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VIRPAFSAVQVSGSARLSHTHWGAFTPEVRDGEVIGVTPIETDLDPSPLLQNIPGSIRHQARVTAPAVRS GWLREGPGPSDKRGADEYVEVSWDELTELLADELRRVVDTHGNEAIYGGSYGWASAGRFHHAQSQVHRFL KLLGGYTFSRHSYSLGATGVIMPHVIGTHDGLFKRSTSWDVIVENTDLLIAFGGIALKNTGVNHGGTTAH PARDALNRFRDRGGRIVSFSPLHDDIDGECEWHAPIPGTDVAVMLALAHVLAVEKLADLTFLSSYCTGYE RFERYLLGVDDGVPKSPEWAAPISGLDAAELRTLARRMAAGRTLVTVSWSLQRVRHGEQAPWMGLTLAAM LGQIGLPGGGFGHGYGSMNEPGLAPVSCPLPTFPQGPNPVETFIPVAAISELLLRPGQTLAYNGQTLTLP DIRCVYWAGGNPFHHHQNLPRLRRALSRVDTVVVHDPVWTAMAKHADIVVPSTTSLERDDFSGSRNDPLL VAMKAVAPPYANSRDDYTTFSALADRLGFGEQFSEGRTAAQWLRHIYTEWAGALNFSVPSFDEFWDRGYL ELPTDAGLTLLSDFRENPAAHPLHTPSGRIEIFSETIDGFGYSDCGGHPQWYEPTEWLGGERAQRFPLHL IANQPRTRLHSQLDFGGTSQGSKVRGREPLRIHPQDAATRGIADGDVVRVFNDRGACLAGAVLDEGLRRQ VVQLSTGAWFDPIEPADPNSACAHGNPNVLTDDSGTSSLAQGCTGQHVLVQIERFEGTPPPVRAHTPPRF VARD
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_3041 | - | - | 100% (774) | putative biotin sulfoxide reductase BisC |
M. abscessus ATCC 19977 | MAB_3870c | - | 1e-22 | 23.66% (655) | molybdopterin oxidoreductase |
M. abscessus ATCC 19977 | MAB_2438 | - | 9e-17 | 22.22% (666) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1477 | bisC | 0.0 | 70.21% (762) | biotin sulfoxide reductase |
M. gilvum PYR-GCK | Mflv_3958 | - | 0.0 | 73.61% (758) | molybdopterin guanine dinucleotide-containing S/N-oxide |
M. tuberculosis H37Rv | Rv1442 | bisC | 0.0 | 70.21% (762) | biotin sulfoxide reductase |
M. leprae Br4923 | - | - | - | - | - |
M. marinum M | MMAR_2605 | - | 4e-15 | 23.93% (422) | anaerobic dehydrogenase |
M. avium 104 | MAV_4535 | - | 4e-14 | 22.73% (739) | nitrate reductase NarB |
M. smegmatis MC2 155 | MSMEG_2738 | - | 0.0 | 76.56% (751) | biotin sulfoxide reductase |
M. thermoresistible (build 8) | TH_4483 | - | 8e-25 | 25.62% (726) | PUTATIVE Formate dehydrogenase |
M. ulcerans Agy99 | MUL_1474 | fdhF | 2e-09 | 20.68% (469) | formate dehydrogenase H FdhF |
M. vanbaalenii PYR-1 | Mvan_2438 | - | 0.0 | 73.83% (768) | molybdopterin guanine dinucleotide-containing S/N-oxide |
CLUSTAL 2.0.9 multiple sequence alignment Mb1477|M.bovis_AF2122/97 -------------------------------------MQVYTSATHWGVF Rv1442|M.tuberculosis_H37Rv -------------------------------------MQVYTSATHWGVF Mflv_3958|M.gilvum_PYR-GCK MLQSTSITKSPRRIDSKERRLFHPSFRRNGVRRLSCVARTRTSLTHWGAF Mvan_2438|M.vanbaalenii_PYR-1 MVG-----------------------RGGRAVRLSSVSATQTSLTHWGAF MSMEG_2738|M.smegmatis_MC2_155 ------------------------------------MPHSPTSLTHWGVF MAB_3041|M.abscessus_ATCC_1997 -------------------------MIRPAFSAVQVSGSARLSHTHWGAF TH_4483|M.thermoresistible__bu ----------------------------------------MTTVHTFCRY MMAR_2605|M.marinum_M -----------------------------------MATVDDGRHLHTCPL MUL_1474|M.ulcerans_Agy99 ------------------------------------MAPNKDAVKTVCAY MAV_4535|M.avium_104 -MATDRIANPWGTRTPYAPGTRWPERIDTYLADGVTAESVDRWVQSAAVL Mb1477|M.bovis_AF2122/97 TARVHGGDIAAVAA------LASDTNPAPQLQNLPGAVRHRSRIANPAVR Rv1442|M.tuberculosis_H37Rv TARVHGGDIAAVAA------LASDTNPAPQLQNLPGAVRHRSRIANPAVR Mflv_3958|M.gilvum_PYR-GCK SATVESGDIASVRP------WSGDADPSPALGNLPGSVRHRSRVTAPAVR Mvan_2438|M.vanbaalenii_PYR-1 SATVEAGEITAVAP------VAGDDDPSVALGNLPGSVRHISRVTTPAVR MSMEG_2738|M.smegmatis_MC2_155 SAEIVDGDIAAVNP------PPDDADPSPLLGNMPGSIRHRARITGPAVR MAB_3041|M.abscessus_ATCC_1997 TPEVRDGEVIGVTP------IETDLDPSPLLQNIPGSIRHQARVTAPAVR TH_4483|M.thermoresistible__bu CLAACGVEVTVEDN------RVVNISADRANPHTWHDFCAKGRTAHQVVE MMAR_2605|M.marinum_M CEAMCGLEIRVADGPSGG--RVVGIRGNRDDVWSRGHICPKGASLGALHD MUL_1474|M.ulcerans_Agy99 CGVGCGIVLQTTTDPQTGKRRVAKSTGDKSHPANLGRLCTKGTTTADLLA MAV_4535|M.avium_104 HSNGDGLDIAVKDG------RIVGVRGRAVDRVNHGRLDPKDLFGWQANA : . Mb1477|M.bovis_AF2122/97 RGWLQHGPGPSSARGAEEFVEVSWDELIELLASELRRTVDRYGNEAIYGS Rv1442|M.tuberculosis_H37Rv RGWLQHGPGPSSARGAEEFVEVSWDELIELLASELRRTVDRYGNEAIYGS Mflv_3958|M.gilvum_PYR-GCK RGWLENGPGPDTLLGADEFVAVTWDDLVELLGGELRRVIDTHGNEAIYGG Mvan_2438|M.vanbaalenii_PYR-1 RGWLDHGPGPDDSRGADDFVAVTWDELTELLGDELRRVIDTHGNGAIYGG MSMEG_2738|M.smegmatis_MC2_155 RGWLRDGPGPSTERGADEFVAVSWDELTDLLATELRRVVDTYGNEAIYGG MAB_3041|M.abscessus_ATCC_1997 SGWLREGPGPSDKRGADEYVEVSWDELTELLADELRRVVDTHGNEAIYGG TH_4483|M.thermoresistible__bu HPRRILAP---MRRVGDRYVEADWDEAITDIATRLNALIDADGPDAIG-- MMAR_2605|M.marinum_M DPDRIRHP---MIKIDGQWHEVSWDAAFRRCTELLAPVIDTYGIGAVT-- MUL_1474|M.ulcerans_Agy99 APGRMESAHLRAHRAG-HLESIPIDDAITQCAMRLRAIIDEHGPDAVGVY MAV_4535|M.avium_104 SADRLTTP---LLRVRGALRPCDWDTAMERIVARSRELLDRHGPSSIGFY . * :* * :: Mb1477|M.bovis_AF2122/97 SYGWASAGRFHHAQSQVHRFLNMLGGYTASRHSYSAGASEVIFPHIVGAA Rv1442|M.tuberculosis_H37Rv SYGWASAGRFHHAQSQVHRFLNMLGGYTASRHSYSAGASEVIFPHIVGAA Mflv_3958|M.gilvum_PYR-GCK SYGWSSAGRFHHAQSQVHRFLNCLGGYTYSRHSYSLGATGVIMPRVVG-T Mvan_2438|M.vanbaalenii_PYR-1 SYGWSSAGRFHHAQSQVHRFLNCLGGYTFSRHSYSLGATGVIMPRVVG-T MSMEG_2738|M.smegmatis_MC2_155 SYGWSSAGRFHHAQSQVHRFLKMLGGYTFSRHSYSLGATGAIMPRVVG-T MAB_3041|M.abscessus_ATCC_1997 SYGWASAGRFHHAQSQVHRFLKLLGGYTFSRHSYSLGATGVIMPHVIG-T TH_4483|M.thermoresistible__bu LYYGNPTGYSTSNLIFMNAWLDAVG----TNNRYAVGSVDQNALHVVA-- MMAR_2605|M.marinum_M AYTGNPLAHSFSLARYAGVLLGMSG----MPVTYSPGTVDQWPKNLSS-- MUL_1474|M.ulcerans_Agy99 VSGQMSIEAQYLANKLTKGFIGTKQIESNSRLCMAGASSGYKLSLGAD-- MAV_4535|M.avium_104 TSGQLFAEEYYTQAAIAHGAIGTNHVDGNTRLCTATAAEALKESFGCD-- : : .: Mb1477|M.bovis_AF2122/97 LFEALAETTTWDVIVDHTALLVAFGGLPVKNTAVMPGGTTAHPDRDYVGR Rv1442|M.tuberculosis_H37Rv LFEALAETTTWDVIVDHTALLVAFGGLPVKNTAVMPGGTTAHPDRDYVGR Mflv_3958|M.gilvum_PYR-GCK HDDLFTRSTQWQVIVENTDTMVCFGGLALKNTAVNDGGTTAHPARDALNR Mvan_2438|M.vanbaalenii_PYR-1 HDDLFKRSTQWDVIVEHTDLMVCFGGVALKNTGVNHGGTTAHPARGALDR MSMEG_2738|M.smegmatis_MC2_155 HDDLFKRSTQWDVIVEHTGLMVCFGGMPLKNTGINDGGTSAHPMRDALRR MAB_3041|M.abscessus_ATCC_1997 HDGLFKRSTSWDVIVENTDLLIAFGGIALKNTGVNHGGTTAHPARDALNR TH_4483|M.thermoresistible__bu -EAMYGSPIMVPVSDVDNCDYFLIVGANPAVSAWNWVESVPDGWRRALRR MMAR_2605|M.marinum_M -HLMYGGWWTFPVPDIERTDLLVIMGANPAAS---QGSLLAAPDVMGLID MUL_1474|M.ulcerans_Agy99 -------GPPGSYQDFDHADVFLVIGAN--------MADCHPILFLRMME MAV_4535|M.avium_104 -------GQPGSYTDVDHADVIALFGHN--------VAETQTVLWARMLD . . . * : Mb1477|M.bovis_AF2122/97 YRARGGR--LVSVSPLRDDIAAIAGPLDDRCRWLAPVPGTDVAIMLGLAY Rv1442|M.tuberculosis_H37Rv YRARGGR--LVSVSPLRDDIAAIAGPLDDRCRWLAPVPGTDVAIMLGLAY Mflv_3958|M.gilvum_PYR-GCK LRARGGR--IVSFSPLRDDV-------DGPCDWHAPVPGTDVAIMLALAH Mvan_2438|M.vanbaalenii_PYR-1 FRARGGH--LVSFSPLRDDV-------DGPCDWFAPVPGTDVAIMLALAH MSMEG_2738|M.smegmatis_MC2_155 FRGRGGR--IVSFSPLRDDV-------DGDCQWLALRPGTDVAVMLGLAY MAB_3041|M.abscessus_ATCC_1997 FRDRGGR--IVSFSPLHDDI-------DGECEWHAPIPGTDVAVMLALAH TH_4483|M.thermoresistible__bu QR-AGAT--IVVVDPIRTET------ADRADIHLAVRPGQDWALLLAMVK MMAR_2605|M.marinum_M AIRQRGK--VIVIDPVRTVT------AARADEWLPIVPGTDAALLLAVAH MUL_1474|M.ulcerans_Agy99 RVKSGAK--LIVVDPRRTAT------ADKADLFLQIAPGTDLALLNGLLH MAV_4535|M.avium_104 RLAGSDPPAIVCVDPRLTPV------ARHATVHLAPLPGTNVALMNGLLH :: ..* ** : *:: .: Mb1477|M.bovis_AF2122/97 VLATESLADRAFLGRYCTGYERFERYLLGLDDGIPKTPEWAAALSGLAAG Rv1442|M.tuberculosis_H37Rv VLATESLADRAFLGRYCTGYERFERYLLGLDDGIPKTPEWAAALSGLAAG Mflv_3958|M.gilvum_PYR-GCK VLATESLADREFLASHCTGYDRFERYLLGADDGIPKSPQWASSLCGLSAD Mvan_2438|M.vanbaalenii_PYR-1 VLAAESLADRDFLATYCTGYDRFERYLLGVDDGTPKSPQWAAQICGLDAD MSMEG_2738|M.smegmatis_MC2_155 VLATEGLADREFLDTHCTGYERFERYLLGHDDGVAKSPEWAAHISGLSAD MAB_3041|M.abscessus_ATCC_1997 VLAVEKLADLTFLSSYCTGYERFERYLLGVDDGVPKSPEWAAPISGLDAA TH_4483|M.thermoresistible__bu IILDEGLEHRGDCTELATGVPRLRELVAAADLDD------LAARCDVPRT MMAR_2605|M.marinum_M TLFDEDLVN---PGPHVDGVDTMRRVAADWPPAR------VSAVTGIEEE MUL_1474|M.ulcerans_Agy99 LIVENEQTDPQFISEFTEGWEVMPSFLEQFTPDR------VSEITGIPSE MAV_4535|M.avium_104 EIIGNGWIDRDYIDAHSVGFDELQCRVSEFTPEW------VAEICGVAAT : : . * : : .: Mb1477|M.bovis_AF2122/97 DLRDLARRMAEHRTLITTSLS-LQRIEHGEQTVWMAATLAAMLGQIGLPG Rv1442|M.tuberculosis_H37Rv DLRDLARRMAEHRTLITTSLS-LQRIEHGEQTVWMAATLAAMLGQIGLPG Mflv_3958|M.gilvum_PYR-GCK DLTALARRMAAGRTLVTVSWS-LQRTRHGEQAPWMGLTLAAMLGQIGLPG Mvan_2438|M.vanbaalenii_PYR-1 DLTALARRMAACRTIVTVSWS-LQRTRHGEQAPWMGLTLAAMLGQIGLPG MSMEG_2738|M.smegmatis_MC2_155 TLRALAHRMAAERTIVTVSWS-LQRTRHGEQAPWMGVTLAAMLGQIGLPG MAB_3041|M.abscessus_ATCC_1997 ELRTLARRMAAGRTLVTVSWS-LQRVRHGEQAPWMGLTLAAMLGQIGLPG TH_4483|M.thermoresistible__bu QIERVARGFATARTAMAVTRTGVSLHATGTVGEWLGHVLNVITGRMDRPG MMAR_2605|M.marinum_M RIRRLARELAGTHKSVVYGRIGLCNQEFGSLASWLVDVINILTGHFDTPG MUL_1474|M.ulcerans_Agy99 DIRTAARWIGTAANWMSCWTMGLNQSTHGTWNTNALCNLHLATGAICRPG MAV_4535|M.avium_104 DLRRAARLIGTAQRLLSTVLQGFYQSHQATAAAVQVNNIHLVRGMLGRPG : *: :. : . . : * : ** Mb1477|M.bovis_AF2122/97 GG-FGHGY-SSNGVGNPPLACG-------LPALPQGNNPVSTFIPVAAIS Rv1442|M.tuberculosis_H37Rv GG-FGHGY-SSNGVGNPPLACG-------LPALPQGNNPVSTFIPVAAIS Mflv_3958|M.gilvum_PYR-GCK GG-FGHGYGSMNEAGLAPIRCG-------LPRLPQGVNPVTTFIPVAAVS Mvan_2438|M.vanbaalenii_PYR-1 GG-FGHGYGSMNEPGLAPVRCG-------LPRLPQGINPVTTFIPVAAVS MSMEG_2738|M.smegmatis_MC2_155 GG-FGHGYGSMNEPGLAPLRCR-------LPSLPQGPNPVRTFIPVAAVT MAB_3041|M.abscessus_ATCC_1997 GG-FGHGYGSMNEPGLAPVSCP-------LPTFPQGPNPVETFIPVAAIS TH_4483|M.thermoresistible__bu GRRFERGYVDAQRLTALVKPPA-------HRSRVHGRPMVAGAHALAELP MMAR_2605|M.marinum_M GAMFPRPAAWSITTQPLPGLEGGVAEFGRWHTRVRGAKEVLGQAPVSCLA MUL_1474|M.ulcerans_Agy99 SGPFSLTGQPNAMGGREMGYMG---------PGLPGQRSVLSAPDREFVE MAV_4535|M.avium_104 CGVLQMNGQPTAENTRECGADG----------DLAGFRNWSNDSHVAELA : * : Mb1477|M.bovis_AF2122/97 ELLQRPGQRLAYNGR---------LLELPDIKCVYWAGGNPFHHHQNLPR Rv1442|M.tuberculosis_H37Rv ELLQRPGQRLAYNGR---------LLELPDIKCVYWAGGNPFHHHQNLPR Mflv_3958|M.gilvum_PYR-GCK DMLLHPGEPFDYNGL---------RLTYPDIRLVYWAGGNPFHHHQNLPR Mvan_2438|M.vanbaalenii_PYR-1 DMLLSPGEPFDYNGL---------RLHYPDIRLVYWAGGNPFHHHQNIPR MSMEG_2738|M.smegmatis_MC2_155 DMLLHPGEPFDYNGL---------RLTYPDIKCVYWSGGNPFHHHQNIPR MAB_3041|M.abscessus_ATCC_1997 ELLLRPGQTLAYNGQ---------TLTLPDIRCVYWAGGNPFHHHQNLPR TH_4483|M.thermoresistible__bu DEITTPGP--------------------GRIRALVINSGNPVVSGPDGAR MMAR_2605|M.marinum_M EEIATPGD--------------------GQLRALITIAGNPVLSTPGGDK MUL_1474|M.ulcerans_Agy99 EQWGLPGGALRTDVSGGVIDMFS-RMADGEIKACWIICSNPVATVANRKT MAV_4535|M.avium_104 DLWNLEPLQIPHYGPPTHAMQMFRFAEEGTLRMLWVTATNPAVSLPELPR : :: ** Mb1477|M.bovis_AF2122/97 LRRALSRVDTIVVHEQYWT-AMAKHADIVVPTTTSFERDDFAASKT---- Rv1442|M.tuberculosis_H37Rv LRRALSRVDTIVVHEQYWT-AMAKHADIVVPTTTSFERDDFAASKT---- Mflv_3958|M.gilvum_PYR-GCK LRRALSRPDTVVVHDPYWT-AMAKHADIVVPSTTFAERDDLSGSRN---- Mvan_2438|M.vanbaalenii_PYR-1 LRRALRRPDTVVVHDPYWT-PMAKHADIVVPSTTFAERHDFSGSRN---- MSMEG_2738|M.smegmatis_MC2_155 LRRALGRVDTIVVHDPYWT-AMAKHADIVVPSTTSFERNDFSGSKN---- MAB_3041|M.abscessus_ATCC_1997 LRRALSRVDTVVVHDPVWT-AMAKHADIVVPSTTSLERDDFSGSRN---- TH_4483|M.thermoresistible__bu LDAALAQLDLLVAIDLVQR-ESHRHAHWLLPAVHWLERDDLLALTSGMHD MMAR_2605|M.marinum_M LDEALSSLEAMISVDLWLN-ETTRHADVILPGLSPLEQPHHDDLVLQFAI MUL_1474|M.ulcerans_Agy99 VLAGLEKAELVISQDAFFETETNEYANVLLPAALWTESDGVMVNCER--- MAV_4535|M.avium_104 IRDILSQQRLFLVVQDIFLTETAALADVVLPAAAWAEKTGTFTNADR--- : * .: : *. ::* * Mb1477|M.bovis_AF2122/97 NPTLIAMPAMVPPYANARDDYHTFSALAHRLGFGKQFTEGRSAREWLEHM Rv1442|M.tuberculosis_H37Rv NPTLIAMPAMVPPYANARDDYHTFSALAHRLGFGKQFTEGRSAREWLEHM Mflv_3958|M.gilvum_PYR-GCK DPMLMAMPRLTETYAQARDDYDTYAALAGHLGVRQAFTEGRSSRQWLRHI Mvan_2438|M.vanbaalenii_PYR-1 DPVLMAMRRLAEPYAQARDDYDTFAALARRLGVADTFTEGRTSAQWLRHL MSMEG_2738|M.smegmatis_MC2_155 DPLLVAMPQLAEPYADSRDDYTTFSALAERLGFGEQFTEGRTAWEWLVHL MAB_3041|M.abscessus_ATCC_1997 DPLLVAMKAVAPPYANSRDDYTTFSALADRLGFGEQFSEGRTAAQWLRHI TH_4483|M.thermoresistible__bu EPYAQYGVRAVDPPPRAREEWRIFVDLALAMGRPLFGVRGINEFVTATRW MMAR_2605|M.marinum_M RSFANYSAPVFDPGDRPHEWEILIRLTGLCTGTPAEDVDVAAIDDGFFDY MUL_1474|M.ulcerans_Agy99 --NMSLFPKAVDPVGDALPDWQIIARIACEMGFSESFSYS-SAAEVFEEI MAV_4535|M.avium_104 --TVHLSEKAVEPPGSARSDLEIFLDYARRMDFRDKDGRPFPPWTDPESA . . . . Mb1477|M.bovis_AF2122/97 YDKWSAELD---FPVP--SFAEFWRTGRLELPTRTGLTWLADFRA----D Rv1442|M.tuberculosis_H37Rv YDKWSAELD---FPVP--SFAEFWRTGRLELPTRTGLTWLADFRA----D Mflv_3958|M.gilvum_PYR-GCK YETWSRTLD---FDVP--AFDGFWAAGALRLPTDDGLTLLADFRA----D Mvan_2438|M.vanbaalenii_PYR-1 YEKWSATLD---FEVP--SFDEFWQVGQVRLPTDEGLTLFADFRA----D MSMEG_2738|M.smegmatis_MC2_155 YEKWAAGLD---FAVP--SFAEFWAAGHVELPTDTGLTLFEDFRA----D MAB_3041|M.abscessus_ATCC_1997 YTEWAGALN---FSVP--SFDEFWDRGYLELPTDAGLTLLSDFRE----N TH_4483|M.thermoresistible__bu LALRTGRPG---VAFG--PHWLDRLMVATSRKINGHRLTWRDLRE----H MMAR_2605|M.marinum_M LAFTKGFDG---AAIR--KRYEHDGWAGGPERILDLTLRTGPFGDRYGQN MUL_1474|M.ulcerans_Agy99 KRFSNPATG---YDLRGISHDRLRETPLQWPCPPDGASNRSPIRY----- MAV_4535|M.avium_104 FEAWKKCSAGRPCDYTGLSYAKLRGGSGIQWPCNTDHPDGIERLYEDGRF Mb1477|M.bovis_AF2122/97 PAAHPLGTPSGRIEIFSDTVDAFALPDCAGHPTWYEPS-------EWLGG Rv1442|M.tuberculosis_H37Rv PAAHPLGTPSGRIEIFSDTVDAFALPDCAGHPTWYEPS-------EWLGG Mflv_3958|M.gilvum_PYR-GCK PSAHPLATPSGRIEIFSADIDSFGYDDCRGHPAWFEPT-------EWLGG Mvan_2438|M.vanbaalenii_PYR-1 PSAHRLATPSGRIEIFSADIAGFGYRDCVGHPAWFEPA-------EWLGG MSMEG_2738|M.smegmatis_MC2_155 PQAHPLGTPSGRIEIFSEDIDSFGYDDCAGHPRWYEPA-------EWLGG MAB_3041|M.abscessus_ATCC_1997 PAAHPLHTPSGRIEIFSETIDGFGYSDCGGHPQWYEPT-------EWLGG TH_4483|M.thermoresistible__bu PHGLVLGPRE--FGHFRSALRTPDKKVHTAPPEFIARVR------ELLAE MMAR_2605|M.marinum_M PGGLTLDMLKANPNGIDFGPMVSQLPDILGTPEKKIRLAPQYLLDDLPRL MUL_1474|M.ulcerans_Agy99 ---LNDGVSQLQFVRADGTVPRLAFPTATGRAVFFARP-------HLVPD MAV_4535|M.avium_104 PAAPDYCEAYGKDLITGAPLQPDEYRSLNPSGKAIIKAAQ-----YLPPH Mb1477|M.bovis_AF2122/97 PRAARYPLHLIANQPRTRLHSQLDHGGASMASKIRGRE-PIRIHPDDAAA Rv1442|M.tuberculosis_H37Rv PRAARYPLHLIANQPRTRLHSQLDHGGASMASKIRGRE-PIRIHPDDAAA Mflv_3958|M.gilvum_PYR-GCK PRAADYPLHLVANQPAGRLHGQLDAGAASQATKVAGRE-PIRMHPADAHA Mvan_2438|M.vanbaalenii_PYR-1 PRAERYPLHLLANQPASRLHSQLDGGATSQASKVAGRE-PVRMHPDDAAE MSMEG_2738|M.smegmatis_MC2_155 ERARRYPLHLLANQPASRLHSQLDGGATSQSSKVQGRE-PVRMHPSDAAA MAB_3041|M.abscessus_ATCC_1997 ERAQRFPLHLIANQPRTRLHSQLDFGGTSQGSKVRGRE-PLRIHPQDAAT TH_4483|M.thermoresistible__bu PHPQAPPGYPFVLGNRRRRHSMNSWLNELPDLHPGGRQNTAILHPDDAAT MMAR_2605|M.marinum_M ASRMDRPAEQLVLVNRRHLRSNNSWLHNVPALMKGKDRCTLLMHPDDAAR MUL_1474|M.ulcerans_Agy99 EMPDGDYPFLLNTGRLAHQWHTLTKTGKIAKLNKLNPGPFVEVHPDDAAD MAV_4535|M.avium_104 ERPGPDYPFALITGRTIYHFHTRTKTARAQQLQDAAPEVWVEVSERDARR . : ** Mb1477|M.bovis_AF2122/97 RELTDGDIVRVFNDRGACLAGVVIDDGLRPK------------------- Rv1442|M.tuberculosis_H37Rv RELTDGDIVRVFNDRGACLAGVVIDDGLRPK------------------- Mflv_3958|M.gilvum_PYR-GCK RDLSGGDVVRVFNDRGACLAGVVLDDRVRPQ------------------- Mvan_2438|M.vanbaalenii_PYR-1 RGLAAGDVVRMFNDSGACLAGVVLDDRVRPR------------------- MSMEG_2738|M.smegmatis_MC2_155 RGLADGDVVRVFNDRGACLAGVVIDDGVLPR------------------- MAB_3041|M.abscessus_ATCC_1997 RGIADGDVVRVFNDRGACLAGAVLDEGLRRQ------------------- TH_4483|M.thermoresistible__bu LGIADGDRVRLSSPVGVVEAEANLSDRPRRG------------------- MMAR_2605|M.marinum_M NGITDNDTVTVRSSAGEITVPVELTSAIKPG------------------- MUL_1474|M.ulcerans_Agy99 MQICEGDHIEIASRRGRAVLPVVITDRVRPGNCFAPFHWNDAFGEYLSIN MAV_4535|M.avium_104 LGIEAGDLVHVSTPRGRITCAARVG-GIRDG------------------- : .* : : . * . : Mb1477|M.bovis_AF2122/97 --------------------VVQLSTGAWFDPADPRDPDSMCVHGNPNAL Rv1442|M.tuberculosis_H37Rv --------------------VVQLSTGAWFDPADPRDPDSMCVHGNPNAL Mflv_3958|M.gilvum_PYR-GCK --------------------VVQLSTGAWFDPADPADPHSMCVHGNPNVL Mvan_2438|M.vanbaalenii_PYR-1 --------------------VVQLSTGAWFDPADPADPDSMCVHGNPNML MSMEG_2738|M.smegmatis_MC2_155 --------------------VVQLATGAWYDPADPADPDSLCLHGNPNVL MAB_3041|M.abscessus_ATCC_1997 --------------------VVQLSTGAWFDPIEPADPNSACAHGNPNVL TH_4483|M.thermoresistible__bu --------------------LVILDHGWGSRVFDPSGHHPPQSYGVNRNL MMAR_2605|M.marinum_M --------------------VVSMPHGWGHG---KPGTRLAVANSAPGVN MUL_1474|M.ulcerans_Agy99 AVTNDAVDPISRQPEYKACAVTLTKVARPQLQPEPGEPADACADATAPKL MAV_4535|M.avium_104 --------------------VLFVPFHYGYWDRDGGDHQRAGNELTATDW : Mb1477|M.bovis_AF2122/97 SNDSGTSSLAHGSTGQHVLVQIERFTGELPPVRAHEPPRLA--------- Rv1442|M.tuberculosis_H37Rv SNDSGTSSLAHGSTGQHVLVQIERFTGELPPVRAHEPPRLA--------- Mflv_3958|M.gilvum_PYR-GCK TDDVGTSKLAHGCTGAHVLVQIEKYAGTPPPVRAHQPPVFTPR------- Mvan_2438|M.vanbaalenii_PYR-1 TDDVGTSALAHGCTGAHALVQIEKYTAAPPPVRAHQPPVFAAR------- MSMEG_2738|M.smegmatis_MC2_155 TDDVGTSSLAKGCTGAHVLVEIEKFAGPVPPVRAHEPPVIRTLR------ MAB_3041|M.abscessus_ATCC_1997 TDDSGTSSLAQGCTGQHVLVQIERFEGTPPPVRAHTPPRFVARD------ TH_4483|M.thermoresistible__bu LVDASIDPLSQTSTLGTANVAIERSGA----------------------- MMAR_2605|M.marinum_M TNVLSPPTLLDEPSGNGVLNGIPVTVS----------------------- MUL_1474|M.ulcerans_Agy99 LADTAQFSVTQVDALAELLGVGNEPTPQFGPSARSYLAGLIAGLRSETGR MAV_4535|M.avium_104 DPASKQPSFKTAAARLDMAPTHTAAPVSEAVAAGSPS------------- . : Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- TH_4483|M.thermoresistible__bu -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- MUL_1474|M.ulcerans_Agy99 RMAGVSTLPISSPFDTGTRLWLDGLLAGMFARAETPPALPFPQTPGAAAQ MAV_4535|M.avium_104 -------------------------------------------------- Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- TH_4483|M.thermoresistible__bu -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- MUL_1474|M.ulcerans_Agy99 SDNAAEAAVEQPPIVVLWASQTGTAEELAASVAAQLSAAELPVVLHGMDE MAV_4535|M.avium_104 -------------------------------------------------- Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- TH_4483|M.thermoresistible__bu -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- MUL_1474|M.ulcerans_Agy99 FAVADLVSTQRLLLVTSTTGDGEPPDNGAAFWRELCAPTAPSLAGTRYSV MAV_4535|M.avium_104 -------------------------------------------------- Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- TH_4483|M.thermoresistible__bu -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- MUL_1474|M.ulcerans_Agy99 LALGDSNYADFCGHGRALDHRLAELGASRITDRVDCEPDYEESAARWLQE MAV_4535|M.avium_104 -------------------------------------------------- Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- TH_4483|M.thermoresistible__bu -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- MUL_1474|M.ulcerans_Agy99 VLDGLRRTAPPVITAEPVRAASIASRPQGYTKKRPLLTSVMRNTTLSRPR MAV_4535|M.avium_104 -------------------------------------------------- Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- TH_4483|M.thermoresistible__bu -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- MUL_1474|M.ulcerans_Agy99 SAKDVRQLVFRVPEQTVSYEAGDALGVWPRNAHQLVDEWLGVTRLDGHTE MAV_4535|M.avium_104 -------------------------------------------------- Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- TH_4483|M.thermoresistible__bu -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- MUL_1474|M.ulcerans_Agy99 VEVAGHGTMSLRAALTDRFEIAHLSPDLLRFVAQRTLDSNTANQLAELMR MAV_4535|M.avium_104 -------------------------------------------------- Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- TH_4483|M.thermoresistible__bu -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- MUL_1474|M.ulcerans_Agy99 PENKAALADWTWGRQSVDLLAQSPVRASVDEWMSVLKPIQPRLYSISSSP MAV_4535|M.avium_104 -------------------------------------------------- Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- TH_4483|M.thermoresistible__bu -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- MUL_1474|M.ulcerans_Agy99 KEHPGEVHLTVSPVRYNFQGVPRRGVCSTYLADRSPSDQIAIYVRKSSNF MAV_4535|M.avium_104 -------------------------------------------------- Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- TH_4483|M.thermoresistible__bu -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- MUL_1474|M.ulcerans_Agy99 RPPSDPRTPMIMIGPGTGIAPFRGFLQERRALGHTGPNWLFFGEQHAATD MAV_4535|M.avium_104 -------------------------------------------------- Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- TH_4483|M.thermoresistible__bu -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- MUL_1474|M.ulcerans_Agy99 FYYRDEIQAMHRDGLLTNLDLAFSRDQRDKVYVQHLMQQRGAQLWQWLQD MAV_4535|M.avium_104 -------------------------------------------------- Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- TH_4483|M.thermoresistible__bu -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- MUL_1474|M.ulcerans_Agy99 GAQVYVCGTADPMAKDVDRMLCQIVAEHGGLDPESATAFVHALSADKRYH MAV_4535|M.avium_104 -------------------------------------------------- Mb1477|M.bovis_AF2122/97 ---- Rv1442|M.tuberculosis_H37Rv ---- Mflv_3958|M.gilvum_PYR-GCK ---- Mvan_2438|M.vanbaalenii_PYR-1 ---- MSMEG_2738|M.smegmatis_MC2_155 ---- MAB_3041|M.abscessus_ATCC_1997 ---- TH_4483|M.thermoresistible__bu ---- MMAR_2605|M.marinum_M ---- MUL_1474|M.ulcerans_Agy99 RDVY MAV_4535|M.avium_104 ----