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M. bovis AF2122 / 97 Mb1477 (bisC)

annotation: biotin sulfoxide reductase
coordinates: 1616119 - 1618419
length: 766

MQVYTSATHWGVFTARVHGGDIAAVAALASDTNPAPQLQNLPGAVRHRSRIANPAVRRGWLQHGPGPSSA
RGAEEFVEVSWDELIELLASELRRTVDRYGNEAIYGSSYGWASAGRFHHAQSQVHRFLNMLGGYTASRHS
YSAGASEVIFPHIVGAALFEALAETTTWDVIVDHTALLVAFGGLPVKNTAVMPGGTTAHPDRDYVGRYRA
RGGRLVSVSPLRDDIAAIAGPLDDRCRWLAPVPGTDVAIMLGLAYVLATESLADRAFLGRYCTGYERFER
YLLGLDDGIPKTPEWAAALSGLAAGDLRDLARRMAEHRTLITTSLSLQRIEHGEQTVWMAATLAAMLGQI
GLPGGGFGHGYSSNGVGNPPLACGLPALPQGNNPVSTFIPVAAISELLQRPGQRLAYNGRLLELPDIKCV
YWAGGNPFHHHQNLPRLRRALSRVDTIVVHEQYWTAMAKHADIVVPTTTSFERDDFAASKTNPTLIAMPA
MVPPYANARDDYHTFSALAHRLGFGKQFTEGRSAREWLEHMYDKWSAELDFPVPSFAEFWRTGRLELPTR
TGLTWLADFRADPAAHPLGTPSGRIEIFSDTVDAFALPDCAGHPTWYEPSEWLGGPRAARYPLHLIANQP
RTRLHSQLDHGGASMASKIRGREPIRIHPDDAAARELTDGDIVRVFNDRGACLAGVVIDDGLRPKVVQLS
TGAWFDPADPRDPDSMCVHGNPNALSNDSGTSSLAHGSTGQHVLVQIERFTGELPPVRAHEPPRLA
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1477bisC-100% (766)biotin sulfoxide reductase
M. bovis AF2122 / 97Mb2924cfdhF6e-0924.40% (336) formate dehydrogenase H
M. bovis AF2122 / 97Mb1193narG6e-0924.47% (331) respiratory nitrate reductase subunit alpha NarG

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_3958-0.068.16% (760) molybdopterin guanine dinucleotide-containing S/N-oxide
M. tuberculosis H37RvRv1442bisC0.0100.00% (766) biotin sulfoxide reductase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_3041-0.070.21% (762) putative biotin sulfoxide reductase BisC
M. marinum MMMAR_2605-1e-1922.95% (671) anaerobic dehydrogenase
M. avium 104MAV_2075-2e-1921.58% (505) FdhF protein
M. smegmatis MC2 155MSMEG_2738-0.070.13% (760) biotin sulfoxide reductase
M. thermoresistible (build 8)TH_4041-5e-3026.29% (677) PUTATIVE Formate dehydrogenase
M. ulcerans Agy99MUL_1474fdhF3e-1922.02% (504) formate dehydrogenase H FdhF
M. vanbaalenii PYR-1Mvan_2438-0.067.23% (763) molybdopterin guanine dinucleotide-containing S/N-oxide

CLUSTAL 2.0.9 multiple sequence alignment


Mb1477|M.bovis_AF2122/97            -------------------------------------MQVYTSATHWGVF
Rv1442|M.tuberculosis_H37Rv         -------------------------------------MQVYTSATHWGVF
Mflv_3958|M.gilvum_PYR-GCK          MLQSTSITKSPRRIDSKERRLFHPSFRRNGVRRLSCVARTRTSLTHWGAF
Mvan_2438|M.vanbaalenii_PYR-1       MVG-----------------------RGGRAVRLSSVSATQTSLTHWGAF
MSMEG_2738|M.smegmatis_MC2_155      ------------------------------------MPHSPTSLTHWGVF
MAB_3041|M.abscessus_ATCC_1997      -------------------------MIRPAFSAVQVSGSARLSHTHWGAF
MMAR_2605|M.marinum_M               -----------------------------------MATVDDGRHLHTCPL
TH_4041|M.thermoresistible__bu      --------------------------------------MATEQRVTYCRI
MAV_2075|M.avium_104                -------------------------------------------MNTMCAY
MUL_1474|M.ulcerans_Agy99           ------------------------------------MAPNKDAVKTVCAY
                                                                                      

Mb1477|M.bovis_AF2122/97            TARVHGGDIAAVAALASDTNPAPQLQNLPGAVRHRSRIANPAVRRGWLQH
Rv1442|M.tuberculosis_H37Rv         TARVHGGDIAAVAALASDTNPAPQLQNLPGAVRHRSRIANPAVRRGWLQH
Mflv_3958|M.gilvum_PYR-GCK          SATVESGDIASVRPWSGDADPSPALGNLPGSVRHRSRVTAPAVRRGWLEN
Mvan_2438|M.vanbaalenii_PYR-1       SATVEAGEITAVAPVAGDDDPSVALGNLPGSVRHISRVTTPAVRRGWLDH
MSMEG_2738|M.smegmatis_MC2_155      SAEIVDGDIAAVNPPPDDADPSPLLGNMPGSIRHRARITGPAVRRGWLRD
MAB_3041|M.abscessus_ATCC_1997      TPEVRDGEVIGVTPIETDLDPSPLLQNIPGSIRHQARVTAPAVRSGWLRE
MMAR_2605|M.marinum_M               CEAMCGLEIRVADGPSGG--RVVGIRGNRDDVWSRGHICPKGASLGALHD
TH_4041|M.thermoresistible__bu      CEPLCGLIATVEDG------RLQSLRPDPDHPLSRGRACPKGIAFTEVQN
MAV_2075|M.avium_104                CGVGCGMVLQITTDPQTGRRHVAKSVGNKEHPANFGRLCTKGATTADLLA
MUL_1474|M.ulcerans_Agy99           CGVGCGIVLQTTTDPQTGKRRVAKSTGDKSHPANLGRLCTKGTTTADLLA
                                                                       .:    .     :  

Mb1477|M.bovis_AF2122/97            GPG-----PSSARGAEEFVEVSWDELIELLASELRRTVDRYGNEAIYGSS
Rv1442|M.tuberculosis_H37Rv         GPG-----PSSARGAEEFVEVSWDELIELLASELRRTVDRYGNEAIYGSS
Mflv_3958|M.gilvum_PYR-GCK          GPG-----PDTLLGADEFVAVTWDDLVELLGGELRRVIDTHGNEAIYGGS
Mvan_2438|M.vanbaalenii_PYR-1       GPG-----PDDSRGADDFVAVTWDELTELLGDELRRVIDTHGNGAIYGGS
MSMEG_2738|M.smegmatis_MC2_155      GPG-----PSTERGADEFVAVSWDELTDLLATELRRVVDTYGNEAIYGGS
MAB_3041|M.abscessus_ATCC_1997      GPG-----PSDKRGADEYVEVSWDELTELLADELRRVVDTHGNEAIYGGS
MMAR_2605|M.marinum_M               DPDRIRHPMIK--IDGQWHEVSWDAAFRRCTELLAPVIDTYGIGAVT---
TH_4041|M.thermoresistible__bu      DPDRVLYPLRRR-ADGEFERVGWDEALDDIAARLTAIRDRHGGGAIG---
MAV_2075|M.avium_104                APGRMDSAHARAGRGEPLEPIGTDQAITRCAKQLRAIIDEHGPDAFA---
MUL_1474|M.ulcerans_Agy99           APGRMESAHLRAHRAGHLESIPIDDAITQCAMRLRAIIDEHGPDAVG---
                                     *.                 :  *         *    * :*  *.    

Mb1477|M.bovis_AF2122/97            YGWASAGRFHHAQSQVHRFLNMLGGYTASRHSYSAGASEVIFPHIVGAAL
Rv1442|M.tuberculosis_H37Rv         YGWASAGRFHHAQSQVHRFLNMLGGYTASRHSYSAGASEVIFPHIVGAAL
Mflv_3958|M.gilvum_PYR-GCK          YGWSSAGRFHHAQSQVHRFLNCLGGYTYSRHSYSLGATGVIMPRVVG-TH
Mvan_2438|M.vanbaalenii_PYR-1       YGWSSAGRFHHAQSQVHRFLNCLGGYTFSRHSYSLGATGVIMPRVVG-TH
MSMEG_2738|M.smegmatis_MC2_155      YGWSSAGRFHHAQSQVHRFLKMLGGYTFSRHSYSLGATGAIMPRVVG-TH
MAB_3041|M.abscessus_ATCC_1997      YGWASAGRFHHAQSQVHRFLKLLGGYTFSRHSYSLGATGVIMPHVIG-TH
MMAR_2605|M.marinum_M               ---AYTGNPLAHSFSLARYAGVLLGMSGMPVTYSP-GTVDQWPKNLSSHL
TH_4041|M.thermoresistible__bu      ---QYFGNPVAFGYATALWSGMFVARLGSRHQYSS-GSQDINSRFVASKL
MAV_2075|M.avium_104                ---MYVSGQMSLEAQYLANK-LTKGFIGTNQIESN-SRLCMASAGSGYKL
MUL_1474|M.ulcerans_Agy99           ---VYVSGQMSIEAQYLANK-LTKGFIGTKQIESN-SRLCMAGASSGYKL
                                          .                 .        *  .         .   

Mb1477|M.bovis_AF2122/97            FEALAETTTWDVIVDHTALLVAFGGLPVKNTAVMPGGTTAHPDRDYVGRY
Rv1442|M.tuberculosis_H37Rv         FEALAETTTWDVIVDHTALLVAFGGLPVKNTAVMPGGTTAHPDRDYVGRY
Mflv_3958|M.gilvum_PYR-GCK          DDLFTRSTQWQVIVENTDTMVCFGGLALKNTAVNDGGTTAHPARDALNRL
Mvan_2438|M.vanbaalenii_PYR-1       DDLFKRSTQWDVIVEHTDLMVCFGGVALKNTGVNHGGTTAHPARGALDRF
MSMEG_2738|M.smegmatis_MC2_155      DDLFKRSTQWDVIVEHTGLMVCFGGMPLKNTGINDGGTSAHPMRDALRRF
MAB_3041|M.abscessus_ATCC_1997      DGLFKRSTSWDVIVENTDLLIAFGGIALKNTGVNHGGTTAHPARDALNRF
MMAR_2605|M.marinum_M               MYGGWWTFP-VPDIERTDLLVIMG----ANPAASQGSLLAAPDVMGLIDA
TH_4041|M.thermoresistible__bu      LYGAASQIP-FPDLPRTDFLFMLG----ANPFVSHGSALRAPRIKDDLTD
MAV_2075|M.avium_104                SLGADGPPGSYQDFEHADVFFVIG----ANMADCHPILFLR-----MMDR
MUL_1474|M.ulcerans_Agy99           SLGADGPPGSYQDFDHADVFLVIG----ANMADCHPILFLR-----MMER
                                                 . .:  :. :*     *                    

Mb1477|M.bovis_AF2122/97            RARGGRLVSVSPLRDDIAAIAGPLDDRCRWLAPVPGTDVAIMLGLAYVLA
Rv1442|M.tuberculosis_H37Rv         RARGGRLVSVSPLRDDIAAIAGPLDDRCRWLAPVPGTDVAIMLGLAYVLA
Mflv_3958|M.gilvum_PYR-GCK          RARGGRIVSFSPLRDDV-------DGPCDWHAPVPGTDVAIMLALAHVLA
Mvan_2438|M.vanbaalenii_PYR-1       RARGGHLVSFSPLRDDV-------DGPCDWFAPVPGTDVAIMLALAHVLA
MSMEG_2738|M.smegmatis_MC2_155      RGRGGRIVSFSPLRDDV-------DGDCQWLALRPGTDVAVMLGLAYVLA
MAB_3041|M.abscessus_ATCC_1997      RDRGGRIVSFSPLHDDI-------DGECEWHAPIPGTDVAVMLALAHVLA
MMAR_2605|M.marinum_M               IRQRGKVIVIDPVRTVT------AARADEWLPIVPGTDAALLLAVAHTLF
TH_4041|M.thermoresistible__bu      ITRRGGRVVVVDPRRTE------TARAFEHIAVRPDSDAWLLLSMLQVIF
MAV_2075|M.avium_104                VKAGAKLIVVDPRRTAT------AEKADLFLQIAPGTDLALLNGLLHLIV
MUL_1474|M.ulcerans_Agy99           VKSGAKLIVVDPRRTAT------ADKADLFLQIAPGTDLALLNGLLHLIV
                                        .  : .   :                    *.:*  :: .:   : 

Mb1477|M.bovis_AF2122/97            TESLADRAFLGRYCTGYERFERYLLGLDDGIPKTPEWAAALSGLAAGDLR
Rv1442|M.tuberculosis_H37Rv         TESLADRAFLGRYCTGYERFERYLLGLDDGIPKTPEWAAALSGLAAGDLR
Mflv_3958|M.gilvum_PYR-GCK          TESLADREFLASHCTGYDRFERYLLGADDGIPKSPQWASSLCGLSADDLT
Mvan_2438|M.vanbaalenii_PYR-1       AESLADRDFLATYCTGYDRFERYLLGVDDGTPKSPQWAAQICGLDADDLT
MSMEG_2738|M.smegmatis_MC2_155      TEGLADREFLDTHCTGYERFERYLLGHDDGVAKSPEWAAHISGLSADTLR
MAB_3041|M.abscessus_ATCC_1997      VEKLADLTFLSSYCTGYERFERYLLGVDDGVPKSPEWAAPISGLDAAELR
MMAR_2605|M.marinum_M               DEDLVN---PGPHVDGVDTMRRVAADWP------PARVSAVTGIEEERIR
TH_4041|M.thermoresistible__bu      AEGLEDTAAIARQTTGCSTLRGLVAGFP------PEATAARTGVPADVVR
MAV_2075|M.avium_104                ENGHTDGEFIAEFTEGWEVMPSFLEQYT------PDRVSEITGIPEQDIR
MUL_1474|M.ulcerans_Agy99           ENEQTDPQFISEFTEGWEVMPSFLEQFT------PDRVSEITGIPSEDIR
                                     :   :         * . :              *  .:   *:    : 

Mb1477|M.bovis_AF2122/97            DLARRMAEHRTLITTSLS-LQRIEHGEQTVWMAATLAAMLGQIGLPGGGF
Rv1442|M.tuberculosis_H37Rv         DLARRMAEHRTLITTSLS-LQRIEHGEQTVWMAATLAAMLGQIGLPGGGF
Mflv_3958|M.gilvum_PYR-GCK          ALARRMAAGRTLVTVSWS-LQRTRHGEQAPWMGLTLAAMLGQIGLPGGGF
Mvan_2438|M.vanbaalenii_PYR-1       ALARRMAACRTIVTVSWS-LQRTRHGEQAPWMGLTLAAMLGQIGLPGGGF
MSMEG_2738|M.smegmatis_MC2_155      ALAHRMAAERTIVTVSWS-LQRTRHGEQAPWMGVTLAAMLGQIGLPGGGF
MAB_3041|M.abscessus_ATCC_1997      TLARRMAAGRTLVTVSWS-LQRVRHGEQAPWMGLTLAAMLGQIGLPGGGF
MMAR_2605|M.marinum_M               RLARELAGTHKSVVYGRIGLCNQEFGSLASWLVDVINILTGHFDTPGGAM
TH_4041|M.thermoresistible__bu      SLARDFAAAPTAAAYGRTGACLGRHGTLVSFLLDALSIVTGNLDREGGLL
MAV_2075|M.avium_104                AAAQLIGEADNFMSCWTMGLNQSTHGTWNTNAICNLHLATGAICKPGSGP
MUL_1474|M.ulcerans_Agy99           TAARWIGTAANWMSCWTMGLNQSTHGTWNTNALCNLHLATGAICRPGSGP
                                      *: :.   .             .*         :    * :   *.  

Mb1477|M.bovis_AF2122/97            GHGY-SSNGVGNPPLACGLPALPQGNNPVSTFIPVAAISELLQRPGQRLA
Rv1442|M.tuberculosis_H37Rv         GHGY-SSNGVGNPPLACGLPALPQGNNPVSTFIPVAAISELLQRPGQRLA
Mflv_3958|M.gilvum_PYR-GCK          GHGYGSMNEAGLAPIRCGLPRLPQGVNPVTTFIPVAAVSDMLLHPGEPFD
Mvan_2438|M.vanbaalenii_PYR-1       GHGYGSMNEPGLAPVRCGLPRLPQGINPVTTFIPVAAVSDMLLSPGEPFD
MSMEG_2738|M.smegmatis_MC2_155      GHGYGSMNEPGLAPLRCRLPSLPQGPNPVRTFIPVAAVTDMLLHPGEPFD
MAB_3041|M.abscessus_ATCC_1997      GHGYGSMNEPGLAPVSCPLPTFPQGPNPVETFIPVAAISELLLRPGQTLA
MMAR_2605|M.marinum_M               FPRPAAWSITTQPLPGLEGG--VAEFGRWHTRV-RGAKEVLGQAPVSCLA
TH_4041|M.thermoresistible__bu      MAH----AVIPFEELGERTG--RLTYGTERSRI-GGLPEVISTFPAALMA
MAV_2075|M.avium_104                FSLTGQPNAMGGREMGYMGPGLPGQRSVASAAD-REFVEDVWGVPRGRLR
MUL_1474|M.ulcerans_Agy99           FSLTGQPNAMGGREMGYMGPGLPGQRSVLSAPD-REFVEEQWGLPGGALR
                                                              .   :             *   : 

Mb1477|M.bovis_AF2122/97            YNGRL--------LELPDIKCVYWAGGNPFHHHQNLPRLRRALSRVDTIV
Rv1442|M.tuberculosis_H37Rv         YNGRL--------LELPDIKCVYWAGGNPFHHHQNLPRLRRALSRVDTIV
Mflv_3958|M.gilvum_PYR-GCK          YNGLR--------LTYPDIRLVYWAGGNPFHHHQNLPRLRRALSRPDTVV
Mvan_2438|M.vanbaalenii_PYR-1       YNGLR--------LHYPDIRLVYWAGGNPFHHHQNIPRLRRALRRPDTVV
MSMEG_2738|M.smegmatis_MC2_155      YNGLR--------LTYPDIKCVYWSGGNPFHHHQNIPRLRRALGRVDTIV
MAB_3041|M.abscessus_ATCC_1997      YNGQT--------LTLPDIRCVYWAGGNPFHHHQNLPRLRRALSRVDTVV
MMAR_2605|M.marinum_M               EEIAT--------PGDGQLRALITIAGNPVLSTPGGDKLDEALSSLEAMI
TH_4041|M.thermoresistible__bu      DEINT--------PGDGQLRALFVTAGNPVLTVPNGPALEKVLGKLDLIV
MAV_2075|M.avium_104                TEVGTGTIDMFSRMADGQIKACWIICTNPVASVANRKTVLAGLERAELVI
MUL_1474|M.ulcerans_Agy99           TDVSGGVIDMFSRMADGEIKACWIICSNPVATVANRKTVLAGLEKAELVI
                                     :               :::       **.    .   :   *   : ::

Mb1477|M.bovis_AF2122/97            VHEQYWT-AMAKHADIVVPTTTSFERD----DFAASKTNPTLIAMPAMVP
Rv1442|M.tuberculosis_H37Rv         VHEQYWT-AMAKHADIVVPTTTSFERD----DFAASKTNPTLIAMPAMVP
Mflv_3958|M.gilvum_PYR-GCK          VHDPYWT-AMAKHADIVVPSTTFAERD----DLSGSRNDPMLMAMPRLTE
Mvan_2438|M.vanbaalenii_PYR-1       VHDPYWT-PMAKHADIVVPSTTFAERH----DFSGSRNDPVLMAMRRLAE
MSMEG_2738|M.smegmatis_MC2_155      VHDPYWT-AMAKHADIVVPSTTSFERN----DFSGSKNDPLLVAMPQLAE
MAB_3041|M.abscessus_ATCC_1997      VHDPVWT-AMAKHADIVVPSTTSLERD----DFSGSRNDPLLVAMKAVAP
MMAR_2605|M.marinum_M               SVDLWLN-ETTRHADVILPGLSPLEQPHHDDLVLQFAIRSFANYSAPVFD
TH_4041|M.thermoresistible__bu      SLDFYVT-ETNRHAHYVLPATTFLERDDYPYGFAANCPTVFIQSAEPVVG
MAV_2075|M.avium_104                AQDAYLGTETSEYADVLLPAALWAETE----GVMVNSERNIT-LSQPAVA
MUL_1474|M.ulcerans_Agy99           SQDAFFETETNEYANVLLPAALWTESD----GVMVNCERNMS-LFPKAVD
                                      :        .:*. ::*     *       .                 

Mb1477|M.bovis_AF2122/97            PYANARDDYHTFSALAHRLG-----------------FGKQFTEGRSARE
Rv1442|M.tuberculosis_H37Rv         PYANARDDYHTFSALAHRLG-----------------FGKQFTEGRSARE
Mflv_3958|M.gilvum_PYR-GCK          TYAQARDDYDTYAALAGHLG-----------------VRQAFTEGRSSRQ
Mvan_2438|M.vanbaalenii_PYR-1       PYAQARDDYDTFAALARRLG-----------------VADTFTEGRTSAQ
MSMEG_2738|M.smegmatis_MC2_155      PYADSRDDYTTFSALAERLG-----------------FGEQFTEGRTAWE
MAB_3041|M.abscessus_ATCC_1997      PYANSRDDYTTFSALADRLG-----------------FGEQFSEGRTAAQ
MMAR_2605|M.marinum_M               P-GDRPHEWEILIRLTGLCTGTPAEDVDVAAIDDGFFDYLAFTKGFDGAA
TH_4041|M.thermoresistible__bu      AYGEARNEWEVFDELARRMG--------LSLFATGPLERLNPVLAWLDRR
MAV_2075|M.avium_104                APGGAMPDWQIIARIACEMG---------------FSEAFSYSCAEEVFE
MUL_1474|M.ulcerans_Agy99           PVGDALPDWQIIARIACEMG---------------FSESFSYSSAAEVFE
                                    . .    ::     ::                            .     

Mb1477|M.bovis_AF2122/97            WLEHMYDKWSAELDFPVPSFAEFWRTGRLELPTRTGLTWLADFRADPAAH
Rv1442|M.tuberculosis_H37Rv         WLEHMYDKWSAELDFPVPSFAEFWRTGRLELPTRTGLTWLADFRADPAAH
Mflv_3958|M.gilvum_PYR-GCK          WLRHIYETWSRTLDFDVPAFDGFWAAGALRLPTDDGLTLLADFRADPSAH
Mvan_2438|M.vanbaalenii_PYR-1       WLRHLYEKWSATLDFEVPSFDEFWQVGQVRLPTDEGLTLFADFRADPSAH
MSMEG_2738|M.smegmatis_MC2_155      WLVHLYEKWAAGLDFAVPSFAEFWAAGHVELPTDTGLTLFEDFRADPQAH
MAB_3041|M.abscessus_ATCC_1997      WLRHIYTEWAGALNFSVPSFDEFWDRGYLELPTDAGLTLLSDFRENPAAH
MMAR_2605|M.marinum_M               IRKRYEHDGWAGGPERILDLTLRTGPFGDRYGQNPGGLTLDMLKANPNGI
TH_4041|M.thermoresistible__bu      GVGRLT-------PRRLMELLLRLGPYGDRFGLRRGGLNPRRLRENPHGI
MAV_2075|M.avium_104                EIKRFWNPTTGYDLRGVSYERLRRQPLQWPCPPQ-STADRNPIRYLNDGV
MUL_1474|M.ulcerans_Agy99           EIKRFSNPATGYDLRGISHDRLRETPLQWPCPPD-GASNRSPIRYLNDGV
                                       :            :                  .      ::    . 

Mb1477|M.bovis_AF2122/97            PLGTPSGRIEIFSDTVDAFALPDCAGHPTWYEPSEWLGGPRAAR-YPLHL
Rv1442|M.tuberculosis_H37Rv         PLGTPSGRIEIFSDTVDAFALPDCAGHPTWYEPSEWLGGPRAAR-YPLHL
Mflv_3958|M.gilvum_PYR-GCK          PLATPSGRIEIFSADIDSFGYDDCRGHPAWFEPTEWLGGPRAAD-YPLHL
Mvan_2438|M.vanbaalenii_PYR-1       RLATPSGRIEIFSADIAGFGYRDCVGHPAWFEPAEWLGGPRAER-YPLHL
MSMEG_2738|M.smegmatis_MC2_155      PLGTPSGRIEIFSEDIDSFGYDDCAGHPRWYEPAEWLGGERARR-YPLHL
MAB_3041|M.abscessus_ATCC_1997      PLHTPSGRIEIFSETIDGFGYSDCGGHPQWYEPTEWLGGERAQR-FPLHL
MMAR_2605|M.marinum_M               DFGPMVSQ--LPDILGTPEKKIRLAPQYLLDDLPRLASR-MDRPAEQLVL
TH_4041|M.thermoresistible__bu      VVADRVPTGVLGKVVRHRGGRVCLAPDEVVAEVHRLGQRHPDDPAYPLLA
MAV_2075|M.avium_104                SQTQLVREDGTVPRLAFPTP----SGRAVFFARPHLQPEEMPDDDYPFLL
MUL_1474|M.ulcerans_Agy99           SQLQFVRADGTVPRLAFPTA----TGRAVFFARPHLVPDEMPDGDYPFLL
                                                                      .            :  

Mb1477|M.bovis_AF2122/97            IANQPRTRLHSQLDHGGASMASKIRGREPIRIHPDDAAARELTDGDIVRV
Rv1442|M.tuberculosis_H37Rv         IANQPRTRLHSQLDHGGASMASKIRGREPIRIHPDDAAARELTDGDIVRV
Mflv_3958|M.gilvum_PYR-GCK          VANQPAGRLHGQLDAGAASQATKVAGREPIRMHPADAHARDLSGGDVVRV
Mvan_2438|M.vanbaalenii_PYR-1       LANQPASRLHSQLDGGATSQASKVAGREPVRMHPDDAAERGLAAGDVVRM
MSMEG_2738|M.smegmatis_MC2_155      LANQPASRLHSQLDGGATSQSSKVQGREPVRMHPSDAAARGLADGDVVRV
MAB_3041|M.abscessus_ATCC_1997      IANQPRTRLHSQLDFGGTSQGSKVRGREPLRIHPQDAATRGIADGDVVRV
MMAR_2605|M.marinum_M               VNRRHLRSNNSWLHN--VPALMKGKDRCTLLMHPDDAARNGITDNDTVTV
TH_4041|M.thermoresistible__bu      IGMREMRSQNTWMHN--SPTLMKGDRRHRARIHPADAAAAGVTHGGPVRI
MAV_2075|M.avium_104                NTGRLPHQWHTMTKTGKVAKLNKLNPGPFVEIHPDDAARLGIGEHDRVEI
MUL_1474|M.ulcerans_Agy99           NTGRLAHQWHTLTKTGKIAKLNKLNPGPFVEVHPDDAADMQICEGDHIEI
                                       :     :   .    .   *        :** **    :   . : :

Mb1477|M.bovis_AF2122/97            FNDRGACLAGVVIDDGLRPKVVQLSTGAWFDPADPRDPDSMCVHGNPNAL
Rv1442|M.tuberculosis_H37Rv         FNDRGACLAGVVIDDGLRPKVVQLSTGAWFDPADPRDPDSMCVHGNPNAL
Mflv_3958|M.gilvum_PYR-GCK          FNDRGACLAGVVLDDRVRPQVVQLSTGAWFDPADPADPHSMCVHGNPNVL
Mvan_2438|M.vanbaalenii_PYR-1       FNDSGACLAGVVLDDRVRPRVVQLSTGAWFDPADPADPDSMCVHGNPNML
MSMEG_2738|M.smegmatis_MC2_155      FNDRGACLAGVVIDDGVLPRVVQLATGAWYDPADPADPDSLCLHGNPNVL
MAB_3041|M.abscessus_ATCC_1997      FNDRGACLAGAVLDEGLRRQVVQLSTGAWFDPIEPADPNSACAHGNPNVL
MMAR_2605|M.marinum_M               RSSAGEITVPVELTSAIKPGVVSMPHGWGHGKPGTRLAVANSAPGVNTNV
TH_4041|M.thermoresistible__bu      ESPYGAIETEALCTDEMTPGTVAIPHGWGHNG-GWRLANRLAGANVNELT
MAV_2075|M.avium_104                ASRRGRAVLPAVVSDRVRPGNCFAPFHWNDAFGEYLSINAVTNDAVDPIS
MUL_1474|M.ulcerans_Agy99           ASRRGRAVLPVVITDRVRPGNCFAPFHWNDAFGEYLSINAVTNDAVDPIS
                                     .  *     .   . :       .                         

Mb1477|M.bovis_AF2122/97            SND----------------------------SGTSSLAHGSTGQHVLVQI
Rv1442|M.tuberculosis_H37Rv         SND----------------------------SGTSSLAHGSTGQHVLVQI
Mflv_3958|M.gilvum_PYR-GCK          TDD----------------------------VGTSKLAHGCTGAHVLVQI
Mvan_2438|M.vanbaalenii_PYR-1       TDD----------------------------VGTSALAHGCTGAHALVQI
MSMEG_2738|M.smegmatis_MC2_155      TDD----------------------------VGTSSLAKGCTGAHVLVEI
MAB_3041|M.abscessus_ATCC_1997      TDD----------------------------SGTSSLAQGCTGQHVLVQI
MMAR_2605|M.marinum_M               LSP-----------------------------------------PTLLDE
TH_4041|M.thermoresistible__bu      SND-----------------------------------------SADLER
MAV_2075|M.avium_104                NQPEFKACAVTLTKVAVSHPDSAIG-TGPSAGHDTPESAPTEVREISVSQ
MUL_1474|M.ulcerans_Agy99           RQPEYKACAVTLTKVARPQLQPEPGEPADACADATAPKLLADTAQFSVTQ
                                     .                                             :  

Mb1477|M.bovis_AF2122/97            ERFTGELPPVRAHEPPRLA-------------------------------
Rv1442|M.tuberculosis_H37Rv         ERFTGELPPVRAHEPPRLA-------------------------------
Mflv_3958|M.gilvum_PYR-GCK          EKYAGTPPPVRAHQPPVFTPR-----------------------------
Mvan_2438|M.vanbaalenii_PYR-1       EKYTAAPPPVRAHQPPVFAAR-----------------------------
MSMEG_2738|M.smegmatis_MC2_155      EKFAGPVPPVRAHEPPVIRTLR----------------------------
MAB_3041|M.abscessus_ATCC_1997      ERFEGTPPPVRAHTPPRFVARD----------------------------
MMAR_2605|M.marinum_M               PSGNGVLNGIPVTVS-----------------------------------
TH_4041|M.thermoresistible__bu      LAGMSVLNGVPVRLVPVG--------------------------------
MAV_2075|M.avium_104                VDALGELLGVATSFKPEFNELGRSYLAGMLTGLRSDVGRRAGGVPTLPPS
MUL_1474|M.ulcerans_Agy99           VDALAELLGVGNEPTPQFGPSARSYLAGLIAGLRSETGRRMAGVSTLPIS
                                        .    :                                        

Mb1477|M.bovis_AF2122/97            --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_3958|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2738|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MAV_2075|M.avium_104                APFDSRTRLWVDGLLAGLFSRADASQQAALPEPPQPAAQQPPAAPAGATP
MUL_1474|M.ulcerans_Agy99           SPFDTGTRLWLDGLLAGMFARAETPPALPFPQTPGAAAQSDNAAEA----
                                                                                      

Mb1477|M.bovis_AF2122/97            --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_3958|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2738|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MAV_2075|M.avium_104                APERAPVVVLWASQTGNAEELAADVAAQLAAAELPVALHSMDDFPAAELA
MUL_1474|M.ulcerans_Agy99           AVEQPPIVVLWASQTGTAEELAASVAAQLSAAELPVVLHGMDEFAVADLV
                                                                                      

Mb1477|M.bovis_AF2122/97            --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_3958|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2738|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MAV_2075|M.avium_104                ATRELLLITSTTGDGDAPDNGSGLWRALTGDAAPRLGNTRYAVLALGDSN
MUL_1474|M.ulcerans_Agy99           STQRLLLVTSTTGDGEPPDNGAAFWRELCAPTAPSLAGTRYSVLALGDSN
                                                                                      

Mb1477|M.bovis_AF2122/97            --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_3958|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2738|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MAV_2075|M.avium_104                YDDFCGHGRKLDARLAELGATRIAERVDCEPDYEQAAAKWVADVIEALTR
MUL_1474|M.ulcerans_Agy99           YADFCGHGRALDHRLAELGASRITDRVDCEPDYEESAARWLQEVLDGLRR
                                                                                      

Mb1477|M.bovis_AF2122/97            --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_3958|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2738|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MAV_2075|M.avium_104                TPTAVGGDGGATVSARTSPVAAPSRPNTPAPHTYSKKHPLITDMVRNTTL
MUL_1474|M.ulcerans_Agy99           TAPPV---------ITAEPVRAASIASR--PQGYTKKRPLLTSVMRNTTL
                                                                                      

Mb1477|M.bovis_AF2122/97            --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_3958|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2738|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MAV_2075|M.avium_104                NGPKSTKDVRHLVFNLPEDAVSYEAGDALGVWPRNSDELVDEWLAVTGLD
MUL_1474|M.ulcerans_Agy99           SRPRSAKDVRQLVFRVPEQTVSYEAGDALGVWPRNAHQLVDEWLGVTRLD
                                                                                      

Mb1477|M.bovis_AF2122/97            --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_3958|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2738|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MAV_2075|M.avium_104                GQTPVEVGEHGLMSLRSALTERIEIAHISRDLVRFVQERTGDA----KLA
MUL_1474|M.ulcerans_Agy99           GHTEVEVAGHGTMSLRAALTDRFEIAHLSPDLLRFVAQRTLDSNTANQLA
                                                                                      

Mb1477|M.bovis_AF2122/97            --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_3958|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2738|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MAV_2075|M.avium_104                ELLKPENKRALADWTWGRQSIDLLAQLPVSASAHEWLRVLKRLQPRLYSI
MUL_1474|M.ulcerans_Agy99           ELMRPENKAALADWTWGRQSVDLLAQSPVRASVDEWMSVLKPIQPRLYSI
                                                                                      

Mb1477|M.bovis_AF2122/97            --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_3958|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2738|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MAV_2075|M.avium_104                SSSPKACPGEVHLTVSPVRYNFQGVPRRGVCSTYLAARSPGDRVAVYLQP
MUL_1474|M.ulcerans_Agy99           SSSPKEHPGEVHLTVSPVRYNFQGVPRRGVCSTYLADRSPSDQIAIYVRK
                                                                                      

Mb1477|M.bovis_AF2122/97            --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_3958|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2738|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MAV_2075|M.avium_104                SSNFRPPSDPDTPMIMIGPGTGIAPFRGFLQERRALGHRGPNWLFFGEQH
MUL_1474|M.ulcerans_Agy99           SSNFRPPSDPRTPMIMIGPGTGIAPFRGFLQERRALGHTGPNWLFFGEQH
                                                                                      

Mb1477|M.bovis_AF2122/97            --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_3958|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2738|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MAV_2075|M.avium_104                AATDFYYRDELEQMREDGFLTELDLAFSRDQQHKVYVQHLMRNRGKQLWS
MUL_1474|M.ulcerans_Agy99           AATDFYYRDEIQAMHRDGLLTNLDLAFSRDQRDKVYVQHLMQQRGAQLWQ
                                                                                      

Mb1477|M.bovis_AF2122/97            --------------------------------------------------
Rv1442|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_3958|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2438|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2738|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3041|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_2605|M.marinum_M               --------------------------------------------------
TH_4041|M.thermoresistible__bu      --------------------------------------------------
MAV_2075|M.avium_104                WLQDGAQLYVCGTADPMAKDVDRALCDIAAEFGNLDPDAAKAYVQSLSAD
MUL_1474|M.ulcerans_Agy99           WLQDGAQVYVCGTADPMAKDVDRMLCQIVAEHGGLDPESATAFVHALSAD
                                                                                      

Mb1477|M.bovis_AF2122/97            --------
Rv1442|M.tuberculosis_H37Rv         --------
Mflv_3958|M.gilvum_PYR-GCK          --------
Mvan_2438|M.vanbaalenii_PYR-1       --------
MSMEG_2738|M.smegmatis_MC2_155      --------
MAB_3041|M.abscessus_ATCC_1997      --------
MMAR_2605|M.marinum_M               --------
TH_4041|M.thermoresistible__bu      --------
MAV_2075|M.avium_104                KRYHRDVY
MUL_1474|M.ulcerans_Agy99           KRYHRDVY