPSRLTTPQLPI
Rv0197|M.tuberculosis_H37Rv         -------------------------------------QTPSRLTTPQLPI
MAV_4983|M.avium_104                -------------------------------------SGPPRLTTEEFPI
Mflv_4342|M.gilvum_PYR-GCK          -------------------------------------RNE---LPEAYPL
Mvan_2003|M.vanbaalenii_PYR-1       -------------------------------------QMR---QPVGYPL
MSMEG_2237|M.smegmatis_MC2_155      -------------------------------------RRR---NPDGFGL
MAB_3870c|M.abscessus_ATCC_199      -------------------------------------ARE---HDPRFPM
TH_4041|M.thermoresistible__bu      -------------------------------------QRHP--DDPAYPL
MMAR_2605|M.marinum_M               -------------------------------------SRM---DRPAEQL
MUL_1474|M.ulcerans_Agy99           ITDRVRPGNCFAPFHWNDAFGEYLSINAVTNDAVDPISRQPEYKACAVTL
                                                                                     :

Mb0203|M.bovis_AF2122/97            VLSVGERRA------YTANDIFRDPSWRKRDANGALRVSVEDAQALGLAD
Rv0197|M.tuberculosis_H37Rv         VLSVGERRA------YTANDIFRDPSWRKRDANGALRVSVEDAQALGLAD
MAV_4983|M.avium_104                VLSVGERRA------YTANDIFRDPSWRKRDAEGALRVSVEDAQALGLAD
Mflv_4342|M.gilvum_PYR-GCK          KMIGMREPR------SENSWMHNAPLLMRGERSHHGLMNADDAAELQIGD
Mvan_2003|M.vanbaalenii_PYR-1       RMIGMREPR------SENSWMHNAPLLMRGDRSHHGLMNADDAAELMIDD
MSMEG_2237|M.smegmatis_MC2_155      RMIGMREPR------SENSWMHNAPLLMRGQRIQRAFLHADDATARGVRD
MAB_3870c|M.abscessus_ATCC_199      RLIGMREAR------SENSWMHNVPMLMRGGRVQRALIHAYDADQLGVTT
TH_4041|M.thermoresistible__bu      LAIGMREMR------SQNTWMHNSPTLMKGDRRHRARIHPADAAAAGVTH
MMAR_2605|M.marinum_M               VLVNRRHLR------SNNSWLHNVPALMKGKDRCTLLMHPDDAARNGITD
MUL_1474|M.ulcerans_Agy99           TKVARPQLQPEPGEPADACADATAPKLLADTAQFSVTQVDALAELLGVGN
                                          .                 *                 *    :  

Mb0203|M.bovis_AF2122/97            G-------------------------------CLARITTAAG-------S
Rv0197|M.tuberculosis_H37Rv         G-------------------------------CLARITTAAG-------S
MAV_4983|M.avium_104                G-------------------------------CRARISTAAG-------S
Mflv_4342|M.gilvum_PYR-GCK          G-------------------------------SEVHVSSPYG-------T
Mvan_2003|M.vanbaalenii_PYR-1       G-------------------------------SDVTVSSPYG-------R
MSMEG_2237|M.smegmatis_MC2_155      G-------------------------------DVVRVRSPFG-------Q
MAB_3870c|M.abscessus_ATCC_199      D-------------------------------DLLAITSPHG-------E
TH_4041|M.thermoresistible__bu      G-------------------------------GPVRIESPYG-------A
MMAR_2605|M.marinum_M               N-------------------------------DTVTVRSSAG-------E
MUL_1474|M.ulcerans_Agy99           EPTPQFGPSARSYLAGLIAGLRSETGRRMAGVSTLPISSPFDTGTRLWLD
                                                                        : :. .        

Mb0203|M.bovis_AF2122/97            AEATVEVTETMLAGHAALPNGFGLDYTGDDGRTVVAG---VAPNALTSTR
Rv0197|M.tuberculosis_H37Rv         AEATVEVTETMLAGHAALPNGFGLDYTGDDGRTVVAG---VAPNALTSTR
MAV_4983|M.avium_104                AEATVEISETMLAGHAALPNGFGLDYVGDDGRTVVPG---VAPNALTSTQ
Mflv_4342|M.gilvum_PYR-GCK          ITVPVTLTKDIMPGVIAVPHGWGHKGTGGWTVANKAGGANVNQLTSSEPD
Mvan_2003|M.vanbaalenii_PYR-1       ITVPVTLTKDIVPGVIALPHGWGHDGTGGWRLANRAGGANVNQLTSSEPD
MSMEG_2237|M.smegmatis_MC2_155      IDIAVSLTTDLVRGTVAIPHGWGHNGSGGWRIANRAGGANVNELMSSDPR
MAB_3870c|M.abscessus_ATCC_199      IELPAQVSKDILPGVVAVPHGWGHRRRAGWSTANANPGANVNLLMSSRPE
TH_4041|M.thermoresistible__bu      IETEALCTDEMTPGTVAIPHGWGHN--GGWRLANRLAGANVNELTSNDSA
MMAR_2605|M.marinum_M               ITVPVELTSAIKPGVVSMPHGWGHG-KPGTRLAVANSAPGVNTNVLSPPT
MUL_1474|M.ulcerans_Agy99           GLLAGMFARAETPPALPFPQTPGAAAQSDNAAEAAVEQPPIVVLWASQTG
                                           :        ..*:  *     .           :     . . 

Mb0203|M.bovis_AF2122/97            WRDPYAGTPWHKHVPAAIRRADAESPIW----------------------
Rv0197|M.tuberculosis_H37Rv         WRDPYAGTPWHKHVPAAIRRADAESPIWYPKWAILPARGVLA--------
MAV_4983|M.avium_104                WRDPYAGTPWHKHVPARIEALADARR------------------------
Mflv_4342|M.gilvum_PYR-GCK          DVESMAGMAWLTGVPVRVERA-----------------------------
Mvan_2003|M.vanbaalenii_PYR-1       DVESLSGMAWLTGVPVRVEPV-----------------------------
MSMEG_2237|M.smegmatis_MC2_155      DVEALAGMSWLTGVPVEVETCHLHCESVGVAAGGSSG-------------
MAB_3870c|M.abscessus_ATCC_199      DLEALAGMAHLNGVPVRVQRA-----------------------------
TH_4041|M.thermoresistible__bu      DLERLAGMSVLNGVPVRLVPVG----------------------------
MMAR_2605|M.marinum_M               LLDEPSGNGVLNGIPVTVS-------------------------------
MUL_1474|M.ulcerans_Agy99           TAEELAASVAAQLSAAELPVVLHGMDEFAVADLVSTQRLLLVTSTTGDGE
                                      :  :.       .. :                                

Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_4983|M.avium_104                --------------------------------------------------
Mflv_4342|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2003|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2237|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3870c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
MUL_1474|M.ulcerans_Agy99           PPDNGAAFWRELCAPTAPSLAGTRYSVLALGDSNYADFCGHGRALDHRLA
                                                                                      

Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_4983|M.avium_104                --------------------------------------------------
Mflv_4342|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2003|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2237|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3870c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
MUL_1474|M.ulcerans_Agy99           ELGASRITDRVDCEPDYEESAARWLQEVLDGLRRTAPPVITAEPVRAASI
                                                                                      

Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_4983|M.avium_104                --------------------------------------------------
Mflv_4342|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2003|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2237|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3870c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
MUL_1474|M.ulcerans_Agy99           ASRPQGYTKKRPLLTSVMRNTTLSRPRSAKDVRQLVFRVPEQTVSYEAGD
                                                                                      

Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_4983|M.avium_104                --------------------------------------------------
Mflv_4342|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2003|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2237|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3870c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
MUL_1474|M.ulcerans_Agy99           ALGVWPRNAHQLVDEWLGVTRLDGHTEVEVAGHGTMSLRAALTDRFEIAH
                                                                                      

Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_4983|M.avium_104                --------------------------------------------------
Mflv_4342|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2003|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2237|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3870c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
MUL_1474|M.ulcerans_Agy99           LSPDLLRFVAQRTLDSNTANQLAELMRPENKAALADWTWGRQSVDLLAQS
                                                                                      

Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_4983|M.avium_104                --------------------------------------------------
Mflv_4342|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2003|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2237|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3870c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
MUL_1474|M.ulcerans_Agy99           PVRASVDEWMSVLKPIQPRLYSISSSPKEHPGEVHLTVSPVRYNFQGVPR
                                                                                      

Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_4983|M.avium_104                --------------------------------------------------
Mflv_4342|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2003|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2237|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3870c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
MUL_1474|M.ulcerans_Agy99           RGVCSTYLADRSPSDQIAIYVRKSSNFRPPSDPRTPMIMIGPGTGIAPFR
                                                                                      

Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_4983|M.avium_104                --------------------------------------------------
Mflv_4342|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2003|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2237|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3870c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
MUL_1474|M.ulcerans_Agy99           GFLQERRALGHTGPNWLFFGEQHAATDFYYRDEIQAMHRDGLLTNLDLAF
                                                                                      

Mb0203|M.bovis_AF2122/97            --------------------------------------------------
Rv0197|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_4983|M.avium_104                --------------------------------------------------
Mflv_4342|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2003|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2237|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3870c|M.abscessus_ATCC_199      --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
MUL_1474|M.ulcerans_Agy99           SRDQRDKVYVQHLMQQRGAQLWQWLQDGAQVYVCGTADPMAKDVDRMLCQ
                                                                                      

Mb0203|M.bovis_AF2122/97            -------------------------------
Rv0197|M.tuberculosis_H37Rv         -------------------------------
MAV_4983|M.avium_104                -------------------------------
Mflv_4342|M.gilvum_PYR-GCK          -------------------------------
Mvan_2003|M.vanbaalenii_PYR-1       -------------------------------
MSMEG_2237|M.smegmatis_MC2_155      -------------------------------
MAB_3870c|M.abscessus_ATCC_199      -------------------------------
TH_4041|M.thermoresistible__bu      -------------------------------
MMAR_2605|M.marinum_M               -------------------------------
MUL_1474|M.ulcerans_Agy99           IVAEHGGLDPESATAFVHALSADKRYHRDVY