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MARLLVTGGAGFIGSNFVHHVLAHTDHHVTVLDKLTYAGNRASLDGLPERRLDFVHGDVADADLVDELVA GTDAVVHYAAESHNDNSLDRPEPFLHSNVIGTFTVLEAVRRHGRRLHHVSTDEVYGDLELDDPARFTESS PYNPSSPYSSTKAGSDLLVRAWTRSFGVAATISNCSNNYGPYQHVEKFIPRQITNVLWGIRPRLYGEGRN VRDWIHADDHSSAVLLILEKGRIGETYLIGANGEKDNKTVVELILTLMGEDADAYDRVPDRLGHDLRYAI DPTKLREELGWQPGYGDFEHGLAATIEWYRTHEDWWTPAKEATEAFYARIGQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3296 | - | - | 100% (332) | dTDP-glucose 4,6-dehydratase |
| M. gilvum PYR-GCK | Mflv_5007 | - | e-124 | 65.37% (335) | dTDP-glucose 4,6-dehydratase |
| M. gilvum PYR-GCK | Mflv_1401 | - | 8e-18 | 28.34% (307) | UDP-glucose 4-epimerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3493 | rmlB1 | 1e-136 | 70.69% (331) | dTDP-glucose 4,6-dehydratase RmlB1 |
| M. tuberculosis H37Rv | Rv3464 | rmlB | 1e-136 | 70.69% (331) | dTDP-glucose 4,6-dehydratase RMLB |
| M. leprae Br4923 | MLBr_01964 | rmlB | 1e-127 | 65.86% (331) | dTDP-glucose 4,6-dehydratase |
| M. abscessus ATCC 19977 | MAB_3779 | - | 1e-132 | 67.98% (331) | dTDP-glucose 4,6-dehydratase RmlB |
| M. marinum M | MMAR_1082 | rmlB | 1e-135 | 69.18% (331) | dTDP-glucose-4,6-dehydratase, RmlB |
| M. avium 104 | MAV_4406 | rfbB | 1e-134 | 69.49% (331) | dTDP-glucose 4,6-dehydratase |
| M. smegmatis MC2 155 | MSMEG_1512 | rfbB | 1e-130 | 68.58% (331) | dTDP-glucose 4,6-dehydratase |
| M. thermoresistible (build 8) | TH_0330 | rfbB | 1e-123 | 69.97% (303) | dTDP-glucose 4,6-dehydratase |
| M. ulcerans Agy99 | MUL_0840 | rmlB | 1e-135 | 69.18% (331) | dTDP-glucose-4,6-dehydratase, RmlB |
| M. vanbaalenii PYR-1 | Mvan_1365 | - | 1e-129 | 68.07% (332) | dTDP-glucose 4,6-dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3493|M.bovis_AF2122/97 -------------MRLLVTGGAGFIGTNFVHSAVREHPDDA--VTVLDAL
Rv3464|M.tuberculosis_H37Rv -------------MRLLVTGGAGFIGTNFVHSAVREHPDDA--VTVLDAL
MMAR_1082|M.marinum_M -------------MRLLVTGGAGFIGANFVHSSVREYPDDA--VTVLDAL
MUL_0840|M.ulcerans_Agy99 -------------MRLLVTGGAGFIGANFVHSSVREYPDDA--VTVLDAL
MAV_4406|M.avium_104 -------------MRLLVTGGAGFIGANFVHSTVREHPEDS--VTVLDAL
MLBr_01964|M.leprae_Br4923 -----------MTMRLLVTGGAGFIGANFVHNAVRDHPDDT--VTVLDAM
MSMEG_1512|M.smegmatis_MC2_155 -------------MRLLVTGGAGFIGANFVHLALREARTSS--ITVLDAL
TH_0330|M.thermoresistible__bu VAAIVAAVRCAAAVSSRSSSGGSIRPRSITPSSEKNPRSEAXXXTGLDAF
Mvan_1365|M.vanbaalenii_PYR-1 -------------MRLLVTGGAGFIGANFVRTTVQQRPDVQ--VTVLDSL
MAB_3779|M.abscessus_ATCC_1997 -------------MRILVTGGAGFIGANFVHATVRERPDVS--VTVLDAL
Mflv_3296|M.gilvum_PYR-GCK ------------MARLLVTGGAGFIGSNFVHH-VLAHTDHH--VTVLDKL
:.*..: .:. * ** :
Mb3493|M.bovis_AF2122/97 TYAGRRESLADVED-AIRLVQGDITDAELVSQLVAESDAVVHFAAESHVD
Rv3464|M.tuberculosis_H37Rv TYAGRRESLADVED-AIRLVQGDITDAELVSQLVAESDAVVHFAAESHVD
MMAR_1082|M.marinum_M TYAGRRESLADLED-AIRLVEGDITDAELVSQLVAESDAVVHFAAESHVD
MUL_0840|M.ulcerans_Agy99 TYAGRRESLADLED-AIRLVEGDITDAELVSQLVAESDAVVHFAAESHVD
MAV_4406|M.avium_104 TYAGRRESLAGVED-SIRLVVGDITDAELVSRLVAESDAVVHFAAESHVD
MLBr_01964|M.leprae_Br4923 TYAGRHESLADVDH-AVRLVQGNITDTKLVFRLVAESDVVVHFAAETHVD
MSMEG_1512|M.smegmatis_MC2_155 TYAGSRESLAPVAD-RIRLVQGDITDAALVGDLVAESDAVVHFAAETHVD
TH_0330|M.thermoresistible__bu TYAGSRESLAPVAD-RIRVVEGDVTDSDLVDKLVAESDAVVHFAAESHVD
Mvan_1365|M.vanbaalenii_PYR-1 TYAGSRESLRGVDS-QIRLVEGDITDAELVGKLVADSDAVVHFAAETHVD
MAB_3779|M.abscessus_ATCC_1997 TYAGSSESLAPVAA-AVQLVQGDICDPDTVERLVADSDVVVHFAAETHND
Mflv_3296|M.gilvum_PYR-GCK TYAGNRASLDGLPERRLDFVHGDVADADLVDELVAGTDAVVHYAAESHND
**** ** : : .* *:: *. * *** :*.***:***:* *
Mb3493|M.bovis_AF2122/97 NALDNPEPFLHTNVIGTFTILEAVRRHG----VRLHHISTDEVYGDLELD
Rv3464|M.tuberculosis_H37Rv NALDNPEPFLHTNVIGTFTILEAVRRHG----VRLHHISTDEVYGDLELD
MMAR_1082|M.marinum_M NALDNPEPFVHTNVLGTFTILEAVRRHG----VRLHHISTDEVYGDLELH
MUL_0840|M.ulcerans_Agy99 NALDNPEPFVHTNVLGTFTILEAVRRHG----VRLHHISTDEVYGDLELH
MAV_4406|M.avium_104 NALAGPEPFLHTNVVGTFTILEAVRRHG----VRLHHISTDEVYGDLELD
MLBr_01964|M.leprae_Br4923 NALDDPEPFLRTNVIGTFTILEAVRHHS----VRLHHISTDEVYGDLELD
MSMEG_1512|M.smegmatis_MC2_155 NALADPEPFLHSNVVGTYTILEAVRRHN----VRLHHVSTDEVYGDLELD
TH_0330|M.thermoresistible__bu NALAEPEPFLRTNVVGTFTVLEAVRRHR----VRLHHISTDEVYGDLPLH
Mvan_1365|M.vanbaalenii_PYR-1 NALADPEPFVHSNVLGTFTVLEAVRHASVTKPVRLHHISTDEVYGDLELD
MAB_3779|M.abscessus_ATCC_1997 NSLADPSPFLRSNIIGTYTLLEAVRRHQ----VRLHHISTDEVFGDLELD
Mflv_3296|M.gilvum_PYR-GCK NSLDRPEPFLHSNVIGTFTVLEAVRRHG----RRLHHVSTDEVYGDLELD
*:* *.**:::*::**:*:*****: ****:*****:*** *.
Mb3493|M.bovis_AF2122/97 DRARFTESTPYNPSSPYSATKAGADMLVRAWVRSYGVRATISNCSNNYGP
Rv3464|M.tuberculosis_H37Rv DRARFTESTPYNPSSPYSATKAGADMLVRAWVRSYGVRATISNCSNNYGP
MMAR_1082|M.marinum_M DPARFTEATPYNPSSPYSATKAGADMLVRAWVRSYGVAATISNCSNNYGP
MUL_0840|M.ulcerans_Agy99 DPARFTEATPYNPSSPYSATKAGADMLVRAWVRSYGVAATISNCSNNYGP
MAV_4406|M.avium_104 DPNRFTESTPYNPSSPYSATKAAADMLVRAWVRSYGVRATISNCSNNYGP
MLBr_01964|M.leprae_Br4923 EPTRFTESTPYNPSSPYSATKAAGDMLVRAWVRSYGVRATISNCSNNYGP
MSMEG_1512|M.smegmatis_MC2_155 NPARFNETTPYNPSSPYSSTKAAADLLVRAWVRSYGVRATISNCSNNYGP
TH_0330|M.thermoresistible__bu DPRRFTESTPYNPSSPYSSTKAAADMLVRAWVRSYGVAATISNCSNNYGP
Mvan_1365|M.vanbaalenii_PYR-1 DPARFTDATPYNPSSPYSSTKAAADMLVRAWVRSYRVAATISNCSNNYGP
MAB_3779|M.abscessus_ATCC_1997 DPNRFTETTPYNPSSPYSATKASADLLVRAWIRSFGISATISNCSNNYGP
Mflv_3296|M.gilvum_PYR-GCK DPARFTESSPYNPSSPYSSTKAGSDLLVRAWTRSFGVAATISNCSNNYGP
: **.:::*********:***..*:***** **: : ************
Mb3493|M.bovis_AF2122/97 YQHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSAVRRILDRG
Rv3464|M.tuberculosis_H37Rv YQHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSAVRRILDRG
MMAR_1082|M.marinum_M YQHIEKFIPRQITNVLTGRRPKLYGTGANVRDWIHVDDHNSAVRRILEKG
MUL_0840|M.ulcerans_Agy99 YQHIEKFIPRQITNVLTGRRPKLYGTGANVRDWIHVDDHNSAVRRILEKG
MAV_4406|M.avium_104 YQHVEKFIPRQITNVLTGRRPKLYGTGANVRDWIHVDDHNSAVRRILESG
MLBr_01964|M.leprae_Br4923 YQHVEKFIPRQITNVLTGRRPKLYGTGVNVRDWIHVDDHNSAVWQILEKG
MSMEG_1512|M.smegmatis_MC2_155 YQHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSAVWRILTDG
TH_0330|M.thermoresistible__bu YQHVEKFIPRQITNVLTGRRPKLYGTGANVRDWIHVEDHNDAVWRILTAG
Mvan_1365|M.vanbaalenii_PYR-1 YQHVEKFIPRQITNVLTGRRPELYGTGANVRDWIHVDDHNSAVWRILHDG
MAB_3779|M.abscessus_ATCC_1997 YQHVEKFIPRQITNILTGRRPRLYGAGANVRDWIHVDDHNSAVWRIIEAG
Mflv_3296|M.gilvum_PYR-GCK YQHVEKFIPRQITNVLWGIRPRLYGEGRNVRDWIHADDHSSAVLLILEKG
***:**********:* * **.*** * *******.:**..** *: *
Mb3493|M.bovis_AF2122/97 RIGRTYLISSEGERDNLTVLRTLLRLMDRDPDDFDHVTDRVGHDLRYAID
Rv3464|M.tuberculosis_H37Rv RIGRTYLISSEGERDNLTVLRTLLRLMDRDPDDFDHVTDRVGHDLRYAID
MMAR_1082|M.marinum_M QIGKTYLISSEGERDNLSVLRTLLRMMDRDPDDFDHVVDRVGHDLRYAID
MUL_0840|M.ulcerans_Agy99 QIGKTYLISSEGERDNLSVLRTLLRMMDRDPDDFDHVVDRVGHDLRYAID
MAV_4406|M.avium_104 EIGRTYLISSEGERDNLTVLRTLLQMMGRDPDDFDHVTDRVGHDLRYAID
MLBr_01964|M.leprae_Br4923 QIGRTYLIGAENGHNNLTVLRTLLQMMGRDPNDFDHVTDRVGHDLRYAID
MSMEG_1512|M.smegmatis_MC2_155 TIGRTYLIGAECERNNLTVMRTILKLMGRDPDDFDHVTDRAGHDLRYAID
TH_0330|M.thermoresistible__bu QIGRTYLIGADGERDNRTVLRTILKLMDRDPDDFDHVTDRAGHDLRYAID
Mvan_1365|M.vanbaalenii_PYR-1 TVGRTYLIGADGERDNLSVMRTILRLMGRSPEDFDHVTDRVGHDLRYAID
MAB_3779|M.abscessus_ATCC_1997 TIGRTYLIGADGERDNLSVLHTILELMGKSSDDFDHVTDRAGHDLRYAID
Mflv_3296|M.gilvum_PYR-GCK RIGETYLIGANGEKDNKTVVELILTLMGEDADAYDRVPDRLGHDLRYAID
:*.****.:: ::* :*:. :* :*....: :*:* ** *********
Mb3493|M.bovis_AF2122/97 PSTLYDELCWAPKHTDFEEGLRTTIDWYRDNESWWRPLKDATEARYQERG
Rv3464|M.tuberculosis_H37Rv PSTLYDELCWAPKHTDFEEGLRTTIDWYRDNESWWRPLKDATEARYQERG
MMAR_1082|M.marinum_M PSLLYNELAWAPKHTDFEEGLRTTIDWYRANESWWRPLKDAAEARYQERG
MUL_0840|M.ulcerans_Agy99 PSLLYNELAWAPKHTDFEEGLRTTIDWYRANESWWRPLKDAAEARYQERG
MAV_4406|M.avium_104 PSTLYDELCWAPKHTDFEEGLRETIDWYRANESWWRPLKDASEARYEERG
MLBr_01964|M.leprae_Br4923 PTPLYNELCWAPKHANFDEGLRATIDWYRNNESWWRPLKDAVEARYEERG
MSMEG_1512|M.smegmatis_MC2_155 PSTLQDELGWAPKHTDFEAGLTDTIDWYRANESWWRPLKDTVEAKYQERG
TH_0330|M.thermoresistible__bu PSALIDELGWTPRHTDFEAGLRDTIQWYRDNEDWWRPLKDATEDAYAERG
Mvan_1365|M.vanbaalenii_PYR-1 PTPLRDELGWRPEHTDFESGLRDTIDWYRDNESWWGPLKDAVEATYQRRR
MAB_3779|M.abscessus_ATCC_1997 PTPLRDELGWKPTHSDFTGGLAATIDWYRRNEEWWRPIKDNVESQYAARG
Mflv_3296|M.gilvum_PYR-GCK PTKLREELGWQPGYGDFEHGLAATIEWYRTHEDWWTPAKEATEAFYARIG
*: * :** * * : :* ** **:*** :*.** * *: * *
Mb3493|M.bovis_AF2122/97 Q
Rv3464|M.tuberculosis_H37Rv Q
MMAR_1082|M.marinum_M Q
MUL_0840|M.ulcerans_Agy99 Q
MAV_4406|M.avium_104 Q
MLBr_01964|M.leprae_Br4923 R
MSMEG_1512|M.smegmatis_MC2_155 Q
TH_0330|M.thermoresistible__bu Q
Mvan_1365|M.vanbaalenii_PYR-1 R
MAB_3779|M.abscessus_ATCC_1997 Q
Mflv_3296|M.gilvum_PYR-GCK Q
: