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MQVYTSATHWGVFTARVHGGDIAAVAALASDTNPAPQLQNLPGAVRHRSRIANPAVRRGWLQHGPGPSSA RGAEEFVEVSWDELIELLASELRRTVDRYGNEAIYGSSYGWASAGRFHHAQSQVHRFLNMLGGYTASRHS YSAGASEVIFPHIVGAALFEALAETTTWDVIVDHTALLVAFGGLPVKNTAVMPGGTTAHPDRDYVGRYRA RGGRLVSVSPLRDDIAAIAGPLDDRCRWLAPVPGTDVAIMLGLAYVLATESLADRAFLGRYCTGYERFER YLLGLDDGIPKTPEWAAALSGLAAGDLRDLARRMAEHRTLITTSLSLQRIEHGEQTVWMAATLAAMLGQI GLPGGGFGHGYSSNGVGNPPLACGLPALPQGNNPVSTFIPVAAISELLQRPGQRLAYNGRLLELPDIKCV YWAGGNPFHHHQNLPRLRRALSRVDTIVVHEQYWTAMAKHADIVVPTTTSFERDDFAASKTNPTLIAMPA MVPPYANARDDYHTFSALAHRLGFGKQFTEGRSAREWLEHMYDKWSAELDFPVPSFAEFWRTGRLELPTR TGLTWLADFRADPAAHPLGTPSGRIEIFSDTVDAFALPDCAGHPTWYEPSEWLGGPRAARYPLHLIANQP RTRLHSQLDHGGASMASKIRGREPIRIHPDDAAARELTDGDIVRVFNDRGACLAGVVIDDGLRPKVVQLS TGAWFDPADPRDPDSMCVHGNPNALSNDSGTSSLAHGSTGQHVLVQIERFTGELPPVRAHEPPRLA
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1477 | bisC | - | 100% (766) | biotin sulfoxide reductase |
M. bovis AF2122 / 97 | Mb2924c | fdhF | 6e-09 | 24.40% (336) | formate dehydrogenase H |
M. bovis AF2122 / 97 | Mb1193 | narG | 6e-09 | 24.47% (331) | respiratory nitrate reductase subunit alpha NarG |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_3958 | - | 0.0 | 68.16% (760) | molybdopterin guanine dinucleotide-containing S/N-oxide |
M. tuberculosis H37Rv | Rv1442 | bisC | 0.0 | 100.00% (766) | biotin sulfoxide reductase |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_3041 | - | 0.0 | 70.21% (762) | putative biotin sulfoxide reductase BisC |
M. marinum M | MMAR_2605 | - | 1e-19 | 22.95% (671) | anaerobic dehydrogenase |
M. avium 104 | MAV_2075 | - | 2e-19 | 21.58% (505) | FdhF protein |
M. smegmatis MC2 155 | MSMEG_2738 | - | 0.0 | 70.13% (760) | biotin sulfoxide reductase |
M. thermoresistible (build 8) | TH_4041 | - | 5e-30 | 26.29% (677) | PUTATIVE Formate dehydrogenase |
M. ulcerans Agy99 | MUL_1474 | fdhF | 3e-19 | 22.02% (504) | formate dehydrogenase H FdhF |
M. vanbaalenii PYR-1 | Mvan_2438 | - | 0.0 | 67.23% (763) | molybdopterin guanine dinucleotide-containing S/N-oxide |
CLUSTAL 2.0.9 multiple sequence alignment Mb1477|M.bovis_AF2122/97 -------------------------------------MQVYTSATHWGVF Rv1442|M.tuberculosis_H37Rv -------------------------------------MQVYTSATHWGVF Mflv_3958|M.gilvum_PYR-GCK MLQSTSITKSPRRIDSKERRLFHPSFRRNGVRRLSCVARTRTSLTHWGAF Mvan_2438|M.vanbaalenii_PYR-1 MVG-----------------------RGGRAVRLSSVSATQTSLTHWGAF MSMEG_2738|M.smegmatis_MC2_155 ------------------------------------MPHSPTSLTHWGVF MAB_3041|M.abscessus_ATCC_1997 -------------------------MIRPAFSAVQVSGSARLSHTHWGAF MMAR_2605|M.marinum_M -----------------------------------MATVDDGRHLHTCPL TH_4041|M.thermoresistible__bu --------------------------------------MATEQRVTYCRI MAV_2075|M.avium_104 -------------------------------------------MNTMCAY MUL_1474|M.ulcerans_Agy99 ------------------------------------MAPNKDAVKTVCAY Mb1477|M.bovis_AF2122/97 TARVHGGDIAAVAALASDTNPAPQLQNLPGAVRHRSRIANPAVRRGWLQH Rv1442|M.tuberculosis_H37Rv TARVHGGDIAAVAALASDTNPAPQLQNLPGAVRHRSRIANPAVRRGWLQH Mflv_3958|M.gilvum_PYR-GCK SATVESGDIASVRPWSGDADPSPALGNLPGSVRHRSRVTAPAVRRGWLEN Mvan_2438|M.vanbaalenii_PYR-1 SATVEAGEITAVAPVAGDDDPSVALGNLPGSVRHISRVTTPAVRRGWLDH MSMEG_2738|M.smegmatis_MC2_155 SAEIVDGDIAAVNPPPDDADPSPLLGNMPGSIRHRARITGPAVRRGWLRD MAB_3041|M.abscessus_ATCC_1997 TPEVRDGEVIGVTPIETDLDPSPLLQNIPGSIRHQARVTAPAVRSGWLRE MMAR_2605|M.marinum_M CEAMCGLEIRVADGPSGG--RVVGIRGNRDDVWSRGHICPKGASLGALHD TH_4041|M.thermoresistible__bu CEPLCGLIATVEDG------RLQSLRPDPDHPLSRGRACPKGIAFTEVQN MAV_2075|M.avium_104 CGVGCGMVLQITTDPQTGRRHVAKSVGNKEHPANFGRLCTKGATTADLLA MUL_1474|M.ulcerans_Agy99 CGVGCGIVLQTTTDPQTGKRRVAKSTGDKSHPANLGRLCTKGTTTADLLA .: . : Mb1477|M.bovis_AF2122/97 GPG-----PSSARGAEEFVEVSWDELIELLASELRRTVDRYGNEAIYGSS Rv1442|M.tuberculosis_H37Rv GPG-----PSSARGAEEFVEVSWDELIELLASELRRTVDRYGNEAIYGSS Mflv_3958|M.gilvum_PYR-GCK GPG-----PDTLLGADEFVAVTWDDLVELLGGELRRVIDTHGNEAIYGGS Mvan_2438|M.vanbaalenii_PYR-1 GPG-----PDDSRGADDFVAVTWDELTELLGDELRRVIDTHGNGAIYGGS MSMEG_2738|M.smegmatis_MC2_155 GPG-----PSTERGADEFVAVSWDELTDLLATELRRVVDTYGNEAIYGGS MAB_3041|M.abscessus_ATCC_1997 GPG-----PSDKRGADEYVEVSWDELTELLADELRRVVDTHGNEAIYGGS MMAR_2605|M.marinum_M DPDRIRHPMIK--IDGQWHEVSWDAAFRRCTELLAPVIDTYGIGAVT--- TH_4041|M.thermoresistible__bu DPDRVLYPLRRR-ADGEFERVGWDEALDDIAARLTAIRDRHGGGAIG--- MAV_2075|M.avium_104 APGRMDSAHARAGRGEPLEPIGTDQAITRCAKQLRAIIDEHGPDAFA--- MUL_1474|M.ulcerans_Agy99 APGRMESAHLRAHRAGHLESIPIDDAITQCAMRLRAIIDEHGPDAVG--- *. : * * * :* *. Mb1477|M.bovis_AF2122/97 YGWASAGRFHHAQSQVHRFLNMLGGYTASRHSYSAGASEVIFPHIVGAAL Rv1442|M.tuberculosis_H37Rv YGWASAGRFHHAQSQVHRFLNMLGGYTASRHSYSAGASEVIFPHIVGAAL Mflv_3958|M.gilvum_PYR-GCK YGWSSAGRFHHAQSQVHRFLNCLGGYTYSRHSYSLGATGVIMPRVVG-TH Mvan_2438|M.vanbaalenii_PYR-1 YGWSSAGRFHHAQSQVHRFLNCLGGYTFSRHSYSLGATGVIMPRVVG-TH MSMEG_2738|M.smegmatis_MC2_155 YGWSSAGRFHHAQSQVHRFLKMLGGYTFSRHSYSLGATGAIMPRVVG-TH MAB_3041|M.abscessus_ATCC_1997 YGWASAGRFHHAQSQVHRFLKLLGGYTFSRHSYSLGATGVIMPHVIG-TH MMAR_2605|M.marinum_M ---AYTGNPLAHSFSLARYAGVLLGMSGMPVTYSP-GTVDQWPKNLSSHL TH_4041|M.thermoresistible__bu ---QYFGNPVAFGYATALWSGMFVARLGSRHQYSS-GSQDINSRFVASKL MAV_2075|M.avium_104 ---MYVSGQMSLEAQYLANK-LTKGFIGTNQIESN-SRLCMASAGSGYKL MUL_1474|M.ulcerans_Agy99 ---VYVSGQMSIEAQYLANK-LTKGFIGTKQIESN-SRLCMAGASSGYKL . . * . . Mb1477|M.bovis_AF2122/97 FEALAETTTWDVIVDHTALLVAFGGLPVKNTAVMPGGTTAHPDRDYVGRY Rv1442|M.tuberculosis_H37Rv FEALAETTTWDVIVDHTALLVAFGGLPVKNTAVMPGGTTAHPDRDYVGRY Mflv_3958|M.gilvum_PYR-GCK DDLFTRSTQWQVIVENTDTMVCFGGLALKNTAVNDGGTTAHPARDALNRL Mvan_2438|M.vanbaalenii_PYR-1 DDLFKRSTQWDVIVEHTDLMVCFGGVALKNTGVNHGGTTAHPARGALDRF MSMEG_2738|M.smegmatis_MC2_155 DDLFKRSTQWDVIVEHTGLMVCFGGMPLKNTGINDGGTSAHPMRDALRRF MAB_3041|M.abscessus_ATCC_1997 DGLFKRSTSWDVIVENTDLLIAFGGIALKNTGVNHGGTTAHPARDALNRF MMAR_2605|M.marinum_M MYGGWWTFP-VPDIERTDLLVIMG----ANPAASQGSLLAAPDVMGLIDA TH_4041|M.thermoresistible__bu LYGAASQIP-FPDLPRTDFLFMLG----ANPFVSHGSALRAPRIKDDLTD MAV_2075|M.avium_104 SLGADGPPGSYQDFEHADVFFVIG----ANMADCHPILFLR-----MMDR MUL_1474|M.ulcerans_Agy99 SLGADGPPGSYQDFDHADVFLVIG----ANMADCHPILFLR-----MMER . .: :. :* * Mb1477|M.bovis_AF2122/97 RARGGRLVSVSPLRDDIAAIAGPLDDRCRWLAPVPGTDVAIMLGLAYVLA Rv1442|M.tuberculosis_H37Rv RARGGRLVSVSPLRDDIAAIAGPLDDRCRWLAPVPGTDVAIMLGLAYVLA Mflv_3958|M.gilvum_PYR-GCK RARGGRIVSFSPLRDDV-------DGPCDWHAPVPGTDVAIMLALAHVLA Mvan_2438|M.vanbaalenii_PYR-1 RARGGHLVSFSPLRDDV-------DGPCDWFAPVPGTDVAIMLALAHVLA MSMEG_2738|M.smegmatis_MC2_155 RGRGGRIVSFSPLRDDV-------DGDCQWLALRPGTDVAVMLGLAYVLA MAB_3041|M.abscessus_ATCC_1997 RDRGGRIVSFSPLHDDI-------DGECEWHAPIPGTDVAVMLALAHVLA MMAR_2605|M.marinum_M IRQRGKVIVIDPVRTVT------AARADEWLPIVPGTDAALLLAVAHTLF TH_4041|M.thermoresistible__bu ITRRGGRVVVVDPRRTE------TARAFEHIAVRPDSDAWLLLSMLQVIF MAV_2075|M.avium_104 VKAGAKLIVVDPRRTAT------AEKADLFLQIAPGTDLALLNGLLHLIV MUL_1474|M.ulcerans_Agy99 VKSGAKLIVVDPRRTAT------ADKADLFLQIAPGTDLALLNGLLHLIV . : . : *.:* :: .: : Mb1477|M.bovis_AF2122/97 TESLADRAFLGRYCTGYERFERYLLGLDDGIPKTPEWAAALSGLAAGDLR Rv1442|M.tuberculosis_H37Rv TESLADRAFLGRYCTGYERFERYLLGLDDGIPKTPEWAAALSGLAAGDLR Mflv_3958|M.gilvum_PYR-GCK TESLADREFLASHCTGYDRFERYLLGADDGIPKSPQWASSLCGLSADDLT Mvan_2438|M.vanbaalenii_PYR-1 AESLADRDFLATYCTGYDRFERYLLGVDDGTPKSPQWAAQICGLDADDLT MSMEG_2738|M.smegmatis_MC2_155 TEGLADREFLDTHCTGYERFERYLLGHDDGVAKSPEWAAHISGLSADTLR MAB_3041|M.abscessus_ATCC_1997 VEKLADLTFLSSYCTGYERFERYLLGVDDGVPKSPEWAAPISGLDAAELR MMAR_2605|M.marinum_M DEDLVN---PGPHVDGVDTMRRVAADWP------PARVSAVTGIEEERIR TH_4041|M.thermoresistible__bu AEGLEDTAAIARQTTGCSTLRGLVAGFP------PEATAARTGVPADVVR MAV_2075|M.avium_104 ENGHTDGEFIAEFTEGWEVMPSFLEQYT------PDRVSEITGIPEQDIR MUL_1474|M.ulcerans_Agy99 ENEQTDPQFISEFTEGWEVMPSFLEQFT------PDRVSEITGIPSEDIR : : * . : * .: *: : Mb1477|M.bovis_AF2122/97 DLARRMAEHRTLITTSLS-LQRIEHGEQTVWMAATLAAMLGQIGLPGGGF Rv1442|M.tuberculosis_H37Rv DLARRMAEHRTLITTSLS-LQRIEHGEQTVWMAATLAAMLGQIGLPGGGF Mflv_3958|M.gilvum_PYR-GCK ALARRMAAGRTLVTVSWS-LQRTRHGEQAPWMGLTLAAMLGQIGLPGGGF Mvan_2438|M.vanbaalenii_PYR-1 ALARRMAACRTIVTVSWS-LQRTRHGEQAPWMGLTLAAMLGQIGLPGGGF MSMEG_2738|M.smegmatis_MC2_155 ALAHRMAAERTIVTVSWS-LQRTRHGEQAPWMGVTLAAMLGQIGLPGGGF MAB_3041|M.abscessus_ATCC_1997 TLARRMAAGRTLVTVSWS-LQRVRHGEQAPWMGLTLAAMLGQIGLPGGGF MMAR_2605|M.marinum_M RLARELAGTHKSVVYGRIGLCNQEFGSLASWLVDVINILTGHFDTPGGAM TH_4041|M.thermoresistible__bu SLARDFAAAPTAAAYGRTGACLGRHGTLVSFLLDALSIVTGNLDREGGLL MAV_2075|M.avium_104 AAAQLIGEADNFMSCWTMGLNQSTHGTWNTNAICNLHLATGAICKPGSGP MUL_1474|M.ulcerans_Agy99 TAARWIGTAANWMSCWTMGLNQSTHGTWNTNALCNLHLATGAICRPGSGP *: :. . .* : * : *. Mb1477|M.bovis_AF2122/97 GHGY-SSNGVGNPPLACGLPALPQGNNPVSTFIPVAAISELLQRPGQRLA Rv1442|M.tuberculosis_H37Rv GHGY-SSNGVGNPPLACGLPALPQGNNPVSTFIPVAAISELLQRPGQRLA Mflv_3958|M.gilvum_PYR-GCK GHGYGSMNEAGLAPIRCGLPRLPQGVNPVTTFIPVAAVSDMLLHPGEPFD Mvan_2438|M.vanbaalenii_PYR-1 GHGYGSMNEPGLAPVRCGLPRLPQGINPVTTFIPVAAVSDMLLSPGEPFD MSMEG_2738|M.smegmatis_MC2_155 GHGYGSMNEPGLAPLRCRLPSLPQGPNPVRTFIPVAAVTDMLLHPGEPFD MAB_3041|M.abscessus_ATCC_1997 GHGYGSMNEPGLAPVSCPLPTFPQGPNPVETFIPVAAISELLLRPGQTLA MMAR_2605|M.marinum_M FPRPAAWSITTQPLPGLEGG--VAEFGRWHTRV-RGAKEVLGQAPVSCLA TH_4041|M.thermoresistible__bu MAH----AVIPFEELGERTG--RLTYGTERSRI-GGLPEVISTFPAALMA MAV_2075|M.avium_104 FSLTGQPNAMGGREMGYMGPGLPGQRSVASAAD-REFVEDVWGVPRGRLR MUL_1474|M.ulcerans_Agy99 FSLTGQPNAMGGREMGYMGPGLPGQRSVLSAPD-REFVEEQWGLPGGALR . : * : Mb1477|M.bovis_AF2122/97 YNGRL--------LELPDIKCVYWAGGNPFHHHQNLPRLRRALSRVDTIV Rv1442|M.tuberculosis_H37Rv YNGRL--------LELPDIKCVYWAGGNPFHHHQNLPRLRRALSRVDTIV Mflv_3958|M.gilvum_PYR-GCK YNGLR--------LTYPDIRLVYWAGGNPFHHHQNLPRLRRALSRPDTVV Mvan_2438|M.vanbaalenii_PYR-1 YNGLR--------LHYPDIRLVYWAGGNPFHHHQNIPRLRRALRRPDTVV MSMEG_2738|M.smegmatis_MC2_155 YNGLR--------LTYPDIKCVYWSGGNPFHHHQNIPRLRRALGRVDTIV MAB_3041|M.abscessus_ATCC_1997 YNGQT--------LTLPDIRCVYWAGGNPFHHHQNLPRLRRALSRVDTVV MMAR_2605|M.marinum_M EEIAT--------PGDGQLRALITIAGNPVLSTPGGDKLDEALSSLEAMI TH_4041|M.thermoresistible__bu DEINT--------PGDGQLRALFVTAGNPVLTVPNGPALEKVLGKLDLIV MAV_2075|M.avium_104 TEVGTGTIDMFSRMADGQIKACWIICTNPVASVANRKTVLAGLERAELVI MUL_1474|M.ulcerans_Agy99 TDVSGGVIDMFSRMADGEIKACWIICSNPVATVANRKTVLAGLEKAELVI : ::: **. . : * : :: Mb1477|M.bovis_AF2122/97 VHEQYWT-AMAKHADIVVPTTTSFERD----DFAASKTNPTLIAMPAMVP Rv1442|M.tuberculosis_H37Rv VHEQYWT-AMAKHADIVVPTTTSFERD----DFAASKTNPTLIAMPAMVP Mflv_3958|M.gilvum_PYR-GCK VHDPYWT-AMAKHADIVVPSTTFAERD----DLSGSRNDPMLMAMPRLTE Mvan_2438|M.vanbaalenii_PYR-1 VHDPYWT-PMAKHADIVVPSTTFAERH----DFSGSRNDPVLMAMRRLAE MSMEG_2738|M.smegmatis_MC2_155 VHDPYWT-AMAKHADIVVPSTTSFERN----DFSGSKNDPLLVAMPQLAE MAB_3041|M.abscessus_ATCC_1997 VHDPVWT-AMAKHADIVVPSTTSLERD----DFSGSRNDPLLVAMKAVAP MMAR_2605|M.marinum_M SVDLWLN-ETTRHADVILPGLSPLEQPHHDDLVLQFAIRSFANYSAPVFD TH_4041|M.thermoresistible__bu SLDFYVT-ETNRHAHYVLPATTFLERDDYPYGFAANCPTVFIQSAEPVVG MAV_2075|M.avium_104 AQDAYLGTETSEYADVLLPAALWAETE----GVMVNSERNIT-LSQPAVA MUL_1474|M.ulcerans_Agy99 SQDAFFETETNEYANVLLPAALWTESD----GVMVNCERNMS-LFPKAVD : .:*. ::* * . Mb1477|M.bovis_AF2122/97 PYANARDDYHTFSALAHRLG-----------------FGKQFTEGRSARE Rv1442|M.tuberculosis_H37Rv PYANARDDYHTFSALAHRLG-----------------FGKQFTEGRSARE Mflv_3958|M.gilvum_PYR-GCK TYAQARDDYDTYAALAGHLG-----------------VRQAFTEGRSSRQ Mvan_2438|M.vanbaalenii_PYR-1 PYAQARDDYDTFAALARRLG-----------------VADTFTEGRTSAQ MSMEG_2738|M.smegmatis_MC2_155 PYADSRDDYTTFSALAERLG-----------------FGEQFTEGRTAWE MAB_3041|M.abscessus_ATCC_1997 PYANSRDDYTTFSALADRLG-----------------FGEQFSEGRTAAQ MMAR_2605|M.marinum_M P-GDRPHEWEILIRLTGLCTGTPAEDVDVAAIDDGFFDYLAFTKGFDGAA TH_4041|M.thermoresistible__bu AYGEARNEWEVFDELARRMG--------LSLFATGPLERLNPVLAWLDRR MAV_2075|M.avium_104 APGGAMPDWQIIARIACEMG---------------FSEAFSYSCAEEVFE MUL_1474|M.ulcerans_Agy99 PVGDALPDWQIIARIACEMG---------------FSESFSYSSAAEVFE . . :: :: . Mb1477|M.bovis_AF2122/97 WLEHMYDKWSAELDFPVPSFAEFWRTGRLELPTRTGLTWLADFRADPAAH Rv1442|M.tuberculosis_H37Rv WLEHMYDKWSAELDFPVPSFAEFWRTGRLELPTRTGLTWLADFRADPAAH Mflv_3958|M.gilvum_PYR-GCK WLRHIYETWSRTLDFDVPAFDGFWAAGALRLPTDDGLTLLADFRADPSAH Mvan_2438|M.vanbaalenii_PYR-1 WLRHLYEKWSATLDFEVPSFDEFWQVGQVRLPTDEGLTLFADFRADPSAH MSMEG_2738|M.smegmatis_MC2_155 WLVHLYEKWAAGLDFAVPSFAEFWAAGHVELPTDTGLTLFEDFRADPQAH MAB_3041|M.abscessus_ATCC_1997 WLRHIYTEWAGALNFSVPSFDEFWDRGYLELPTDAGLTLLSDFRENPAAH MMAR_2605|M.marinum_M IRKRYEHDGWAGGPERILDLTLRTGPFGDRYGQNPGGLTLDMLKANPNGI TH_4041|M.thermoresistible__bu GVGRLT-------PRRLMELLLRLGPYGDRFGLRRGGLNPRRLRENPHGI MAV_2075|M.avium_104 EIKRFWNPTTGYDLRGVSYERLRRQPLQWPCPPQ-STADRNPIRYLNDGV MUL_1474|M.ulcerans_Agy99 EIKRFSNPATGYDLRGISHDRLRETPLQWPCPPD-GASNRSPIRYLNDGV : : . :: . Mb1477|M.bovis_AF2122/97 PLGTPSGRIEIFSDTVDAFALPDCAGHPTWYEPSEWLGGPRAAR-YPLHL Rv1442|M.tuberculosis_H37Rv PLGTPSGRIEIFSDTVDAFALPDCAGHPTWYEPSEWLGGPRAAR-YPLHL Mflv_3958|M.gilvum_PYR-GCK PLATPSGRIEIFSADIDSFGYDDCRGHPAWFEPTEWLGGPRAAD-YPLHL Mvan_2438|M.vanbaalenii_PYR-1 RLATPSGRIEIFSADIAGFGYRDCVGHPAWFEPAEWLGGPRAER-YPLHL MSMEG_2738|M.smegmatis_MC2_155 PLGTPSGRIEIFSEDIDSFGYDDCAGHPRWYEPAEWLGGERARR-YPLHL MAB_3041|M.abscessus_ATCC_1997 PLHTPSGRIEIFSETIDGFGYSDCGGHPQWYEPTEWLGGERAQR-FPLHL MMAR_2605|M.marinum_M DFGPMVSQ--LPDILGTPEKKIRLAPQYLLDDLPRLASR-MDRPAEQLVL TH_4041|M.thermoresistible__bu VVADRVPTGVLGKVVRHRGGRVCLAPDEVVAEVHRLGQRHPDDPAYPLLA MAV_2075|M.avium_104 SQTQLVREDGTVPRLAFPTP----SGRAVFFARPHLQPEEMPDDDYPFLL MUL_1474|M.ulcerans_Agy99 SQLQFVRADGTVPRLAFPTA----TGRAVFFARPHLVPDEMPDGDYPFLL . : Mb1477|M.bovis_AF2122/97 IANQPRTRLHSQLDHGGASMASKIRGREPIRIHPDDAAARELTDGDIVRV Rv1442|M.tuberculosis_H37Rv IANQPRTRLHSQLDHGGASMASKIRGREPIRIHPDDAAARELTDGDIVRV Mflv_3958|M.gilvum_PYR-GCK VANQPAGRLHGQLDAGAASQATKVAGREPIRMHPADAHARDLSGGDVVRV Mvan_2438|M.vanbaalenii_PYR-1 LANQPASRLHSQLDGGATSQASKVAGREPVRMHPDDAAERGLAAGDVVRM MSMEG_2738|M.smegmatis_MC2_155 LANQPASRLHSQLDGGATSQSSKVQGREPVRMHPSDAAARGLADGDVVRV MAB_3041|M.abscessus_ATCC_1997 IANQPRTRLHSQLDFGGTSQGSKVRGREPLRIHPQDAATRGIADGDVVRV MMAR_2605|M.marinum_M VNRRHLRSNNSWLHN--VPALMKGKDRCTLLMHPDDAARNGITDNDTVTV TH_4041|M.thermoresistible__bu IGMREMRSQNTWMHN--SPTLMKGDRRHRARIHPADAAAAGVTHGGPVRI MAV_2075|M.avium_104 NTGRLPHQWHTMTKTGKVAKLNKLNPGPFVEIHPDDAARLGIGEHDRVEI MUL_1474|M.ulcerans_Agy99 NTGRLAHQWHTLTKTGKIAKLNKLNPGPFVEVHPDDAADMQICEGDHIEI : : . . * :** ** : . : : Mb1477|M.bovis_AF2122/97 FNDRGACLAGVVIDDGLRPKVVQLSTGAWFDPADPRDPDSMCVHGNPNAL Rv1442|M.tuberculosis_H37Rv FNDRGACLAGVVIDDGLRPKVVQLSTGAWFDPADPRDPDSMCVHGNPNAL Mflv_3958|M.gilvum_PYR-GCK FNDRGACLAGVVLDDRVRPQVVQLSTGAWFDPADPADPHSMCVHGNPNVL Mvan_2438|M.vanbaalenii_PYR-1 FNDSGACLAGVVLDDRVRPRVVQLSTGAWFDPADPADPDSMCVHGNPNML MSMEG_2738|M.smegmatis_MC2_155 FNDRGACLAGVVIDDGVLPRVVQLATGAWYDPADPADPDSLCLHGNPNVL MAB_3041|M.abscessus_ATCC_1997 FNDRGACLAGAVLDEGLRRQVVQLSTGAWFDPIEPADPNSACAHGNPNVL MMAR_2605|M.marinum_M RSSAGEITVPVELTSAIKPGVVSMPHGWGHGKPGTRLAVANSAPGVNTNV TH_4041|M.thermoresistible__bu ESPYGAIETEALCTDEMTPGTVAIPHGWGHNG-GWRLANRLAGANVNELT MAV_2075|M.avium_104 ASRRGRAVLPAVVSDRVRPGNCFAPFHWNDAFGEYLSINAVTNDAVDPIS MUL_1474|M.ulcerans_Agy99 ASRRGRAVLPVVITDRVRPGNCFAPFHWNDAFGEYLSINAVTNDAVDPIS . * . . : . Mb1477|M.bovis_AF2122/97 SND----------------------------SGTSSLAHGSTGQHVLVQI Rv1442|M.tuberculosis_H37Rv SND----------------------------SGTSSLAHGSTGQHVLVQI Mflv_3958|M.gilvum_PYR-GCK TDD----------------------------VGTSKLAHGCTGAHVLVQI Mvan_2438|M.vanbaalenii_PYR-1 TDD----------------------------VGTSALAHGCTGAHALVQI MSMEG_2738|M.smegmatis_MC2_155 TDD----------------------------VGTSSLAKGCTGAHVLVEI MAB_3041|M.abscessus_ATCC_1997 TDD----------------------------SGTSSLAQGCTGQHVLVQI MMAR_2605|M.marinum_M LSP-----------------------------------------PTLLDE TH_4041|M.thermoresistible__bu SND-----------------------------------------SADLER MAV_2075|M.avium_104 NQPEFKACAVTLTKVAVSHPDSAIG-TGPSAGHDTPESAPTEVREISVSQ MUL_1474|M.ulcerans_Agy99 RQPEYKACAVTLTKVARPQLQPEPGEPADACADATAPKLLADTAQFSVTQ . : Mb1477|M.bovis_AF2122/97 ERFTGELPPVRAHEPPRLA------------------------------- Rv1442|M.tuberculosis_H37Rv ERFTGELPPVRAHEPPRLA------------------------------- Mflv_3958|M.gilvum_PYR-GCK EKYAGTPPPVRAHQPPVFTPR----------------------------- Mvan_2438|M.vanbaalenii_PYR-1 EKYTAAPPPVRAHQPPVFAAR----------------------------- MSMEG_2738|M.smegmatis_MC2_155 EKFAGPVPPVRAHEPPVIRTLR---------------------------- MAB_3041|M.abscessus_ATCC_1997 ERFEGTPPPVRAHTPPRFVARD---------------------------- MMAR_2605|M.marinum_M PSGNGVLNGIPVTVS----------------------------------- TH_4041|M.thermoresistible__bu LAGMSVLNGVPVRLVPVG-------------------------------- MAV_2075|M.avium_104 VDALGELLGVATSFKPEFNELGRSYLAGMLTGLRSDVGRRAGGVPTLPPS MUL_1474|M.ulcerans_Agy99 VDALAELLGVGNEPTPQFGPSARSYLAGLIAGLRSETGRRMAGVSTLPIS . : Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- TH_4041|M.thermoresistible__bu -------------------------------------------------- MAV_2075|M.avium_104 APFDSRTRLWVDGLLAGLFSRADASQQAALPEPPQPAAQQPPAAPAGATP MUL_1474|M.ulcerans_Agy99 SPFDTGTRLWLDGLLAGMFARAETPPALPFPQTPGAAAQSDNAAEA---- Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- TH_4041|M.thermoresistible__bu -------------------------------------------------- MAV_2075|M.avium_104 APERAPVVVLWASQTGNAEELAADVAAQLAAAELPVALHSMDDFPAAELA MUL_1474|M.ulcerans_Agy99 AVEQPPIVVLWASQTGTAEELAASVAAQLSAAELPVVLHGMDEFAVADLV Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- TH_4041|M.thermoresistible__bu -------------------------------------------------- MAV_2075|M.avium_104 ATRELLLITSTTGDGDAPDNGSGLWRALTGDAAPRLGNTRYAVLALGDSN MUL_1474|M.ulcerans_Agy99 STQRLLLVTSTTGDGEPPDNGAAFWRELCAPTAPSLAGTRYSVLALGDSN Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- TH_4041|M.thermoresistible__bu -------------------------------------------------- MAV_2075|M.avium_104 YDDFCGHGRKLDARLAELGATRIAERVDCEPDYEQAAAKWVADVIEALTR MUL_1474|M.ulcerans_Agy99 YADFCGHGRALDHRLAELGASRITDRVDCEPDYEESAARWLQEVLDGLRR Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- TH_4041|M.thermoresistible__bu -------------------------------------------------- MAV_2075|M.avium_104 TPTAVGGDGGATVSARTSPVAAPSRPNTPAPHTYSKKHPLITDMVRNTTL MUL_1474|M.ulcerans_Agy99 TAPPV---------ITAEPVRAASIASR--PQGYTKKRPLLTSVMRNTTL Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- TH_4041|M.thermoresistible__bu -------------------------------------------------- MAV_2075|M.avium_104 NGPKSTKDVRHLVFNLPEDAVSYEAGDALGVWPRNSDELVDEWLAVTGLD MUL_1474|M.ulcerans_Agy99 SRPRSAKDVRQLVFRVPEQTVSYEAGDALGVWPRNAHQLVDEWLGVTRLD Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- TH_4041|M.thermoresistible__bu -------------------------------------------------- MAV_2075|M.avium_104 GQTPVEVGEHGLMSLRSALTERIEIAHISRDLVRFVQERTGDA----KLA MUL_1474|M.ulcerans_Agy99 GHTEVEVAGHGTMSLRAALTDRFEIAHLSPDLLRFVAQRTLDSNTANQLA Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- TH_4041|M.thermoresistible__bu -------------------------------------------------- MAV_2075|M.avium_104 ELLKPENKRALADWTWGRQSIDLLAQLPVSASAHEWLRVLKRLQPRLYSI MUL_1474|M.ulcerans_Agy99 ELMRPENKAALADWTWGRQSVDLLAQSPVRASVDEWMSVLKPIQPRLYSI Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- TH_4041|M.thermoresistible__bu -------------------------------------------------- MAV_2075|M.avium_104 SSSPKACPGEVHLTVSPVRYNFQGVPRRGVCSTYLAARSPGDRVAVYLQP MUL_1474|M.ulcerans_Agy99 SSSPKEHPGEVHLTVSPVRYNFQGVPRRGVCSTYLADRSPSDQIAIYVRK Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- TH_4041|M.thermoresistible__bu -------------------------------------------------- MAV_2075|M.avium_104 SSNFRPPSDPDTPMIMIGPGTGIAPFRGFLQERRALGHRGPNWLFFGEQH MUL_1474|M.ulcerans_Agy99 SSNFRPPSDPRTPMIMIGPGTGIAPFRGFLQERRALGHTGPNWLFFGEQH Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- TH_4041|M.thermoresistible__bu -------------------------------------------------- MAV_2075|M.avium_104 AATDFYYRDELEQMREDGFLTELDLAFSRDQQHKVYVQHLMRNRGKQLWS MUL_1474|M.ulcerans_Agy99 AATDFYYRDEIQAMHRDGLLTNLDLAFSRDQRDKVYVQHLMQQRGAQLWQ Mb1477|M.bovis_AF2122/97 -------------------------------------------------- Rv1442|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_3958|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2438|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2738|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3041|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_2605|M.marinum_M -------------------------------------------------- TH_4041|M.thermoresistible__bu -------------------------------------------------- MAV_2075|M.avium_104 WLQDGAQLYVCGTADPMAKDVDRALCDIAAEFGNLDPDAAKAYVQSLSAD MUL_1474|M.ulcerans_Agy99 WLQDGAQVYVCGTADPMAKDVDRMLCQIVAEHGGLDPESATAFVHALSAD Mb1477|M.bovis_AF2122/97 -------- Rv1442|M.tuberculosis_H37Rv -------- Mflv_3958|M.gilvum_PYR-GCK -------- Mvan_2438|M.vanbaalenii_PYR-1 -------- MSMEG_2738|M.smegmatis_MC2_155 -------- MAB_3041|M.abscessus_ATCC_1997 -------- MMAR_2605|M.marinum_M -------- TH_4041|M.thermoresistible__bu -------- MAV_2075|M.avium_104 KRYHRDVY MUL_1474|M.ulcerans_Agy99 KRYHRDVY